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1. 发明申请

WO2011081971A2 EGFR/VEGFR DUAL MODULATORS AND METHODS OF USING 审中-公开
标题翻译： EGFR / VEGFR双重调节剂及其使用方法
公开(公告)号：WO2011081971A2
公开(公告)日：2011-07-07
申请号：PCT/US2010/060663
申请日：2010-12-16
申请人： CORNING INCORPORATED , FANG, Ye , DENG, Huayun , FERRIE, Ann, M. , SUN, Haiyan , TRAN, Elizabeth , HE, Mingqian , NIU, Weijun , WEI, Ying
发明人： FANG, Ye , DENG, Huayun , FERRIE, Ann, M. , SUN, Haiyan , TRAN, Elizabeth , HE, Mingqian , NIU, Weijun , WEI, Ying
IPC分类号： A61K31/381 , A61P35/00
CPC分类号： A61K31/381 , A61K45/06 , G01N33/5011 , A61K2300/00
摘要： Disclosed are compositions and methods related to identification of modulators of EGFR and VEGFR.
摘要翻译：公开了与鉴定EGFR和VEGFR调节剂相关的组合物和方法。

2. 发明申请

WO2011081970A2 MOLECULES RELATED hERG Ion CHANNELS AND THE USE THEREOF 审中-公开
标题翻译：分子相关的hERG离子通道及其用途
公开(公告)号：WO2011081970A2
公开(公告)日：2011-07-07
申请号：PCT/US2010/060655
申请日：2010-12-16
申请人： CORNING INCORPORATED , FANG, Ye , DENG, Huayun , FERRIE, Ann M. , SUN, Haiyan , TRAN, Elizabeth , HE, Mingqian , NIU, Weijun , WEI, Ying
发明人： FANG, Ye , DENG, Huayun , FERRIE, Ann M. , SUN, Haiyan , TRAN, Elizabeth , HE, Mingqian , NIU, Weijun , WEI, Ying
IPC分类号： A61K31/341 , A61P9/06 , A61P35/00 , G01N33/48
CPC分类号： A61K31/341 , G01N33/6872 , G01N2500/10 , G01N2800/52
摘要： Disclosed are compounds having structural formula (I, II) or a pharmaceutically acceptable sale, solvate, clathrate, or prodrug thereof, wherein R 1 , R 2 , R 3 , R 6 , R 5 , and R 4 are defined herein. These compounds can be useful as therapeutic agents for modulating hERG ion channels, and for improving prevention and treatment of hERG associated cardiac repolarization disorders.
摘要翻译：公开了具有结构式（I，II）的化合物或其可药用的销售，溶剂化物，包合物或前药，其中R 1， R 3，R 6，R 5和R 4如本文所定义。这些化合物可用作调节hERG离子通道的治疗剂，并用于改善hERG相关心脏复极障碍的预防和治疗。

3. 发明申请

WO2010065372A1 LIVER CELL TOXICITY ASSAY 审中-公开
标题翻译：肝细胞毒性测定
公开(公告)号：WO2010065372A1
公开(公告)日：2010-06-10
申请号：PCT/US2009/065527
申请日：2009-11-23
申请人： CORNING INCORPORATED , FANG, Ye , FERRIE, Ann M , TRAN, Elizabeth , SUN, Haiyan , WEI, Ying
发明人： FANG, Ye , FERRIE, Ann M , TRAN, Elizabeth , SUN, Haiyan , WEI, Ying
IPC分类号： G01N33/50 , G01N33/543 , C12Q1/02
CPC分类号： G01N33/5067 , C12N2503/00 , C12Q1/025 , G01N33/5014 , G01N33/54373
摘要： The disclosure provides methods for characterizing the toxicity of a candidate molecule to liver cells as defined herein; methods of culturing metabolically active liver cells on a biosensor as defined herein; and biosensor liver culture systems as defined herein.
摘要翻译：本公开提供了表征候选分子对本文定义的肝细胞的毒性的方法; 在本文定义的生物传感器上培养代谢活性肝细胞的方法; 和如本文所定义的生物传感器肝脏培养系统。

