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1. 发明申请

WO2021175701A1 PROCESS FOR MANUFACTURE OF A COMPLEXING AGENT 审中-公开
公开(公告)号：WO2021175701A1
公开(公告)日：2021-09-10
申请号：PCT/EP2021/054723
申请日：2021-02-25
申请人： BASF SE
发明人： SCHMIDT, Thomas , STAMM, Armin , TANG, Daniel, Dan-Tam , SHYMANSKA, Nataliia , MORMUL, Verena
IPC分类号： C07C227/26 , C07C227/36 , C07C227/18 , C07C253/00 , C07C253/06 , C07C229/16 , C07C229/76 , C07C255/25
摘要： A process for making a complexing agent with an enantiomeric excess of at least 60%, wherein said process comprises the following steps: (a) reacting an aqueous slurry of alanine with an enantiomeric excess of at least 60% with formaldehyde and hydrocyanic acid, thereby forming an aqueous solution of alanine- bisacetonitrile, (b) saponifying the alanine-bisacetonitrile from step (a) by combining the aqueous solution obtained in step (a) with an aqueous solution of alkali metal hydroxide.

2. 发明申请

WO2019101040A1 含有双环铂的组合产品、其制备方法及其用途审中-公开
公开(公告)号：WO2019101040A1
公开(公告)日：2019-05-31
申请号：PCT/CN2018/116213
申请日：2018-11-19
申请人：湖南湘源美东医药科技有限公司
发明人：刘晓忠 , 李雄 , 靳奇峰 , 郑和校
IPC分类号： A61K31/282 , C07C229/76 , C07F15/00 , A61P29/00 , A61P29/02 , A61P31/14 , A61P31/18
摘要：本发明涉及含有双环铂的组合产品、所述组合产品在制备用于治疗和/或预防疼痛、炎症和与病毒相关的疾病的药物中的用途以及制备所述组合产品的方法。

3. 发明申请

WO2015166491A3 FLUORESCENT MOLECULAR SENSOR FOR TARGETING CHANGES IN PROTEIN SURFACES, AND METHODS OF USE THEREOF 审中-公开
标题翻译：用于蛋白质表面变化的荧光分子传感器及其使用方法
公开(公告)号：WO2015166491A3
公开(公告)日：2015-12-23
申请号：PCT/IL2015050441
申请日：2015-04-28
申请人： YEDA RES & DEV
发明人： MARGULIES DAVID , MOTIEI LEILA , MANKOVSKI NAAMA , NISSINKORN YAEL
IPC分类号： G01N33/50 , C07C229/76 , C07D249/04 , C07K1/13 , C07K14/47 , G01N33/533
CPC分类号： G01N33/582 , C07D249/04 , C07K1/13 , G01N33/5005 , G01N33/5008 , G01N33/533 , G01N33/6803 , G01N2570/00
摘要： This invention is directed to monomolecular sensors, comprising a selective binder, a non-selective binder and a fluorophore, which can track changes that occur on the surface of labeled proteins. This invention is further directed to the use of such sensors for identifying binding partners of specific proteins. This invention is further directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins.
摘要翻译：本发明涉及单分子传感器，其包括选择性粘合剂，非选择性粘合剂和荧光团，其可以跟踪标记蛋白质表面上发生的变化。本发明还涉及这种传感器用于鉴定特定蛋白质的结合伴侣的用途。本发明进一步涉及His-标签结合化合物及其在制备可特异性结合标签标记的蛋白质的遗传可靶向可检测分子和传感器的用途。

