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1. 发明申请

WO2008080121A1 FLUID MEDIA FOR BIO-SENSITIVE APPLICATIONS 审中-公开
标题翻译：用于生物敏感应用的流媒体
公开(公告)号：WO2008080121A1
公开(公告)日：2008-07-03
申请号：PCT/US2007/088697
申请日：2007-12-21
申请人： CORNOVA, INC. , RYAN, S. Eric , TANG, Jing , FLINDERS, Matthew
发明人： RYAN, S. Eric , TANG, Jing , FLINDERS, Matthew
IPC分类号： A61B6/00
CPC分类号： A61B5/0075 , A61B5/0066 , A61B5/0084 , A61B5/0086 , A61B5/6853 , A61B18/24 , A61B2017/00274 , A61B2017/22051 , A61B2018/00547 , A61B2562/146
摘要： Systems, methods, and apparatus for providing a fluid and reduced-toxicity optical media with optical analysis and therapeutic energy delivery. An aspect of the invention provides an aqueous solution of increased-salinity of between about 1% and 35%. An increasing salinity in accordance with the invention provides improved transmissive efficiency at many wavelengths and less toxicity than many existing systems and methods. A catheter having integrated fibers for probing or treating internal lumens or other tissues can include a liquid-inflatable balloon or flushing mechanism using the solution for displacing blood or other obstructions in an optical path between the fiber and targeted tissue. Methods including spectroscopy can be employed with the solution for diagnosing medical conditions associated with diseased vessels or other tissues while reducing the risk of permanent damage resulting from the diagnosis. Additional applications include the deliver of therapeutic radiation externally and internally to tissues through h the solution media.
摘要翻译：用于提供具有光学分析和治疗能量递送的流体和减毒光学介质的系统，方法和装置。本发明的一个方面提供了约1％至35％之间的增加盐度的水溶液。根据本发明的增加的盐度提供了许多波长的改进的透射效率和比许多现有的系统和方法更少的毒性。具有用于探测或治疗内部腔或其他组织的集成纤维的导管可以包括使用溶液替代在纤维和靶组织之间的光路中的血液或其它障碍物的液体充气球囊或冲洗机构。可以使用包括光谱学的方法用于诊断与患病血管或其他组织相关的医学病症的解决方案，同时降低由诊断引起的永久性损伤的风险。其他应用包括通过溶液介质在组织外部和内部传递治疗辐射。

2. 发明申请

WO2007147058A2 METHOD AND APPARATUS FOR IDENTIFYING AND TREATING MYOCARDIAL INFARCTION 审中-公开
标题翻译：用于鉴别和治疗心肌梗塞的方法和装置
公开(公告)号：WO2007147058A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/071221
申请日：2007-06-14
申请人： CORNOVA, INC. , RYAN, S. Eric , TANG, Jing
发明人： RYAN, S. Eric , TANG, Jing
IPC分类号： A61M25/06
CPC分类号： A61M25/06 , A61B5/01 , A61B5/145 , A61B10/04 , A61B18/24 , A61B2010/045 , A61B2017/00061 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2018/00392 , A61B2018/2238 , A61M25/0147 , A61M2025/0096
摘要： A method and apparatus for analyzing and treating internal tissues and, in particular, tissues affected by myocardial infarct. The apparatus includes a catheterized device integrating an optical probe and treatment delivery system. The probe component includes fiber optic lines that can be used in conjunction with infrared spectroscopy to analyze various characteristics of tissues, including chemical, blood, and oxygen content, in order to locate those tissues associated with myocardial infarct, to determine the best location for applying treatment, and to monitor treatment and its effects. Physically integrated with the probe component is a treatment component for delivering treatments including stem cell and gene therapy, known for having beneficial effects on tissues associated with myocardial infarct. A control system coordinates operation of the catheter, including performing chemometric analysis with the use of model data, and for providing control and visual feedback to an operator.
摘要翻译：一种用于分析和治疗内部组织，特别是受到心肌梗死影响的组织的方法和装置。该装置包括集成光学探针和治疗递送系统的导管装置。探针组件包括光纤线路，其可以与红外光谱结合使用以分析组织的各种特征，包括化学，血液和氧气含量，以便定位与心肌梗死相关的那些组织，以确定应用的最佳位置治疗，并监测治疗及其影响。与探针组分物理整合是用于递送治疗的治疗组件，包括干细胞和基因治疗，已知对于与心肌梗死相关的组织具有有益作用。控制系统协调导管的操作，包括使用模型数据执行化学计量分析，以及向操作者提供控制和视觉反馈。

