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1. 发明申请

WO2012017185A1 METHOD AND APPARATUS FOR SENSING A PROPERTY OF A FLUID 审中-公开
标题翻译：用于检测流体特性的方法和设备
公开(公告)号：WO2012017185A1
公开(公告)日：2012-02-09
申请号：PCT/GB2010/051299
申请日：2010-08-06
申请人： DNA ELECTRONICS LTD , CONSTANDINOU, Timothy, G , REED, Sam , GEORGIOU, Pantelis
发明人： CONSTANDINOU, Timothy, G , REED, Sam , GEORGIOU, Pantelis
IPC分类号： G01N27/28 , G01N27/414 , B01L3/00 , H01L27/12 , G01D5/12
CPC分类号： G01N27/227 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L2200/12 , B01L2300/023 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0816 , B01L2300/0887 , G01D5/30 , G01N27/4148 , H01L2224/48465 , H01L2224/73265
摘要： A device for sensing a property of a fluid comprising a first substrate having formed thereon a sensor configured in use to come into contact with a fluid in order to sense a property of the fluid, and a wireless transmitter for transmitting data over a wireless data link and a second substrate having formed thereon a wireless receiver for receiving data transmitted over said wireless link by said wireless transmitter. The first substrate is fixed to or within said second substrate. Additionally or alternatively, the device comprises a first substrate defining one or more microfluidic structures for receiving a fluid to be sensed and a second substrate comprising or having attached thereto a multiplicity of fluid sensors, the number of sensors being greater than the number of microfluidic structures. The second substrate is in contact with the first substrate such that at least one of the sensors is aligned with the or each microfluidic structure so as to provide an active sensor for the or each structure, and such that one or more of the sensors is or are not aligned with any microfluidic structure and is or are thereby redundant.
摘要翻译：一种用于感测流体属性的装置，包括第一基底和第二基底，所述第一基底上形成有传感器，所述传感器被构造用于与流体接触以感测所述流体的性质，以及无线发射器用于通过无线数据链路传输数据和其上形成有用于接收由所述无线发射机通过所述无线链路传输的数据的无线接收机的第二基底。第一衬底固定在所述第二衬底上或在所述第二衬底内。附加地或替代地，该装置包括限定用于接收待感测的流体的一个或多个微流体结构的第一基底和包括或附接有多个流体传感器的第二基底，传感器的数量大于微流体结构的数量。第二基底与第一基底接触，使得至少一个传感器与该微流体结构或每个微流体结构对齐，以便为该结构或每个结构提供有源传感器，并且使得一个或多个传感器为不与任何微流体结构对齐，并且因此是冗余的。

2. 发明申请

WO2012056247A1 CHEMICAL SENSING DEVICE 审中-公开
标题翻译：化学传感装置
公开(公告)号：WO2012056247A1
公开(公告)日：2012-05-03
申请号：PCT/GB2011/052105
申请日：2011-10-28
申请人： DNA ELECTRONICS LTD , TOUMAZOU, Christofer , LIU, Yan , GEORGIOU, Pantelis , OU, Chung Pei , REED, Sam
发明人： TOUMAZOU, Christofer , LIU, Yan , GEORGIOU, Pantelis , OU, Chung Pei , REED, Sam
IPC分类号： G01N27/44 , G01N27/414 , C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6825 , C12Q1/6858 , G01N27/4145 , G01N27/44 , C12Q2533/101 , C12Q2565/301 , C12Q2565/607 , C12Q2565/501
摘要： An apparatus comprises a transducer having a first output signal and arranged to receive an electrical input. The transducer switches the first output signal between an ON and OFF state. The apparatus comprises a chemical sensing surface coupled to the transducer arranged to receive a chemical input.A signal generator oscillates one or more of said inputs to vary the switching point of the transducer. The oscillating input may be the chemical input and/or the electrical input. The output signal may be a pulse whose period ON or OFF is determined by the oscillating input modulated by the chemical input.
摘要翻译：一种装置包括具有第一输出信号并被布置成接收电输入的换能器。传感器在ON和OFF状态之间切换第一个输出信号。该装置包括耦合到换能器的化学感测表面，布置成接收化学输入。信号发生器振荡一个或多个所述输入以改变换能器的切换点。振荡输入可以是化学输入和/或电输入。输出信号可以是其周期ON或OFF由通过化学输入调制的振荡输入确定的脉冲。

