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1. 发明申请

WO2013024044A2 INSULIN PUMP 审中-公开
标题翻译：胰岛素泵
公开(公告)号：WO2013024044A2
公开(公告)日：2013-02-21
申请号：PCT/EP2012/065725
申请日：2012-08-10
申请人： GENE ONYX LIMITED , TOUMAZOU, Christofer , GEORGIOU, Pantelis , VINAS, Pau Herrero , SIM, Calvin
发明人： TOUMAZOU, Christofer , GEORGIOU, Pantelis , VINAS, Pau Herrero
IPC分类号： G06F19/00
CPC分类号： A61M5/1723 , A61M5/142 , A61M2005/14208 , A61M2005/1726 , A61M2205/52 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： The present invention relates to a controller unit and methods for controlling an insulin pump. The controller unit includes a user input that receives a gain factor. The gain factor has been calculated based on historical data in relation to a patient. The controller unit includes a measurement input for receiving data representative of a measured blood glucose level for the patient. Processing logic of the controller unit is configured to apply the measured blood glucose level to a pancreatic beta-cell insulin secretion computational model to predict an insulin output level, apply the gain factor to the predicted insulin output level to determine a patient insulin deficiency level, and calculate a control signal for controlling the insulin output level of the insulin pump based on the patient insulin deficiency level. Methods are provided for optimising the gain factor based on the historical data in relation to the patient.
摘要翻译：用于控制胰岛素泵的控制器单元和方法技术领域本发明涉及用于控制胰岛素泵的控制器单元和方法。控制器单元包括接收增益因子的用户输入。增益因子是根据与患者相关的历史数据计算出来的。控制器单元包括用于接收代表患者的测量的血糖水平的数据的测量输入。控制器单元的处理逻辑被配置为将测量的血糖水平应用于胰腺β-细胞胰岛素分泌计算模型以预测胰岛素输出水平，将增益因子应用于预测的胰岛素输出水平以确定患者胰岛素缺乏水平，并基于患者胰岛素缺乏水平计算用于控制胰岛素泵的胰岛素输出水平的控制信号。提供了基于与患者有关的历史数据优化增益因子的方法。

2. 发明申请

WO2015059468A1 A GENETIC TEST CONTROL APPARATUS 审中-公开
标题翻译：遗传测试控制装置
公开(公告)号：WO2015059468A1
公开(公告)日：2015-04-30
申请号：PCT/GB2014/053147
申请日：2014-10-22
申请人： GENE ONYX LIMITED , GENEU LIMITED
发明人： WONG, Danny Yuk-Kun , SIM, Calvin Teck Yong
IPC分类号： G01N33/487 , B01L3/00
CPC分类号： G01N33/4875 , B01L7/52 , B01L2200/04 , B01L2300/1844
摘要： A test control apparatus (4) for electrically coupling a genetic material analyser (2), such as for DNA sequencing or nucleic acid amplification and assay, and associated test cartridge (3) to a computer system is provided. The apparatus (4) disclosed incorporates all the components of an electronic microchip-based genetic test apparatus within a single enclosure. The apparatus (4) minimizes the number of steps required for a user to run a genetic test and is configured to provide temperature control through heating or cooling to a genetic material analyser (2) and associated test cartridge (3) within the enclosure. The test control apparatus (4) includes as well an ejection mechanism (8) for ejecting the analyser (2) and test cartridge (3) after genetic test completion.
摘要翻译：提供了一种用于将遗传物质分析仪（2）如DNA测序或核酸扩增和测定以及相关测试盒（3）电耦合到计算机系统的测试控制装置（4）。所公开的装置（4）将单个外壳内基于电子微芯片的遗传测试装置的所有组件结合在一起。设备（4）使用户进行基因测试所需的步骤数量最小化，并且被配置为通过加热或冷却来提供温度控制到遗传材料分析仪（2）和相关联的测试盒（3）。测试控制装置（4）还包括用于在基因测试完成之后弹出分析器（2）和测试盒（3）的弹出机构（8）。

