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1. 发明申请

WO2012040362A3 SYSTEMS AND METHODS FOR ANALYSIS AND TREATMENT OF A BODY LUMEN 审中-公开
标题翻译：用于分析和治疗体液的系统和方法
公开(公告)号：WO2012040362A3
公开(公告)日：2012-06-14
申请号：PCT/US2011052609
申请日：2011-09-21
申请人： CORNOVA INC , RYAN S ERIC , TANG JING , GAMBALE RICHARD
发明人： RYAN S ERIC , TANG JING , GAMBALE RICHARD
IPC分类号： A61B1/00 , A61B5/027 , G01J3/00
CPC分类号： A61B5/0086 , A61B5/0062 , A61B5/0075 , A61B5/0084 , A61B5/02007 , A61B5/1076 , A61B5/4836 , A61B5/6853 , A61M25/104 , G01J3/0218 , G01J3/0264 , G01J3/42
摘要： A system is provided for probing a body lumen that includes a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end, at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located along a distal portion of the conduit. A spectrometer is connected to the at least one delivery waveguide and the at least one collection waveguide, the spectrometer configured to perform spectroscopy. A controller system is configured to calculate a distance between the flexible conduit and the wall of the body lumen based on a spectroscopic measurement of the at least one primary radiation signal that traveled between the flexible conduit and body lumen.
摘要翻译：提供了一种用于探测体腔的系统，所述体腔包括沿着纵向轴线伸长的柔性导管，所述柔性导管具有近端和远端，至少一个输送波导和至少一个收集波导，所述收集波导沿着柔性导管，所述至少一个传送波导的传输输出和沿着所述导管的远端部分定位的所述至少一个收集波导的传输输入。分光计连接到至少一个传送波导和至少一个收集波导，分光计配置成执行光谱分析。控制器系统被配置为基于在柔性导管和体腔之间行进的至少一个初级辐射信号的光谱测量来计算柔性导管和体腔的壁之间的距离。

2. 发明申请

WO2010135596A3 SYSTEMS AND METHODS FOR ANALYSIS AND TREATMENT OF A BODY LUMEN 审中-公开
标题翻译：体温分析与处理系统与方法
公开(公告)号：WO2010135596A3
公开(公告)日：2011-04-07
申请号：PCT/US2010035677
申请日：2010-05-20
申请人： CORNOVA INC , RYAN S ERIC , TANG JING , GAMBALE RICHARD
发明人： RYAN S ERIC , TANG JING , GAMBALE RICHARD
IPC分类号： A61F2/958 , A61M25/092 , A61M25/16
CPC分类号： A61B5/0086 , A61B5/0066 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/02007 , A61B5/6852 , A61B5/6853 , A61B2017/22001 , A61N5/0601
摘要： A catheter for placement within a body lumen, the catheter including a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end, at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a lumen-expanding inflatable balloon disposed about a portion of the conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located within the balloon; and, at least one elongate arm connected to the conduit and positioned within the balloon, the at least one elongate arm radially translatable with respect to the conduit, and wherein at least one of the transmission output and transmission input is coupled to the elongate arm.
摘要翻译：一种用于放置在体腔内的导管，所述导管包括沿着纵向轴线细长的柔性导管，所述柔性导管具有近端和远端，至少一个输送波导和沿着所述柔性导管延伸的至少一个收集波导导管，围绕导管的一部分设置的管腔扩张的可充气气囊，所述至少一个输送波导的透射输出和位于气囊内的至少一个收集波导的透射输入; 以及连接到所述导管并且定位在所述球囊内的至少一个细长臂，所述至少一个细长臂相对于所述导管可径向平移，并且其中所述变速器输出和变速器输入中的至少一个联接到所述细长臂。

