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1. 发明申请

WO2006072182A1 LASER AMPLIFIERS WITH HIGH GAIN AND SMALL THERMAL ABERRATIONS 审中-公开
标题翻译：具有高增益和小热辐射的激光放大器
公开(公告)号：WO2006072182A1
公开(公告)日：2006-07-13
申请号：PCT/CA2006/000019
申请日：2006-01-10
申请人： FRANJIC, Kresimir , HUA, Renzhong , MILLER, R.j. Dwayne
发明人： FRANJIC, Kresimir , HUA, Renzhong , MILLER, R.j. Dwayne
IPC分类号： H01S5/50 , H01S5/30 , H01S5/10 , H01S5/024
CPC分类号： H01S3/0941 , H01S3/005 , H01S3/025 , H01S3/0407 , H01S3/042 , H01S3/0604 , H01S3/0606 , H01S3/0612 , H01S3/0615 , H01S3/0632 , H01S3/094053 , H01S3/094057 , H01S3/094084 , H01S3/1611 , H01S3/1673 , H01S3/2333 , H01S3/2341 , H01S2301/02
摘要： The present invention discloses a laser amplifier with high gain and low thermally induced optical aberrations. The amplifier designs allow simple multipass configurations making it possible to obtain an amplified laser beam of high quality combined very high overall gains comparable to those achievable with expensive regenerative amplifiers. The amplifier includes a thin active laser solid to create the population inversion and associated heat generation within the thin laser active solid possible for the desired gain value. The system includes a cooling device in thermal contact with the thin active laser solid to provide good heat transport and high reflectivity coatings at the wavelengths of the pump and laser wavelengths. The pump light source are laser diodes tuned to the maximum absorption of the laser active material. The amplifier also includes an optical system to transport the pump light to the laser active solid in such a way as to further confine the absorption of light along the two orthogonal directions in the plane of the laser active solid in order to get high population inversion and consequently high gains possible.
摘要翻译：本发明公开了一种具有高增益和低热诱导光学像差的激光放大器。放大器设计允许简单的多通道配置，使得可以获得高质量的放大激光束，结合了非常高的总体增益，与用昂贵的再生放大器实现的相当。该放大器包括薄的有源激光器固体，以产生可用于所需增益值的薄激光器活性固体内的群体反演和相关的热量生成。该系统包括与薄活性激光器固体热接触的冷却装置，以在泵和激光波长的波长处提供良好的热传递和高反射率涂层。泵浦光源是被调整为激光活性材料的最大吸收的激光二极管。该放大器还包括一个光学系统，以将泵浦光输送到激光活性固体，以进一步限制沿着激光活性固体平面中的两个正交方向的光的吸收，以获得高的群体反转，因此可能获得高收益。

2. 发明申请

WO2006072183A2 LASER SYSTEM FOR GENERATION OF HIGH-POWER SUB- NANOSECOND PULSES WITH CONTROLABLE WAVELENGTHS IN 2-15 µm REGION 审中-公开
标题翻译：用于生成2-15μm区域中具有可控波长的大功率亚纳米脉冲激光器系统
公开(公告)号：WO2006072183A2
公开(公告)日：2006-07-13
申请号：PCT/CA2006/000020
申请日：2006-01-10
申请人： FRANJIC, Kresimir , KRAEMER, Darren , COWAN, Michael, L. , HUA, Renzhong , MILLER, R.j. Dwayne
发明人： FRANJIC, Kresimir , KRAEMER, Darren , COWAN, Michael, L. , HUA, Renzhong , MILLER, R.j. Dwayne
CPC分类号： G02F1/39 , A61B18/20 , A61C1/0046 , A61N2005/0659 , B23K26/0624 , B23K26/38 , B23K2203/32 , B23K2203/50 , G02F1/3534 , G02F2201/16 , G02F2203/11 , H01S3/0092 , H01S3/2383
摘要： A laser system capable of efficient production of high energy sub-nanosecond pulses in the 2-15 um spectral region is disclosed. Diode pumped solid state lasers are used as pump sources. The system design is simple, reliable and compact allowing for easy integration. The laser system includes a combination of compact solid-state ~1 micron laser sources, producing high power picosecond pulses, with optical parametric amplification and a quasi-continuous wave laser for seeding the amplification process that enables the efficient conversion of the high power ~1 micron laser radiation to tuneable mid-infrared sub-ns pulses. New parametric processes are presented for achieving high gains in bulk nonlinear crystals. Furthermore, a method of exceeding the fundamental conversion efficiency limit of direct three wave mixing is presented. The compact and robust nature of this novel laser system opens up the use of high power and high peak power mid-infrared laser pulses to a wide variety of important medical and dental applications.
摘要翻译：公开了一种能够在2-15μm光谱区域高效率地产生高能亚纳秒脉冲的激光系统。二极管泵浦固体激光器用作泵浦源。系统设计简单，可靠，紧凑，易于集成。激光系统包括紧凑型固态〜1微米激光源的组合，产生高功率皮秒脉冲，具有光学参量放大和准连续波激光器，用于播种放大过程，可实现高功率〜1的高效转换微米激光辐射可调谐中红外sub-ns脉冲。提出了新的参数化过程，以获得大量非线性晶体的高增益。此外，提出了一种超过直接三波混频的基本转换效率极限的方法。这种新颖的激光系统的紧凑和坚固的性质开启了大功率和高峰值功率的中红外激光脉冲对各种重要医疗和牙科应用的使用。

