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1. 发明申请

WO2011110873A1 DETECTION OF METHYLATED DNA 审中-公开
标题翻译：检测甲基化DNA
公开(公告)号：WO2011110873A1
公开(公告)日：2011-09-15
申请号：PCT/GB2011/050501
申请日：2011-03-14
申请人： DNA ELECTRONICS LTD , TOUMAZOU, Christofer , KALOFONOU, Melpomeni
发明人： TOUMAZOU, Christofer , KALOFONOU, Melpomeni
IPC分类号： C12Q1/68 , G01N27/414
CPC分类号： G01N27/4145 , C12Q1/6825 , C12Q1/6827 , C12Q1/6858 , C12Q1/6869 , C12Q2523/125 , C12Q2527/119 , C12Q2565/607
摘要： The use of ion sensitive field effect transistor (ISFET) to detect methylated nucleotides in a DNA sample is described. A method of detecting methylated nucleotides in a DNA sample may include the steps of treating a sample of DNA with a reagent which discriminates between methylated and non-methylated nucleotides to provide treated DNA, amplifying the treated DNA and optionally sequencing the amplified DNA. An ISFET is used to monitor the addition of one or more dNTPs in the strand extension reactions during the amplification and/or sequencing step. Suitable apparatus is also provided.
摘要翻译：描述了使用离子敏感场效应晶体管（ISFET）来检测DNA样品中的甲基化核苷酸。检测DNA样品中的甲基化核苷酸的方法可以包括用鉴别甲基化和非甲基化核苷酸之间的试剂处理DNA样品以提供处理的DNA，扩增经处理的DNA和任选地对扩增的DNA进行测序的步骤。 ISFET用于监测在扩增和/或测序步骤期间在链延伸反应中添加一种或多种dNTP。还提供了合适的装置。

2. 发明申请

WO2012098409A1 CHEMICAL SENSOR 审中-公开
标题翻译：化学传感器
公开(公告)号：WO2012098409A1
公开(公告)日：2012-07-26
申请号：PCT/GB2012/050125
申请日：2012-01-20
申请人： DNA ELECTRONICS LTD , PRODROMAKIS, Themistoklis , TOUMAZOU, Christofer
发明人： PRODROMAKIS, Themistoklis , TOUMAZOU, Christofer
IPC分类号： G01N27/414
CPC分类号： G01N27/4148
摘要： A chemical sensor having a substrate, an electrode formed on or within the substrate, a chemical sensing area formed on the electrode, and coupling means on the substrate to couple the electrode to an active device arranged to receive a signal from the electrode. The active device comprises a transducer arranged to receive the signal from the electrode and provide an output signal. The signal corresponds to the concentration of ions in a sample in contact with the sensor. The sensor may be used to detect neural transmitters in a neural tissue.
摘要翻译：具有衬底，形成在衬底上或衬底内的电极的化学传感器，形成在电极上的化学感测区域以及衬底上的耦合装置，以将电极耦合到被布置成从电极接收信号的有源器件。有源器件包括被布置成从电极接收信号并提供输出信号的换能器。该信号对应于与传感器接触的样品中的离子浓度。传感器可用于检测神经组织中的神经传递器。

3. 发明申请

WO2012017424A1 CHEMICAL SENSOR 审中-公开
标题翻译：化学传感器
公开(公告)号：WO2012017424A1
公开(公告)日：2012-02-09
申请号：PCT/IB2011/053900
申请日：2011-09-06
申请人： DNA ELECTRONICS LTD , PRODROKAKIS, Themistoklis , TOUMAZOU, Christofer
发明人： PRODROKAKIS, Themistoklis , TOUMAZOU, Christofer
IPC分类号： G01N27/12 , G01N27/327 , G01N33/543
CPC分类号： G01N27/60 , G01N27/127 , G01N27/3278 , G01N33/5438
摘要： A sensor comprising a memory device having a first electrode and a first chemical- sensing layer coupled to the first electrode. The chemical-sensing layer, in the presence of an analyte, is arranged to change a property of the Memristive device. The sensor can detect an analyte by providing a sample to be detected proximate the chemical sensing layer, observing the state of the memory element; and determining a property of the sample by comparing the observed state of the memory element with a previous state. The sensor is manufactured by depositing a second electrode on a surface, depositing an active layer or layers onto said second electrode, depositing a first electrode onto said active layer(s), and coupling a chemically sensitive layer to the first electrode.
摘要翻译：一种传感器，包括具有第一电极和耦合到第一电极的第一化学感测层的存储器件。在分析物存在下的化学感测层被布置成改变记忆装置的性质。传感器可以通过在化学感测层附近提供要检测的样本来检测分析物，观察存储元件的状态; 以及通过将所述存储元件的观察状态与先前状态进行比较来确定所述样本的属性。通过在表面上沉积第二电极来制造传感器，将活性层沉积到所述第二电极上，在第一电极上沉积第一电极，以及将化学敏感层耦合到第一电极。

