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1. 发明申请

WO2004074504A2 FLUORESCENT SILICA-BASED NANOPARTICLES 审中-公开
标题翻译：荧光硅基纳米粒子
公开(公告)号：WO2004074504A2
公开(公告)日：2004-09-02
申请号：PCT/US0337963
申请日：2003-11-26
申请人： CORNELL RES FOUNDATION INC , WIESNER ULRICH , OW HOOISWENG , LARSON DANIEL E , WEBB WATT W
发明人： WIESNER ULRICH , OW HOOISWENG , LARSON DANIEL E , WEBB WATT W
IPC分类号： G01N33/50 , G01N33/58 , C12Q
CPC分类号： C09K11/025 , B82Y30/00 , C01B33/18 , C01P2002/80 , C01P2004/03 , C01P2004/64 , C07K16/00 , C07K2317/52 , C09K11/06 , G01N33/5005 , G01N33/54346 , G01N33/582 , G01N33/587 , Y10T428/2438 , Y10T428/31663
摘要： The invention generally relates to fluorescent nanoparticles and more specifically to silica-based fluorescent nanoparticles of less than 30nm with covalently attached organic dyes. The invention provides a fluorescent monodisperse silica nanoparticle comprising fluorophore center core and a silica shell wherein the radiative properties of the nanoparticle are dependent upon the chemistry (composition) of the core and presence of the silica shell. In one aspect of the invention, the core-shell architecture provides an enhancement in fluorescence quantum efficiency. The invention generally provides control of photophysical properties of dye molecules encapsulated within silica particles with sizes down to 30 nm and below. This control is accomplished through changes in silica chemistry and particle architecture on the nanometer size scale and results in significant brightness enhancement compared to free dye.
摘要翻译：本发明总体上涉及荧光纳米颗粒，更具体地涉及具有共价连接的有机染料的小于30nm的基于二氧化硅的荧光纳米颗粒。本发明提供包含荧光团中心核和二氧化硅壳的荧光单分散二氧化硅纳米粒子，其中纳米粒子的辐射特性取决于核的化学（组成）和二氧化硅壳的存在。在本发明的一个方面中，核 - 壳结构提供荧光量子效率的增强。本发明通常提供对包封在二氧化硅颗粒内的染料分子的光物理性质的控制，其尺寸低至30nm及以下。这种控制是通过改变二氧化硅化学和纳米尺寸的粒子结构来实现的，并且与游离染料相比导致明显的亮度增强。

2. 发明申请

WO2009029870A3 PEG-COATED CORE-SHELL SILICA NANOPARTICLES AND METHODS OF MANUFACTURE AND USE 审中-公开
标题翻译： PEG涂层核心二氧化硅纳米粒子及其制造和使用方法
公开(公告)号：WO2009029870A3
公开(公告)日：2009-05-07
申请号：PCT/US2008074894
申请日：2008-08-29
申请人： HYBRID SILICA TECHNOLOGIES INC , WIESNER ULRICH , OW HOOISWENG
发明人： WIESNER ULRICH , OW HOOISWENG
IPC分类号： C01B33/12 , B32B5/16 , B82B1/00 , C09K11/02
CPC分类号： C09K11/025 , A61K49/0032 , A61K49/0093 , C09K11/06
摘要： Described herein are PEG-coated, core-shell nanoparticles, which display reduced aggregation and/or reduced non-specific or undesired attachment characteristics. These fluorescent nanoparticle include: a silica-based core having an organic functional group that includes a mercapto substitituent, an organic fluorescent compound, a silica shell; and a silane-PEG compound. The silica shell of the nanoparticle encapsulates the silica-based core and the silane-PEG compound is conjugated to the silica shell.
摘要翻译：本文描述的是PEG-包覆的核 - 壳纳米颗粒，其显示减少的聚集和/或降低的非特异性或不期望的附着特征。这些荧光纳米粒子包括：具有巯基取代基的有机官能团的二氧化硅类核，有机荧光化合物，二氧化硅壳; 和硅烷-PEG化合物。纳米颗粒的二氧化硅壳包封二氧化硅基核，硅烷-PEG化合物与二氧化硅壳结合。

