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1. 发明申请

WO2006008739A3 MODIFIED CONDUCTIVE SURFACES HAVING ACTIVE SUBSTANCES ATTACHED THERETO 审中-公开
标题翻译：具有附着活性物质的改性导电表面
公开(公告)号：WO2006008739A3
公开(公告)日：2006-06-01
申请号：PCT/IL2005000769
申请日：2005-07-19
申请人： ELUTEX LTD , DOMB ABRAHAM J , MANDLER DANIEL , DANZIGER ISHAIAHU , OROM MIRIAM , OKNER REGINA , SHUSTAK GALIT , SWED AVI , TAL NOAM
发明人： DOMB ABRAHAM J , MANDLER DANIEL , DANZIGER ISHAIAHU , OROM MIRIAM , OKNER REGINA , SHUSTAK GALIT , SWED AVI , TAL NOAM
IPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L31/16
CPC分类号： C09D5/4476 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/62 , B82Y30/00
摘要： Novel processes for coating metal surfaces and/or for attaching active substances to metal surfaces, objects having coated metal surfaces and/or active substances attached thereto and uses thereof in the preparation of implantable devices are disclosed.
摘要翻译：公开了用于将金属表面和/或用于将活性物质附着到金属表面，具有涂覆金属表面的物体和/或附着于其上的活性物质的新方法及其在可植入装置的制备中的用途。

2. 发明申请

WO2007010536A3 ELECTROPOLYMERIZABLE MONOMERS AND POLYMERIC COATINGS ON IMPLANTABLE DEVICES PREPARED THEREFROM 审中-公开
标题翻译：在其上制备可植入装置的电解聚合单体和聚合物涂层
公开(公告)号：WO2007010536A3
公开(公告)日：2007-06-21
申请号：PCT/IL2006000839
申请日：2006-07-19
申请人： ELUTEX LTD , DOMB ABRAHAM J
发明人： DOMB ABRAHAM J
IPC分类号： A61L27/54 , A61F2/02 , A61F2/06 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/00
CPC分类号： C07D207/327 , A61L27/042 , A61L27/34 , A61L31/022 , A61L31/10 , A61L31/16 , A61L33/0088 , A61L2300/80 , A61L2400/12 , A61L2420/02 , C08F2/58 , C08F226/06 , C09D5/4476 , C08L39/06
摘要： Conductive surfaces of e.g., implantable devices, coated with electropolymerized polymers having active substances attached thereto are disclosed. Electropolymerizable monomers designed and used for obtaining such conductive surfaces and processes, devices and methods for attaching the electropolymerized polymers to conductive surfaces are also disclosed. The polymers, processes and devices presented herein can be beneficially used in the preparation of implantable medical devices.
摘要翻译：公开了涂有电活性物质的电聚合聚合物的可植入装置的导电表面。还公开了设计并用于获得这样的导电表面和工艺的可电聚合单体，用于将电聚合聚合物附着到导电表面的装置和方法。本文呈现的聚合物，方法和装置可有益地用于制备可植入医疗装置。

3. 发明申请

WO2013005215A2 PHMG MODIFIED ANTIMICROBIAL AGENTS 审中-公开
标题翻译： PHMG改性抗微生物剂
公开(公告)号：WO2013005215A2
公开(公告)日：2013-01-10
申请号：PCT/IL2012050237
申请日：2012-07-05
申请人： STRAUSS WATER LTD , DOMB ABRAHAM J , RATNER STANISLAV , MIZRAHI OREN , WILDER HAIM , FRENKEL HELLA
发明人： DOMB ABRAHAM J , RATNER STANISLAV , MIZRAHI OREN , WILDER HAIM , FRENKEL HELLA
IPC分类号： A01N47/44 , A01P1/00
CPC分类号： A01N47/44 , A01N25/10
摘要： The invention concerns an antimicrobial agent comprising modified polyhexamethylene guanidine (PHMG), products containing it and uses thereof.
摘要翻译：本发明涉及包含改性聚六亚甲基胍（PHMG），含有它的产品及其用途的抗微生物剂。

4. 发明申请

WO2011092653A3 POLYMER GEL FORMULATION 审中-公开
标题翻译：聚合物凝胶配方
公开(公告)号：WO2011092653A3
公开(公告)日：2011-11-24
申请号：PCT/IB2011050384
申请日：2011-01-28
申请人： JUVENIS LTD , DOMB ABRAHAM J , YANIV MORAN , VAISMAN BORIS , YANKELSON LIOR
发明人： DOMB ABRAHAM J , YANIV MORAN , VAISMAN BORIS , YANKELSON LIOR
IPC分类号： A61L27/18 , A61L27/52
CPC分类号： A61L27/52 , A61L27/18
摘要： A polymer gel, in at least some embodiments, featuring both cross-linked castor oil and branched castor oil components, in which the castor oil is optionally replaced by ricinoleic acid.
摘要翻译：在至少一些实施方案中，聚合物凝胶以交联蓖麻油和支化蓖麻油组分为特征，其中蓖麻油任选地被蓖麻油酸代替。

