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1. 发明申请

WO2011081971A2 EGFR/VEGFR DUAL MODULATORS AND METHODS OF USING 审中-公开
标题翻译： EGFR / VEGFR双重调节剂及其使用方法
公开(公告)号：WO2011081971A2
公开(公告)日：2011-07-07
申请号：PCT/US2010/060663
申请日：2010-12-16
申请人： CORNING INCORPORATED , FANG, Ye , DENG, Huayun , FERRIE, Ann, M. , SUN, Haiyan , TRAN, Elizabeth , HE, Mingqian , NIU, Weijun , WEI, Ying
发明人： FANG, Ye , DENG, Huayun , FERRIE, Ann, M. , SUN, Haiyan , TRAN, Elizabeth , HE, Mingqian , NIU, Weijun , WEI, Ying
IPC分类号： A61K31/381 , A61P35/00
CPC分类号： A61K31/381 , A61K45/06 , G01N33/5011 , A61K2300/00
摘要： Disclosed are compositions and methods related to identification of modulators of EGFR and VEGFR.
摘要翻译：公开了与鉴定EGFR和VEGFR调节剂相关的组合物和方法。

2. 发明申请

WO2011081970A2 MOLECULES RELATED hERG Ion CHANNELS AND THE USE THEREOF 审中-公开
标题翻译：分子相关的hERG离子通道及其用途
公开(公告)号：WO2011081970A2
公开(公告)日：2011-07-07
申请号：PCT/US2010/060655
申请日：2010-12-16
申请人： CORNING INCORPORATED , FANG, Ye , DENG, Huayun , FERRIE, Ann M. , SUN, Haiyan , TRAN, Elizabeth , HE, Mingqian , NIU, Weijun , WEI, Ying
发明人： FANG, Ye , DENG, Huayun , FERRIE, Ann M. , SUN, Haiyan , TRAN, Elizabeth , HE, Mingqian , NIU, Weijun , WEI, Ying
IPC分类号： A61K31/341 , A61P9/06 , A61P35/00 , G01N33/48
CPC分类号： A61K31/341 , G01N33/6872 , G01N2500/10 , G01N2800/52
摘要： Disclosed are compounds having structural formula (I, II) or a pharmaceutically acceptable sale, solvate, clathrate, or prodrug thereof, wherein R 1 , R 2 , R 3 , R 6 , R 5 , and R 4 are defined herein. These compounds can be useful as therapeutic agents for modulating hERG ion channels, and for improving prevention and treatment of hERG associated cardiac repolarization disorders.
摘要翻译：公开了具有结构式（I，II）的化合物或其可药用的销售，溶剂化物，包合物或前药，其中R 1， R 3，R 6，R 5和R 4如本文所定义。这些化合物可用作调节hERG离子通道的治疗剂，并用于改善hERG相关心脏复极障碍的预防和治疗。

3. 发明申请

WO2010065372A1 LIVER CELL TOXICITY ASSAY 审中-公开
标题翻译：肝细胞毒性测定
公开(公告)号：WO2010065372A1
公开(公告)日：2010-06-10
申请号：PCT/US2009/065527
申请日：2009-11-23
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann M , TRAN, Elizabeth , SUN, Haiyan , WEI, Ying
发明人： FANG, Ye , FERRIE, Ann M , TRAN, Elizabeth , SUN, Haiyan , WEI, Ying
IPC分类号： G01N33/50 , G01N33/543 , C12Q1/02
CPC分类号： G01N33/5067 , C12N2503/00 , C12Q1/025 , G01N33/5014 , G01N33/54373
摘要： The disclosure provides methods for characterizing the toxicity of a candidate molecule to liver cells as defined herein; methods of culturing metabolically active liver cells on a biosensor as defined herein; and biosensor liver culture systems as defined herein.
摘要翻译：本公开提供了表征候选分子对本文定义的肝细胞的毒性的方法; 在本文定义的生物传感器上培养代谢活性肝细胞的方法; 和如本文所定义的生物传感器肝脏培养系统。