4. 发明申请

WO2014052087A1 BIFUNCTIONAL CHELATING AGENTS 审中-公开
标题翻译：双功能螯合剂
公开(公告)号：WO2014052087A1
公开(公告)日：2014-04-03
申请号：PCT/US2013/060041
申请日：2013-09-17
申请人： GENERAL ELECTRIC COMPANY
发明人： GRIMMOND, Brian, James , RISHEL, Michael, James
IPC分类号： A61K49/10 , C07F9/655 , C07C229/16 , C07C229/76 , C07F9/38
CPC分类号： C07F15/025 , A61K49/103 , C07C229/16 , C07C229/76 , C07F7/0812 , C07F9/3808 , C07F9/4006 , C07F9/409 , C07F9/65586 , Y02P20/55
摘要： A chelating agent, a metal-chelate, and a contrast agent are provided, wherein the chelating agent comprises a compound of structure (I), wherein R 1 R 2 ,R 3 ,R 8 ,R 7 ,R' 7 R' 1 ,R' 2 ,R' 3 and R 8 ' are selected from a hydrogen, a protected C 1 -C 3 hydroxyalkyl group, a C 1 -C 3 alkyl group; R 4 and R' 4 are selected from a hydrogen, a hydroxyl group, a protected hydroxy group, a protected C 1 -C 3 hydroxyalkyl group, a C 1 -C 3 alkyl group; n is an integer between 0 and 4; R 5 and R' 5 are selected from a hydrogen, a protecting group selected from the group consisting of C 1 -C 30 aliphatic radicals, C 3 -C 30 cycloaliphatic radicals, C 2 -C 30 aromatic radicals; R 9 and R' 9 are selected form a hydrogen or a protecting group selected from the group consisting of C 1 -C 30 aliphatic radicals, C 3 -C 30 cycloaliphatic radicals, C 2 -C 30 aromatic radicals, m is an integer between 0 and 10; and at least one of R 7 and R' 7 is acidic group or a protected acidic group.
摘要翻译：提供螯合剂，金属螯合物和对比剂，其中螯合剂包括结构式（I）的化合物，其中R1R2，R3，R8，R7，R'7R'1，R'2， R'3和R 8'选自氢，被保护的C 1 -C 3羟烷基，C 1 -C 3烷基; R 4和R 4选自氢，羟基，保护的羟基，被保护的C 1 -C 3羟烷基，C 1 -C 3烷基; n是0和4之间的整数; R 5和R 5选自氢，选自C 1 -C 30脂族基，C 3 -C 30脂环族基，C 2 -C 30芳族基的保护基; R 9和R 9选自由C 1 -C 30脂族基团，C 3 -C 30脂环族基团，C 2 -C 30芳族基团组成的组中的氢或保护基团，m为0至10的整数; 并且R 7和R 7中的至少一个是酸性基团或被保护的酸性基团。

5. 发明申请

WO2011023382A3 METHOD FOR PRODUCING A CRYSTALLINE SOLID FROM GLYCINE-N, N-DIACETIC ACID DERIVATIVES 审中-公开
标题翻译：用于生产结晶固体OFF甘氨酸-N，N-二衍生物
公开(公告)号：WO2011023382A3
公开(公告)日：2011-05-12
申请号：PCT/EP2010005219
申请日：2010-08-25
申请人： INPROTEC AG , BARANYAI ANDREAS
发明人： BARANYAI ANDREAS
IPC分类号： C07C227/42 , C07C229/16 , C07C229/76 , C11D3/33
CPC分类号： C07C229/16 , C07B2200/13 , C07C227/42 , C11D3/33 , C11D7/3245 , C07C229/76
摘要： The invention relates to a method for producing a cyristalline solid from glycine-N,N- diacetic derivatives (e.g. MGDA) with sufficiently reduced hygroscopicity, characterised in that at least one crystalline compound of formula (I) is provided as germ, and a spray granulation is produced with at least one compound of formula (I), preferably followed by a heat treatment.
摘要翻译：本发明涉及一种用于制备的固体甘氨酸-N结晶，具有足够低的吸湿性，其特征在于在式（I）的至少一种结晶化合物N-二乙酸衍生物（例如MGDA）被呈现为种子，与式（I）中的至少一种化合物的喷雾造粒中进行时，优选随后进行热处理。