3. 发明申请

WO2007121580A1 REDUCTION OF SURFACE HEATING EFFECTS IN NONLINEAR CRYSTALS FOR HIGH POWER FREQUENCY CONVERSION OF LASER LIGHT 审中-公开
标题翻译：减少非线性晶体的表面加热效应，实现激光的高功率频率转换
公开(公告)号：WO2007121580A1
公开(公告)日：2007-11-01
申请号：PCT/CA2007/000693
申请日：2007-04-25
申请人： MILLER, R.J. Dwayne , LIN, Shujie , FRANJIC, Kresimir
发明人： MILLER, R.J. Dwayne , LIN, Shujie , FRANJIC, Kresimir
IPC分类号： H01S3/10 , G02F2/02 , H01S5/026 , H01S5/06
CPC分类号： G02F1/353 , G02F1/3525 , G02F1/3534 , G02F1/3551 , G02F2001/3503 , G02F2001/3509 , H01S3/0092
摘要： A device for generating a frequency converted laser beam includes a nonlinear crystal having a first end face and a second end face opposed to the first end face. The nonlinear crystal is configured to receive at least one input laser beam at the first end face and output a frequency converted beam at the second face. A beam waist of the at least one input laser beam is positioned between the first end face and the second end face during a frequency conversion process. The device also includes a second crystal having a first end face bonded to the second end face of the nonlinear crystal and a second end face opposed to the first end face. A beam diameter of the frequency converted beam at the first end face of the second crystal is less than a beam diameter of the frequency converted beam at the second end face of the second crystal.
摘要翻译：用于产生变频激光束的装置包括具有与第一端面相对的第一端面和第二端面的非线性晶体。非线性晶体被配置为在第一端面处接收至少一个输入激光束并且在第二面处输出频率转换的光束。在频率转换过程中，至少一个输入激光束的束腰定位在第一端面和第二端面之间。该装置还包括具有接合到非线性晶体的第二端面的第一端面和与第一端面相对的第二端面的第二晶体。在第二晶体的第一端面处的频率转换光束的光束直径小于第二晶体的第二端面处的频率转换光束的光束直径。

4. 发明申请

WO2016008041A1 FINGER CONTROLLED MEDICAL DEVICE INTERFACE 审中-公开
标题翻译：手指控制医疗设备接口
公开(公告)号：WO2016008041A1
公开(公告)日：2016-01-21
申请号：PCT/CA2015/050650
申请日：2015-07-13
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , FRANJIC, Kresimir , HYNNA, Kai , JAGGA, Victor
发明人： FRANJIC, Kresimir , HYNNA, Kai , JAGGA, Victor
IPC分类号： A61B19/00
CPC分类号： A61B34/74 , A61B17/34 , A61B18/1445 , A61B34/20 , A61B34/37 , A61B34/76 , A61B42/10 , A61B90/37 , A61B2017/00973 , A61B2018/00595 , A61B2034/2055 , A61B2034/2063 , A61B2034/741 , A61B2090/373 , A61B2090/3735 , G08C17/02 , G08C2201/32 , G08C2201/50
摘要： A wearable remote control worn on a finger of a user is provided. The wearable remote control is for use with a medical equipment component. The wearable remote control has a housing, a switch located on the housing, the switch configured to provide a control signal to a control module, and an interface connector attached to the housing and the switch. The interface connector connects the wearable remote control to the control module. The housing of the wearable remote control may include a collar worn around the finger.
摘要翻译：提供佩戴在用户手指上的可穿戴遥控器。可穿戴式遥控器可用于医疗设备部件。所述可佩戴式遥控器具有壳体，位于所述壳体上的开关，所述开关被配置为向控制模块提供控制信号，以及连接到所述壳体和所述开关的接口连接器。接口连接器将可穿戴遥控器连接到控制模块。可穿戴遥控器的外壳可以包括围绕手指佩戴的衣领。

