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1. 发明申请

WO2010059583A1 SPACED PROJECTION SUBSTRATES AND DEVICES FOR CELL CULTURE 审中-公开
标题翻译：间隔投影基质和细胞培养装置
公开(公告)号：WO2010059583A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/064684
申请日：2009-11-17
申请人： CORNING INCORPORATED , FANG, Ye , HSIEH, Yi-Cheng , HUANG, Ling , WEI, Ying
发明人： FANG, Ye , HSIEH, Yi-Cheng , HUANG, Ling , WEI, Ying
IPC分类号： C12M3/00 , C12N5/00 , C12N5/07
CPC分类号： C12N5/067 , C12M25/02 , C12N2502/13 , C12N2533/54
摘要： An article for culturing cells (100) includes a substrate (110) on which cells can be cultured. The substrate has a base surface. An array of projections (200) extends from the base surface. The projections have a height of about 1 micrometer to about 100 micrometers, and have a gap distance along the major surface from center to center between neighboring projections of about 10 micrometers to 80 micrometers. A plurality of arrays of projections may extend from the surface with gaps in the base surface between the arrays. Hepatocytes cultures on such microprojection array substrates maintained in vivo like morphology and membrane polarity. Hepatocytes co-cultured with helper cells on such substrates tended to grow in the area of the arrays, while the helper cells tended to grow in the areas between the arrays.
摘要翻译：用于培养细胞（100）的制品包括其上可培养细胞的底物（110）。基板具有基面。突起（200）的阵列从基面延伸。突起具有约1微米至约100微米的高度，并且在约10微米至80微米的相邻突起之间的中心至中心的主表面具有间隙距离。多个突起阵列可以从阵列之间的基部表面中的间隙从表面延伸。在这样的微喷射阵列基板上的肝细胞培养物保持体内，如形态和膜极性。与这种底物上的辅助细胞共培养的肝细胞趋向于在阵列区域中生长，而辅助细胞趋向于在阵列之间的区域中生长。

2. 发明申请

WO2011123424A1 SCREENING METHODS FOR MITOCHONDRIA KATP MODULATORS USING CELL LINES 审中-公开
标题翻译：使用细胞线的MITOCHONDRIA KATP调制器的筛选方法
公开(公告)号：WO2011123424A1
公开(公告)日：2011-10-06
申请号：PCT/US2011/030284
申请日：2011-03-29
申请人： CORNING INCORPORATED , FANG, Ye , LAHIRI, Joydeep , SUN, Haiyan , WEI, Ying
发明人： FANG, Ye , LAHIRI, Joydeep , SUN, Haiyan , WEI, Ying
IPC分类号： G01N33/50
CPC分类号： G01N33/6872 , G01N21/553 , G01N21/7703 , G01N33/48714 , G01N33/54373 , Y02A50/60 , Y02A90/26
摘要： Disclosed are compositions and methods related to modulation of K ATP channels and methods of treating liver disorders by modulating K ATP and mito-K ATP channels.
摘要翻译：公开了与调节KATP通道有关的组合物和方法以及通过调节KATP和mito-KATP通道治疗肝脏疾病的方法。

3. 发明申请

WO2011081971A2 EGFR/VEGFR DUAL MODULATORS AND METHODS OF USING 审中-公开
标题翻译： EGFR / VEGFR双重调节剂及其使用方法
公开(公告)号：WO2011081971A2
公开(公告)日：2011-07-07
申请号：PCT/US2010/060663
申请日：2010-12-16
申请人： CORNING INCORPORATED , FANG, Ye , DENG, Huayun , FERRIE, Ann, M. , SUN, Haiyan , TRAN, Elizabeth , HE, Mingqian , NIU, Weijun , WEI, Ying
发明人： FANG, Ye , DENG, Huayun , FERRIE, Ann, M. , SUN, Haiyan , TRAN, Elizabeth , HE, Mingqian , NIU, Weijun , WEI, Ying
IPC分类号： A61K31/381 , A61P35/00
CPC分类号： A61K31/381 , A61K45/06 , G01N33/5011 , A61K2300/00
摘要： Disclosed are compositions and methods related to identification of modulators of EGFR and VEGFR.
摘要翻译：公开了与鉴定EGFR和VEGFR调节剂相关的组合物和方法。

