专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2016149900A1 AN OPTICAL LENS AND A SPOTLIGHT INCLUDING THE SAME 审中-公开
标题翻译：一个光学镜头和一个包括它的镜头
公开(公告)号：WO2016149900A1
公开(公告)日：2016-09-29
申请号：PCT/CN2015/074916
申请日：2015-03-24
申请人： XU, Hong
发明人： XU, Hong
IPC分类号： F21V7/09 , F21Y101/02
CPC分类号： G02B3/04 , F21V5/048 , F21V7/0091 , F21Y2115/10
摘要： A conical frustum shaped optical lens (110) is made of transparent material, the conical frustum shaped optical lens (110) having a long diameter at a first end and a short diameter at a second end and the conical frustum shaped optical lens (110) defined by multiple rotational surfaces (210, 220, 230, 240) and a flat fifth surface (250). The conical frustum shaped optical lens (110) is configured to create folded light paths within the conical frustum shaped optical lens (110) such that a majority of light from a light source is reflected twice within the conical frustum shaped optical lens (110) before being output. An MR16 form factor LED spotlight including the conical frustum shaped optical lens (110) can achieve a reduced light beam angle and a higher central luminous intensity.
摘要翻译：锥形截头锥形光学透镜（110）由透明材料制成，锥形截头锥形光学透镜（110）在第一端具有长直径，在第二端具有短直径，并且锥形截头锥形光学透镜（110）由多个旋转表面（210,220,230,240）和平坦的第五表面（250）限定。锥形截头锥形光学透镜（110）构造成在锥形截头锥形光学透镜（110）内产生折叠光路，使得来自光源的大部分光在锥形截头锥形光学透镜（110）内反射两次，之前被输出。包括锥形截头锥形光学透镜（110）的MR16形状因子LED射灯可以实现减小的光束角度和较高的中心发光强度。

2. 发明申请

WO2012087451A1 DUAL HEAT STABILED POLYMER SENSOR FILMS 审中-公开
标题翻译：双热稳定聚合物传感器膜
公开(公告)号：WO2012087451A1
公开(公告)日：2012-06-28
申请号：PCT/US2011/060153
申请日：2011-11-10
申请人： GENERAL ELECTRIC COMPANY , CHEN, Bingzhi , SUNDARESAN, Vidyasankar , BOYETTE, Scott, Martell , CLEMENS, Janine , XU, Hong
发明人： CHEN, Bingzhi , SUNDARESAN, Vidyasankar , BOYETTE, Scott, Martell , CLEMENS, Janine , XU, Hong
IPC分类号： G01N31/22
CPC分类号： G01N31/22
摘要： Methods are provided for improving the stability and shelf life of film sensors. The film sensors include a combination of polymeric matrix film material, analyte indicator, and solvent which has been heated in a first heat treatment application to volatilize most of the solvent and to solidify the analyte indicator to form the film sensor. The improvement comprises subjecting the film sensor to a second heat treatment to set the film and improve stability and shelf life.
摘要翻译：提供了用于提高薄膜传感器的稳定性和保质期的方法。膜传感器包括聚合物基质膜材料，分析物指示剂和在第一热处理应用中被加热以溶解大部分溶剂并固化分析物指示剂以形成膜传感器的溶剂的组合。改进之处在于使薄膜传感器进行第二次热处理以设置薄膜并提高稳定性和保质期。