3. 发明申请

WO2010135601A2 SYSTEMS AND METHODS FOR ANALYSIS AND TREATMENT OF A BODY LUMEN 审中-公开
标题翻译：体温分析与处理系统与方法
公开(公告)号：WO2010135601A2
公开(公告)日：2010-11-25
申请号：PCT/US2010035682
申请日：2010-05-20
申请人： CORNOVA INC , RYAN S ERIC , TANG JING , GAMBALE RICHARD
发明人： RYAN S ERIC , TANG JING , GAMBALE RICHARD
IPC分类号： A61B5/1455 , A61F2/958 , A61B5/1459
CPC分类号： A61B5/0086 , A61B5/0066 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/02007 , A61B5/6852 , A61B5/6853 , A61B2017/22001 , A61N5/0601
摘要： A system for analyzing a body lumen including a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end; at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located along a distal portion of the conduit; a spectrometer connected to the at least one delivery waveguide and the at least one collection waveguide, the spectrometer configured to perform diffuse reflectance spectroscopy, wherein the spectrometer emits at least one primary radiation signal of a wavelength having an absorption coefficient of between about 8 cm-1 and about 10 cm-1 when transmitted through a highly aqueous media; a controller system configured to calculate at least one of an extent, area, and volume of highly aqueous media based on the amount of absorption of the at least one primary radiation signal measured through the highly aqueous media by the spectrometer.
摘要翻译：一种用于分析体腔的系统，包括沿着纵向轴线细长的柔性导管，所述柔性导管具有近端和远端; 至少一个输送波导和沿着柔性导管延伸的至少一个收集波导，所述至少一个输送波导的透射输出和沿着导管远端部分定位的至少一个收集波导的透射输入; 光谱仪，其连接到所述至少一个传送波导和所述至少一个收集波导，所述光谱仪被配置为执行漫反射光谱，其中所述光谱仪发射具有约8cm -3的吸收系数的波长的至少一个初级辐射信号， 1和约10cm -1，当透过高含量介质时; 控制器系统，其被配置为基于由所述光谱仪通过所述高度水性介质测量的所述至少一个主要辐射信号的吸收量来计算高度含水介质的程度，面积和体积中的至少一个。

4. 发明申请

WO2008067273A2 IMPLANTABLE DEVICES WITH THERAPY DELIVERING SURFACES AND METHODS 审中-公开
标题翻译：具有治疗传递表面和方法的可植入装置
公开(公告)号：WO2008067273A2
公开(公告)日：2008-06-05
申请号：PCT/US2007085570
申请日：2007-11-27
申请人： CORNOVA INC , TANG JING , RYAN S ERIC
发明人： TANG JING , RYAN S ERIC
IPC分类号： A61F2/02
CPC分类号： A61F2/86 , A61F2250/0067
摘要： An implantable device is provided having a therapy-delivering surface thereon. Upon deployment, the surface elutes a therapeutically effective dosage of dipyridamole sufficient to reduce the likelihood of thrombosis, restenosis, or both. A steady dosage of dipyridamole is delivered so as to maintain between at least about.000275 to.001 micrograms of the drug per square millimeter of tissue directly surrounding the device for a target therapy period. The device can be a cardiovascular stent in which the therapy is applied during at least the initial 7 days after deployment.
摘要翻译：提供在其上具有治疗递送表面的可植入装置。部署后，表面洗脱治疗有效剂量的双嘧达莫足以减少血栓形成，再狭窄或两者的可能性。输送稳定剂量的双嘧达莫以便在目标治疗期间保持至少约0.000275至0.001微克每平方毫米组织直接围绕该装置的药物。该装置可以是在部署后的至少7天内应用治疗的心血管支架。