3. 发明申请

WO2014091177A1 GENETIC TESTING KIT 审中-公开
标题翻译：遗传测试工具包
公开(公告)号：WO2014091177A1
公开(公告)日：2014-06-19
申请号：PCT/GB2012/053147
申请日：2012-12-14
申请人： GENE ONYX LIMITED , BEARD, Lara
发明人： BEARD, Lara , SIM, Calvin
IPC分类号： C12Q1/68 , B01L9/06 , B01L99/00
CPC分类号： B01L9/06 , B01L99/00 , B01L2300/0609 , B01L2300/12 , C12Q1/6806 , C12Q1/6883 , C12Q2600/106 , C12Q2600/148 , C12Q2600/156
摘要： A kit of parts comprising a set of two or more components and a substantially rigid box having provided on a surface thereof a visual representation of a sequence of ordered steps in a biological testing procedure. The box is provided with formations, coinciding with respective steps in said visual representation, adapted to permit insertion of said components through the surface of the box to allow the components to be supported in an upright position.
摘要翻译：包括一组两个或更多个部件的部件套件和在其表面上提供生物测试程序中有序步骤序列的视觉表示的基本上刚性的盒子。盒子具有与所述视觉表现中的相应步骤重合的结构，适于允许所述部件通过所述箱的表面插入，以允许所述部件被支撑在直立位置。

4. 发明申请

WO2013144580A1 ISFET ARRAY FOR DETECTING A SINGLE NUCLEOTIDE POLYMORPHISM 审中-公开
标题翻译：用于检测单核多核苷酸多态性的ISFET阵列
公开(公告)号：WO2013144580A1
公开(公告)日：2013-10-03
申请号：PCT/GB2013/050715
申请日：2013-03-19
申请人： GENE ONYX LIMITED , TOUMAZOU, Christofer
发明人： SOHBATI, Mohammadreza , SIM, Calvin
IPC分类号： G01N27/414 , C12Q1/68
CPC分类号： G01N27/26 , G01N27/4145 , G01N33/6803
摘要： Apparatus comprising a module for detecting a single nucleotide polymorphism, SNP, within a genome and comprising: four reaction chambers for receiving a fluid sample, the reaction chambers each containing a different one of the bases A, C, G, T, and a primer; a reference electrode which in use is immersed in said fluid sample; a pair of Ion Sensitive Field Effect Transistors, ISFETs, associated with each reaction chamber, the ISFETs of each pair comprising respective sensing membranes, or a common sensing membrane, exposed within the associated reaction chamber; and a plurality of difference detectors, each difference detector having a pair of inputs coupled respectively to outputs of ISFETs associated with different reaction chambers.
摘要翻译：包括用于检测基因组内的单核苷酸多态性（SNP）的模块的装置，包括：用于接收流体样品的四个反应室，所述反应室各自含有不同的碱基A，C，G，T和底物 ; 将使用中的参考电极浸入所述流体样品中; 与每个反应室相关联的一对离子敏感场效应晶体管，ISFET，每对的ISFET包括相关的感测膜或暴露在相关联的反应室内的公共检测膜; 以及多个差分检测器，每个差分检测器具有分别耦合到与不同反应室相关联的ISFET的输出的一对输入。

5. 发明申请

WO2013093407A1 PRODUCT SELECTION USING GENETIC ANALYSIS 审中-公开
标题翻译：使用遗传分析的产品选择
公开(公告)号：WO2013093407A1
公开(公告)日：2013-06-27
申请号：PCT/GB2012/052725
申请日：2012-11-01
申请人： GENE ONYX LIMITED , TOUMAZOU, Christofer
发明人： TOUMAZOU, Christofer , NEDJAI, Belinda , SIM, Calvin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/148 , C12Q2600/156 , G06F19/28
摘要： A method of assessing the suitability of a set of cosmetic and/or nutricosmetic and/or skin care products for an individual. The method comprises testing a sample of genetic material for an individual to identify the presence or absence of single-nucleotide polymorphisms at a predefined set of single-nucleotide locations. One or more weights for each location are identified in dependence upon the presence or absence of a single-nucleotide polymorphism at the location and the single-nucleotide location weights used in order to determine a product score for each of said products, a score being indicative of the suitability of a product to the individual.
摘要翻译：评估一组化妆品和/或营养物质和/或护肤品对个体的适用性的方法。该方法包括测试个体的遗传物质样品，以在预定义的单核苷酸位置集合中鉴定单核苷酸多态性的存在或不存在。根据在该位置存在或不存在单核苷酸多态性以及使用单核苷酸位置权重来确定每个位置的一个或多个权重，以确定每个所述产品的产品得分，分数指示产品对个人的适用性。

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