5. 发明申请

WO2004073794A3 DEVICE, METHODS AND SPONGES FOR IONTOPHORETIC DRUG DELIVERY 审中-公开
标题翻译：用于静脉输送药物的装置，方法和通道
公开(公告)号：WO2004073794A3
公开(公告)日：2004-11-25
申请号：PCT/IL2004000167
申请日：2004-02-19
申请人： YISSUM RES DEV CO , DOMB ABRAHAM J
发明人： DOMB ABRAHAM J
IPC分类号： A61N1/30 , A61K9/51
CPC分类号： A61N1/30
摘要： Disclosed are devices and methods for administration of charged drugs to tissues of the oral cavity and for intra-tissue administration. The disclosed drug applicator for intra-tissue use includes an introducer such as a needle or catheter that is adapted to penetrate into a living tissue. The introducer has a drug-providing portion, and the applicator has current-generating element to pass through it an electrical current. Passing an electrical current through the drug-providing portion causes the drug to eject into treated tissue. Also disclosed are charged drugs suitable for iontophoretic administration, which include a bioactive agent encapsulated in charged nano-particles.
摘要翻译：公开了用于将带电药物施用于口腔组织和组织内施用的装置和方法。所公开的用于组织内使用的药物施用器包括适于渗入生物体组织的引导器，例如针或导管。导引器具有药物提供部分，并且施加器具有电流产生元件以使其通过电流。将电流通过药物提供部分导致药物喷射到处理过的组织中。还公开了适用于离子电渗治疗的带电药物，其包括包封在带电的纳米颗粒中的生物活性剂。

6. 发明申请

WO2009044403A2 INJECTABLE BIODEGRADABLE POLYMER COMPOSITIONS FOR SOFT TISSUE REPAIR AND AUGMENTATION 审中-公开
标题翻译：用于软组织修复和补充的可注射的生物可降解聚合物组合物
公开(公告)号：WO2009044403A2
公开(公告)日：2009-04-09
申请号：PCT/IL2008001320
申请日：2008-10-05
申请人： JUVENIS LTD , YANKELSON LIOR , DOMB ABRAHAM J
发明人： YANKELSON LIOR , DOMB ABRAHAM J
IPC分类号： A61L27/26 , A61L27/50
CPC分类号： A61L27/58 , A61L27/18 , A61L27/50 , A61L2400/06 , C08L67/04
摘要： Methods for soft tissue repair and/or augmentation using injectable, biodegradable polymers are described herein. In one embodiment, the polymer compositions are liquid or pastes at room temperature. In a preferred embodiment, the polymer composition contains liquid or pasty hydroxy fatty acid-based copolyesters, polyester-anhydrides, or combinations thereof. The viscosity of the polymers increases upon contact with bodily fluid to form a solid or semisolid implant suitable for soft tissue repair and/or augmentation. In another embodiment, the polymer composition contains particles of a polymer stereocomplex. One or more active agents may be incorporated into the polymer compositions. Suitable classes of active agents include local anesthetics, anti-inflammatory agents, antibiotics, analgesics, growth factors and agents that induce and/or enhance growth of tissue within the filled cavity or control the growth of a certain type of tissue, and combinations thereof. The polymer compositions may also contain one or more additives or excipients that modify the physical and/or mechanical properties of the polymer. The polymer compositions are typically administered by injection. The injectable polymers can be used for a variety of soft tissue repair and augmentation procedures.
摘要翻译：本文描述了使用可注射的可生物降解的聚合物进行软组织修复和/或增加的方法。在一个实施方案中，聚合物组合物在室温下为液体或糊状物。在优选的实施方案中，聚合物组合物含有液体或糊状羟基脂肪酸基共聚酯，聚酯酸酐或其组合。当与体液接触时，聚合物的粘度增加，以形成适于软组织修复和/或增加的固体或半固体植入物。在另一个实施方案中，聚合物组合物含有聚合物立体络合物的颗粒。一种或多种活性剂可以并入聚合物组合物中。合适类别的活性剂包括局部麻醉剂，抗炎剂，抗生素，止痛剂，生长因子和诱导和/或增强填充腔内组织生长或控制某种类型组织生长的试剂及其组合。聚合物组合物还可以含有改变聚合物的物理和/或机械性能的一种或多种添加剂或赋形剂。聚合物组合物通常通过注射施用。可注射聚合物可用于各种软组织修复和增强程序。