5. 发明申请

WO2018100414A1 A CAMERA SYSTEM FOR PROVIDING IMAGES WITH SIMULTANEOUS HIGH RESOLUTION AND LARGE DEPTH OF FIELD 审中-公开
公开(公告)号：WO2018100414A1
公开(公告)日：2018-06-07
申请号：PCT/IB2016/057276
申请日：2016-12-01
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , FRANJIC, Kresimir , HYNNA, Kai Michael , BAI, Yanhui , WOOD, Michael Frank Gunter , BULK, Michael Peter , LEE, Tammy Kee-Wai
发明人： FRANJIC, Kresimir , HYNNA, Kai Michael , BAI, Yanhui , WOOD, Michael Frank Gunter , BULK, Michael Peter , LEE, Tammy Kee-Wai
IPC分类号： G03B7/00 , A61B34/20 , A61B34/30 , A61B90/20 , G03B9/04 , G06T11/60
摘要： A camera system for providing images with simultaneous high resolution and large depth of field is provided. The system includes: a camera device having a field of view, the camera device configured to automatically acquire: a first image of the field of view at a first numerical aperture; and a second image of the field of view at a second numerical aperture smaller than the first numerical aperture; an image processing unit configured to combine the first image with the second image into a single image by: extracting a higher- resolution in-focus portion of the first image; and replacing a corresponding lower- resolution portion of the second image with the higher-resolution in-focus portion of the first image; and, a display device in communication with the image processing unit, the display device configured to render the single image.

6. 发明申请

WO2018154362A1 SUCTION TOOL WITH INTEGRATED OPTICAL PROBE AND USE THEREOF 审中-公开
公开(公告)号：WO2018154362A1
公开(公告)日：2018-08-30
申请号：PCT/IB2017/051096
申请日：2017-02-24
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , FRANJIC, Kresimir , CHARRON, Luc Gilles , MAK, Siu Wai Jacky
发明人： FRANJIC, Kresimir , CHARRON, Luc Gilles , MAK, Siu Wai Jacky
IPC分类号： A61F2/958 , A61B5/00 , A61B5/0215 , A61M25/00
摘要： A device and method is provided for a suction tool combined with an optical probe. A suction device is provided having a tip with a hollow tubular body, a plurality of optical fibers embedded in the tip and a concentric ring attached to the tip, wherein the ring end has an inner beveled reflective surface opposing the optical fibers. A method is provided for optically measuring tissue in a medical procedure comprising suctioning a tissue using a suction device, sending optical signals along optical fibers through the suction device; directing the signals from the optical fibers onto the tissue using a beveled surface; receiving optical signals from the tissue in optical fibers via the beveled reflective surface; measuring the received optical signals in a spectrometer or detector; and releasing, resecting or ablating the tissue through the suction device.