3. 发明申请

WO2006007476A2 VOLUME PHASE TRANSITION TO INDUCE GEL MOVEMENT 审中-公开
标题翻译：体积相转移以引起凝胶运动
公开(公告)号：WO2006007476A2
公开(公告)日：2006-01-19
申请号：PCT/US2005022280
申请日：2005-06-24
申请人： CORNELL RES FOUNDATION INC
发明人： YEGHIAZARIAN LILIT L , WIESNER ULRICH , MONTEMAGNO CARLO D
IPC分类号： H01B1/00
CPC分类号： F04B19/24 , B01L3/50273 , B01L2400/0475 , B01L2400/0478 , B01L2400/0672 , F04B19/006
摘要： Movement of a gel structure is propagated by successively applying external stimuli to cause volume phase transition in the gel structure by alternately causing the gel structure to collapse and swell to move the center of mass of the gel structure in the direction of successive stimuli application. The movement is mediated by confining structure for the gel and anchoring- the starting side of the gel in the swelling cycle.
摘要翻译：凝胶结构的运动通过连续地施加外部刺激而传播，以通过交替地使凝胶结构塌陷和膨胀以使凝胶结构的质心在连续刺激施加的方向上引起体积相变。该运动由凝胶的限制结构介导，并且在溶胀循环中锚定 - 凝胶的起始侧。

4. 发明申请

WO2011003109A8 FLUORESCENT SILICA-BASED NANOPARTICLES 审中-公开
标题翻译：荧光二氧化硅纳米颗粒
公开(公告)号：WO2011003109A8
公开(公告)日：2012-02-23
申请号：PCT/US2010040994
申请日：2010-07-02
申请人： SLOAN KETTERING INST CANCER , BRADBURY MICHELLE , WIESNER ULRICH , PENATE MEDINA OULA , OW HOOSWENG , BURNS ANDREW , LEWIS JASON , LARSON STEVEN , UNIV CORNELL
发明人： BRADBURY MICHELLE , WIESNER ULRICH , PENATE MEDINA OULA , OW HOOSWENG , BURNS ANDREW , LEWIS JASON , LARSON STEVEN
IPC分类号： G01N33/50
CPC分类号： A61K51/1244 , A61K9/5115 , A61K9/5146 , A61K9/5169 , A61K49/0019 , A61K49/0032 , A61K49/0054 , A61K49/0056 , A61K49/0093 , A61K51/08 , A61K51/082 , A61K51/086 , A61K51/1255 , B82Y5/00 , B82Y15/00 , G01N33/54346 , G01N33/552 , G01N33/574 , G01N33/582 , G01N33/587 , G01N33/60 , Y10S977/773 , Y10S977/927
摘要： The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as polyethylene glycol) (PEG) The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo The nanoparticle may further be conjugated to a ligand capable of binding to a cellular component associated with the specific cell type, such as a tumor marker A therapeutic agent may be attached to the nanoparticle Radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle to permit the nanoparticle to be detectable by various imaging techniques.
摘要翻译：本发明提供一种荧光二氧化硅基纳米颗粒，其允许精确检测，表征，监测和治疗诸如癌症的疾病。纳米颗粒具有位于纳米颗粒内的荧光化合物，并且具有比游离荧光素更高的亮度和荧光量子产率化合物为了促进纳米颗粒的有效的尿液排泄，可以用有机聚合物如聚乙二醇（PEG）包被）（PEG）小粒径的纳米颗粒，二氧化硅基底和有机聚合物涂层在施用时使纳米颗粒的毒性最小化在体内纳米颗粒还可以与能够结合与特定细胞类型相关的细胞成分的配体缀合，例如肿瘤标记物A治疗剂可以连接到纳米颗粒放射性核素/放射性金属或顺磁性离子可以与纳米颗粒以允许纳米颗粒可以通过各种i检测搜索技巧