3. 发明申请

WO2012040362A2 SYSTEMS AND METHODS FOR ANALYSIS AND TREATMENT OF A BODY LUMEN 审中-公开
标题翻译：体温分析与处理系统与方法
公开(公告)号：WO2012040362A2
公开(公告)日：2012-03-29
申请号：PCT/US2011/052609
申请日：2011-09-21
申请人： CORNOVA, INC. , RYAN, S. Eric , TANG, Jing , GAMBALE, Richard
发明人： RYAN, S. Eric , TANG, Jing , GAMBALE, Richard
IPC分类号： A61B1/00 , A61B5/027 , G01J3/00
CPC分类号： A61B5/0086 , A61B5/0062 , A61B5/0075 , A61B5/0084 , A61B5/02007 , A61B5/1076 , A61B5/4836 , A61B5/6853 , A61M25/104 , G01J3/0218 , G01J3/0264 , G01J3/42
摘要： A system is provided for probing a body lumen that includes a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end, at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located along a distal portion of the conduit. A spectrometer is connected to the at least one delivery waveguide and the at least one collection waveguide, the spectrometer configured to perform spectroscopy. A controller system is configured to calculate a distance between the flexible conduit and the wall of the body lumen based on a spectroscopic measurement of the at least one primary radiation signal that traveled between the flexible conduit and body lumen.
摘要翻译：提供了一种用于探测体腔的系统，其包括沿着纵向轴线细长的柔性导管，所述柔性导管具有近端和远端，至少一个输送波导和沿柔性导管延伸的至少一个收集波导，所述至少一个输送波导的透射输出和沿着所述导管的远端部分定位的所述至少一个收集波导的透射输入。光谱仪连接到至少一个传送波导和至少一个收集波导，该光谱仪被配置为执行光谱。控制器系统被配置为基于在柔性导管和体腔之间行进的至少一个主要辐射信号的光谱测量来计算柔性导管和体腔壁之间的距离。

4. 发明申请

WO2008157760A1 SYSTEMS AND METHODS FOR GUIDING THE ANALYSIS AND TREATMENT OF A BODY LUMEN 审中-公开
标题翻译：用于指导身体的分析和治疗的系统和方法
公开(公告)号：WO2008157760A1
公开(公告)日：2008-12-24
申请号：PCT/US2008/067669
申请日：2008-06-20
申请人： CORNOVA, INC. , RYAN, S. Eric , TANG, Jing
发明人： RYAN, S. Eric , TANG, Jing
IPC分类号： A61B18/18
CPC分类号： A61B5/0071 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/02007 , A61B5/6852 , A61F2/856 , A61F2/954 , A61F2/958 , A61F2002/821 , A61M25/1002 , A61M25/1011 , A61M2025/0166 , A61M2025/1052
摘要： A system for treating a body lumen comprises a catheter including a flexible conduit that is elongated along a longitudinal axis and suitable for insertion into a body lumen, the conduit having a proximal end and a distal end, one or more waveguides integrated with the flexible conduit, the one or more waveguides constructed and arranged to deliver and collect radiation concentrated along a predetermined radial axis of the conduit, the predetermined radial axis of the conduit substantially aligned with respect to at least one therapy delivery component of the catheter, at least one radiation source connected to a transmission input of the one or more waveguides integrated with the flexible conduit, and at least one optical detector connected to a transmission output of the one or more waveguides integrated with the flexible conduit.
摘要翻译：用于治疗体腔的系统包括导管，其包括沿着纵向轴线细长并适于插入体腔的柔性导管，所述导管具有近端和远端，一个或多个与柔性导管一体化的波导所述一个或多个波导被构造和布置成递送和收集沿着所述导管的预定径向轴线集中的辐射，所述导管的预定径向轴线相对于所述导管的至少一个治疗递送部件基本对齐，至少一个辐射源连接到与柔性导管集成的一个或多个波导的传输输入，以及连接到与柔性导管集成的一个或多个波导的传输输出的至少一个光学检测器。

