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1. 发明申请

WO2004092332A3 SARS VIRUS POLYPEPTIDES 审中-公开
标题翻译： SARS病毒多糖
公开(公告)号：WO2004092332A3
公开(公告)日：2006-03-02
申请号：PCT/US2004010729
申请日：2004-04-08
申请人： CIPHERGEN BIOSYSTEMS INC , LOMAS LEE , PAK BRIAN , FU SIYU , TORNATORE PETE , VINER ROSA , WEINBERGER SCOT R , YIP TAI-TUNG
发明人： LOMAS LEE , PAK BRIAN , FU SIYU , TORNATORE PETE , VINER ROSA , WEINBERGER SCOT R , YIP TAI-TUNG
IPC分类号： C07K7/00 , A61K39/215 , C07K4/02 , C07K14/165 , C07K16/10 , C12N20060101 , C12N15/50 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/12 , A61K39/215 , C07K16/10 , C12N2770/20022 , C12N2770/20034 , G01N2333/165 , G01N2333/4721 , G01N2469/20
摘要： The present invention provides, inter alia, SARS-related polypeptides, i.e., polypeptides associated with Severe Acute Respiratory Syndrome (SARS). The present invention also provides antibodies that specifically bind SARS-related polypeptides. In addition, the present invention provides methods for detecting an infection associated with SARS.
摘要翻译：本发明尤其提供了SARS相关多肽，即与严重急性呼吸综合征（SARS）相关的多肽。本发明还提供了特异性结合SARS相关多肽的抗体。此外，本发明提供了检测与SARS有关的感染的方法。

2. 发明申请

WO2004009798A2 PROTEIN INTERACTION DIFFERENCE MAPPING 审中-公开
标题翻译：蛋白质相互作用差异图
公开(公告)号：WO2004009798A2
公开(公告)日：2004-01-29
申请号：PCT/US0323320
申请日：2003-07-23
申请人： CIPHERGEN BIOSYSTEMS INC , RICH WILLIAM , BOSCHETTI EGISTO , LOMAS LEE O , YIP TAI-TUNG
发明人： RICH WILLIAM , BOSCHETTI EGISTO , LOMAS LEE O , YIP TAI-TUNG
IPC分类号： G01N27/62 , B01J20/281 , B01J20/285 , C40B30/04 , G01N30/02 , G01N30/08 , G01N30/34 , G01N30/72 , G01N30/88 , G01N33/53 , G01N33/543 , G01N33/68 , C12N
CPC分类号： C40B30/04 , G01N33/54306 , G01N33/6803
摘要： This invention provides methods and materials for mapping interaction characteristics between components of a multicomponent biological complex. The methods involve capturing a multicomponent complex on a solid support and washing the support with a series of elution washes forming a gradient of solute concentrations, and determining whether a particular elution wash eluted a particular component.
摘要翻译：本发明提供了用于映射多组分生物复合物组分之间相互作用特征的方法和材料。该方法涉及在固体支持物上捕获多组分复合物，并用一系列洗脱洗液洗涤载体，形成溶质浓度梯度，并确定特定洗脱洗液是否洗脱了特定组分。

3. 发明申请

WO2004031724A3 APPARATUS AND METHOD FOR EXPRESSION AND CAPTURE OF BIOMOLECULES AND COMPLEXES ON ADSORBENT SURFACES 审中-公开
标题翻译：生物分子和复合物在吸附表面上的表达和捕获的装置和方法
公开(公告)号：WO2004031724A3
公开(公告)日：2005-04-14
申请号：PCT/US0330760
申请日：2003-09-29
申请人： CIPHERGEN BIOSYSTEMS INC , LOMAS LEE O , BOSCHETTI EGISTO , YIP TAI-TUNG
发明人： LOMAS LEE O , BOSCHETTI EGISTO , YIP TAI-TUNG
IPC分类号： C12M1/34 , G01N20060101 , G01N33/543
CPC分类号： G01N33/54366 , B01J2219/00283 , B01J2219/00317 , B01J2219/00423 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00639 , B01J2219/00641 , B01J2219/00659 , B01J2219/00695 , B01J2219/007 , B01J2219/00725 , G01N33/54353
摘要： The present invention relates to the fields of molecular biology, combinatorial chemistry and biochemistry. Particularly, the present invention describes apparatus and methods for the detection and isolation of binding partners and activity modulators for biomolecules. The apparatus described allows for expression, capture and analysis of one or more biomolecules in a single step.
摘要翻译：本发明涉及分子生物学，组合化学和生物化学领域。特别地，本发明描述了用于检测和分离用于生物分子的结合配偶体和活性调节剂的装置和方法。所描述的装置允许在单个步骤中表达，捕获和分析一种或多种生物分子。