4. 发明申请

WO2011081968A1 PI3K MODULATORS, RHO KINASE MODULATORS AND METHODS OF IDENTIFYING AND USING SAME 审中-公开
标题翻译： PI3K调节剂，RHO激酶调节剂及其鉴定和使用方法
公开(公告)号：WO2011081968A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/060648
申请日：2010-12-16
申请人： CORNING INCORPORATED , FANG, Ye , SUN, Haiyan , DENG, Huayun , FERRIE, Ann, M. , TRAN, Elizabeth
发明人： FANG, Ye , SUN, Haiyan , DENG, Huayun , FERRIE, Ann, M. , TRAN, Elizabeth
IPC分类号： G01N33/543 , C12Q1/48
CPC分类号： G01N33/5041 , G01N33/54373 , G01N2333/91215
摘要： Disclosed are methods to characterize PI3K inhibitors and Rho kinase inhibitors using label-free cellular assays. Disclosed are also methods to characterize a cell whether it has a deregulated PI3K pathway or not.
摘要翻译：公开了使用无标记细胞测定来表征PI3K抑制剂和Rho激酶抑制剂的方法。还公开了表征细胞是否具有失去PI3K途径的方法。

5. 发明申请

WO2011123424A1 SCREENING METHODS FOR MITOCHONDRIA KATP MODULATORS USING CELL LINES 审中-公开
标题翻译：使用细胞线的MITOCHONDRIA KATP调制器的筛选方法
公开(公告)号：WO2011123424A1
公开(公告)日：2011-10-06
申请号：PCT/US2011/030284
申请日：2011-03-29
申请人： CORNING INCORPORATED , FANG, Ye , LAHIRI, Joydeep , SUN, Haiyan , WEI, Ying
发明人： FANG, Ye , LAHIRI, Joydeep , SUN, Haiyan , WEI, Ying
IPC分类号： G01N33/50
CPC分类号： G01N33/6872 , G01N21/553 , G01N21/7703 , G01N33/48714 , G01N33/54373 , Y02A50/60 , Y02A90/26
摘要： Disclosed are compositions and methods related to modulation of K ATP channels and methods of treating liver disorders by modulating K ATP and mito-K ATP channels.
摘要翻译：公开了与调节KATP通道有关的组合物和方法以及通过调节KATP和mito-KATP通道治疗肝脏疾病的方法。

6. 发明申请

WO2011081973A1 LABEL-FREE METHODS RELATED TO HERG POTASSIUM ION CHANNELS 审中-公开
标题翻译：与烟草离子通道相关的无标记方法
公开(公告)号：WO2011081973A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/060688
申请日：2010-12-16
申请人： CORNING INCORPORATED , FANG, Ye , SUN, Haiyan
发明人： FANG, Ye , SUN, Haiyan
IPC分类号： G01N33/68 , G01N33/94
CPC分类号： G01N33/6872 , G01N2500/10
摘要： Disclosed are methods to classify human ether-à-go-go related gene (hERG) ion channel modulators using label-free biosensors. Disclosed is the use of label-free resonant waveguide grating (RWG) biosensors to reveal the patterns of the DMR signals of hERG modulators across three types of cell lines (a native cell line endogenously expressing hERG, a native cell line without hERG and its engineered cell line stably expressed hERG), as well as the corresponding modulation index of the modulators molecules against a hERG activator acting on a panel of markers/cells, particularly the known hERG activator mallotoxin DMR signals in the two hERG expressing cell lines.
摘要翻译：公开了使用无标记生物传感器分类人类醚转运相关基因（hERG）离子通道调节剂的方法。公开了使用无标记谐振波导光栅（RWG）生物传感器来显示三种类型的细胞系（内源性表达hERG的天然细胞系，没有hERG的天然细胞系及其工程设计的）的hERG调节剂的DMR信号的模式细胞系稳定表达hERG），以及调节剂分子对作用于一组标志物/细胞的hERG激活剂的相应调节指数，特别是两种hERG表达细胞系中已知的hERG活化剂mallotoxin DMR信号。

