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1. 发明申请

WO2012040362A3 SYSTEMS AND METHODS FOR ANALYSIS AND TREATMENT OF A BODY LUMEN 审中-公开
标题翻译：用于分析和治疗体液的系统和方法
公开(公告)号：WO2012040362A3
公开(公告)日：2012-06-14
申请号：PCT/US2011052609
申请日：2011-09-21
申请人： CORNOVA INC , RYAN S ERIC , TANG JING , GAMBALE RICHARD
发明人： RYAN S ERIC , TANG JING , GAMBALE RICHARD
IPC分类号： A61B1/00 , A61B5/027 , G01J3/00
CPC分类号： A61B5/0086 , A61B5/0062 , A61B5/0075 , A61B5/0084 , A61B5/02007 , A61B5/1076 , A61B5/4836 , A61B5/6853 , A61M25/104 , G01J3/0218 , G01J3/0264 , G01J3/42
摘要： A system is provided for probing a body lumen that includes a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end, at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located along a distal portion of the conduit. A spectrometer is connected to the at least one delivery waveguide and the at least one collection waveguide, the spectrometer configured to perform spectroscopy. A controller system is configured to calculate a distance between the flexible conduit and the wall of the body lumen based on a spectroscopic measurement of the at least one primary radiation signal that traveled between the flexible conduit and body lumen.
摘要翻译：提供了一种用于探测体腔的系统，所述体腔包括沿着纵向轴线伸长的柔性导管，所述柔性导管具有近端和远端，至少一个输送波导和至少一个收集波导，所述收集波导沿着柔性导管，所述至少一个传送波导的传输输出和沿着所述导管的远端部分定位的所述至少一个收集波导的传输输入。分光计连接到至少一个传送波导和至少一个收集波导，分光计配置成执行光谱分析。控制器系统被配置为基于在柔性导管和体腔之间行进的至少一个初级辐射信号的光谱测量来计算柔性导管和体腔的壁之间的距离。

2. 发明申请

WO2007102926A3 FLEXIBLE EXPANDABLE STENT 审中-公开
标题翻译：灵活可扩展的支架
公开(公告)号：WO2007102926A3
公开(公告)日：2008-10-02
申请号：PCT/US2006062478
申请日：2006-12-21
申请人： CORNOVA INC , FLIEDNER THILO U , RYAN S ERIC , SAHAGIAN RICHARD
发明人： FLIEDNER THILO U , RYAN S ERIC , SAHAGIAN RICHARD
IPC分类号： A61F2/82
CPC分类号： A61F2/856 , A61F2/91 , A61F2/915 , A61F2002/821 , A61F2002/91508 , A61F2002/91533 , A61F2002/91583
摘要： A flexible, expandable stent assembly comprised of a generally cylindrically shaped channel, having a longitudinal axis, and having a plurality of openings therein. The openings are defined by longitudinally aligned circumferential arrays of generally "hairpin-like curved web arrays or bends of metal, creating a plurality of circumferentially disposed "Palm Tree" shaped annular spaces between longitudinally adjacent web arrays.
摘要翻译：一种柔性的，可扩张的支架组件，其包括具有纵向轴线的大致圆柱形通道，并且在其中具有多个开口。开口由通常为“发夹状弯曲网状物阵列或金属弯曲部”的纵向排列的圆周阵列限定，在纵向相邻的卷筒阵列之间形成多个周向布置的“棕榈树”形环形空间。