4. 发明申请

WO2004097368A3 IMPROVED IMMUNOASSAYS 审中-公开
标题翻译：改善免疫力
公开(公告)号：WO2004097368A3
公开(公告)日：2005-06-30
申请号：PCT/US2004011843
申请日：2004-04-16
申请人： CIPHERGEN BIOSYSTEMS INC , YIP TAI-TUNG , FUNG ERIC THOMAS
发明人： YIP TAI-TUNG , FUNG ERIC THOMAS
IPC分类号： G01N20060101 , G01N33/53 , G01N33/68 , G06F19/00
CPC分类号： G01N33/6851 , G06F19/18 , G06F19/24
摘要： Methods for discriminating between related proteins and other analytes in a sample and for correlating protein expression with disease states.
摘要翻译：用于区分样品中相关蛋白质和其他分析物以及将蛋白质表达与疾病状态相关联的方法。

5. 发明申请

WO9859360A9 RETENTATE CHROMATOGRAPHY AND PROTEIN CHIP ARRAYS WITH APPLICATIONS IN BIOLOGY AND MEDICINE 审中-公开
标题翻译：再生色素和蛋白质芯片阵列与生物医学应用
公开(公告)号：WO9859360A9
公开(公告)日：1999-04-15
申请号：PCT/US9812843
申请日：1998-06-19
申请人： CIPHERGEN BIOSYSTEMS INC , HUTCHENS T WILLIAM , YIP TAI TUNG
发明人： HUTCHENS T WILLIAM , YIP TAI-TUNG
IPC分类号： G01N33/52 , A61K49/00 , B01D15/38 , B01J20/281 , B01J20/286 , B01J20/32 , C12M1/34 , C12M1/42 , C12N15/09 , C12Q1/00 , C12Q1/68 , C40B30/04 , C40B40/10 , G01N27/62 , G01N27/64 , G01N30/00 , G01N30/02 , G01N30/46 , G01N30/90 , G01N30/95 , G01N33/15 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/531 , G01N33/538 , G01N33/543 , G01N33/566 , G01N33/68 , G01N37/00 , G06F19/00 , H01J49/04 , H01J49/26
CPC分类号： C40B30/04 , B01D15/1878 , B01D15/305 , B01D15/3809 , B01J20/281 , B01J20/286 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3265 , B01J20/3274 , B01J20/3289 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2220/54 , C12Q1/00 , C40B40/10 , G01N30/00 , G01N30/02 , G01N30/461 , G01N30/463 , G01N30/466 , G01N30/48 , G01N30/482 , G01N30/90 , G01N30/95 , G01N33/531 , G01N33/538 , G01N33/543 , G01N33/54306 , G01N33/54353 , G01N33/54373 , G01N33/54393 , G01N33/566 , G01N33/6803 , G01N33/6845 , G01N33/6851 , G01N2030/008 , G01N2030/009 , Y02A90/26 , Y10S422/906 , Y10S435/803 , Y10S435/81 , Y10S435/814 , Y10S435/815 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/808 , Y10S436/809 , Y10S436/811 , Y10S436/813 , Y10S436/824 , Y10S436/825 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , B01D15/363 , B01D15/322 , B01D15/327 , B01D15/3804 , B01D15/362 , B01D15/38 , B01D15/26
摘要： This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectively conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
摘要翻译：本发明提供了用于分析样品中分析物的滞留层析方法。所述方法包括在多种不同选择性条件下将分析物吸附到基底上，并通过解吸光谱法检测保留在底物上的分析物。这些方法在生物学和医学中是有用的，包括临床诊断和药物发现。