7. 发明申请

WO2012012278A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL CONDITION(S) RELATED TO GPR35 AND/OR GPR35-HERG COMPLEX 审中-公开
标题翻译：治疗与GPR35和/或GPR35-HERG复合物相关的病理学条件的组合物和方法
公开(公告)号：WO2012012278A2
公开(公告)日：2012-01-26
申请号：PCT/US2011/044124
申请日：2011-07-15
申请人： CORNING INCORPORATED , DENG, Huayun , FANG, Ye , HE, Mingqian , HU, Haibei , NIU, Weijun , SUN, Haiyan
发明人： DENG, Huayun , FANG, Ye , HE, Mingqian , HU, Haibei , NIU, Weijun , SUN, Haiyan
IPC分类号： A61K31/44 , C07D307/68 , C12Q1/02 , A61K31/341 , C07D495/04 , A61K31/381 , C07D333/40 , C07D409/04 , C07C229/56 , A61K31/196 , C07C229/58 , C07D213/74 , C07D307/66 , C07D333/36 , C07D207/34 , A61K31/40 , C07C255/42 , A61K31/277 , C40B30/06 , A61P29/00 , A61P3/10 , A61P9/06 , A61P3/00 , A61P9/00 , A61P35/00 , A61P3/06 , A61P3/04 , A61P9/10 , A61P9/12 , G01N21/64
CPC分类号： C07D207/34 , C07C229/56 , C07C229/58 , C07C255/34 , C07D213/74 , C07D307/52 , C07D307/66 , C07D333/16 , C07D333/20 , C07D333/22 , C07D333/36 , C07D333/38
摘要： Disclosed are compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically related to GPR35, and/or GPR35-hERG signaling complex. For example, disclosed are compounds for preventing and/or treating diseases which are pathophysiologically related to GPR35 in a subject.
摘要翻译：公开了用于预防和/或治疗与GPR35和/或GPR35-hERG信号传导复合物病理生理学相关的疾病的组合物和方法。例如，公开了用于预防和/或治疗受试者与病理生理学上与GPR35相关的疾病的化合物。

8. 发明申请

WO2011037988A1 METHOD FOR IMPARTING TOPICAL HOLOGRAPHIC EFFECT TO A POLYMERIC FILM SUBSTRATE 审中-公开
标题翻译：用于将局部全息影响的方法用于聚合薄膜基底
公开(公告)号：WO2011037988A1
公开(公告)日：2011-03-31
申请号：PCT/US2010/049802
申请日：2010-09-22
申请人： THE PROCTER & GAMBLE COMPANY , SUN, Haiyan , ZHANG, Jing
发明人： SUN, Haiyan , ZHANG, Jing
IPC分类号： G03H1/00 , G03H1/02
CPC分类号： G03H1/0236 , G03H1/0011 , G03H1/0244 , G03H1/0252 , G03H2001/184 , G03H2001/187 , G03H2210/54 , G03H2250/40 , G03H2250/42
摘要： A method for imparting topical holographic effect to a polymeric film substrate (20) comprising a first surface and a second surface. The method comprises the steps of embossing the first surface (25) of the polymeric film substrate (20) to impart a holographic effect to the polymeric film substrate and printing the embossed first surface of the polymeric film substrate with ink and/or varnish on selected area (24) which is intended not to have holographic effect and leaving the unprinted embossed area to provide a holographic effect.
摘要翻译：一种用于赋予聚合物膜基底（20）局部全息效应的方法，该方法包括第一表面和第二表面。该方法包括以下步骤：对聚合物膜基材（20）的第一表面（25）进行压花，以赋予聚合物薄膜基材全息效果，并在所选择的墨水和/或清漆上印刷聚合物薄膜基材的压花的第一表面区域（24），其不具有全息效果并且留下未打印的压花区域以提供全息效果。