3. 发明申请

WO2008027872A2 IMPLANTABLE DEVICES HAVING TEXTURED SURFACES AND METHODS OF FORMING THE SAME 审中-公开
标题翻译：具有纹理表面的可植入装置及其形成方法
公开(公告)号：WO2008027872A2
公开(公告)日：2008-03-06
申请号：PCT/US2007/076961
申请日：2007-08-28
申请人： CORNOVA, INC. , RYAN, Eric, S. , SAHAGIAN, Richard
发明人： RYAN, Eric, S. , SAHAGIAN, Richard
IPC分类号： A61F2/06
CPC分类号： C23C14/025 , A61F2/82 , A61L31/088 , A61L31/18 , C23C14/027 , C23C14/165 , C23C14/505
摘要： Textured coatings for implantable medical devices can be provided in metallic or polymer surface layers having surface texture factors down to nanometer and sub-nanometer levels. Implantable devices having such textured surfaces and methods of coating such devices comprises providing a substrate surface of an implantable device and forming a coating layer of the substrate surface by directing a mixture of atoms of a first type of material and a second type of material toward the substrate surface while simultaneously and collinearly bombarding the substrate surface with ions, wherein the first type of material is substantially resistant to a removal process and the second type of material is substantially susceptible to a removal process.
摘要翻译：可以在具有低至纳米和亚纳米级的表面纹理因子的金属或聚合物表面层中提供用于可植入医疗装置的纹理涂层。具有这种纹理表面的可植入装置和涂覆这种装置的方法包括提供可植入装置的基底表面，并通过将第一类型材料和第二类型材料的原子混合物朝向衬底表面，同时并且共线地用离子轰击衬底表面，其中第一类型的材料基本上抵抗去除过程，并且第二类型的材料基本上易于去除过程。

4. 发明申请

WO2008019359A3 MULTI-FACETED OPTICAL REFLECTOR 审中-公开
公开(公告)号：WO2008019359A3
公开(公告)日：2008-02-14
申请号：PCT/US2007/075336
申请日：2007-08-07
申请人： CORNOVA, INC. , TANG, Jing , LOONEY, Timothy, M. , RYAN, S., Eric
发明人： TANG, Jing , LOONEY, Timothy, M. , RYAN, S., Eric
IPC分类号： A61B5/05
摘要： A reflecting element with multiple reflective facets is integrated with the distal end of a multi-fiber optical probe. The facets are shaped depending on the type of analysis performed and according to the desired distribution of radiation to and from internal body tissues and fluids. The probe can include a protective transparent balloon or other covering that separates the reflecting element from interior tissue walls and provides a window for radiation to be transmitted between the reflecting facets and a region of interest. The probe can be integrated with treatment-based devices, including lumen-expanding angioplasty balloon catheters. The probe can also be adapted as an imaging device such as an endoscope.

5. 发明申请

WO2012040362A2 SYSTEMS AND METHODS FOR ANALYSIS AND TREATMENT OF A BODY LUMEN 审中-公开
标题翻译：体温分析与处理系统与方法
公开(公告)号：WO2012040362A2
公开(公告)日：2012-03-29
申请号：PCT/US2011/052609
申请日：2011-09-21
申请人： CORNOVA, INC. , RYAN, S. Eric , TANG, Jing , GAMBALE, Richard
发明人： RYAN, S. Eric , TANG, Jing , GAMBALE, Richard
IPC分类号： A61B1/00 , A61B5/027 , G01J3/00
CPC分类号： A61B5/0086 , A61B5/0062 , A61B5/0075 , A61B5/0084 , A61B5/02007 , A61B5/1076 , A61B5/4836 , A61B5/6853 , A61M25/104 , G01J3/0218 , G01J3/0264 , G01J3/42
摘要： A system is provided for probing a body lumen that includes a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end, at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located along a distal portion of the conduit. A spectrometer is connected to the at least one delivery waveguide and the at least one collection waveguide, the spectrometer configured to perform spectroscopy. A controller system is configured to calculate a distance between the flexible conduit and the wall of the body lumen based on a spectroscopic measurement of the at least one primary radiation signal that traveled between the flexible conduit and body lumen.
摘要翻译：提供了一种用于探测体腔的系统，其包括沿着纵向轴线细长的柔性导管，所述柔性导管具有近端和远端，至少一个输送波导和沿柔性导管延伸的至少一个收集波导，所述至少一个输送波导的透射输出和沿着所述导管的远端部分定位的所述至少一个收集波导的透射输入。光谱仪连接到至少一个传送波导和至少一个收集波导，该光谱仪被配置为执行光谱。控制器系统被配置为基于在柔性导管和体腔之间行进的至少一个主要辐射信号的光谱测量来计算柔性导管和体腔壁之间的距离。

