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2. 发明申请

WO2009044403A2 INJECTABLE BIODEGRADABLE POLYMER COMPOSITIONS FOR SOFT TISSUE REPAIR AND AUGMENTATION 审中-公开
标题翻译：用于软组织修复和补充的可注射的生物可降解聚合物组合物
公开(公告)号：WO2009044403A2
公开(公告)日：2009-04-09
申请号：PCT/IL2008001320
申请日：2008-10-05
申请人： JUVENIS LTD , YANKELSON LIOR , DOMB ABRAHAM J
发明人： YANKELSON LIOR , DOMB ABRAHAM J
IPC分类号： A61L27/26 , A61L27/50
CPC分类号： A61L27/58 , A61L27/18 , A61L27/50 , A61L2400/06 , C08L67/04
摘要： Methods for soft tissue repair and/or augmentation using injectable, biodegradable polymers are described herein. In one embodiment, the polymer compositions are liquid or pastes at room temperature. In a preferred embodiment, the polymer composition contains liquid or pasty hydroxy fatty acid-based copolyesters, polyester-anhydrides, or combinations thereof. The viscosity of the polymers increases upon contact with bodily fluid to form a solid or semisolid implant suitable for soft tissue repair and/or augmentation. In another embodiment, the polymer composition contains particles of a polymer stereocomplex. One or more active agents may be incorporated into the polymer compositions. Suitable classes of active agents include local anesthetics, anti-inflammatory agents, antibiotics, analgesics, growth factors and agents that induce and/or enhance growth of tissue within the filled cavity or control the growth of a certain type of tissue, and combinations thereof. The polymer compositions may also contain one or more additives or excipients that modify the physical and/or mechanical properties of the polymer. The polymer compositions are typically administered by injection. The injectable polymers can be used for a variety of soft tissue repair and augmentation procedures.
摘要翻译：本文描述了使用可注射的可生物降解的聚合物进行软组织修复和/或增加的方法。在一个实施方案中，聚合物组合物在室温下为液体或糊状物。在优选的实施方案中，聚合物组合物含有液体或糊状羟基脂肪酸基共聚酯，聚酯酸酐或其组合。当与体液接触时，聚合物的粘度增加，以形成适于软组织修复和/或增加的固体或半固体植入物。在另一个实施方案中，聚合物组合物含有聚合物立体络合物的颗粒。一种或多种活性剂可以并入聚合物组合物中。合适类别的活性剂包括局部麻醉剂，抗炎剂，抗生素，止痛剂，生长因子和诱导和/或增强填充腔内组织生长或控制某种类型组织生长的试剂及其组合。聚合物组合物还可以含有改变聚合物的物理和/或机械性能的一种或多种添加剂或赋形剂。聚合物组合物通常通过注射施用。可注射聚合物可用于各种软组织修复和增强程序。

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