4. 发明申请

WO2011081970A2 MOLECULES RELATED hERG Ion CHANNELS AND THE USE THEREOF 审中-公开
标题翻译：分子相关的hERG离子通道及其用途
公开(公告)号：WO2011081970A2
公开(公告)日：2011-07-07
申请号：PCT/US2010/060655
申请日：2010-12-16
申请人： CORNING INCORPORATED , FANG, Ye , DENG, Huayun , FERRIE, Ann M. , SUN, Haiyan , TRAN, Elizabeth , HE, Mingqian , NIU, Weijun , WEI, Ying
发明人： FANG, Ye , DENG, Huayun , FERRIE, Ann M. , SUN, Haiyan , TRAN, Elizabeth , HE, Mingqian , NIU, Weijun , WEI, Ying
IPC分类号： A61K31/341 , A61P9/06 , A61P35/00 , G01N33/48
CPC分类号： A61K31/341 , G01N33/6872 , G01N2500/10 , G01N2800/52
摘要： Disclosed are compounds having structural formula (I, II) or a pharmaceutically acceptable sale, solvate, clathrate, or prodrug thereof, wherein R 1 , R 2 , R 3 , R 6 , R 5 , and R 4 are defined herein. These compounds can be useful as therapeutic agents for modulating hERG ion channels, and for improving prevention and treatment of hERG associated cardiac repolarization disorders.
摘要翻译：公开了具有结构式（I，II）的化合物或其可药用的销售，溶剂化物，包合物或前药，其中R 1， R 3，R 6，R 5和R 4如本文所定义。这些化合物可用作调节hERG离子通道的治疗剂，并用于改善hERG相关心脏复极障碍的预防和治疗。

5. 发明申请

WO2010065372A1 LIVER CELL TOXICITY ASSAY 审中-公开
标题翻译：肝细胞毒性测定
公开(公告)号：WO2010065372A1
公开(公告)日：2010-06-10
申请号：PCT/US2009/065527
申请日：2009-11-23
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann M , TRAN, Elizabeth , SUN, Haiyan , WEI, Ying
发明人： FANG, Ye , FERRIE, Ann M , TRAN, Elizabeth , SUN, Haiyan , WEI, Ying
IPC分类号： G01N33/50 , G01N33/543 , C12Q1/02
CPC分类号： G01N33/5067 , C12N2503/00 , C12Q1/025 , G01N33/5014 , G01N33/54373
摘要： The disclosure provides methods for characterizing the toxicity of a candidate molecule to liver cells as defined herein; methods of culturing metabolically active liver cells on a biosensor as defined herein; and biosensor liver culture systems as defined herein.
摘要翻译：本公开提供了表征候选分子对本文定义的肝细胞的毒性的方法; 在本文定义的生物传感器上培养代谢活性肝细胞的方法; 和如本文所定义的生物传感器肝脏培养系统。

6. 发明申请

WO2013022584A1 MODULATION OF THE MAMMALIAN RECEPTOR MTOR TO INHIBIT STEM CELL DIFFERENTIATION INTO NEURONS 审中-公开
标题翻译：调节MAMMALIAN受体MTOR以抑制干细胞分化为神经元
公开(公告)号：WO2013022584A1
公开(公告)日：2013-02-14
申请号：PCT/US2012/047289
申请日：2012-07-19
申请人： CORNING INCORPORATED , FANG, Ye , FARIS, Ronald, Allen , PAI, Sadashiva, Karnire , PETZOLD, Odessa, Natalie
发明人： FANG, Ye , FARIS, Ronald, Allen , PAI, Sadashiva, Karnire , PETZOLD, Odessa, Natalie
IPC分类号： C12N5/0797
CPC分类号： C12N5/0606 , C12N5/0607 , C12N5/0623 , C12N2501/04
摘要： The present application relates to compositions and methods for inhibiting the differentiation of isolated embryonic stem cells, induced pluripotent stem cells, parthenogentic stem cells, or isolated embryoid bodies into neuronal progenitor cells or neuron cells comprising a mTOR inhibitor and an effective amount of cell culture growth media. The mTOR inhibitor can be Rapamycin.
摘要翻译：本申请涉及用于抑制分离的胚胎干细胞，诱导的多能干细胞，特异性干细胞或分离的胚状体分化成神经元祖细胞或包含mTOR抑制剂和有效量的细胞培养生长的神经元细胞的分化的组合物和方法媒体。 mTOR抑制剂可以是雷帕霉素。