5. 发明申请

WO2009089372A2 SYSTEMS AND METHODS FOR ANALYSIS AND TREATMENT OF A BODY LUMEN 审中-公开
标题翻译：用于分析和治疗体液的系统和方法
公开(公告)号：WO2009089372A2
公开(公告)日：2009-07-16
申请号：PCT/US2009030467
申请日：2009-01-08
申请人： CORNOVA INC , TANG JING , RYAN S ERIC
发明人： TANG JING , RYAN S ERIC
IPC分类号： A61F2/958 , A61M31/00
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/02007 , A61B5/14539 , A61B5/6853 , A61B6/12 , A61B2017/22001 , A61B2018/00345 , A61B2018/00386 , A61B2018/00404 , A61B2018/00577 , A61B2018/00982 , A61B2562/0242 , A61F2/958 , A61M25/1011 , A61M25/1027 , A61M25/104 , A61M29/02 , A61M2025/1079 , A61M2025/1088
摘要： A catheter is provided for placement within a body lumen, the catheter including a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end. The catheter further includes at least one delivery waveguide and at least one collection waveguide positioned along the flexible conduit, the at least one delivery waveguide and the at least one collection waveguide constructed and arranged to transmit radiation at a wavelength in a range of about 250 to 2500 nanometers. The catheter further includes a flexible, expandable first surface encircling surrounding a segment of the conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located within the flexible, expandable first surface, and the distal end of at least one of the at least one delivery waveguide and the at least one collection waveguide tethered to the flexible, expandable first surface radially translatable with respect to the flexible, expandable first surface, the at least one transmission input located between a portion of the flexible, expandable first surface and a portion of the second surface.
摘要翻译：提供用于放置在体腔内的导管，所述导管包括沿着纵向轴线伸长的柔性导管，所述柔性导管具有近端和远端。所述导管还包括至少一个传送波导和至少一个收集波导，所述至少一个收集波导沿着所述柔性管道设置，所述至少一个传送波导和所述至少一个收集波导构造并布置成传送波长范围为约250至 2500纳米。所述导管还包括柔性的可扩张的第一表面，所述第一表面环绕所述导管的一部分，所述至少一个递送波导的传输输出和位于所述柔性的可扩张的第一表面内的所述至少一个收集波导的传输输入，所述至少一个输送波导和所述至少一个收集波导中的至少一个的远侧端部系于所述柔性可扩展第一表面，所述柔性可扩展第一表面相对于所述柔性可扩展第一表面可径向平移，所述至少一个变速器输入位于部分柔性可膨胀的第一表面和第二表面的一部分。

6. 发明申请

WO2007147058A3 METHOD AND APPARATUS FOR IDENTIFYING AND TREATING MYOCARDIAL INFARCTION 审中-公开
标题翻译：用于鉴别和治疗心肌梗塞的方法和装置
公开(公告)号：WO2007147058A3
公开(公告)日：2008-11-06
申请号：PCT/US2007071221
申请日：2007-06-14
申请人： CORNOVA INC , RYAN S ERIC , TANG JING
发明人： RYAN S ERIC , TANG JING
IPC分类号： A61B6/00
CPC分类号： A61M25/06 , A61B5/01 , A61B5/145 , A61B10/04 , A61B18/24 , A61B2010/045 , A61B2017/00061 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2018/00392 , A61B2018/2238 , A61M25/0147 , A61M2025/0096
摘要： A method and apparatus for analyzing and treating internal tissues and, in particular, tissues affected by myocardial infarct. The apparatus includes a catheterized device integrating an optical probe and treatment delivery system. The probe component includes fiber optic lines that can be used in conjunction with infrared spectroscopy to analyze various characteristics of tissues, including chemical, blood, and oxygen content, in order to locate those tissues associated with myocardial infarct, to determine the best location for applying treatment, and to monitor treatment and its effects. Physically integrated with the probe component is a treatment component for delivering treatments including stem cell and gene therapy, known for having beneficial effects on tissues associated with myocardial infarct. A control system coordinates operation of the catheter, including performing chemometric analysis with the use of model data, and for providing control and visual feedback to an operator.
摘要翻译：一种用于分析和治疗内部组织，特别是受到心肌梗死影响的组织的方法和装置。该装置包括集成光学探针和治疗递送系统的导管装置。探针组件包括光纤线路，其可以与红外光谱结合使用以分析组织的各种特征，包括化学，血液和氧气含量，以便定位与心肌梗死相关的那些组织，以确定应用的最佳位置治疗，并监测治疗及其影响。与探针组分物理整合是用于递送治疗的治疗组件，包括干细胞和基因治疗，已知对于与心肌梗死相关的组织具有有益作用。控制系统协调导管的操作，包括使用模型数据执行化学计量分析，以及向操作者提供控制和视觉反馈。