6. 发明申请

WO2009016235A2 CHELATING AGENT BASED IONIC LIQUIDS, A PROCESS TO PREPARE THEM, AND THEIR USE 审中-公开
标题翻译：基于代理的离子液体，制备方法及其使用
公开(公告)号：WO2009016235A2
公开(公告)日：2009-02-05
申请号：PCT/EP2008/060066
申请日：2008-07-31
申请人： Akzo Nobel N.V. , DE WOLF, Cornelia Adriana , KUZMANOVIC, Boris , BEMELAAR, Johanna Hendrika , VAN STRIEN, Cornelis Johannes Govardus , HEUS, Martin , TEN KATE, Antoon
发明人： DE WOLF, Cornelia Adriana , KUZMANOVIC, Boris , BEMELAAR, Johanna Hendrika , VAN STRIEN, Cornelis Johannes Govardus , HEUS, Martin , TEN KATE, Antoon
IPC分类号： C07C211/63 , C07C215/40 , C07C229/16 , C07C229/76 , C07F9/54
CPC分类号： C07C229/16 , C07C211/63 , C07C215/40 , C07C229/76 , C07F9/5407
摘要： The present invention relates to ionic liquids of the formula: (M m+ ) x H + y nN + R 1 R 2 R 3 R 4 Z-N(-CHXCOO - ) p Y 2-p or (M m+ ) x H + y nP + R 1 R 2 R 3 R 4 Z-N(-CHXCOO - ) p Y 2-p wherein any one of R 1 to R 4 independently represents a hydrogen, alkyl, cycloalkyl, aryl or aralkyl group that may be unsubstituted or substituted with one or more groups selected from OH, Cl, Br, F, I, phenyl, NH 2 , CN, NO 2, an ether group, COOR 5 , CHO, COR 5 or OR 5 , wherein R 5 is an alkyl or cycloalkyl group, and wherein two of the groups R 1 to R 4 together with the N atom may form a heteroaromatic or heterocyclic group such as a pyridinium, pyrrolidinium or imidazolium group; the Z-N(-CHXCOO - )pY 2-p is the anion derived from a chelating agent, wherein Z is a group selected from hydrogen, alkyl, an alkyl group optionally substituted with one or more carboxylate groups, hydroxyl groups and/or optionally containing one or more ether functionalities, or Z is a group of the formula -CH 2 -CHR 6 -R 7 -N-(CH 2 COO - ) 2 , R 6 is hydrogen or a C 1 -C 3 alkyl group, R 7 is a single bond, a C 1 -C 3 alkylene group or one or more groups of the formula -N(CH 2 COO - )-CH 2 -CHR 6 -R 8 -, R 8 is a single bond or a C 1 -C 3 alkylene group, p is 2 or 1, X is H, an aryl group that may be unsubstituted or substituted with an OH and/or CH 3 substituent, or CH 2 COO - , and when p is 1, Y is H, a benzyl group that may be unsubstituted or substituted with an OH and/or CH 3 group, or a phenyl group that may be unsubstituted or substituted with an OH and/or CH 3 substituent, M m+ is a m-valent metal cation, n is 1 or higher, x is from 0 to 5, y is from 0 to 3, the total positive charge of (M m+ ) x , H + y ,and nN + R 1 R 2 R 3 R 4 or nP + R 1 R 2 R 3 R 4 equals the negative charge of the Z-N(-CHXCOO - ) p Y 2-p anion, wherein at least one of the following conditions is fulfilled: i) the chelating agent has a connectivity index 1 X/ 3 X of below 2.17, ii) at least two different cations are present in the salt, whereby a proton cation does not count as one of the at least two, iii) at least one cation is a bivalent, trivalent, tetravalent or pentavalent cation, and having a melting point below 120°C. The invention further relates to a process to prepare them and their use.
摘要翻译：本发明涉及下式的离子液体：（Mm +）xH + y nN + R1R2R3R4ZN（-CHXCOO-）pY2-p或（Mm +）xH + ynP + R1R2R3R4Z-N（-CHXCOO-）pY2-p其中任何 R 1至R 4中的一个独立地表示氢，烷基，环烷基，芳基或芳烷基，其可以是未取代的或被一个或多个选自OH，Cl，Br，F，I，苯基，NH 2，CN，NO 2，醚基，COOR 5，CHO，COR 5或OR 5，其中R 5是烷基或环烷基，并且其中R 1至R 4中的两个与N原子一起可以形成杂芳族或杂环基，例如吡啶鎓，吡咯烷鎓或咪唑鎓基团 ; ZN（-CHXCOO-）pY2-p是衍生自螯合剂的阴离子，其中Z是选自氢，烷基，任选被一个或多个羧酸酯基团取代的烷基，羟基和/或任选地含有一个或更多的醚官能团，或Z是式-CH2-CHR6-R7-N-（CH2COO-）2的基团，R6是氢或C1-C3烷基，R7是单键，C1-C3亚烷基基团或一个或多个式-N（CH 2 COO - ） - CH 2 - CHR 6 -R 8 - 的基团，R 8是单键或C 1 -C 3亚烷基，p是2或1，X是H，可以是未被取代的或被OH和/或CH 3取代基或CH 2 COO-取代的，当p是1时，Y是H，可以是未取代的或被OH和/或CH 3基团取代的苄基或苯基其可以是未取代的或被OH和/或CH 3取代基取代，M m +是m价金属阳离子，n为1或更高，x为0至5，y为0至3，（ Mm +）x，H + y和nN + R1R2R3R4或 nP + R1R2R3R4等于ZN（-CHXCOO-）pY2-p阴离子的负电荷，其中满足以下条件中的至少一个：i）螯合剂具有低于2.17的连续性指数1 X / 3 X，ii ）盐中存在至少两种不同的阳离子，其中质子阳离子不计为至少两种，iii）至少一种阳离子之一是二价，三价，四价或五价阳离子，并且具有低于 120℃。本发明还涉及制备它们及其用途的方法。