7. 发明申请

WO2012009602A1 LABEL-FREE CELLULAR PHARMACOLOGY FOR DRUG ANTITARGET ASSESSMENT 审中-公开
标题翻译：用于药物抗体评估的无标签免疫细胞药理学
公开(公告)号：WO2012009602A1
公开(公告)日：2012-01-19
申请号：PCT/US2011/044120
申请日：2011-07-15
申请人： CORNING INCORPORATED , FANG, Ye
发明人： FANG, Ye
IPC分类号： G01N33/50 , G01N33/543
CPC分类号： G01N33/5014 , G01N33/54373 , G01N2333/70571
摘要： Described are methods relating to assessing antitargets of molecules. Also described are methods of screening molecules. In some aspects of the methods, the molecules are analyzed using a label free biosensor.
摘要翻译：描述了评估分子抗靶物的方法。还描述了筛选分子的方法。在该方法的某些方面，使用无标记的生物传感器分析分子。

8. 发明申请

WO2011116260A1 LABEL-FREE ON-TARGET PHARMACOLOGY METHODS 审中-公开
标题翻译：无标签目标药物方法
公开(公告)号：WO2011116260A1
公开(公告)日：2011-09-22
申请号：PCT/US2011/028947
申请日：2011-03-18
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann M.
发明人： FANG, Ye , FERRIE, Ann M.
IPC分类号： G06F19/00
CPC分类号： G06F19/707 , G06F19/706
摘要： Disclosed are methods and machines to determine on-target pharmacology of molecules using label-free biosensor cellular assays and label-free biosensor integrative pharmacology.
摘要翻译：公开了使用无标签生物传感器细胞测定和无标记生物传感器综合药理学确定分子的靶向药理学的方法和机器。

9. 发明申请

WO2011081973A1 LABEL-FREE METHODS RELATED TO HERG POTASSIUM ION CHANNELS 审中-公开
标题翻译：与烟草离子通道相关的无标记方法
公开(公告)号：WO2011081973A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/060688
申请日：2010-12-16
申请人： CORNING INCORPORATED , FANG, Ye , SUN, Haiyan
发明人： FANG, Ye , SUN, Haiyan
IPC分类号： G01N33/68 , G01N33/94
CPC分类号： G01N33/6872 , G01N2500/10
摘要： Disclosed are methods to classify human ether-à-go-go related gene (hERG) ion channel modulators using label-free biosensors. Disclosed is the use of label-free resonant waveguide grating (RWG) biosensors to reveal the patterns of the DMR signals of hERG modulators across three types of cell lines (a native cell line endogenously expressing hERG, a native cell line without hERG and its engineered cell line stably expressed hERG), as well as the corresponding modulation index of the modulators molecules against a hERG activator acting on a panel of markers/cells, particularly the known hERG activator mallotoxin DMR signals in the two hERG expressing cell lines.
摘要翻译：公开了使用无标记生物传感器分类人类醚转运相关基因（hERG）离子通道调节剂的方法。公开了使用无标记谐振波导光栅（RWG）生物传感器来显示三种类型的细胞系（内源性表达hERG的天然细胞系，没有hERG的天然细胞系及其工程设计的）的hERG调节剂的DMR信号的模式细胞系稳定表达hERG），以及调节剂分子对作用于一组标志物/细胞的hERG激活剂的相应调节指数，特别是两种hERG表达细胞系中已知的hERG活化剂mallotoxin DMR信号。

10. 发明申请

WO2009148509A1 CELL CULTURE APPARATUS HAVING DIFFERENT MICRO-WELL TOPOGRAPHY 审中-公开
标题翻译：细胞培养装置具有不同的微观形态
公开(公告)号：WO2009148509A1
公开(公告)日：2009-12-10
申请号：PCT/US2009/003115
申请日：2009-05-20
申请人： CORNING INCORPORATED , FANG, Ye , WANG, Jianguo , ZHANG, Ying
发明人： FANG, Ye , WANG, Jianguo , ZHANG, Ying
IPC分类号： C12M1/18 , B01L3/00
CPC分类号： C12M23/16 , B01L3/5085 , B01L2300/0829 , B01L2300/0851 , B01L2300/163 , B81B2201/06 , B81B2203/0346 , B81B2203/0376 , B81C99/0085 , B81C99/009 , C12M23/12
摘要： A cell culture apparatus includes a substrate having formed therein a micro-well array, the micro-well array comprising a plurality of micro-wells. Each micro-well is defined by a curved surface which is concave. At least two of the micro-wells have different topgraphy.
摘要翻译：细胞培养装置包括其中形成有微孔阵列的基底，微孔阵列包括多个微孔。每个微孔由凹入的曲面限定。至少有两个微孔具有不同的地层。

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