4. 发明申请

WO2011123424A1 SCREENING METHODS FOR MITOCHONDRIA KATP MODULATORS USING CELL LINES 审中-公开
标题翻译：使用细胞线的MITOCHONDRIA KATP调制器的筛选方法
公开(公告)号：WO2011123424A1
公开(公告)日：2011-10-06
申请号：PCT/US2011/030284
申请日：2011-03-29
申请人： CORNING INCORPORATED , FANG, Ye , LAHIRI, Joydeep , SUN, Haiyan , WEI, Ying
发明人： FANG, Ye , LAHIRI, Joydeep , SUN, Haiyan , WEI, Ying
IPC分类号： G01N33/50
CPC分类号： G01N33/6872 , G01N21/553 , G01N21/7703 , G01N33/48714 , G01N33/54373 , Y02A50/60 , Y02A90/26
摘要： Disclosed are compositions and methods related to modulation of K ATP channels and methods of treating liver disorders by modulating K ATP and mito-K ATP channels.
摘要翻译：公开了与调节KATP通道有关的组合物和方法以及通过调节KATP和mito-KATP通道治疗肝脏疾病的方法。

5. 发明申请

WO2010059583A1 SPACED PROJECTION SUBSTRATES AND DEVICES FOR CELL CULTURE 审中-公开
标题翻译：间隔投影基质和细胞培养装置
公开(公告)号：WO2010059583A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/064684
申请日：2009-11-17
申请人： CORNING INCORPORATED , FANG, Ye , HSIEH, Yi-Cheng , HUANG, Ling , WEI, Ying
发明人： FANG, Ye , HSIEH, Yi-Cheng , HUANG, Ling , WEI, Ying
IPC分类号： C12M3/00 , C12N5/00 , C12N5/07
CPC分类号： C12N5/067 , C12M25/02 , C12N2502/13 , C12N2533/54
摘要： An article for culturing cells (100) includes a substrate (110) on which cells can be cultured. The substrate has a base surface. An array of projections (200) extends from the base surface. The projections have a height of about 1 micrometer to about 100 micrometers, and have a gap distance along the major surface from center to center between neighboring projections of about 10 micrometers to 80 micrometers. A plurality of arrays of projections may extend from the surface with gaps in the base surface between the arrays. Hepatocytes cultures on such microprojection array substrates maintained in vivo like morphology and membrane polarity. Hepatocytes co-cultured with helper cells on such substrates tended to grow in the area of the arrays, while the helper cells tended to grow in the areas between the arrays.
摘要翻译：用于培养细胞（100）的制品包括其上可培养细胞的底物（110）。基板具有基面。突起（200）的阵列从基面延伸。突起具有约1微米至约100微米的高度，并且在约10微米至80微米的相邻突起之间的中心至中心的主表面具有间隙距离。多个突起阵列可以从阵列之间的基部表面中的间隙从表面延伸。在这样的微喷射阵列基板上的肝细胞培养物保持体内，如形态和膜极性。与这种底物上的辅助细胞共培养的肝细胞趋向于在阵列区域中生长，而辅助细胞趋向于在阵列之间的区域中生长。