4. 发明申请

WO2013132202A1 METHOD AND APPRATUS FOR MEASURING CHEMICAL ION CONCENTRATION USING A FEEDBACK- CONTROLLED TITRATOR 审中-公开
标题翻译：使用反馈控制的搅拌器测量化学离子浓度的方法和装置
公开(公告)号：WO2013132202A1
公开(公告)日：2013-09-12
申请号：PCT/GB2012/050494
申请日：2012-03-06
申请人： DNA ELECTRONICS LTD , TOUMAZOU, Christofer , LIU, Yan
发明人： TOUMAZOU, Christofer , LIU, Yan
IPC分类号： G01N27/414 , G01N27/416
CPC分类号： G01N31/16 , G01N27/4148
摘要： There is provided a method and device for measuring an ion concentration of a sample. The method comprises exposing a chemical sensor to the sample to provide an electrical output signal 5 representing said ion concentration and controlling a titrator exposed to the sample to release or absorb a quantity of ions to the sample. The method may use feedback means comprising Pulse Width Modulation control to drive the titrator such that the sample maintains a stable ion concentration.
摘要翻译：提供了用于测量样品的离子浓度的方法和装置。该方法包括将化学传感器暴露于样品以提供代表所述离子浓度的电输出信号5并控制暴露于样品的滴定剂以释放或吸收一定量的离子到样品。该方法可以使用包括脉宽调制控制的反馈装置来驱动滴定器，使样品保持稳定的离子浓度。

5. 发明申请

WO2012056247A1 CHEMICAL SENSING DEVICE 审中-公开
标题翻译：化学传感装置
公开(公告)号：WO2012056247A1
公开(公告)日：2012-05-03
申请号：PCT/GB2011/052105
申请日：2011-10-28
申请人： DNA ELECTRONICS LTD , TOUMAZOU, Christofer , LIU, Yan , GEORGIOU, Pantelis , OU, Chung Pei , REED, Sam
发明人： TOUMAZOU, Christofer , LIU, Yan , GEORGIOU, Pantelis , OU, Chung Pei , REED, Sam
IPC分类号： G01N27/44 , G01N27/414 , C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6825 , C12Q1/6858 , G01N27/4145 , G01N27/44 , C12Q2533/101 , C12Q2565/301 , C12Q2565/607 , C12Q2565/501
摘要： An apparatus comprises a transducer having a first output signal and arranged to receive an electrical input. The transducer switches the first output signal between an ON and OFF state. The apparatus comprises a chemical sensing surface coupled to the transducer arranged to receive a chemical input.A signal generator oscillates one or more of said inputs to vary the switching point of the transducer. The oscillating input may be the chemical input and/or the electrical input. The output signal may be a pulse whose period ON or OFF is determined by the oscillating input modulated by the chemical input.
摘要翻译：一种装置包括具有第一输出信号并被布置成接收电输入的换能器。传感器在ON和OFF状态之间切换第一个输出信号。该装置包括耦合到换能器的化学感测表面，布置成接收化学输入。信号发生器振荡一个或多个所述输入以改变换能器的切换点。振荡输入可以是化学输入和/或电输入。输出信号可以是其周期ON或OFF由通过化学输入调制的振荡输入确定的脉冲。