6. 发明申请

WO2004094460A2 POLYPEPTIDES RELATED TO NATRIURETIC PEPTIDES AND METHODS OF THEIR IDENTIFICATION AND USE 审中-公开
标题翻译：与NATRIURETIC PEPDES相关的多肽及其鉴定和使用方法
公开(公告)号：WO2004094460A2
公开(公告)日：2004-11-04
申请号：PCT/US2004012067
申请日：2004-04-19
申请人： CIPHERGEN BIOSYSTEMS INC , BIOSITE INC , BUECHLER KENNETH F , FUNG ERIC THOMAS , YIP TAI-TUNG
发明人： BUECHLER KENNETH F , FUNG ERIC THOMAS , YIP TAI-TUNG
IPC分类号： C07K20060101 , G01N33/53 , G01N33/74 , C07K
CPC分类号： G01N33/74 , G01N2500/04
摘要： The present invention relates to the identification and use of polypeptides that bind to antibodies directed to a desired polypeptide of interest. Using natriuretic peptides and their precursors, and in particular BNP, as an example, the present invention describes a number of natriuretic peptides fragments produced in biological samples, most preferably blood-derived samples, that bind to antibodies directed to BNP. Because production of such fragments is an ongoing process that may be a function of, inter alia, the elapsed time between onset of an event triggering natriuretic peptide release into the tissues and the time the sample is obtained or analyzed; the elapsed time between sample acquisition and the time the sample is analyzed; the type of tissue sample at issue; the storage conditions; the quantity of proteolytic enzymes present; etc., such fragments may be used when both designing an assay for one or more natriuretic peptides, and when performing such an assay, in order to provide an accurate prognostic or diagnostic result.
摘要翻译：本发明涉及与靶向所需感兴趣的多肽的抗体结合的多肽的鉴定和使用。使用利尿钠肽及其前体，特别是BNP作为实例，本发明描述了与生物样品中产生的许多利钠肽片段，最优选血液衍生的样品，其结合针对BNP的抗体。因为这样的片段的产生是一个持续的过程，其可以是尤其是引发利钠肽释放到组织中的事件发生之间经过的时间与获得或分析样品的时间的函数; 样品采集与样品分析时间之间的经过时间; 有关组织样本的类型; 储存条件; 存在蛋白水解酶的数量; 当设计用于一种或多种利钠肽的测定法和进行这样的测定时，可以使用这样的片段，以便提供准确的预后或诊断结果。

7. 发明申请

WO0125791A3 PROSTATE CANCER MARKER PROTEINS 审中-公开
标题翻译：前列腺癌标记蛋白
公开(公告)号：WO0125791A3
公开(公告)日：2001-12-27
申请号：PCT/US0027682
申请日：2000-10-06
申请人： CIPHERGEN BIOSYSTEMS INC , EASTERN VIRGINIA MED SCHOOL , YIP TAI TUNG , YIP CHRISTINE , WRIGHT GEORGE L JR
发明人： YIP TAI-TUNG , YIP CHRISTINE , WRIGHT GEORGE L JR
IPC分类号： G01N33/574
CPC分类号： G01N33/57434
摘要： The invention provides methods and kits that can be used as an aid for prostate cancer diagnosis using markers that are differentially present in the samples of prostate cancer patients and subjects who do not have prostate cancer (e.g., benign prostate hyperplasia patients or normal, healthy subjects).
摘要翻译：本发明提供可用作前列腺癌诊断辅助的方法和试剂盒，所述方法和试剂盒使用在前列腺癌患者和不具有前列腺癌的受试者（例如，良性前列腺增生患者或正常，健康受试者）。