6. 发明申请

WO2012135294A2 ANTIMICROBIAL ACTION OF CU, CUO AND CU2O NANOPARTICLES ON GLASS SURFACES AND DURABLE COATINGS 审中-公开
标题翻译： CU，CUO和CU2O纳米粒子在玻璃表面和耐用涂料上的抗微生物作用
公开(公告)号：WO2012135294A2
公开(公告)日：2012-10-04
申请号：PCT/US2012/030863
申请日：2012-03-28
申请人： CORNING INCORPORATED , BORRELLI, Nicholas Francis , PETZOLD, Odessa Natalie , SCHROEDER, Joseph Francis III , SENARATNE, Wageesha , VERRIER, Florence , WEI, Ying
发明人： BORRELLI, Nicholas Francis , PETZOLD, Odessa Natalie , SCHROEDER, Joseph Francis III , SENARATNE, Wageesha , VERRIER, Florence , WEI, Ying
IPC分类号： A01N59/20
CPC分类号： A01N59/20 , A01N25/08 , C03C17/006 , C03C17/007 , C03C17/3692 , C03C17/42 , C03C21/002 , C03C2217/228 , C03C2217/253 , C03C2217/42 , C03C2217/475 , C03C2217/48 , C03C2218/322 , C03C2218/324 , Y10T428/24909 , Y10T428/24926 , Y10T428/259 , Y10T428/265 , Y10T428/31544 , A01N2300/00 , A01N25/34
摘要： A transparent cover glass for applications such as, but not limited to, touch screen devices that embody antimicrobial properties that include s being antibacterial, antifungal, and antiviral. The antimicrobial glasses contain nanoparticles of Cu or Cu 2 0 on the surface of the glass. The antimicrobial glasses can further have a fluorosilane coating or other coating on the surface to make the glasses easy-to -clean. Also, glass surfaces having an antibacterial or antimicrobial surfaces and a protective coating on the surface that do not inhibit the antibacterial or antimicrobial properties of the glass are described. The disclosure is further directed to methods of making such articles.
摘要翻译：用于例如但不限于体现抗菌性，包括抗菌，抗真菌和抗病毒的抗微生物性能的触摸屏装置的透明盖玻璃。抗微生物玻璃在玻璃表面含有Cu或Cu20纳米颗粒。抗微生物玻璃还可以在表面上具有氟硅烷涂层或其他涂层，以使玻璃易于清洁。此外，描述了具有抗菌或抗微生物表面的玻璃表面和表面上不会抑制玻璃的抗菌或抗微生物性能的保护涂层。本公开进一步涉及制造这种制品的方法。

7. 发明申请

WO2008112170A1 THREE DIMENSIONAL GUM MATRICES FOR CELL CULTURE, MANUFACTURING METHODS AND METHODS OF USE 审中-公开
标题翻译：用于细胞培养，制造方法和使用方法的三维GUM矩阵
公开(公告)号：WO2008112170A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/003099
申请日：2008-03-07
申请人： CORNING INCORPORATED , NOLL, Frederick, E. , SENARATNE, Wageesha , WEI, Ying
发明人： NOLL, Frederick, E. , SENARATNE, Wageesha , WEI, Ying
IPC分类号： C12N5/00 , C12N5/06
CPC分类号： C12N5/0068 , C12N5/0671 , C12N2533/70
摘要： This invention relates three dimensional porous cell culture matrices or scaffolds. More particularly, this invention relates to three dimensional porous cell culture matrices or scaffolds for cell culture which are derived from or contain gums including naturally occurring gums, plant gums, galactomannan gums or derivatives thereof. The invention also relates to articles of manufacture (e.g., cell culture vessels and labware) having such matrices or scaffolds, methods of applying these materials to cell culture surfaces, and methods of using cell culture vessels having these three dimensional porous cell culture matrices or scaffolds.
摘要翻译：本发明涉及三维多孔细胞培养基质或支架。更具体地，本发明涉及用于细胞培养的三维多孔细胞培养基质或支架，其衍生自或含有包括天然存在的树胶，植物胶，半乳甘露聚糖树胶或其衍生物的树胶。本发明还涉及具有这种基质或支架的制造品（例如，细胞培养容器和实验器皿），将这些材料应用于细胞培养物表面的方法，以及使用具有这些三维多孔细胞培养基质或支架的细胞培养容器的方法。

8. 发明申请

WO2008112163A1 GUM COATINGS FOR CELL CULTURE, METHODS OF MANUFACTURE AND METHODS OF USE 审中-公开
标题翻译：细胞培养的胶体涂料，制造方法和使用方法
公开(公告)号：WO2008112163A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/003091
申请日：2008-03-07
申请人： CORNING INCORPORATED , ELLISON, Adam, J. , SENARATNE, Wageesha , WEI, Ying
发明人： ELLISON, Adam, J. , SENARATNE, Wageesha , WEI, Ying
IPC分类号： C12N5/00 , C12N5/06
CPC分类号： C12N5/0068 , C12N5/067 , C12N2533/70
摘要： This invention relates to coatings for cell culture surfaces. More particularly, this invention relates to coatings for cell culture surfaces which are derived from or contain gums including naturally occurring gums, plant gums, galactomannan gums or derivatives thereof. The invention also relates to articles of manufacture (e.g., cell culture vessels and labware) having such coatings, methods of applying these coatings to cell culture surfaces, and methods of using coated cell culture vessel.
摘要翻译：本发明涉及细胞培养物表面的涂层。更具体地说，本发明涉及来自或含有包括天然存在的树胶，植物胶，半乳甘露聚糖胶或其衍生物的树胶的细胞培养物表面的涂层。本发明还涉及具有这种涂层的制品（例如，细胞培养容器和实验器皿），将这些涂层施用于细胞培养表面的方法以及使用包被的细胞培养容器的方法。