3. 发明申请

WO2009120313A3 IDENTIFICATION OF HUMAN T2R RECEPTORS THAT RESPOND TO BITTER LIGANDS IN SOY AND RELATED ASSAYS FOR IDENTIFYING BITTER TASTE MODULATORS 审中-公开
标题翻译：识别大豆中双歧杆菌配偶体的人类T2R受体的鉴定和相关测定用于鉴别叮咬调味品
公开(公告)号：WO2009120313A3
公开(公告)日：2009-12-30
申请号：PCT/US2009001829
申请日：2009-03-24
申请人： SENOMYX INC , LI XIAODONG , XU HONG , ZHANG LAN , LIU HANGHUI , WU KEPING
发明人： LI XIAODONG , XU HONG , ZHANG LAN , LIU HANGHUI , WU KEPING
IPC分类号： C12Q1/68 , A23L11/00 , A61K36/48 , C07K14/705 , C12Q1/00 , G01N33/566 , G01N33/567
CPC分类号： C12Q1/6895 , G01N33/5008 , G01N33/566 , G01N2500/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in hydrolyzed soy protein derived materials. The invention further relates to the use of these T2R receptors in assays for identifying ligands that modulate the activation of these taste receptors by specific bitter ligands present in hydrolyzed soy protein materials and derivatives thereof and related compounds. These compounds may be used as additives and/or removed from soy-based foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste elicited by bitter ligands present in hydrolyzed soy protein materials. Also these T2R ligands potentially may be used as therapeutics to treat and modulate hT2R1, hT2R8, hT2R14, hT2R44, hT2R55, hT2R61, hT2R63, hT2R64, hT2R67 and hT2R71 associated gastrointestinal and metabolic functions such as serum cholesterol levels as well as treat gastrointestinal and metabolic diseases such as eating disorders, food sensing, food absorption, obesity, diabetes, Crohn's disease, celiac disease, et al.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对存在于水解大豆蛋白衍生物质中的特定苦味化合物的反应的发现。本发明还涉及这些T2R受体在用于鉴定通过存在于水解大豆蛋白材料及其衍生物和相关化合物中的特定苦味配体调节这些味觉受体的活化的配体的测定中的用途。这些化合物可以用作添加剂和/或从大豆基食品，饮料，化妆品和药物中去除，以便改变（阻断）水解大豆蛋白材料中存在的苦配子引起的与T2R相关的苦味。此外，这些T2R配体潜在地可以用作治疗和调节hT2R1，hT2R8，hT2R14，hT2R44，hT2R55，hT2R61，hT2R63，hT2R64，hT2R67和hT2R71相关的胃肠道和代谢功能如血清胆固醇水平以及治疗胃肠道和代谢疾病如饮食失调，食物感染，食物吸收，肥胖，糖尿病，克罗恩病，乳糜泻等。

4. 发明申请

WO2009025793A2 IDENTIFICATION OF HUMAN T2R RECEPTORS THAT RESPOND TO BITTER COMPOUNDS THAT ELICIT THE BITTER TASTE IN COMPOSITIONS, AND THE USE THEREOF IN ASSAYS TO IDENTIFY COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITIONS AND USE THEREOF 审中-公开
标题翻译：识别符合组合物中双歧杆菌组合物的双特异度化合物的人类T2R受体，以及其在测定中的用途，以鉴定组合物中的禁止（块状）双歧杆菌组合物及其用途的化合物
公开(公告)号：WO2009025793A2
公开(公告)日：2009-02-26
申请号：PCT/US2008/009864
申请日：2008-08-19
申请人： SENOMYX, INC. , LI, Xiaodong , PATRON, Andrew , TACHDJIAN, Catherine , XU, Hong , LI, Qing , PRONIN, Alexey , SERVANT, Guy , ZHANG, Lan , BRADY, Thomas , DARMOHUSODO, Vincent , ARELLANO, Melissa , SELCHAU, Victor , CHING, Brett Weylan , KARANEWSKY, Donald S. , BRUST, Paul , LING, Jing , ZHAO, Wen , PRIEST, Chad
发明人： LI, Xiaodong , PATRON, Andrew , TACHDJIAN, Catherine , XU, Hong , LI, Qing , PRONIN, Alexey , SERVANT, Guy , ZHANG, Lan , BRADY, Thomas , DARMOHUSODO, Vincent , ARELLANO, Melissa , SELCHAU, Victor , CHING, Brett Weylan , KARANEWSKY, Donald S. , BRUST, Paul , LING, Jing , ZHAO, Wen , PRIEST, Chad
IPC分类号： C12Q1/68
CPC分类号： C07C311/17 , A23L27/86 , A61K8/46 , A61K8/466 , A61K8/4933 , A61K8/494 , A61K8/4973 , A61K8/498 , A61K8/4986 , A61K31/135 , A61K31/4439 , A61K31/485 , A61K31/60 , A61K31/704 , A61K45/06 , A61Q11/00 , C07C233/73 , C07C311/04 , C07C311/13 , C07C311/16 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/21 , C07C311/29 , C07C311/46 , C07C323/49 , C07C335/16 , C07C335/18 , C07D213/42 , C07D213/71 , C07D217/08 , C07D223/18 , C07D307/14 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/34 , A61K2300/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对存在于例如咖啡中的特定苦味化合物的反应的发现。此外，本发明涉及含有作为苦味抑制剂的特定化合物和组合物的发现，以及其作为例如咖啡和咖啡风味食品，饮料和药物中的苦味抑制剂或风味调节剂的用途。此外，本发明涉及一种拮抗多种不同人类T2R的化合物的发现及其在测定中的用途以及用于摄取人类和动物的组合物中的苦味阻滞剂。