8. 发明申请

WO2006022895A2 PLATELET BIOMARKERS FOR CANCER 审中-公开
标题翻译：癌症生物标志物
公开(公告)号：WO2006022895A2
公开(公告)日：2006-03-02
申请号：PCT/US2005013859
申请日：2005-04-22
申请人： CHILDRENS MEDICAL CENTER , CIPHERGEN BIOSYSTEMS INC , FOLKMAN JUDAH M , KLEMENT GIANNOULA , YIP TAI-TUNG , RICH WILLIAM , PODUST VLADIMIR
发明人： FOLKMAN JUDAH M , KLEMENT GIANNOULA , YIP TAI-TUNG , RICH WILLIAM , PODUST VLADIMIR
CPC分类号： G01N33/6872 , G01N33/57484 , G01N2333/49 , G01N2333/503 , G01N2333/515 , G01N2800/24 , G01N2800/368
摘要： The present invention relates to the fields of immunology and biochemistry. Particularly, the present invention describes methods, devices and kits for early detection of clinical conditions having associated changes in systemic angiogenic activity, particularly cancers, inflammatory conditions, infections, and events associated with pregnancy and abortion.
摘要翻译：本发明涉及免疫学和生物化学领域。特别地，本发明描述了用于早期检测具有全身血管生成活性相关变化，特别是癌症，炎性病症，感染和与怀孕和流产有关的事件的临床病症的方法，装置和试剂盒。

9. 发明申请

WO2005071421A8 SPECIFIC DETECTION OF TROPONIN AND MODIFIED FORMS OF TROPONIN 审中-公开
标题翻译：特异性检测TROPONIN和修饰形式的TROPONIN
公开(公告)号：WO2005071421A8
公开(公告)日：2005-10-27
申请号：PCT/US2005000548
申请日：2005-01-07
申请人： CIPHERGEN BIOSYSTEMS INC , YIP TAI-TUNG , FUNG ERIC THOMAS
发明人： YIP TAI-TUNG , FUNG ERIC THOMAS
IPC分类号： G01N33/68
CPC分类号： G01N33/6887 , G01N33/6893 , G01N2800/324
摘要： Methods of specifically detecting troponin, modified forms of troponin and biomolecular interactors of these are provided. Modified forms of troponin include troponin fragments. All of the aforementioned polypeptides can be detected, e.g., by affinity mass spectrometry.
摘要翻译：提供特异性检测肌钙蛋白，肌钙蛋白修饰形式和生物分子相互作用因子的方法。肌钙蛋白的修饰形式包括肌钙蛋白片段。可以例如通过亲和质谱法检测所有上述多肽。

10. 发明申请

WO2004061410A2 SERUM BIOMARKERS IN LUNG CANCER 审中-公开
标题翻译：肺癌中的血清生物标志物
公开(公告)号：WO2004061410A2
公开(公告)日：2004-07-22
申请号：PCT/US0337090
申请日：2003-12-16
申请人： CIPHERGEN BIOSYSTEMS INC , YIP TIMOTHY TAK CHUN , CHO CHI SHING , AU SIU KIE , YIP TAI-TUNG , YIP CHRISTINE L , YIP VICTOR F , QUEEN ELIZABETH HOSPITAL
发明人： YIP TIMOTHY TAK CHUN , CHO CHI SHING , AU SIU KIE , YIP TAI-TUNG , YIP CHRISTINE L , YIP VICTOR F
IPC分类号： A61K49/00 , C12Q1/00 , G01N20060101 , G01N33/53 , G01N33/574 , G01N
CPC分类号： G01N33/6851 , G01N33/57423 , G06F19/18
摘要： Certain biomarkers and biomarker combinations are useful in a qualifying lung cancer status in a subject. A diagnostic methodology employing these biomarkers and combinations can detect whether a subject has lung cancer.
摘要翻译：某些生物标志物和生物标志物组合在受试者的合格肺癌状态中是有用的。使用这些生物标志物和组合的诊断方法可以检测受试者是否患有肺癌。

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