7. 发明申请

WO2008019359A2 MULTI-FACETED OPTICAL REFLECTOR 审中-公开
标题翻译：多面光学反射器
公开(公告)号：WO2008019359A2
公开(公告)日：2008-02-14
申请号：PCT/US2007075336
申请日：2007-08-07
申请人： CORNOVA INC , TANG JING , LOONEY TIMOTHY M , RYAN S ERIC
发明人： TANG JING , LOONEY TIMOTHY M , RYAN S ERIC
IPC分类号： A61N5/06
CPC分类号： A61B1/3137 , A61B1/00096 , A61B1/00165 , A61B1/00167 , A61B1/00177 , A61B1/00179 , A61B1/0615 , A61B1/0623 , A61B1/07 , A61B5/0075 , A61B5/0084 , A61M25/10 , G02B5/09 , G02B6/0006 , G02B6/262 , G02B6/264 , G02B23/2423
摘要： A reflecting element with multiple reflective facets is integrated with the distal end of a multi-fiber optical probe. The facets are shaped depending on the type of analysis performed and according to the desired distribution of radiation to and from internal body tissues and fluids. The probe can include a protective transparent balloon or other covering that separates the reflecting element from interior tissue walls and provides a window for radiation to be transmitted between the reflecting facets and a region of interest. The probe can be integrated with treatment-based devices, including lumen-expanding angioplasty balloon catheters. The probe can also be adapted as an imaging device such as an endoscope.
摘要翻译：具有多个反射面的反射元件与多光纤光学探针的远端集成。小平面根据所进行的分析的类型和根据所需的辐射来自内部身体组织和流体的分布而成形。探针可以包括保护性透明球囊或其他覆盖物，其将反射元件与内部组织壁分离，并提供用于在反射面和感兴趣区域之间传播的辐射的窗口。探针可以与基于治疗的装置集成，包括腔扩张血管成形术球囊导管。探针也可以适用于诸如内窥镜的成像装置。

8. 发明申请

WO2009089372A3 SYSTEMS AND METHODS FOR ANALYSIS AND TREATMENT OF A BODY LUMEN 审中-公开
标题翻译：体温分析与处理系统与方法
公开(公告)号：WO2009089372A3
公开(公告)日：2009-10-08
申请号：PCT/US2009030467
申请日：2009-01-08
申请人： CORNOVA INC , TANG JING , RYAN S ERIC
发明人： TANG JING , RYAN S ERIC
IPC分类号： A61F2/958 , A61M31/00
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/02007 , A61B5/14539 , A61B5/6853 , A61B6/12 , A61B2017/22001 , A61B2018/00345 , A61B2018/00386 , A61B2018/00404 , A61B2018/00577 , A61B2018/00982 , A61B2562/0242 , A61F2/958 , A61M25/1011 , A61M25/1027 , A61M25/104 , A61M29/02 , A61M2025/1079 , A61M2025/1088
摘要： A catheter is provided for placement within a body lumen, the catheter including a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end. The catheter further includes at least one delivery waveguide and at least one collection waveguide positioned along the flexible conduit, the at least one delivery waveguide and the at least one collection waveguide constructed and arranged to transmit radiation at a wavelength in a range of about 250 to 2500 nanometers. The catheter further includes a flexible, expandable first surface encircling surrounding a segment of the conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located within the flexible, expandable first surface, and the distal end of at least one of the at least one delivery waveguide and the at least one collection waveguide tethered to the flexible, expandable first surface radially translatable with respect to the flexible, expandable first surface, the at least one transmission input located between a portion of the flexible, expandable first surface and a portion of the second surface.
摘要翻译：提供用于放置在体腔内的导管，所述导管包括沿着纵向轴线细长的柔性导管，所述柔性导管具有近端和远端。所述导管还包括至少一个输送波导和至少一个沿着柔性导管定位的收集波导，所述至少一个输送波导和所述至少一个收集波导被构造和布置成将波长在约250〜 2500纳米。所述导管还包括围绕所述导管段的柔性可扩张第一表面，所述至少一个输送波导的透射输出和位于所述柔性可扩张第一表面内的所述至少一个收集波导的透射输入，所述至少一个输送波导中的至少一个的至少一个远端和所述至少一个收集波导束缚于所述柔性可扩张第一表面，所述第一表面可相对于所述柔性可扩张第一表面径向平移，所述至少一个传输输入位于所述至少一个的柔性可扩张的第一表面和第二表面的一部分。