6. 发明申请

WO2010011400A2 SHAPED FIBER ENDS AND METHODS OF MAKING SAME 审中-公开
标题翻译：形状纤维端及其制造方法
公开(公告)号：WO2010011400A2
公开(公告)日：2010-01-28
申请号：PCT/US2009044078
申请日：2009-05-15
申请人： CORNOVA INC , TANG JING
发明人： TANG JING
IPC分类号： A61B5/1459 , A61B5/1455
CPC分类号： A61B5/0084 , A61B1/00096 , A61B1/0017 , A61B5/0075 , A61B5/6852 , A61B5/6853
摘要： An optical fiber tip comprises a core and a recess formed in said core at a distal end of the optical fiber tip, said recess having a vertex within said core.
摘要翻译：光纤尖端包括芯部和在光纤末端的远端处形成在所述芯部中的凹部，所述凹部在所述芯部内具有顶点。

7. 发明申请

WO2008080121A1 FLUID MEDIA FOR BIO-SENSITIVE APPLICATIONS 审中-公开
标题翻译：用于生物敏感应用的流媒体
公开(公告)号：WO2008080121A1
公开(公告)日：2008-07-03
申请号：PCT/US2007/088697
申请日：2007-12-21
申请人： CORNOVA, INC. , RYAN, S. Eric , TANG, Jing , FLINDERS, Matthew
发明人： RYAN, S. Eric , TANG, Jing , FLINDERS, Matthew
IPC分类号： A61B6/00
CPC分类号： A61B5/0075 , A61B5/0066 , A61B5/0084 , A61B5/0086 , A61B5/6853 , A61B18/24 , A61B2017/00274 , A61B2017/22051 , A61B2018/00547 , A61B2562/146
摘要： Systems, methods, and apparatus for providing a fluid and reduced-toxicity optical media with optical analysis and therapeutic energy delivery. An aspect of the invention provides an aqueous solution of increased-salinity of between about 1% and 35%. An increasing salinity in accordance with the invention provides improved transmissive efficiency at many wavelengths and less toxicity than many existing systems and methods. A catheter having integrated fibers for probing or treating internal lumens or other tissues can include a liquid-inflatable balloon or flushing mechanism using the solution for displacing blood or other obstructions in an optical path between the fiber and targeted tissue. Methods including spectroscopy can be employed with the solution for diagnosing medical conditions associated with diseased vessels or other tissues while reducing the risk of permanent damage resulting from the diagnosis. Additional applications include the deliver of therapeutic radiation externally and internally to tissues through h the solution media.
摘要翻译：用于提供具有光学分析和治疗能量递送的流体和减毒光学介质的系统，方法和装置。本发明的一个方面提供了约1％至35％之间的增加盐度的水溶液。根据本发明的增加的盐度提供了许多波长的改进的透射效率和比许多现有的系统和方法更少的毒性。具有用于探测或治疗内部腔或其他组织的集成纤维的导管可以包括使用溶液替代在纤维和靶组织之间的光路中的血液或其它障碍物的液体充气球囊或冲洗机构。可以使用包括光谱学的方法用于诊断与患病血管或其他组织相关的医学病症的解决方案，同时降低由诊断引起的永久性损伤的风险。其他应用包括通过溶液介质在组织外部和内部传递治疗辐射。