7. 发明申请

WO2006078725A8 SOFT POLYLACTIDES 审中-公开
标题翻译：软聚酯
公开(公告)号：WO2006078725A8
公开(公告)日：2007-07-12
申请号：PCT/US2006001748
申请日：2006-01-19
申请人： MASSACHUSETTS INST TECHNOLOGY , DOMB ABRAHAM J , LANGER ROBERT S
发明人： DOMB ABRAHAM J , LANGER ROBERT S
IPC分类号： C08G63/00
CPC分类号： A61K9/0024 , A61K9/0019 , A61K47/34 , C08G63/06
摘要： Biodegradable polymeric compositions that are liquids or pastes at temperatures below 370C are described. Immersion of the compositions in aqueous medium, such as body fluids, increases the viscosity of the composition resulting in the formation of a semisolid material. The polymeric material is a hydroxyalkanoic acid polyester derived from the copolymerization of at least one unsaturated hydroxy fatty acid copolymerized with hydroxyalkanoic acids of 2-6 carbons.
摘要翻译：描述了在低于370℃的温度下是液体或糊状物的可生物降解的聚合物组合物。组合物在水性介质（例如体液）中的浸渍增加了组合物的粘度，从而形成半固体材料。聚合物材料是由至少一种与2-6个碳原子的羟基链烷酸共聚的不饱和羟基脂肪酸的共聚得到的羟基链烷酸聚酯。

8. 发明申请

WO2006129320A3 BIODEGRADABLE POLYMERS HAVING A PRE-DETERMINED CHIRALITY 审中-公开
标题翻译：具有预先确定的CHIRALITY的生物可降解聚合物
公开(公告)号：WO2006129320A3
公开(公告)日：2007-01-25
申请号：PCT/IL2006000643
申请日：2006-06-04
申请人： YISSUM RES DEV CO , KATZHENDLER YEHOSHUA , DOMB ABRAHAM J
发明人： KATZHENDLER YEHOSHUA , DOMB ABRAHAM J
IPC分类号： C08G63/78 , A61K9/16 , C08G63/06 , C12P7/42
CPC分类号： C08G63/00 , C12P7/625 , Y02P20/582
摘要： Optically active polymers that are composed of monomer residues derived from chiral pre-polymerized monomers, which maintain the chirality of the pre-polymerized monomers upon polymerization are disclosed. These polymers can be composed of monomer residues that are derived from readily available chiral monomers and can be designed to have pre-determined characteristics such as chirality, biodegradability and functionality. Uses of these polymers as therapeutically active agents, and/or as carriers of therapeutically active agents, for delivering the active agents to a targeted bodily site and/or for a sustained release of the active agent, are further disclosed. Also disclosed are processed of preparing the polymers, compositions and medical devices containing the polymers, and conjugates of these polymers and various agents.
摘要翻译：公开了由衍生自手性预聚单体的单体残基组成的光聚合物，其在聚合时保持预聚单体的手性。这些聚合物可以由衍生自容易获得的手性单体的单体残基组成，并且可以设计成具有预定特性，例如手性，生物可降解性和官能度。进一步公开了这些聚合物作为治疗活性剂和/或作为治疗活性剂的载体用于将活性剂递送至靶向身体部位和/或持续释放活性剂的用途。还公开了制备包含聚合物的聚合物，组合物和医疗装置以及这些聚合物和各种试剂的共轭物。

9. 发明申请

WO2009027971A3 ANTIMICROBIAL POLYMERS 审中-公开
标题翻译：抗微生物聚合物
公开(公告)号：WO2009027971A3
公开(公告)日：2009-04-30
申请号：PCT/IL2008001160
申请日：2008-08-27
申请人： H2Q WATER IND LTD , DOMB ABRAHAM J , WILDER HAIM , RATNER STANISLAW
发明人： DOMB ABRAHAM J , WILDER HAIM , RATNER STANISLAW
IPC分类号： C08J3/20 , A61L31/10 , C08K9/08
CPC分类号： C08J3/203 , A01N33/12 , A61L27/34 , A61L27/446 , A61L27/54 , A61L29/085 , A61L29/126 , A61L29/16 , A61L31/10 , A61L31/128 , A61L31/16 , A61L2300/21 , A61L2300/404 , A61L2420/04 , C08J3/201 , C08K9/08 , A01N25/10 , A01N25/22 , A01N25/34 , A01N2300/00
摘要： This application discloses a process for the manufacture of articles having antimicrobial characteristics.
摘要翻译：该申请公开了用于制造具有抗微生物特性的制品的方法。

10. 发明申请

WO2007034495A2 CONJUGATES OF THERAPEUTICALLY ACTIVE COMPOUNDS 审中-公开
标题翻译：治疗活性化合物的结合
公开(公告)号：WO2007034495A2
公开(公告)日：2007-03-29
申请号：PCT/IL2006001118
申请日：2006-09-25
申请人： HADASIT MED RES SERVICE , YISSUM RES DEV CO , DOMB ABRAHAM J , POLACHECK ITZHACK , SOSKOLNI MARINA , GOLENSER JACOB
发明人： DOMB ABRAHAM J , POLACHECK ITZHACK , SOSKOLNI MARINA , GOLENSER JACOB
IPC分类号： A61K47/48
CPC分类号： A61K47/61
摘要： The present invention discloses modified polymer conjugates of a polymer and a drug having reduced toxicity relative to the unmodified parent compound while retaining substantially the same degree of therapeutic activity as of the unmodified parent compound.
摘要翻译：本发明公开了相对于未修饰的母体化合物具有降低的毒性的聚合物和药物的改性聚合物缀合物，同时保留与未修饰的母体化合物基本相同的治疗活性程度。

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