7. 发明申请

WO2005112207A1 METHOD AND APPARATUS FOR HIGH POWER OPTICAL AMPLIFICATION IN THE INFRARED WAVELENGTH RANGE (0.7-20 μm) 审中-公开
标题翻译：红外波长范围内高功率光学放大的方法和装置（0.7-20 mum）
公开(公告)号：WO2005112207A1
公开(公告)日：2005-11-24
申请号：PCT/CA2005/000765
申请日：2005-05-16
申请人： MILLER, Robert John Dwayne , FRANJIC, Kresimir , KRAEMER, Darren , PICHE, Michel
发明人： MILLER, Robert John Dwayne , FRANJIC, Kresimir , KRAEMER, Darren , PICHE, Michel
IPC分类号： H01S3/094
CPC分类号： G02F1/39 , G02F2001/392 , H01S3/0057 , H01S3/109
摘要： Method for high power optical amplification of ultra-short pulses in IR wavelength range (0.7- 20 µm). The method is based on the optical parametric chirp pulse amplification (OPCPA) technique where a pico-second or nanosecond mode locked laser system synchronized to a signal laser oscillator is used as a pump source or alternatively the pump pulse is created from the signal pulse by using certain types of optical nonlinear processes described later in the document. This significantly increases stability, extraction efficiency and bandwidth of the amplified signal pulse.á Further, we disclose several practical methods of shaping the temporal and spatial profiles of the signal and pump pulses for optimization of the OPCPA interaction.
摘要翻译： IR波长范围（0.7〜20μm）超短脉冲大功率光放大的方法。该方法基于光学参量啁啾脉冲放大（OPCPA）技术，其中与信号激光振荡器同步的微秒级或纳秒模式锁定激光系统用作泵浦源，或者，泵浦脉冲是由信号脉冲由使用文献中稍后描述的某些类型的光学非线性过程。这显着增加了放大信号脉冲的稳定性，提取效率和带宽。此外，我们公开了形成信号和泵浦脉冲的时间和空间分布的几种实际方法，以优化OPCPA相互作用。

8. 发明申请

WO2018018147A1 METHOD AND SYSTEM FOR PRODUCING LASER ABLATION PLUMES WITHOUT ABLATION RECOIL PRODUCTS 审中-公开
标题翻译：生产激光消融标本没有消融再利用产品的方法和系统
公开(公告)号：WO2018018147A1
公开(公告)日：2018-02-01
申请号：PCT/CA2017/050897
申请日：2017-07-25
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , FRANJIC, Kresimir
发明人： FRANJIC, Kresimir
IPC分类号： G01N1/42 , G01N1/28 , H01J49/10
摘要： A method for preparing thin layers from liquid samples is disclosed. Such thin layers can be useful when analyzing samples with probes whose penetration length in these samples is short The method consists of squeezing a certain amount of a liquid sample between two approximately flat and parallel surfaces separated by a small distance then cooling down the liquid sample until it freezes in a way that the frozen sample adheres only to one of these two flat surfaces. Removing the non- adhered flat surface leaves the frozen sample layer with the thickness approximately equal to the initial distance between the two parallel surfaces.
摘要翻译：公开了由液体样品制备薄层的方法。当用这些样品中的穿透长度很短的探针分析样品时，这样的薄层可能是有用的。该方法包括将一定量的液体样品挤压在两个分开一小段距离的大致平坦和平行的表面之间，然后冷却液体样品直到它以冻结的样品仅粘附于这两个平坦表面中的一个的方式冻结。去除未粘附的平坦表面使冷冻样品层的厚度大致等于两个平行表面之间的初始距离。

9. 发明申请

WO2018014140A1 METHOD FOR MULTIMODAL TISSUE IMAGING BASED ON RESONANCE RAMAN EFFECT ON METAL BASED MRI CONTRAST AGENTS AND METHOD FOR IONIZING LASER PLUMES THROUGH ATMOSPHERIC PRESSURE CHEMICAL IONIZATION 审中-公开
标题翻译：基于共振拉曼效应的基于金属的MRI造影剂的多组织成像方法以及通过大气压力离子化激光的方法化学电离
公开(公告)号：WO2018014140A1
公开(公告)日：2018-01-25
申请号：PCT/CA2017/050887
申请日：2017-07-24
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , FRANJIC, Kresimir
发明人： FRANJIC, Kresimir
IPC分类号： G01R33/58 , A61B5/055 , A61K49/10 , C07C229/76 , C07D257/00 , H01J49/16
摘要： Disclosed herein is a method for multimodal imaging during a medical procedure using magnetic resonance imaging (MRI) and Raman optical imaging which involves administering an MRI imaging contrast agent that a chemical structure having charge-transfer electronic transitions. The tissue is imaged using and MRI device and the tissue is illuminated with excitation light that has spectral components that are approximately tuned close to one of the charge-transfer electronic transitions thereby producing enhanced Raman optical signals which are analyzed to produce Raman imaging data followed by registering the MRI and Raman imaging data. The present disclosure also provides a method for ionizing laser plumes through atmospheric pressure chemical ionization.
摘要翻译：本文公开了一种用于在使用磁共振成像（MRI）和拉曼光学成像的医学程序期间的多模式成像的方法，其涉及施用具有电荷转移电子跃迁的化学结构的MRI成像造影剂。使用MRI装置对组织进行成像，并且用具有近似调谐到靠近电荷转移电子跃迁之一的光谱分量的激发光照射组织，从而产生增强的拉曼光学信号，其被分析以产生拉曼成像数据，然后是记录MRI和拉曼成像数据。本公开还提供了一种通过大气压化学电离来电离激光羽流的方法。

