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    • 1. 发明申请
    • INSULIN PUMP
    • 胰岛素泵
    • WO2013024044A2
    • 2013-02-21
    • PCT/EP2012/065725
    • 2012-08-10
    • GENE ONYX LIMITEDTOUMAZOU, ChristoferGEORGIOU, PantelisVINAS, Pau HerreroSIM, Calvin
    • TOUMAZOU, ChristoferGEORGIOU, PantelisVINAS, Pau Herrero
    • G06F19/00
    • A61M5/1723A61M5/142A61M2005/14208A61M2005/1726A61M2205/52A61M2230/201G06F19/00G06F19/3468
    • The present invention relates to a controller unit and methods for controlling an insulin pump. The controller unit includes a user input that receives a gain factor. The gain factor has been calculated based on historical data in relation to a patient. The controller unit includes a measurement input for receiving data representative of a measured blood glucose level for the patient. Processing logic of the controller unit is configured to apply the measured blood glucose level to a pancreatic beta-cell insulin secretion computational model to predict an insulin output level, apply the gain factor to the predicted insulin output level to determine a patient insulin deficiency level, and calculate a control signal for controlling the insulin output level of the insulin pump based on the patient insulin deficiency level. Methods are provided for optimising the gain factor based on the historical data in relation to the patient.
    • 用于控制胰岛素泵的控制器单元和方法技术领域本发明涉及用于控制胰岛素泵的控制器单元和方法。 控制器单元包括接收增益因子的用户输入。 增益因子是根据与患者相关的历史数据计算出来的。 控制器单元包括用于接收代表患者的测量的血糖水平的数据的测量输入。 控制器单元的处理逻辑被配置为将测量的血糖水平应用于胰腺β-细胞胰岛素分泌计算模型以预测胰岛素输出水平,将增益因子应用于预测的胰岛素输出水平以确定患者胰岛素缺乏水平, 并基于患者胰岛素缺乏水平计算用于控制胰岛素泵的胰岛素输出水平的控制信号。 提供了基于与患者有关的历史数据优化增益因子的方法。
    • 4. 发明申请
    • A GLUCAGON PUMP CONTROLLER
    • GLUCAGON泵控制器
    • WO2010142734A1
    • 2010-12-16
    • PCT/EP2010/058101
    • 2010-06-09
    • IMPERIAL INNOVATIONS LIMITEDGEORGIOU, PantelisLIM, Kok ThayTOUMAZOU, Christofer
    • GEORGIOU, PantelisLIM, Kok ThayTOUMAZOU, Christofer
    • A61M5/172
    • A61M5/1723A61M2005/14208G06F19/00G06F19/3468
    • According to a first aspect of the present invention there is provided a controller for controlling a glucagon pump. The controller comprises an input 8 for receiving an input signal indicative of a measured blood glucose concentration, an output 9 for providing a pulsed glucagon pump drive signal, each pulse being arranged to cause a glucagon pump to deliver a volume of glucagon, and a processing unit 10 for setting the pulse frequency of the pump drive signal in dependence upon the input signal, such that when the input signal indicates that the measured blood glucose concentration is above a threshold concentration the pulse frequency is zero and when the input signal indicates that the measured blood glucose concentration is below the threshold concentration the pulse frequency is increased as the measured blood glucose concentration decreases.
    • 根据本发明的第一方面,提供了一种用于控制胰高血糖素泵的控制器。 控制器包括用于接收指示测量的血糖浓度的输入信号的输入8,用于提供脉冲胰高血糖素泵驱动信号的输出9,每个脉冲被布置成使胰高血糖素泵输送一定量的胰高血糖素,以及处理 单元10,用于根据输入信号设置泵驱动信号的脉冲频率,使得当输入信号指示所测量的血糖浓度高于阈值浓度时,脉冲频率为零,并且当输入信号指示 测量血糖浓度低于阈值浓度,脉搏频率随着测量血糖浓度的降低而增加。
    • 5. 发明申请
    • METHOD AND APPARATUS FOR SENSING A PROPERTY OF A FLUID
    • 用于检测流体特性的方法和设备
    • WO2012017185A1
    • 2012-02-09
    • PCT/GB2010/051299
    • 2010-08-06
    • DNA ELECTRONICS LTDCONSTANDINOU, Timothy, GREED, SamGEORGIOU, Pantelis
    • CONSTANDINOU, Timothy, GREED, SamGEORGIOU, Pantelis
    • G01N27/28G01N27/414B01L3/00H01L27/12G01D5/12
    • G01N27/227B01L3/5027B01L3/502707B01L3/502715B01L2200/12B01L2300/023B01L2300/0636B01L2300/0645B01L2300/0654B01L2300/0816B01L2300/0887G01D5/30G01N27/4148H01L2224/48465H01L2224/73265
    • A device for sensing a property of a fluid comprising a first substrate having formed thereon a sensor configured in use to come into contact with a fluid in order to sense a property of the fluid, and a wireless transmitter for transmitting data over a wireless data link and a second substrate having formed thereon a wireless receiver for receiving data transmitted over said wireless link by said wireless transmitter. The first substrate is fixed to or within said second substrate. Additionally or alternatively, the device comprises a first substrate defining one or more microfluidic structures for receiving a fluid to be sensed and a second substrate comprising or having attached thereto a multiplicity of fluid sensors, the number of sensors being greater than the number of microfluidic structures. The second substrate is in contact with the first substrate such that at least one of the sensors is aligned with the or each microfluidic structure so as to provide an active sensor for the or each structure, and such that one or more of the sensors is or are not aligned with any microfluidic structure and is or are thereby redundant.
    • 一种用于感测流体属性的装置,包括第一基底和第二基底,所述第一基底上形成有传感器,所述传感器被构造用于与流体接触以感测所述流体的性质,以及无线发射器 用于通过无线数据链路传输数据和其上形成有用于接收由所述无线发射机通过所述无线链路传输的数据的无线接收机的第二基底。 第一衬底固定在所述第二衬底上或在所述第二衬底内。 附加地或替代地,该装置包括限定用于接收待感测的流体的一个或多个微流体结构的第一基底和包括或附接有多个流体传感器的第二基底,传感器的数量大于微流体结构的数量 。 第二基底与第一基底接触,使得至少一个传感器与该微流体结构或每个微流体结构对齐,以便为该结构或每个结构提供有源传感器,并且使得一个或多个传感器为 不与任何微流体结构对齐,并且因此是冗余的。