5. 发明申请

WO2009000296A2 COMPOUNDS FOR USE IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES AND TRANSPLANT REJECTION 审中-公开
标题翻译：用于治疗自身免疫和炎症疾病和移植物排斥的化合物
公开(公告)号：WO2009000296A2
公开(公告)日：2008-12-31
申请号：PCT/EP2007/005620
申请日：2007-06-25
申请人： ONCOREG AB , GLAS, Rickard , XU, Hong
发明人： GLAS, Rickard , XU, Hong
IPC分类号： A61K38/00 , A61K38/06 , A61P37/00 , A61P29/00 , A61P43/00 , A61P37/06 , A61P17/00 , A61P1/04 , A61P19/02 , A61P3/10 , A61P27/02 , A61P25/28 , A61P9/10
CPC分类号： A61K38/06
摘要： TPP Il (tripeptidyl peptidase II) inhibitors are useful in the treatment of autoimmune and/or inflammatory diseases, for example Systemic Lupus Erythematosus, Rheumatoid Arthritis, Multiple Sclerosis, Sjögrens Syndrome, Diabetes Mellitus Type I or II, Psoriasis, Eczema, Ulcerous Colitis, and Chron's Disease, or transplant rejection. Suitable compounds comprise tripeptide compounds of general formula R N1 R N2 N-A 1 -A 2 -A 3 -CO-R C1 wherein R N1 , R N2 , A 1 , A 2 , A 3 and R C1 are as defined herein, and which include for example the tripeptide sequences GLA and GPG.
摘要翻译： TPP II（三肽基肽酶II）抑制剂可用于治疗自身免疫性和/或炎症性疾病，例如系统性红斑狼疮，类风湿关节炎，多发性硬化症，Sjögren综合征，I型或II型糖尿病，牛皮癣，湿疹，溃疡性结肠炎，和Chron病，或移植排斥。合适的化合物包括通式为RN1RN2N-A1-A2-A3-CO-RC1的三肽化合物，其中RN1，RN2，A1，A2，A3和RC1如本文所定义，并且其包括例如三肽序列GLA和GPG。

6. 发明申请

WO2008057470A3 IDENTIFICATION OF BITTER LIGANDS THAT SPECIFICALLY ACTIVATE HUMAN T2R RECEPTORS AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS 审中-公开
标题翻译：识别特异性激活人类T2R受体的双键配体和用于鉴定人类叮咬调味剂的相关测定
公开(公告)号：WO2008057470A3
公开(公告)日：2008-10-23
申请号：PCT/US2007023230
申请日：2007-11-01
申请人： SENOMYX INC , LI XIAODONG , XU HONG , LI QING , TANG HUIXIAN , PRONIN ALEXEY
发明人： LI XIAODONG , XU HONG , LI QING , TANG HUIXIAN , PRONIN ALEXEY
IPC分类号： C12N15/12 , G01N33/53 , G01N33/566
CPC分类号： G01N33/566 , G01N33/5008 , G01N33/5023 , G01N2500/00 , G01N2500/10
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. Also, the invention relates to the discovery of specific hT2R9 alleles and their disparate activity in functional assays with the same biter ligands. The invention further relates to the use of these T2R receptors in assays for identifying ligands that modulate the activation of these taste receptors by specific bitter ligands and related compounds. These compounds may be used as additives and/or removed from foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste. Also T2R ligands may be used as therapeutics to treat and modulate T2R associated gastrointestinal and metabolic functions as well as treat gastrointestinal and metabolic diseases such as eating disorders, food sensing, food absorption, obesity, diabetes, Crohn's diseae, celiac disease, et al.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味化合物的反应的发现。此外，本发明涉及特异性hT2R9等位基因的发现及其在具有相同配体配体的功能测定中的不同活性。本发明还涉及这些T2R受体在用于鉴定通过特定的苦配体和相关化合物调节这些味觉受体的活化的配体的测定中的用途。这些化合物可以用作添加剂和/或从食品，饮料，化妆品和药物中去除，以便改变（阻断）T2R相关的苦味。也可以使用T2R配体作为治疗和调节T2R相关胃肠道和代谢功能以及治疗胃肠道和代谢疾病如饮食失调，食物感觉，食物吸收，肥胖，糖尿病，克罗恩病，乳糜泻等的治疗剂。