5. 发明申请

WO2011109702A2 MONOCRYSTALLINE EPITAXIALLY ALIGNED NANOSTRUCTURES AND RELATED METHODS 审中-公开
标题翻译：单结构外延对齐的纳米结构和相关方法
公开(公告)号：WO2011109702A2
公开(公告)日：2011-09-09
申请号：PCT/US2011027172
申请日：2011-03-04
申请人： UNIV CORNELL , WIESNER ULRICH , THOMPSON MICHAEL , ARORA HITESH
发明人： WIESNER ULRICH , THOMPSON MICHAEL , ARORA HITESH
CPC分类号： B81C1/00031 , B81C2201/0149 , B81C2201/0169 , C30B1/023 , C30B29/08 , C30B29/605 , H01L21/02381 , H01L21/02532 , H01L21/02603 , H01L21/02642 , H01L21/28518 , Y10T428/24372 , Y10T428/24413
摘要： A method for fabricating a nanostructure utilizes a templated monocrystalline substrate. The templated monocrystalline substrate is energetically (i.e., preferably thermally) treated, with an optional precleaning and an optional amorphous material layer located thereupon, to form a template structured monocrystalline substrate that includes the monocrystalline substrate with a plurality of epitaxially aligned contiguous monocrystalline pillars extending therefrom. The monocrystalline substrate and the plurality of epitaxially aligned contiguous monocrystalline pillars may comprise the same or different monocrystalline materials. The method provides the nanostructure where when the monocrystalline substrate and the plurality of epitaxial aligned contiguous monocrystalline pillars comprise different monocrystalline materials having a bulk crystal structure mismatch of up to about 10 percent, lattice mismatch induced crystal structure defects may be avoided interposed between the monocrystalline substrate and the plurality of epitaxially aligned contiguous monocrystalline pillars, which may have an irregular sidewall shape.
摘要翻译：制造纳米结构的方法使用模板化单晶衬底。模板化的单晶衬底在能量上（即，优选热处理），具有可选的预清洗和位于其上的任选的非晶材料层，以形成模板结构的单晶衬底，其包括具有从其延伸的多个外延比对的邻接单晶柱的单晶衬底。单晶衬底和多个外延排列的邻接单晶柱可以包括相同或不同的单晶材料。该方法提供纳米结构，其中当单晶衬底和多个外延对准的邻接单晶柱包含具有高达约10％的体晶结构失配的不同单晶材料时，晶格失配诱发的晶体结构缺陷可以避免插入在单晶衬底以及可能具有不规则侧壁形状的多个外延排列的邻接单晶柱。

6. 发明申请

WO2009097184A3 ORDERED POROUS MESOSTRUCTURED MATERIALS FROM NANOPARTICLE-BLOCK COPOLYMER SELF-ASSEMBLY 审中-公开
标题翻译：来自纳米颗粒嵌段共聚物的自组装多孔结构材料自组装
公开(公告)号：WO2009097184A3
公开(公告)日：2010-03-18
申请号：PCT/US2009030860
申请日：2009-01-13
申请人： UNIV CORNELL , WARREN SCOTT , WIESNER ULRICH , DISALVO FRANCIS
发明人： WARREN SCOTT , WIESNER ULRICH , DISALVO FRANCIS
IPC分类号： C08K7/22 , B82B1/00 , C08J9/22 , C08K3/00 , C08K3/04 , C08K3/10 , C08K5/37 , C08K7/24 , C08L33/04
CPC分类号： C08F297/02 , B22F9/02 , B22F2998/00 , B22F2998/10 , B22F2999/00 , C04B38/0022 , C08F297/026 , C08L53/00 , C09D153/00 , C04B35/565 , C04B35/58 , C04B35/583 , C04B38/0054 , C08L2666/02 , B22F1/0018 , B22F9/24 , B22F9/30 , B22F2201/02
摘要： The invention provides mesostructured materials and methods of preparing mesostructured materials including metal-rich mesostructured nanoparticle-block copolymer hybrids, porous metal-nonmetal nanocomposite mesostructures, and ordered metal mesostructures with uniform pores. The nanoparticles can be metal, metal alloy, metal mixture, intermetallic, metal-carbon, metal-ceramic, semiconductor-carbon, semiconductor-ceramic, insulator-carbon or insulator-ceramic nanoparticles, or combinations thereof. A block copolymer/ligand-stabilized nanoparticle solution is cast, resulting in the formation of a metal-rich (or semiconductor-rich or insulator-rich) mesostructured nanoparticle-block copolymer hybrid. The hybrid is heated to an elevated temperature, resulting in the formation of an ordered porous nanocomposite mesostructure. A nonmetal component (e.g., carbon or ceramic) is then removed to produce an ordered mesostructure with ordered and large uniform pores.
摘要翻译：本发明提供介孔结构材料和制备介孔结构材料的方法，包括富金属介孔结构的纳米颗粒 - 嵌段共聚物杂化物，多孔金属 - 非金属纳米复合材料结构和具有均匀孔的有序金属介孔结构。纳米颗粒可以是金属，金属合金，金属混合物，金属间化合物，金属碳，金属陶瓷，半导体 - 碳，半导体 - 陶瓷，绝缘体 - 碳或绝缘体陶瓷纳米颗粒或其组合。浇铸嵌段共聚物/配体稳定的纳米颗粒溶液，导致形成富含金属（或富含半导体的或富含绝缘体的）介孔结构的纳米颗粒 - 嵌段共聚物杂化物。将混合物加热到升高的温度，导致形成有序的多孔纳米复合材料的介孔结构。然后去除非金属组分（例如碳或陶瓷）以产生具有有序和大的均匀孔的有序介孔结构。

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