7. 发明申请

WO2007147222A9 NOVEL IONIC LIQUIDS 审中-公开
标题翻译：新鲜离子液体
公开(公告)号：WO2007147222A9
公开(公告)日：2008-02-14
申请号：PCT/BE2007000062
申请日：2007-06-21
申请人： UNIV LEUVEN KATH , BINNEMANS KOEN , GOERLLER-WALRAND CHRISTIANE AN , NOCKEMANN PETER , THIJS BEN
发明人： BINNEMANS KOEN , GOERLLER-WALRAND CHRISTIANE AN , NOCKEMANN PETER , THIJS BEN
IPC分类号： C07C229/76 , C07C311/02 , C07D213/20 , C07D295/14 , C07F9/54
CPC分类号： C25D3/665 , C07C229/12 , C07C229/22 , C07C311/48 , C07D213/20 , C07F9/5407 , C23C26/00 , C23C30/00 , C25F1/00 , C25F3/00 , H01M6/162 , H01M8/14 , H01M10/0566 , H01M2300/0025
摘要： The present invention provides for novel organic salts, more specifically ionic liquids and for methods for the preparation of such novel ionic liquids. The invention also provides for the use of the ionic liquids in chemistry applications, for example for the solubilization of metal oxides, hydroxides and salts, for the deposition of metals or for extraction procedures, among others. The invention furthermore provides for a method for the solubilization of metal oxides and metal salts, for the deposition of metals and for extraction procedures, this by using the novel ionic liquids. The present invention furthermore provides for materials obtained by the methods hereof.
摘要翻译：本发明提供新颖的有机盐，更具体地说是离子液体和制备这种新型离子液体的方法。本发明还提供了在化学应用中使用离子液体，例如用于金属氧化物，氢氧化物和盐的溶解，用于沉积金属或用于萃取程序等。本发明还提供了一种通过使用新型离子液体来溶解金属氧化物和金属盐，用于金属沉积和萃取方法的方法。本发明还提供了通过本发明的方法获得的材料。

8. 发明申请

WO03099762A8 AGENTS AND METHODS FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS 审中-公开
标题翻译：用于治疗与氧化应激相关的疾病的代理和方法
公开(公告)号：WO03099762A8
公开(公告)日：2005-01-20
申请号：PCT/AU0300644
申请日：2003-05-27
申请人： UNIV MONASH , CHEEMA SURINDAR SINGH , LANGFORD STEVEN , CHEUNG NAM SANG , BEART PHILIP MARK , MACFARLANE KATHERINE JANE , MULCAIR MARK
发明人： CHEEMA SURINDAR SINGH , LANGFORD STEVEN , CHEUNG NAM SANG , BEART PHILIP MARK , MACFARLANE KATHERINE JANE , MULCAIR MARK
IPC分类号： A61K45/00 , A61K31/198 , A61K31/215 , A61K31/216 , A61K31/335 , A61K31/343 , A61K31/353 , A61K31/355 , A61K31/357 , A61K31/7105 , A61K38/00 , A61K38/22 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/28 , A61P39/04 , A61P39/06 , C07C229/18 , C07D273/08 , C07D311/58 , C07D323/00 , C07C229/76
CPC分类号： C07D311/58 , A61K31/198 , A61K31/216 , A61K31/335 , A61K31/357 , C07C229/18 , C07D323/00
摘要： The invention provides a method for preventing or reducing the effects of oxidative stress on a substrate. The method includes the step of treating the substrate with a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein: R is one or more substituents selected from -H, -alkyl, -alkoxy, -aryl, -aryloxy, -halogen, -amino (mono-, di- and tri-substituted), -alkylthio, -NO2, -COOH, -COOAlkyl, -CO-alkyl, -CN; R is one or more substituents selected from -H, -alkyl, -(CH2CH2O)n-R , a sugar moiety; R is -H, -alkyl, -aryl, -alkylOR , -alkylC(O)R ; R is selected from -H, -alkyl, -aryl; and R and R are independently selected from -OH, -O-alkyl, -O-polyalkyleneoxy, -O-aryl, -OC(O)O-alkyl, -S-alkyl and -amino.
摘要翻译：本发明提供一种预防或减少氧化应激对基质的影响的方法。该方法包括用式（I）化合物或其药学上可接受的盐处理底物的步骤，其中：R 1是一个或多个选自-H， - 烷基， - 烷氧基， - 芳基， - 芳氧基， - 卤素， - 氨基（单 - ，二 - 和三 - 取代的） - - 烷硫基，-NO 2，-COOH，-COOA烷基， - - - - 烷基，-CN; R 2是一个或多个选自-H， - 烷基， - （CH 2 CH 2 O）n -R 5，糖部分的取代基; R 3是-H， - 烷基， - 芳基， - 烷基OR 6， - 烷基C（O）R 6; R 5选自-H， - 烷基， - 芳基; R 4和R 6独立地选自-OH，-O-烷基，-O-聚亚烷基氧基，-O-芳基，-OC（O）O-烷基，-S-烷基和 - 氨基。