7. 发明申请

WO2007080194A3 USE OF TPP II INHIBITORS IN COMBINATION WITH GAMMA-IRRADIATION FOR THE TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2007080194A3
公开(公告)日：2007-07-19
申请号：PCT/EP2007/050363
申请日：2007-01-15
申请人： ONCOREG AB , GLAS, Rickard , XU, Hong
发明人： GLAS, Rickard , XU, Hong
IPC分类号： A61K38/06 , A61P35/00 , A61N5/10
摘要： TPP II (tripeptidyl peptidase II) inhibitors are useful in enhancing the efficacy of gamma- irradiation cancer therapy or increasing the in vivo gamma-irradiation susceptibility of tumour cells. Suitable compounds comprise tripeptide compounds of general formula R N1 R N2 N-A 1 -A 2 -A 3 -CO-R C1 wherein R N1 , R N2 , A 1 , A 2 , A 3 and R C1 are as defined herein, and which include for example the tripeptide sequences GLA and GPG. Complete in vivo tumor regression in mice injected with TPPII inhibitors is observed, during treatment in combination with gamma-irradiation.

8. 发明申请

WO2007047988A2 CHIMERIC HUMAN SWEET-UMAMI AND UMAMI-SWEET TASTE RECEPTORS 审中-公开
标题翻译： CHIMERIC人类SWEET-UMAMI和UMAMI-SWEET TASTE RECEPTORS
公开(公告)号：WO2007047988A2
公开(公告)日：2007-04-26
申请号：PCT/US2006/041158
申请日：2006-10-19
申请人： SENOMYX, INC. , LI, Xiaodong , ZHANG, Feng , XU, Hong , LI, Qing
发明人： LI, Xiaodong , ZHANG, Feng , XU, Hong , LI, Qing
IPC分类号： C07K14/705
CPC分类号： C07K14/705 , C12N2503/00 , C12N2510/00
摘要： This invention relates to chimeric taste receptors comprising the extracellular portion of one TlR or a variant or fragment thereof, either TlRl or T1R2, and the transmembrane portion of another TlR or a variant or fragment thereof, either TlRl or T1R2, preferably associated with a T1R3 polypeptide and a suitable G protein. These chimeric taste receptors and cells which express such chimeric taste receptors are useful in assays for identifying sweet and umami ligands as well in assays for identifying sweet and umami enhancers. Additionally, these chimeric taste receptors and cells which express same can be used to map and determine where specific sweet and umami ligands interact with their respective receptors and to elucidate the mechanism of receptor activation.
摘要翻译：本发明涉及包含一种TlR的细胞外部分或其变体或片段，即T1R1或T1R2的嵌合味觉感受器，以及T1R1或其变体或片段的跨膜部分，T1R1或T1R2，优选与T1R3相关多肽和合适的G蛋白。这些嵌合味觉受体和表达这种嵌合味觉受体的细胞可用于鉴定甜味和鲜味配体的测定以及用于鉴定甜味和鲜味增强剂的测定中。此外，这些嵌合味觉受体和表达相同的细胞可以用于绘制和确定特定甜味和鲜味配体与其各自受体相互作用的位置，并阐明受体活化的机制。