9. 发明申请

WO2023004577A1 DISPENSER FOR VISCOUS PRODUCTS 审中-公开
公开(公告)号：WO2023004577A1
公开(公告)日：2023-02-02
申请号：PCT/CN2021/108633
申请日：2021-07-27
申请人： THE PROCTER & GAMBLE COMPANY , BARTOLUCCI, Stefano , SUN, Haiyan , KING, Geoffrey, Allen , SCHLASINGER, Michael, Vincent , CLEAR III, Joseph, Frank
发明人： BARTOLUCCI, Stefano , SUN, Haiyan , KING, Geoffrey, Allen , SCHLASINGER, Michael, Vincent , CLEAR III, Joseph, Frank
IPC分类号： B01L3/02 , B05B11/00 , B65D47/18
摘要： Disclosed is a product dispenser, comprising: (A) a reservoir for a product, having a cap fastening mechanism; (B) a cap having the following (B-1) to (B-3) : (B-1) a first assembly having: a housing for a sealing element; a chamber volume controlling mechanism; and a button configured to dispense the product through a lower end orifice of the pipette, when the button is actuated; (B-2) a second assembly having: a pipette having an upper end orifice and a lower end orifice, and rigidly connected and in fluidic communication with a chamber; a sealing element configured to seal relative to the housing, and to slide between a high position and a low position in the housing; a corresponding fastening mechanism to the cap fastening mechanism of the reservoir; (B-3) a chamber configured to change its volume depending on the movement of the first assembly relative to the second assembly and the movement of the button, wherein when the cap is in a closed position, the sealing element is located at a higher position relative to the housing, wherein a movement of the cap in a direction of opening the product dispenser causes the housing to move up relatively to the sealing element via the chamber volume controlling mechanism, so that the sealing element slides from the higher to the lower position in the housing and the volume of the chamber increases, wherein this increase of the chamber volume causes a suction of the product in the pipette, wherein when the sealing element reaches to the lower position in the housing, a further movement of the cap in the direction of opening causes the corresponding fastening mechanism of the cap to disengage from the cap fastening mechanism of the reservoir, and wherein when the button is actuated, the volume of the chamber decreases by which the product is dispensed from the pipette.

10. 发明申请

WO2012024096A1 EDDY CURRENT INSPECTION OF CASE-HARDENED METAL COMPONENTS 审中-公开
标题翻译：案例硬化金属部件的EDDY当前检查
公开(公告)号：WO2012024096A1
公开(公告)日：2012-02-23
申请号：PCT/US2011/046590
申请日：2011-08-04
申请人： GENERAL ELECTRIC COMPANY , SUN, Haiyan , GIAMMARISE, Anthony , WANG, Changting , SIRAK, Michael , TRALSHAWALA, Nilesh , GODBOLE, Mandar , BATZINGER, Thomas, James , SHEILA-VADDE, Aparna , LIU, Shubin
发明人： SUN, Haiyan , GIAMMARISE, Anthony , WANG, Changting , SIRAK, Michael , TRALSHAWALA, Nilesh , GODBOLE, Mandar , BATZINGER, Thomas, James , SHEILA-VADDE, Aparna , LIU, Shubin
IPC分类号： G01N27/80 , G01N27/90
CPC分类号： G01N27/9046 , G01N27/80
摘要： A method for determining a case depth of a hardened layer in a surface of a metal object includes: (a) placing an eddy current probe at a location adjacent the surface; (b) using the eddy current probe, generating a time-varying eddy current in the object; (c) using the eddy current probe, outputting a measured eddy current and providing a signal representative of the measured eddy current to a computer; (d) using the computer, comparing the time-varying measured eddy current to a correlation of measured eddy currents to known case depths; and (e) determining the case depth at the location of the probe based on the correlation.
摘要翻译：用于确定金属物体的表面中的硬化层的壳体深度的方法包括：（a）在与表面相邻的位置放置涡流探针; （b）使用涡流探头，在物体中产生时变涡流; （c）使用涡电流探头，输出测量的涡流并向计算机提供表示测量的涡流的信号; （d）使用计算机，将随时间变化的测量涡流与测量涡流与已知情况深度的相关性进行比较; 和（e）基于所述相关性来确定探针位置处的病例深度。

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