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1. 发明申请

WO2013024044A2 INSULIN PUMP 审中-公开
标题翻译：胰岛素泵
公开(公告)号：WO2013024044A2
公开(公告)日：2013-02-21
申请号：PCT/EP2012/065725
申请日：2012-08-10
申请人： GENE ONYX LIMITED , TOUMAZOU, Christofer , GEORGIOU, Pantelis , VINAS, Pau Herrero , SIM, Calvin
发明人： TOUMAZOU, Christofer , GEORGIOU, Pantelis , VINAS, Pau Herrero
IPC分类号： G06F19/00
CPC分类号： A61M5/1723 , A61M5/142 , A61M2005/14208 , A61M2005/1726 , A61M2205/52 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： The present invention relates to a controller unit and methods for controlling an insulin pump. The controller unit includes a user input that receives a gain factor. The gain factor has been calculated based on historical data in relation to a patient. The controller unit includes a measurement input for receiving data representative of a measured blood glucose level for the patient. Processing logic of the controller unit is configured to apply the measured blood glucose level to a pancreatic beta-cell insulin secretion computational model to predict an insulin output level, apply the gain factor to the predicted insulin output level to determine a patient insulin deficiency level, and calculate a control signal for controlling the insulin output level of the insulin pump based on the patient insulin deficiency level. Methods are provided for optimising the gain factor based on the historical data in relation to the patient.
摘要翻译：用于控制胰岛素泵的控制器单元和方法技术领域本发明涉及用于控制胰岛素泵的控制器单元和方法。控制器单元包括接收增益因子的用户输入。增益因子是根据与患者相关的历史数据计算出来的。控制器单元包括用于接收代表患者的测量的血糖水平的数据的测量输入。控制器单元的处理逻辑被配置为将测量的血糖水平应用于胰腺β-细胞胰岛素分泌计算模型以预测胰岛素输出水平，将增益因子应用于预测的胰岛素输出水平以确定患者胰岛素缺乏水平，并基于患者胰岛素缺乏水平计算用于控制胰岛素泵的胰岛素输出水平的控制信号。提供了基于与患者有关的历史数据优化增益因子的方法。

2. 发明申请

WO2012017185A8 METHOD AND APPARATUS FOR SENSING A PROPERTY OF A FLUID 审中-公开
标题翻译：用于感测流体性质的方法和装置
公开(公告)号：WO2012017185A8
公开(公告)日：2012-03-22
申请号：PCT/GB2010051299
申请日：2010-08-06
申请人： DNA ELECTRONICS LTD , CONSTANDINOU TIMOTHY G , REED SAM , GEORGIOU PANTELIS
发明人： CONSTANDINOU TIMOTHY G , REED SAM , GEORGIOU PANTELIS
IPC分类号： G01N27/28 , B01L3/00 , G01D5/12 , G01N27/414 , H01L27/12
CPC分类号： G01N27/227 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L2200/12 , B01L2300/023 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0816 , B01L2300/0887 , G01D5/30 , G01N27/4148 , H01L2224/48465 , H01L2224/73265
摘要： A device for sensing a property of a fluid comprising a first substrate having formed thereon a sensor configured in use to come into contact with a fluid in order to sense a property of the fluid, and a wireless transmitter for transmitting data over a wireless data link and a second substrate having formed thereon a wireless receiver for receiving data transmitted over said wireless link by said wireless transmitter. The first substrate is fixed to or within said second substrate. Additionally or alternatively, the device comprises a first substrate defining one or more microfluidic structures for receiving a fluid to be sensed and a second substrate comprising or having attached thereto a multiplicity of fluid sensors, the number of sensors being greater than the number of microfluidic structures. The second substrate is in contact with the first substrate such that at least one of the sensors is aligned with the or each microfluidic structure so as to provide an active sensor for the or each structure, and such that one or more of the sensors is or are not aligned with any microfluidic structure and is or are thereby redundant.
摘要翻译：一种用于感测流体性质的装置，包括其上形成有用于与流体接触的传感器的第一基板，以便感测流体的性质;以及无线发射器，用于通过无线数据链路传送数据以及第二基板，其上形成有无线接收器，用于接收由所述无线发射机在所述无线链路上发送的数据。第一衬底被固定到所述第二衬底内或所述第二衬底内。附加地或替代地，该装置包括限定用于接收待感测流体的一个或多个微流体结构的第一基板和包括多个流体传感器的多个流体传感器的第二基板，传感器的数量大于微流体结构的数量。所述第二基板与所述第一基板接触，使得所述传感器中的至少一个与所述或每个微流体结构对准，以便为所述或每个结构提供有源传感器，并且使得所述传感器中的一个或多个位于或不与任何微流体结构对准，并且因此是多余的。