5. 发明申请

WO2008067273A3 IMPLANTABLE DEVICES WITH THERAPY DELIVERING SURFACES AND METHODS 审中-公开
公开(公告)号：WO2008067273A3
公开(公告)日：2008-06-05
申请号：PCT/US2007/085570
申请日：2007-11-27
申请人： CORNOVA, INC. , TANG, Jing , RYAN, S. Eric
发明人： TANG, Jing , RYAN, S. Eric
IPC分类号： A61F2/02
摘要： An implantable device is provided having a therapy-delivering surface thereon. Upon deployment, the surface elutes a therapeutically effective dosage of dipyridamole sufficient to reduce the likelihood of thrombosis, restenosis, or both. A steady dosage of dipyridamole is delivered so as to maintain between at least about.000275 to.001 micrograms of the drug per square millimeter of tissue directly surrounding the device for a target therapy period. The device can be a cardiovascular stent in which the therapy is applied during at least the initial 7 days after deployment.

6. 发明申请

WO2009089372A9 SYSTEMS AND METHODS FOR ANALYSIS AND TREATMENT OF A BODY LUMEN 审中-公开
公开(公告)号：WO2009089372A9
公开(公告)日：2009-07-16
申请号：PCT/US2009/030467
申请日：2009-01-08
申请人： CORNOVA, INC. , TANG, Jing , RYAN, S. Eric
发明人： TANG, Jing , RYAN, S. Eric
IPC分类号： A61M25/10 , A61M31/00
摘要： A catheter is provided for placement within a body lumen, the catheter including a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end. The catheter further includes at least one delivery waveguide and at least one collection waveguide positioned along the flexible conduit, the at least one delivery waveguide and the at least one collection waveguide constructed and arranged to transmit radiation at a wavelength in a range of about 250 to 2500 nanometers. The catheter further includes a flexible, expandable first surface encircling surrounding a segment of the conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located within the flexible, expandable first surface, and the distal end of at least one of the at least one delivery waveguide and the at least one collection waveguide tethered to the flexible, expandable first surface radially translatable with respect to the flexible, expandable first surface, the at least one transmission input located between a portion of the flexible, expandable first surface and a portion of the second surface.

7. 发明申请

WO2002096484A2 APPARATUS AND METHOD FOR THE OPTICAL IMAGING OF TISSUE SAMPLES 审中-公开
标题翻译：用于组织样品的光学成像的装置和方法
公开(公告)号：WO2002096484A2
公开(公告)日：2002-12-05
申请号：PCT/US2002/017202
申请日：2002-05-30
申请人： INFRAREDX, INC. , TANG, Jing , RYAN, S. Eric , BOUMA, Brett, E. , TEARNEY, Guillermo, J. , FURNISH, Simon , ZULUAGA, Andres
发明人： TANG, Jing , RYAN, S. Eric , BOUMA, Brett, E. , TEARNEY, Guillermo, J. , FURNISH, Simon , ZULUAGA, Andres
IPC分类号： A61M
CPC分类号： A61B5/0084
摘要： A catheter based optical system for generating data as to the condition of a tissue sample of a mammalian vessel. The system includes an elongated catheter shaft having a tissue engaging distal end and a coupled proximal end and an elongated optical delivery fiber arrangement disposed through a lumen of said catheter, said optical delivery fiber arrangement having a distal end and a proximal end. The distal end of the delivery fiber arrangement has a re-director light emitter thereon for directing light against mammalian tissues. An elongated optical collection fiber arrangement is disposed through a lumen of the catheter, the optical collection fiber arrangement having distal end and a proximal most end. The distal end of the collection fiber arrangement has a re-director light receiver thereon for receiving light reflected from the mammalian tissue by the light emitter. The light emitter and the light receiver are longitudinally space apart from one another in the distal end of the catheter. The catheter apparatus includes a light source in communication with the delivery fiber and a signal detector in communication with the receiving fiber for receiving and presenting data collected.
摘要翻译：一种用于产生关于哺乳动物血管（W）的组织样本的状况的数据的基于导管的光学系统（10）。该系统包括具有组织接合远端（18）和耦合的近端（20）的细长导管轴（16）和通过所述导管（16）的内腔设置的细长的光学输送纤维布置（24），所述光学具有远端（28）和近端（32）的输送纤维布置（24）。输送纤维布置（28）的远端在其上具有引导光发射器（30），用于将光引导到哺乳动物组织（W）上。细长的光学收集纤维布置（26）穿过导管（16）的内腔设置，光学收集纤维布置（26）具有远端（34）和最近端（36）。收集纤维布置（34）的远端在其上具有重新引导光接收器（30），用于接收由光发射器（30）从哺乳动物组织（W）反射的光。光发射器（42）和光接收器（40）在导管（18）的远端中彼此分开的纵向空间（d）。导管装置包括与输送光纤（24）通信的光源（12）和与接收光纤（26）通信的用于接收和呈现收集的数据的信号（50）。