9. 发明申请

WO02034211A2 ANTIPERSPIRANT SALTS FOR ENHANCED COSMETIC PRODUCTS 审中-公开
标题翻译：增强化妆品的防晒剂
公开(公告)号：WO02034211A2
公开(公告)日：2002-05-02
申请号：PCT/US2001/032348
申请日：2001-10-18
IPC分类号： A61K20060101 , A61K8/28 , A61K8/44 , A61Q15/00 , C07C229/76 , A61K7/00
CPC分类号： A61Q15/00 , A61K8/28 , A61K8/44
摘要： This invention comprises aluminum zirconium salts which have a metal to chloride molar ratio in the range of 0.9-1.2:1 and a glycine:zirconium molar ratio greater than 1.3:1 and antiperspirant compositions made with such salts.
摘要翻译：本发明包括具有0.9-1.2:1范围内的金属氯化物摩尔比和甘氨酸：锆摩尔比大于1.3:1的铝锆盐和由这些盐制成的止汗组合物。

10. 发明申请

WO01039769A1 HYPOGLYCEMICS COMPRISING ORGANIC ZINC (II) COMPLEXES 审中-公开
标题翻译：包含有机锌（II）复合物的高分子化合物
公开(公告)号：WO01039769A1
公开(公告)日：2001-06-07
申请号：PCT/JP2000/007991
申请日：2000-11-13
IPC分类号： C07D333/40 , A61K31/136 , A61K31/145 , A61K31/198 , A61K31/315 , A61K31/351 , A61K31/381 , A61K31/40 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/455 , A61K31/555 , A61K33/30 , A61P3/10 , A61P31/10 , A61P43/00 , C07C229/76 , C07C323/34 , C07C323/52 , C07D207/06 , C07D213/55 , C07D213/79 , C07D213/80 , C07D213/89 , C07D277/06 , C07D295/21 , C07D309/38 , C07D309/40
CPC分类号： A61K31/351 , A61K31/315 , A61K31/381 , A61K31/44 , A61K31/555 , A61K33/30 , C07D213/55 , C07D213/79 , A61K2300/00
摘要： Hypoglycemics having a lower toxicity than vanadium and an adequate stability and exerting an adequate fat-soluble insulin-like effect; and medicinal preparations having an insulin-like effect and being useful as preventives and remedies for diabetes. Hypoglycemics comprising organic zinc (II) complexes which contain as the ligand selected from among ligands having pyridine ring, ligands having pyrone ring, ligands having thiazolidine ring, ligands comprising amino acids, ligands comprising 2-aminothiophenols and ligands comprising pyrrolinedithiocarbamic acids; and medicinal preparations containing the above-described organic zinc (II) complexes which are useful as remedies for diabetes.
摘要翻译：低血糖药物的毒性低于钒，具有足够的稳定性，并发挥足够的脂溶性胰岛素样作用; 和具有胰岛素样效应的药物制剂，并且可用作糖尿病的预防剂和治疗剂。含有选自具有吡啶环的配体，具有吡喃酮环的配位体，具有噻唑烷环的配位体，含有氨基酸的配位体，含有2-氨基硫酚的配位体和包含吡咯烷二硫代氨基甲酸的配位体的配位体的有机锌（II）配合物的低血糖药和含有上述有机锌（II）配合物的药物制剂，其可用作糖尿病的补救剂。

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