3. 发明申请

WO2011095793A1 SENSOR ARRAY FOR MEASURING NEURAL ACTIVITY 审中-公开
标题翻译：传感器阵列测量神经活动
公开(公告)号：WO2011095793A1
公开(公告)日：2011-08-11
申请号：PCT/GB2011/050133
申请日：2011-01-28
申请人： DNA ELECTRONICS LTD , GEORGIOU, Pantelis , PRODROKAKIS, Themistoklis , CONSTANDINOU, Timothy G , TOUMAZOU, Christofer
发明人： GEORGIOU, Pantelis , PRODROKAKIS, Themistoklis , CONSTANDINOU, Timothy G , TOUMAZOU, Christofer
IPC分类号： G01N27/414 , G01N33/487 , B01L3/00
CPC分类号： G01N27/4163 , G01N27/4145 , G01N33/4836
摘要： A sensor system comprising a substrate and integrated onto the substrate an array (7) of sensor elements (1), each sensor element comprising one or more inductors (3), one or more electrochemical sensors (4), and one or more optical sensors (2). The system further comprising a controller configured in use to separately address each of the sensor elements (1) to drive the respective inductors and receive outputs of the respective sensors.
摘要翻译：一种传感器系统，包括基板并将传感器元件（1）的阵列（7）集成到所述基板上，每个传感器元件包括一个或多个电感器（3），一个或多个电化学传感器（4）和一个或多个光学传感器（2）。所述系统还包括控制器，其被配置为用于单独地寻址每个所述传感器元件（1）以驱动相应的电感器并接收各个传感器的输出。

4. 发明申请

WO2010142734A1 A GLUCAGON PUMP CONTROLLER 审中-公开
标题翻译： GLUCAGON泵控制器
公开(公告)号：WO2010142734A1
公开(公告)日：2010-12-16
申请号：PCT/EP2010/058101
申请日：2010-06-09
申请人： IMPERIAL INNOVATIONS LIMITED , GEORGIOU, Pantelis , LIM, Kok Thay , TOUMAZOU, Christofer
发明人： GEORGIOU, Pantelis , LIM, Kok Thay , TOUMAZOU, Christofer
IPC分类号： A61M5/172
CPC分类号： A61M5/1723 , A61M2005/14208 , G06F19/00 , G06F19/3468
摘要： According to a first aspect of the present invention there is provided a controller for controlling a glucagon pump. The controller comprises an input 8 for receiving an input signal indicative of a measured blood glucose concentration, an output 9 for providing a pulsed glucagon pump drive signal, each pulse being arranged to cause a glucagon pump to deliver a volume of glucagon, and a processing unit 10 for setting the pulse frequency of the pump drive signal in dependence upon the input signal, such that when the input signal indicates that the measured blood glucose concentration is above a threshold concentration the pulse frequency is zero and when the input signal indicates that the measured blood glucose concentration is below the threshold concentration the pulse frequency is increased as the measured blood glucose concentration decreases.
摘要翻译：根据本发明的第一方面，提供了一种用于控制胰高血糖素泵的控制器。控制器包括用于接收指示测量的血糖浓度的输入信号的输入8，用于提供脉冲胰高血糖素泵驱动信号的输出9，每个脉冲被布置成使胰高血糖素泵输送一定量的胰高血糖素，以及处理单元10，用于根据输入信号设置泵驱动信号的脉冲频率，使得当输入信号指示所测量的血糖浓度高于阈值浓度时，脉冲频率为零，并且当输入信号指示测量血糖浓度低于阈值浓度，脉搏频率随着测量血糖浓度的降低而增加。

5. 发明申请

WO2013024044A3 INSULIN PUMP 审中-公开
标题翻译：胰岛素泵
公开(公告)号：WO2013024044A3
公开(公告)日：2013-06-06
申请号：PCT/EP2012065725
申请日：2012-08-10
申请人： GENE ONYX LTD , TOUMAZOU CHRISTOFER , GEORGIOU PANTELIS , VINAS PAU HERRERO , SIM CALVIN
发明人： TOUMAZOU CHRISTOFER , GEORGIOU PANTELIS , VINAS PAU HERRERO
IPC分类号： G06F19/00 , A61M5/00
CPC分类号： A61M5/1723 , A61M5/142 , A61M2005/14208 , A61M2005/1726 , A61M2205/52 , A61M2230/201 , G06F19/3468
摘要： The present invention relates to a controller unit and methods for controlling an insulin pump. The controller unit includes a user input that receives a gain factor. The gain factor has been calculated based on historical data in relation to a patient. The controller unit includes a measurement input for receiving data representative of a measured blood glucose level for the patient. Processing logic of the controller unit is configured to apply the measured blood glucose level to a pancreatic beta-cell insulin secretion computational model to predict an insulin output level, apply the gain factor to the predicted insulin output level to determine a patient insulin deficiency level, and calculate a control signal for controlling the insulin output level of the insulin pump based on the patient insulin deficiency level. Methods are provided for optimising the gain factor based on the historical data in relation to the patient.
摘要翻译：本发明涉及一种用于控制胰岛素泵的控制器单元和方法。控制器单元包括接收增益因子的用户输入。增益因子是根据与患者相关的历史数据计算的。控制器单元包括测量输入，用于接收表示患者的测量血糖水平的数据。控制器单元的处理逻辑被配置为将测量的血糖水平应用于胰腺β细胞胰岛素分泌计算模型以预测胰岛素输出水平，将增益因子应用于预测的胰岛素输出水平以确定患者胰岛素缺乏水平，并且基于患者胰岛素缺乏水平计算用于控制胰岛素泵的胰岛素输出水平的控制信号。提供了基于与患者相关的历史数据来优化增益因子的方法。