8. 发明申请

WO2008019359A3 MULTI-FACETED OPTICAL REFLECTOR 审中-公开
公开(公告)号：WO2008019359A3
公开(公告)日：2008-02-14
申请号：PCT/US2007/075336
申请日：2007-08-07
申请人： CORNOVA, INC. , TANG, Jing , LOONEY, Timothy, M. , RYAN, S., Eric
发明人： TANG, Jing , LOONEY, Timothy, M. , RYAN, S., Eric
IPC分类号： A61B5/05
摘要： A reflecting element with multiple reflective facets is integrated with the distal end of a multi-fiber optical probe. The facets are shaped depending on the type of analysis performed and according to the desired distribution of radiation to and from internal body tissues and fluids. The probe can include a protective transparent balloon or other covering that separates the reflecting element from interior tissue walls and provides a window for radiation to be transmitted between the reflecting facets and a region of interest. The probe can be integrated with treatment-based devices, including lumen-expanding angioplasty balloon catheters. The probe can also be adapted as an imaging device such as an endoscope.

9. 发明申请

WO2010135596A2 SYSTEMS AND METHODS FOR ANALYSIS AND TREATMENT OF A BODY LUMEN 审中-公开
标题翻译：体温分析与处理系统与方法
公开(公告)号：WO2010135596A2
公开(公告)日：2010-11-25
申请号：PCT/US2010/035677
申请日：2010-05-20
申请人： CORNOVA, INC. , RYAN, S., Eric , TANG, Jing , GAMBALE, Richard
发明人： RYAN, S., Eric , TANG, Jing , GAMBALE, Richard
IPC分类号： A61M25/10 , A61M25/092 , A61M25/16
CPC分类号： A61B5/0086 , A61B5/0066 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/02007 , A61B5/6852 , A61B5/6853 , A61B2017/22001 , A61N5/0601
摘要： A catheter for placement within a body lumen, the catheter including a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end, at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a lumen-expanding inflatable balloon disposed about a portion of the conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located within the balloon; and, at least one elongate arm connected to the conduit and positioned within the balloon, the at least one elongate arm radially translatable with respect to the conduit, and wherein at least one of the transmission output and transmission input is coupled to the elongate arm.
摘要翻译：一种用于放置在体腔内的导管，所述导管包括沿着纵向轴线细长的柔性导管，所述柔性导管具有近端和远端，至少一个输送波导和沿着所述柔性导管延伸的至少一个收集波导导管，围绕导管的一部分设置的管腔扩张的可充气气囊，所述至少一个输送波导的透射输出和位于气囊内的至少一个收集波导的透射输入; 以及连接到所述导管并且定位在所述球囊内的至少一个细长臂，所述至少一个细长臂相对于所述导管可径向平移，并且其中所述变速器输出和变速器输入中的至少一个联接到所述细长臂。

10. 发明申请

WO2007041542A2 SYSTEMS AND METHODS FOR ANALYSIS AND TREATMENT OF A BODY LUMEN 审中-公开
标题翻译：体温分析与处理系统与方法
公开(公告)号：WO2007041542A2
公开(公告)日：2007-04-12
申请号：PCT/US2006/038547
申请日：2006-09-29
申请人： CORNOVA, INC. , RYAN, Eric, S. , TANG, Jing
发明人： RYAN, Eric, S. , TANG, Jing
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/01 , A61B5/015 , A61B5/02007 , A61B5/6853 , A61B2017/22001 , A61N5/0601
摘要： In a system and method for analyzing and treating a body lumen, a lumen-expanding balloon catheter with integrated one or more delivery waveguides and one or more collection waveguides is used to perform optical analysis of the tissues surrounding the lumen during expansion. The catheter can comprise an angioplasty catheter with integrated delivery waveguides and collection waveguides to perform spectroscopy of a stenotic plaque during angioplasty.
摘要翻译：在用于分析和处理体腔的系统和方法中，使用具有集成的一个或多个输送波导和一个或多个收集波导的管腔膨胀气囊导管，以在扩张期间对管腔周围的组织执行光学分析。导管可以包括具有集成输送波导和收集波导的血管成形术导管，以在血管成形术期间执行狭窄斑块的光谱。

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