6. 发明申请

WO2008107014A1 QPCR USING SOLID-STATE PH SENSING 审中-公开
标题翻译： QPCR使用固态PH感测
公开(公告)号：WO2008107014A1
公开(公告)日：2008-09-12
申请号：PCT/EP2007/052010
申请日：2007-03-02
申请人： DNA ELECTRONICS LTD , TOUMAZOU, Christofer , PURUSHOTHAMAN, Sunil
发明人： TOUMAZOU, Christofer , PURUSHOTHAMAN, Sunil
IPC分类号： C12Q1/68 , G01N27/414
CPC分类号： C12Q1/6851 , G01N27/4145 , C12Q2565/607 , C12Q2561/113 , C12Q2527/119
摘要： Use of a pH sensor comprising an ion-sensitive field effect transistor (ISFET) to perform real time detection/ quantification of nucleic acid amplification, e.g. polymerase chain reaction (PCR) nucleic acid amplification, based on detection of protons released during the primer extension phase.
摘要翻译：使用包含离子敏感场效应晶体管（ISFET）的pH传感器来执行核酸扩增的实时检测/定量，例如，基于检测在引物延伸期释放的质子的聚合酶链反应（PCR）核酸扩增。

7. 发明申请

WO2011095793A1 SENSOR ARRAY FOR MEASURING NEURAL ACTIVITY 审中-公开
标题翻译：传感器阵列测量神经活动
公开(公告)号：WO2011095793A1
公开(公告)日：2011-08-11
申请号：PCT/GB2011/050133
申请日：2011-01-28
申请人： DNA ELECTRONICS LTD , GEORGIOU, Pantelis , PRODROKAKIS, Themistoklis , CONSTANDINOU, Timothy G , TOUMAZOU, Christofer
发明人： GEORGIOU, Pantelis , PRODROKAKIS, Themistoklis , CONSTANDINOU, Timothy G , TOUMAZOU, Christofer
IPC分类号： G01N27/414 , G01N33/487 , B01L3/00
CPC分类号： G01N27/4163 , G01N27/4145 , G01N33/4836
摘要： A sensor system comprising a substrate and integrated onto the substrate an array (7) of sensor elements (1), each sensor element comprising one or more inductors (3), one or more electrochemical sensors (4), and one or more optical sensors (2). The system further comprising a controller configured in use to separately address each of the sensor elements (1) to drive the respective inductors and receive outputs of the respective sensors.
摘要翻译：一种传感器系统，包括基板并将传感器元件（1）的阵列（7）集成到所述基板上，每个传感器元件包括一个或多个电感器（3），一个或多个电化学传感器（4）和一个或多个光学传感器（2）。所述系统还包括控制器，其被配置为用于单独地寻址每个所述传感器元件（1）以驱动相应的电感器并接收各个传感器的输出。

8. 发明申请

WO2011083327A1 ELECTRICALLY ACTUATED SWITCH 审中-公开
标题翻译：电动执行开关
公开(公告)号：WO2011083327A1
公开(公告)日：2011-07-14
申请号：PCT/GB2011/050009
申请日：2011-01-06
申请人： DNA ELECTRONICS LTD , PRODROMAKIS, Themistoklis , TOUMAZOU, Christofer , MICHELAKIS, Konstantios
发明人： PRODROMAKIS, Themistoklis , TOUMAZOU, Christofer , MICHELAKIS, Konstantios
IPC分类号： H01L45/00
CPC分类号： H01L45/1633 , H01L45/08 , H01L45/1233 , H01L45/146 , H01L45/1625 , H01L45/1641 , H01L45/1666 , H01L45/1675
摘要： A method of manufacturing an electrically actuable switch and comprising: depositing a first electrode on a surface; depositing an active layer or layers on top of said first electrode; and depositing a second electrode on top of said active layer(s), wherein said step of depositing an active layer or layers is performed in an atmosphere into which a reactive gas is introduced, the partial pressure of the reactive gas being varied during the process so as to introduce dopants into the active layer in a concentration which varies across the active layer.
摘要翻译：一种制造可电致动开关的方法，包括：在表面上沉积第一电极; 在所述第一电极的顶部上沉积有源层; 以及在所述有源层的顶部上沉积第二电极，其中沉积有源层的步骤在引入反应气体的气氛中进行，反应气体的分压在该过程中变化以便以有效层的变化浓度将掺杂剂引入到有源层中。