9. 发明申请

WO02096484B1 APPARATUS AND METHOD FOR THE OPTICAL IMAGING OF TISSUE SAMPLES 审中-公开
标题翻译：用于组织样本光学成像的装置和方法
公开(公告)号：WO02096484B1
公开(公告)日：2003-09-12
申请号：PCT/US0217202
申请日：2002-05-30
申请人： INFRAREDX INC , RYAN S ERIC , BOUMA BRETT E , TEARNEY GUILLERMO J , FURNISH SIMON , TANG JING , ZULUAGA ANDRES
发明人： RYAN S ERIC , BOUMA BRETT E , TEARNEY GUILLERMO J , FURNISH SIMON , TANG JING , ZULUAGA ANDRES
IPC分类号： G01N21/27 , A61B5/00 , A61B6/00
CPC分类号： A61B5/0084
摘要： A catheter based optical system (10) for generating data as to the condition of a tissue sample of a mammalian vessel (W). The system includes an elongated catheter shaft (16) having a tissue engaging distal end (18) and a coupled proximal end (20) and an elongated optical delivery fiber arrangement (24) disposed through a lumen of said catheter (16), said optical delivery fiber arrangement (24) having a distal end (28) and a proximal end (32). The distal end of the delivery fiber arrangement (28) has a re-director light emitter (30) thereon for directing light against mammalian tissues (W). An elongated optical collection fiber arrangement (26) is disposed through a lumen of the catheter (16), the optical collection fiber arrangement (26) having distal end (34) and a proximal most end (36). The distal end of the collection fiber arrangement (34) has a re-director light receiver (30) thereon for receiving light reflected from the mammalian tissue (W) by the light emitter (30). The light emitter (42) and the light receiver (40) are longitudinally space (d) apart from one another in the distal end of the catheter (18). The catheter apparatus includes a light source (12) in communication with the delivery fiber (24) and a signal (50) in communication with the receiving fiber (26) for receiving and presenting data collected.
摘要翻译：一种基于导管的光学系统（10），用于产生关于哺乳动物血管（W）的组织样本的数据的数据。该系统包括具有组织接合远端（18）和联接近端（20）的细长导管轴（16）和穿过所述导管（16）的内腔设置的细长光学传送纤维布置（24），所述光学输送纤维装置（24）具有远端（28）和近端（32）。输送纤维装置（28）的远端在其上具有用于将光导向哺乳动物组织（W）的重导向器光发射器（30）。细长光学收集光纤布置（26）设置成穿过导管（16）的内腔，光学收集光纤布置（26）具有远端（34）和最近端（36）。收集光纤布置（34）的远端在其上具有用于接收由光发射器（30）从哺乳动物组织（W）反射的光的重导向光接收器（30）。光发射器（42）和光接收器（40）在导管（18）的远端中在纵向上彼此间隔开（d）。导管设备包括与输送光纤（24）通信的光源（12）和与接收光纤（26）通信的信号（50），用于接收和呈现收集的数据。

10. 发明申请

WO02096479A2 BALLOON CATHETER 审中-公开
标题翻译：气球导管
公开(公告)号：WO02096479A2
公开(公告)日：2002-12-05
申请号：PCT/US0215118
申请日：2002-05-14
申请人： INFRAREDX INC , RYAN S ERIC , BOUMA BRETT E , TEARNEY GUILLERMO J , FURNISH SIMON , TANG JING , ZULUAGA ANDRES
发明人： RYAN S ERIC , BOUMA BRETT E , TEARNEY GUILLERMO J , FURNISH SIMON , TANG JING , ZULUAGA ANDRES
IPC分类号： A61B5/00 , A61M
CPC分类号： A61B5/6853 , A61B5/0086 , A61B5/0507 , A61B5/6886
摘要： An apparatus includes a feedback loop for controlling an extent of a gap between a wall of a balloon mounted on a catheter and a wall of a lumen into which the catheter is inserted. The apparatus includes a radiation detector mounted within the balloon for generating a feedback signal having information indicative of whether the extent of the gap is greater than or less than a desired value. The feedback loop receives the feedback signal and controls a size of the balloon to cause the extent of the gap to approach the desired value.
摘要翻译：一种装置包括用于控制安装在导管上的球囊的壁与插入其中的内腔的壁之间的间隙的程度的反馈回路。该装置包括安装在气球内的放射线检测器，用于产生具有指示间隙的程度是否大于或小于期望值的信息的反馈信号。反馈回路接收反馈信号并控制气囊的尺寸以使间隙的程度接近所需值。

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