3. 发明申请

WO2012045889A1 IONIC SIGNAL ENHANCEMENT 审中-公开
标题翻译：离子信号增强
公开(公告)号：WO2012045889A1
公开(公告)日：2012-04-12
申请号：PCT/EP2011/067661
申请日：2011-10-10
申请人： DNA ELECTRONICS LTD , OU, Chung Pei , WANG, Chan Ju , MORLEY, Daniel , REED, Sam
发明人： OU, Chung Pei , WANG, Chan Ju , MORLEY, Daniel , REED, Sam
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , C12Q1/6825 , C12Q1/6869 , C12Q2533/101 , C12Q2527/119 , C12Q2521/319 , C12Q2521/525 , C12Q2565/607 , C12Q2525/125 , C12Q2535/125 , C12Q2565/301 , C12Q2563/113 , C12Q2563/116
摘要： Provided is a method of identifying an unknown nucleic acid comprising the steps of combining the unknown polynucleic acid with known nucleic acid reagents in a reaction chamber; producing a first quantity of protons from a polymerisation reaction when bases of one or more of the unknown nucleic acids are complementary to the bases of one or more known nucleic acids comprised within the known reagents; producing a second quantity of protons from a hydrolysis reaction of by-products of the polymerisation reaction with one or more enzymes; monitoring an electrical output signal derived from an ISFET exposed to the reaction chamber; and correlating changes in an output signal with said reactions between the unknown polynucleic acid and said known reagents to thereby identify the unknown nucleic acid.
摘要翻译：提供了鉴定未知核酸的方法，包括将未知多核酸与已知核酸试剂合并在反应室中的步骤; 当一种或多种未知核酸的碱基与已知试剂中包含的一种或多种已知核酸的碱基互补时，从聚合反应产生第一量的质子; 由聚合反应的副产物与一种或多种酶的水解反应产生第二量的质子; 监测从暴露于反应室的ISFET得到的电输出信号; 并将输出信号的变化与未知多核酸与所述已知试剂之间的反应相关，从而鉴定未知核酸。

4. 发明申请

WO2015162301A2 NUCLEIC ACID TEST SYSTEM, APPARATUS AND METHOD 审中-公开
标题翻译：核酸测试系统，装置和方法
公开(公告)号：WO2015162301A2
公开(公告)日：2015-10-29
申请号：PCT/EP2015/059097
申请日：2015-04-27
申请人： DNA ELECTRONICS LTD
发明人： TOUMAZOU, Christofer , DAVIDSON, David , REED, Sam
IPC分类号： C12Q1/68
CPC分类号： C12M1/34 , B01L3/5027 , B01L7/52 , B01L2200/10 , B01L2300/0645 , B01L2300/0816 , B01L2300/087 , C12M41/48 , C12Q1/6825 , C12Q1/6844 , C12Q1/6874 , G01N27/4146 , C12Q2537/149 , C12Q2565/629 , C12Q2565/537 , C12Q2565/607
摘要： A method of analysing nucleic acid using apparatus comprising a reaction chamber and plurality of sensors located in the base of the chamber, with each sensor preferably located within a respective well. The method comprises flowing a fluid containing the nucleic acid or fragments thereof into the reaction chamber. While the chamber is fully or at least partially sealed, amplification of the nucleic acid or said fragments is performed within the chamber using an amplification primer or primers whilst detecting the generation of amplicons using said sensors. Sequencing or hybridisation is then performed on the amplicons, and sequencing or hybridisation is detected using said sensors.
摘要翻译：一种使用装置分析核酸的方法，所述设备包括反应室和位于所述室的底部中的多个传感器，每个传感器优选地位于相应的孔内。该方法包括将含有核酸或其片段的流体流入反应室。当室完全或至少部分密封时，使用扩增引物或引物在室内进行核酸或所述片段的扩增，同时使用所述传感器检测扩增子的产生。然后对扩增子进行测序或杂交，并使用所述传感器检测测序或杂交。