9. 发明申请

WO2013024044A2 INSULIN PUMP 审中-公开
标题翻译：胰岛素泵
公开(公告)号：WO2013024044A2
公开(公告)日：2013-02-21
申请号：PCT/EP2012/065725
申请日：2012-08-10
申请人： GENE ONYX LIMITED , TOUMAZOU, Christofer , GEORGIOU, Pantelis , VINAS, Pau Herrero , SIM, Calvin
发明人： TOUMAZOU, Christofer , GEORGIOU, Pantelis , VINAS, Pau Herrero
IPC分类号： G06F19/00
CPC分类号： A61M5/1723 , A61M5/142 , A61M2005/14208 , A61M2005/1726 , A61M2205/52 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： The present invention relates to a controller unit and methods for controlling an insulin pump. The controller unit includes a user input that receives a gain factor. The gain factor has been calculated based on historical data in relation to a patient. The controller unit includes a measurement input for receiving data representative of a measured blood glucose level for the patient. Processing logic of the controller unit is configured to apply the measured blood glucose level to a pancreatic beta-cell insulin secretion computational model to predict an insulin output level, apply the gain factor to the predicted insulin output level to determine a patient insulin deficiency level, and calculate a control signal for controlling the insulin output level of the insulin pump based on the patient insulin deficiency level. Methods are provided for optimising the gain factor based on the historical data in relation to the patient.
摘要翻译：用于控制胰岛素泵的控制器单元和方法技术领域本发明涉及用于控制胰岛素泵的控制器单元和方法。控制器单元包括接收增益因子的用户输入。增益因子是根据与患者相关的历史数据计算出来的。控制器单元包括用于接收代表患者的测量的血糖水平的数据的测量输入。控制器单元的处理逻辑被配置为将测量的血糖水平应用于胰腺β-细胞胰岛素分泌计算模型以预测胰岛素输出水平，将增益因子应用于预测的胰岛素输出水平以确定患者胰岛素缺乏水平，并基于患者胰岛素缺乏水平计算用于控制胰岛素泵的胰岛素输出水平的控制信号。提供了基于与患者有关的历史数据优化增益因子的方法。

10. 发明申请

WO2003017180A1 HYBRID DIGITAL/ANALOG PROCESSING CIRCUIT 审中-公开
标题翻译：混合数字/模拟处理电路
公开(公告)号：WO2003017180A1
公开(公告)日：2003-02-27
申请号：PCT/GB2002/003796
申请日：2002-08-16
申请人： TOUMAZ TECHNOLOGY LIMITED , BURDETT, Alison , TOUMAZOU, Christofer
发明人： BURDETT, Alison , TOUMAZOU, Christofer
IPC分类号： G06J1/00
CPC分类号： G06J1/00
摘要： A circuit comprising a digital processor, analogue processing means, a digital to analogue converter for converting digital values output from the digital processor into analogue values which are processed by the analogue processing means, and an analogue to digital converter for converting resulting analogue values into digital values for input to the digital processor, wherein the analogue processing means comprises one or more analogue processors, and the circuit is dynamically reconfigurable under the control of the digital processor, such that analogue values are processed according to a first function by the analogue processing means, and following reconfiguration, analogue values are processed according to a second function by the analogue processing means.
摘要翻译：一种包括数字处理器，模拟处理装置，用于将从数字处理器输出的数字值转换成由模拟处理装置处理的模拟值的数模转换器的电路，以及用于将所得到的模拟值转换为数字用于输入到数字处理器的值，其中所述模拟处理装置包括一个或多个模拟处理器，并且所述电路在数字处理器的控制下动态地可重新配置，使得模拟值根据模拟处理装置根据第一功能被处理，并且在重新配置之后，通过模拟处理装置根据第二功能处理模拟值。

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