10. 发明申请

WO2017185161A1 MULTI-MODAL OPTICAL IMAGING SYSTEM FOR TISSUE ANALYSIS 审中-公开
标题翻译：用于组织分析的多模式光学成像系统
公开(公告)号：WO2017185161A1
公开(公告)日：2017-11-02
申请号：PCT/CA2016/050502
申请日：2016-04-29
申请人： SYNAPTIVE MEDICAL (BARBADOS) INC. , FRANJIC, Kresimir , MAK, Siu Wai Jacky , HYNNA, Kai Michael , WOOD, Michael Frank Gunter , KUCHNIO, Piotr , BISMILLA, Yusuf , HOLMES, Lachlan Noel , BRIGHT, Stewart , CHEUNG, Aaron Yu Lai , KUZYK, Yuri Alexander , TAUB, Aryeh Benjamin , REZAEI, Sanaz
发明人： FRANJIC, Kresimir , MAK, Siu Wai Jacky , HYNNA, Kai Michael , WOOD, Michael Frank Gunter , KUCHNIO, Piotr , BISMILLA, Yusuf , HOLMES, Lachlan Noel , BRIGHT, Stewart , CHEUNG, Aaron Yu Lai , KUZYK, Yuri Alexander , TAUB, Aryeh Benjamin , REZAEI, Sanaz
IPC分类号： G01N35/00 , G01B11/24 , G01B21/20 , G01N21/84 , G01N33/02 , G01N33/483
CPC分类号： G01N21/65 , G01B9/02091 , G01B11/24 , G01N21/31 , G01N21/35 , G01N21/474 , G01N21/4795 , G01N21/636 , G01N21/6408 , G01N21/6456 , G01N21/6486 , G01N2021/653 , G01N2021/655
摘要： A modular system for organic sample analysis is disclosed which includes a sample stage including a support platform and a motorized positioning mechanism mounted on the support platform, and a sample holder mounted on the motorized positioning mechanism upon which a sample is placed. A probe support rack is mounted on the support platform and two or more bio-imaging probes mounted on the probe support and arranged in a pre- defined geometry with respect to each other, and at least one bio-imaging probe havs a field of view independent of all other bio-imaging probes. The system includes a computer controller connected to the motorized positioning mechanism and the two or more bio-imaging probes. The computer is programmed for controlling motorized positioning mechanism to move the sample holder having the sample located thereon to positions in the field of view of each bio-imaging probe where the sample can be analyzed individually by each of the bio-imaging probes. The computer includes a storage medium for storing an imaging data from each bio-imaging probe. The computer is programmed for spatially correlating imaging data of the selected volume of interest with the imaging data obtained from at least one other bio-imaging probe and storing the spatially correlated imaging data in the computer storage medium.
摘要翻译：公开了一种用于有机样品分析的模块化系统，其包括样品台和样品架，样品台包括支撑平台和安装在支撑平台上的机动定位机构，样品架安装在机动定位机构上，样品被放置。探针支撑架安装在支撑平台上并且两个或更多个生物成像探针安装在探针支撑件上并且相对于彼此以预定几何形状布置，并且至少一个生物成像探针具有视场独立于所有其他生物成像探针。该系统包括连接到机动定位机构和两个或更多个生物成像探针的计算机控制器。计算机被编程为用于控制机动定位机构以将其上具有样品的样品保持器移动到每个生物成像探头的视场中的位置，其中样品可由每个生物成像探头单独分析。该计算机包括用于存储来自每个生物成像探头的成像数据的存储介质。计算机被编程用于将所选感兴趣体积的成像数据与从至少一个其他生物成像探针获得的成像数据在空间上相关联，并将空间相关成像数据存储在计算机存储介质中。

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