9. 发明申请

WO2013055994A1 ANTIMICROBIAL GLASS-CERAMICS 审中-公开
标题翻译：防霉玻璃陶瓷
公开(公告)号：WO2013055994A1
公开(公告)日：2013-04-18
申请号：PCT/US2012/059872
申请日：2012-10-12
申请人： CORNING INCORPORATED , BEALL, George, Halsey , BORRELLI, Nicholas, Francis , SMITH, Charlene, Marie , WEI, Ying
发明人： BEALL, George, Halsey , BORRELLI, Nicholas, Francis , SMITH, Charlene, Marie , WEI, Ying
IPC分类号： A01N25/08 , A01N59/16 , A01N59/20 , A01P1/00
CPC分类号： A01N59/16 , A01N59/20 , A01N25/08 , A01N2300/00
摘要： The application discloses the formation of antimicrobial glass ceramic articles having an amorphous phase and a crystalline phase and an antimicrobial agent selected from the group consisting of silver, copper and a mixture of silver and copper. The antimicrobial glass ceramic can have a Log Reduction of >2.
摘要翻译：该申请公开了具有非晶相和结晶相的抗微生物玻璃陶瓷制品的形成和选自银，铜和银和铜的混合物的抗微生物剂。抗菌玻璃陶瓷可以具有> 2的对数减少。

10. 发明申请

WO2012019067A1 COATED, ANTIMICROBIAL, CHEMICALLY STRENGTHENED GLASS AND METHOD OF MAKING 审中-公开
标题翻译：涂层，抗微生物，化学增强玻璃及其制备方法
公开(公告)号：WO2012019067A1
公开(公告)日：2012-02-09
申请号：PCT/US2011/046685
申请日：2011-08-05
申请人： CORNING INCORPORATED , BORRELLI, Nicholas F , MORSE, David Lathrop , SENARATNE, Wageesha , VERRIER, Florence , WEI, Ying
发明人： BORRELLI, Nicholas F , MORSE, David Lathrop , SENARATNE, Wageesha , VERRIER, Florence , WEI, Ying
IPC分类号： C03C17/30 , C03C21/00
CPC分类号： A01N59/16 , A01N25/08 , C03C3/083 , C03C3/087 , C03C3/091 , C03C3/093 , C03C3/095 , C03C4/00 , C03C17/30 , C03C21/002 , C03C21/005 , C03C2204/02 , C03C2204/04 , C03C2217/76 , Y10T428/24926 , Y10T428/265 , Y10T428/27 , Y10T428/273 , Y10T428/315 , Y10T428/31612
摘要： The disclosure is directed to a chemically strengthened glass having antimicrobial properties and to a method of making such glass. In particular, the disclosure is directed to a chemically strengthened glass with antimicrobial properties and with a low surface energy coating on the glass that does not interfere with the antimicrobial properties of the glass. The antimicrobial has an Ag ion concentration on the surface in the range of greater than zero to 0.047 µg/cm2. The glass has particular applications as antimicrobial shelving, table tops and other applications in hospitals, laboratories and other institutions handling biological substances, where color in the glass is not a consideration.
摘要翻译：本公开涉及具有抗微生物性质的化学强化玻璃和制造这种玻璃的方法。特别地，本公开涉及具有抗微生物性质的化学强化玻璃，并且在玻璃上具有不影响玻璃的抗微生物性能的低表面能涂层。抗微生物剂在表面上具有大于0至0.047μg/ cm 2的范围内的Ag离子浓度。该玻璃在医院，实验室和其他处理生物物质的机构中具有抗菌架，桌面和其他应用的特殊应用，其中不考虑玻璃中的颜色。

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