8. 发明申请

WO2008067273A2 IMPLANTABLE DEVICES WITH THERAPY DELIVERING SURFACES AND METHODS 审中-公开
标题翻译：具有治疗传递表面和方法的可植入装置
公开(公告)号：WO2008067273A2
公开(公告)日：2008-06-05
申请号：PCT/US2007085570
申请日：2007-11-27
申请人： CORNOVA INC , TANG JING , RYAN S ERIC
发明人： TANG JING , RYAN S ERIC
IPC分类号： A61F2/02
CPC分类号： A61F2/86 , A61F2250/0067
摘要： An implantable device is provided having a therapy-delivering surface thereon. Upon deployment, the surface elutes a therapeutically effective dosage of dipyridamole sufficient to reduce the likelihood of thrombosis, restenosis, or both. A steady dosage of dipyridamole is delivered so as to maintain between at least about.000275 to.001 micrograms of the drug per square millimeter of tissue directly surrounding the device for a target therapy period. The device can be a cardiovascular stent in which the therapy is applied during at least the initial 7 days after deployment.
摘要翻译：提供在其上具有治疗递送表面的可植入装置。部署后，表面洗脱治疗有效剂量的双嘧达莫足以减少血栓形成，再狭窄或两者的可能性。输送稳定剂量的双嘧达莫以便在目标治疗期间保持至少约0.000275至0.001微克每平方毫米组织直接围绕该装置的药物。该装置可以是在部署后的至少7天内应用治疗的心血管支架。

9. 发明申请

WO2007041542A2 SYSTEMS AND METHODS FOR ANALYSIS AND TREATMENT OF A BODY LUMEN 审中-公开
标题翻译：体温分析与处理系统与方法
公开(公告)号：WO2007041542A2
公开(公告)日：2007-04-12
申请号：PCT/US2006/038547
申请日：2006-09-29
申请人： CORNOVA, INC. , RYAN, Eric, S. , TANG, Jing
发明人： RYAN, Eric, S. , TANG, Jing
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/01 , A61B5/015 , A61B5/02007 , A61B5/6853 , A61B2017/22001 , A61N5/0601
摘要： In a system and method for analyzing and treating a body lumen, a lumen-expanding balloon catheter with integrated one or more delivery waveguides and one or more collection waveguides is used to perform optical analysis of the tissues surrounding the lumen during expansion. The catheter can comprise an angioplasty catheter with integrated delivery waveguides and collection waveguides to perform spectroscopy of a stenotic plaque during angioplasty.
摘要翻译：在用于分析和处理体腔的系统和方法中，使用具有集成的一个或多个输送波导和一个或多个收集波导的管腔膨胀气囊导管，以在扩张期间对管腔周围的组织执行光学分析。导管可以包括具有集成输送波导和收集波导的血管成形术导管，以在血管成形术期间执行狭窄斑块的光谱。

10. 发明申请

WO2010135601A3 SYSTEMS AND METHODS FOR ANALYSIS AND TREATMENT OF A BODY LUMEN 审中-公开
公开(公告)号：WO2010135601A3
公开(公告)日：2010-11-25
申请号：PCT/US2010/035682
申请日：2010-05-20
申请人： CORNOVA, INC. , RYAN, S., Eric , TANG, Jing , GAMBALE, Richard
发明人： RYAN, S., Eric , TANG, Jing , GAMBALE, Richard
IPC分类号： A61B5/1455 , A61B5/1459
摘要： A system for analyzing a body lumen including a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end; at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located along a distal portion of the conduit; a spectrometer connected to the at least one delivery waveguide and the at least one collection waveguide, the spectrometer configured to perform diffuse reflectance spectroscopy, wherein the spectrometer emits at least one primary radiation signal of a wavelength having an absorption coefficient of between about 8 cm-1 and about 10 cm-1 when transmitted through a highly aqueous media; a controller system configured to calculate at least one of an extent, area, and volume of highly aqueous media based on the amount of absorption of the at least one primary radiation signal measured through the highly aqueous media by the spectrometer.

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