6. 发明申请

WO2012056247A1 CHEMICAL SENSING DEVICE 审中-公开
标题翻译：化学传感装置
公开(公告)号：WO2012056247A1
公开(公告)日：2012-05-03
申请号：PCT/GB2011/052105
申请日：2011-10-28
申请人： DNA ELECTRONICS LTD , TOUMAZOU, Christofer , LIU, Yan , GEORGIOU, Pantelis , OU, Chung Pei , REED, Sam
发明人： TOUMAZOU, Christofer , LIU, Yan , GEORGIOU, Pantelis , OU, Chung Pei , REED, Sam
IPC分类号： G01N27/44 , G01N27/414 , C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6825 , C12Q1/6858 , G01N27/4145 , G01N27/44 , C12Q2533/101 , C12Q2565/301 , C12Q2565/607 , C12Q2565/501
摘要： An apparatus comprises a transducer having a first output signal and arranged to receive an electrical input. The transducer switches the first output signal between an ON and OFF state. The apparatus comprises a chemical sensing surface coupled to the transducer arranged to receive a chemical input.A signal generator oscillates one or more of said inputs to vary the switching point of the transducer. The oscillating input may be the chemical input and/or the electrical input. The output signal may be a pulse whose period ON or OFF is determined by the oscillating input modulated by the chemical input.
摘要翻译：一种装置包括具有第一输出信号并被布置成接收电输入的换能器。传感器在ON和OFF状态之间切换第一个输出信号。该装置包括耦合到换能器的化学感测表面，布置成接收化学输入。信号发生器振荡一个或多个所述输入以改变换能器的切换点。振荡输入可以是化学输入和/或电输入。输出信号可以是其周期ON或OFF由通过化学输入调制的振荡输入确定的脉冲。

7. 发明申请

WO2012017185A1 METHOD AND APPARATUS FOR SENSING A PROPERTY OF A FLUID 审中-公开
标题翻译：用于检测流体特性的方法和设备
公开(公告)号：WO2012017185A1
公开(公告)日：2012-02-09
申请号：PCT/GB2010/051299
申请日：2010-08-06
申请人： DNA ELECTRONICS LTD , CONSTANDINOU, Timothy, G , REED, Sam , GEORGIOU, Pantelis
发明人： CONSTANDINOU, Timothy, G , REED, Sam , GEORGIOU, Pantelis
IPC分类号： G01N27/28 , G01N27/414 , B01L3/00 , H01L27/12 , G01D5/12
CPC分类号： G01N27/227 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L2200/12 , B01L2300/023 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0816 , B01L2300/0887 , G01D5/30 , G01N27/4148 , H01L2224/48465 , H01L2224/73265
摘要： A device for sensing a property of a fluid comprising a first substrate having formed thereon a sensor configured in use to come into contact with a fluid in order to sense a property of the fluid, and a wireless transmitter for transmitting data over a wireless data link and a second substrate having formed thereon a wireless receiver for receiving data transmitted over said wireless link by said wireless transmitter. The first substrate is fixed to or within said second substrate. Additionally or alternatively, the device comprises a first substrate defining one or more microfluidic structures for receiving a fluid to be sensed and a second substrate comprising or having attached thereto a multiplicity of fluid sensors, the number of sensors being greater than the number of microfluidic structures. The second substrate is in contact with the first substrate such that at least one of the sensors is aligned with the or each microfluidic structure so as to provide an active sensor for the or each structure, and such that one or more of the sensors is or are not aligned with any microfluidic structure and is or are thereby redundant.
摘要翻译：一种用于感测流体属性的装置，包括第一基底和第二基底，所述第一基底上形成有传感器，所述传感器被构造用于与流体接触以感测所述流体的性质，以及无线发射器用于通过无线数据链路传输数据和其上形成有用于接收由所述无线发射机通过所述无线链路传输的数据的无线接收机的第二基底。第一衬底固定在所述第二衬底上或在所述第二衬底内。附加地或替代地，该装置包括限定用于接收待感测的流体的一个或多个微流体结构的第一基底和包括或附接有多个流体传感器的第二基底，传感器的数量大于微流体结构的数量。第二基底与第一基底接触，使得至少一个传感器与该微流体结构或每个微流体结构对齐，以便为该结构或每个结构提供有源传感器，并且使得一个或多个传感器为不与任何微流体结构对齐，并且因此是冗余的。

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