9. 发明申请

WO2007011859A2 IDENTIFICATION OF A NOVEL BITTER TASTE RECEPTOR T2R76 THAT SPECIFICALLY RESPONDS TO BRUCINE AND PROP BITTER LIGANDS 审中-公开
标题翻译：鉴定对BRUCINE和PROP BITTER LIGANDS的特殊反应的新型双体态TASTE RECEPTOR T2R76
公开(公告)号：WO2007011859A2
公开(公告)日：2007-01-25
申请号：PCT/US2006/027656
申请日：2006-07-17
申请人： SENOMYX , XU, Hong , LI, Xiaodong
发明人： XU, Hong , LI, Xiaodong
IPC分类号： C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： C07K14/705 , A61K38/00 , C12N2799/026 , G01N2500/00
摘要： Isolated nucleic acids encoding T2R76 polypeptides, recombinants expressed T2R76 polypeptides, heterologous expression systems for recombinant expression of T2R76 polypeptides, assay methods employing the same, and methods for altering taste perception via administration of a T2R76 modulator. These T22R76 polypeptides can be expressed alone or co-expressed with another T2R polypeptide, preferably a different human T2R polypeptide. These T2R76 polypeptides specifcally respond to bitter ligands including brucine and propylthiouracil (PROP) and therefore can be used in assays that identify compounds that modulate, preferably block bitter taste.
摘要翻译：编码T2R76多肽的分离的核酸，表达T2R76多肽的重组体，用于重组表达T2R76多肽的异源表达系统，使用该多肽的测定方法，以及通过施用T2R76调节剂改变味觉的方法。这些T22R76多肽可以单独表达或与另一个T2R多肽，优选不同的人T2R多肽共表达。这些T2R76多肽特异性地响应苦味配体，包括芥子酸和丙基硫尿嘧啶（PROP），因此可以用于鉴别调节，优选阻断苦味的化合物的测定中。

10. 发明申请

WO2004069191A2 FUNCTIONAL COUPLING OF T1RS AND T2RS BY GI PROTEINS, AND CELL-BASED ASSAYS FOR THE IDENTIFICATION OF T1R AND T2R MODULATORS 审中-公开
标题翻译：通过GI蛋白的T1RS和T2RS的功能性联合，以及用于鉴定T1R和T2R调节剂的基于细胞的测定
公开(公告)号：WO2004069191A2
公开(公告)日：2004-08-19
申请号：PCT/US2004/002987
申请日：2004-02-03
申请人： SENOMYX INC. , SERVANT, Guy , OZECK, Mark , BRUST, Paul , XU, Hong
发明人： SERVANT, Guy , OZECK, Mark , BRUST, Paul , XU, Hong
IPC分类号： A61K
CPC分类号： G01N33/5041 , G01N33/5008 , G01N33/566 , G01N2333/726 , G01N2500/10
摘要： The invention resides in part in the discovery that G proteins other than Gα 15 couples to T1R and T2R taste receptors, particularly G i proteins such as G αi . Related to this discovery, the invention provides cell-based assay methods for identifying compounds that modulate the activity of specific T1R or T2R taste receptors or which modulate the effect of other T1R or T2R modulators on T1R or T2R activity. These assay methods preferably detect the effect of a putative T1R or T2R modulator compound on MAPK activation, cAMP accumulation, or adenylyl cyclase activity or another signaling pathway regulated by G i proteins. The level of MAPK activation, cAMP accumulation or adenylyl cyclase is preferably determined by immunoassay methods that use ligands (monoclonal or polyclonal antibodies) that specifically bind an activated (phosphorylated) MAPK, cAMP, or adenylyl cyclase.
摘要翻译：本发明部分在于发现除了Galpha15之外的G蛋白与T1R和T2R味觉受体特别是Gi蛋白如Galphai偶联。与这一发现有关，本发明提供基于细胞的测定方法，用于鉴定调节特异性T1R或T2R味觉受体的活性或调节其他T1R或T2R调节剂对T1R或T2R活性的影响的化合物。这些测定方法优选检测推定的T1R或T2R调节剂化合物对MAPK激活，cAMP积聚或腺苷酸环化酶活性或由Gi蛋白调节的另一信号传导途径的影响。 MAPK活化水平，cAMP积聚或腺苷酸环化酶优选通过使用特异性结合活化（磷酸化）MAPK，cAMP或腺苷酸环化酶的配体（单克隆或多克隆抗体）的免疫测定方法来确定。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式