5. 发明申请

WO2014013263A1 SENSING APPARATUS AND METHOD 审中-公开
标题翻译：感应装置和方法
公开(公告)号：WO2014013263A1
公开(公告)日：2014-01-23
申请号：PCT/GB2013/051930
申请日：2013-07-18
申请人： DNA ELECTRONICS LTD
发明人： ANSARI, Zahid , AMIN, Krishna , JORGENSEN, Ginny , KOLB, Kurt , MORLEY, Daniel , PATEL, Alpesh , REED, Sam , SHEPHERD, Leila , TOUMAZOU, Christofer
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6874 , C12Q2527/101 , C12Q2527/119 , C12Q2535/122 , C12Q2543/101 , C12Q2547/101 , C12Q2565/537 , C12Q2565/629
摘要： Provided is a sensing apparatus comprising a chip for integrated amplification and sequencing of a template polynucleotide in a sample. The apparatus comprises a chip with at least one ISFET in a well or chamber, amplification means for amplifying the template polynucleotide on a surface of said chip and comprising at least one heating means suitable for conducting amplification of the template polynucleotide at temperatures elevated with respect to room temperature, and sequencing means for sequencing the amplified template polynucleotide in said well or chamber. Methods of use are also provided.
摘要翻译：提供了一种感测装置，包括用于样本中模板多核苷酸的集成扩增和测序的芯片。该装置包括在井或室中具有至少一个ISFET的芯片，用于在所述芯片的表面上扩增模板多核苷酸的扩增装置，并且包含至少一种适于在相对于以及用于测序所述孔或室中扩增的模板多核苷酸的测序装置。还提供了使用方法。

6. 发明申请

WO2013144643A2 BIOSENSOR DEVICE AND SYSTEM 审中-公开
标题翻译：生物传感器设备和系统
公开(公告)号：WO2013144643A2
公开(公告)日：2013-10-03
申请号：PCT/GB2013/050832
申请日：2013-03-28
申请人： DNA ELECTRONICS LTD
发明人： ATHANASIOU, Panteleimon , PATEL, Alpesh , WHITAKER, David , BAI, Hua , PALMER-FELGATE, John , COOMBER-ALFORD, Daniel , REED, Sam , FISHER, Jessica , SCHNEIDER, Chad , FLAMM, Alex , LANE, Ben
IPC分类号： B01L3/00
CPC分类号： G01N27/327 , B01F5/0647 , B01F5/065 , B01F13/0059 , B01F2215/0037 , B01F2215/0431 , B01L3/502 , B01L3/5025 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L3/5029 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/048 , B01L2300/0609 , B01L2300/0636 , B01L2300/0645 , B01L2300/0819 , B01L2300/0867 , B01L2300/0883 , B01L2300/1827 , B01L2400/0478 , B01L2400/0638 , B01L2400/0677 , G01N27/4145 , G01N27/4148
摘要： A system, device, and method for receiving, preparing and identifying a biological sample. Some parts may be user held and actuated. The sample may be detected by an array of sensors. The system may comprise reusable and disposable components arranged to be connected together. The biological sample may contain nucleic acids, proteins, or other molecules to be detected.
摘要翻译：用于接收，准备和鉴定生物样品的系统，装置和方法。一些部件可能被用户保持和启动。样品可以由传感器阵列检测。该系统可以包括被布置成连接在一起的可重复使用和一次性部件。生物样品可能含有待检测的核酸，蛋白质或其他分子。

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