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1. 发明申请

WO2018174876A1 METHODS AND COMPOSITIONS FOR PROVIDING A PREECLAMPSIA ASSESSMENT WITH METABOLITES 审中-公开
公开(公告)号：WO2018174876A1
公开(公告)日：2018-09-27
申请号：PCT/US2017/023680
申请日：2017-03-22
申请人： MPROBE INC.
发明人： LING, Bruce, Xuefeng , CHEN, Limin , HAO, Shiying
IPC分类号： A61B5/00 , G01N33/48 , G01N33/68
CPC分类号： G01N33/6848 , A61B5/00 , G01N33/48 , G01N33/6893 , G01N2570/00 , G01N2800/368
摘要： Preeclampsia markers, preeclampsia marker panels, and methods for obtaining a preeclampsia marker level representation for a sample are provided, based upon small molecule metabolic profiling. These composition and methods find use in a number of applications, including, for example, diagnosing preeclampsia, prognosing preeclampsia, monitoring a subject with preeclampsia, and determining a treatment for preeclampsia, in addition, systems, devices, and kits thereof that find use in practicing the subject methods are provided.

2. 发明申请

WO2018051125A1 ASSAY METHOD FOR DETERMINING THE RISK OF PRE-ECLAMPSIA 审中-公开
标题翻译：分析方法，以确定风险的前ECLAMPSIA
公开(公告)号：WO2018051125A1
公开(公告)日：2018-03-22
申请号：PCT/GB2017/052751
申请日：2017-09-15
申请人： THE QUEEN'S UNIVERSITY OF BELFAST
发明人： MCCLEMENTS, Lana , ROBSON, Tracy , LYONS, Timothy
IPC分类号： G01N33/68
CPC分类号： G01N33/689 , G01N33/68 , G01N2333/99 , G01N2800/368
摘要： The present invention relates to the detection of FK506-binding protein like (FKBPL) in samples from pregnant women and the use of FKBPL as a predictive biomarker for the development of pre-eclampsia. The present invention further relates to kitsfor the detection of FKBPL and methods of preventing pre-eclampsia.
摘要翻译：本发明涉及检测孕妇样品中FK506结合蛋白样（FKBPL）和使用FKBPL作为发展先兆子痫的预测性生物标志物。本发明进一步涉及用于检测FKBPL的试剂盒和预防先兆子痫的方法。

3. 发明申请

WO2017180984A1 FIRST TRIMESTER EPIGENETIC AND MICRORNA BIOMARKERS FOR PREECLAMPSIA 审中-公开
标题翻译：用于PREECLAMPSIA的第一个TRIMESTER基因和微生物生物标记
公开(公告)号：WO2017180984A1
公开(公告)日：2017-10-19
申请号：PCT/US2017/027593
申请日：2017-04-14
申请人： THE TEXAS A&M UNIVERSITY SYSTEM
发明人： CHOUDHURY, Mahua
IPC分类号： C12N15/113 , C12Q1/68 , G01N33/68
CPC分类号： A47B97/00 , A44B11/00 , A47B2097/008 , C12Q1/6883 , C12Q2600/118 , C12Q2600/178 , F16M13/02 , G01N33/689 , G01N2800/368
摘要： The subject invention pertains to biomarkers for identifying a subject as having high risk of the development PE. The biomarkers presented herein include miRNAs, post- translational modification of histone proteins, amount, expression and/or activity of histone or DNA modifying enzymes and methylation of sites in the genomic DNA. In certain embodiments, increased miR-17, increased acetylation of H4 histone protein, decreased amount, expression and/or activity of HDAC5 mRNA or protein or increased methylation of DNA at the genomic site CYP19A1 in the blood, serum or plasma of a subject compared to that of a control subject is used to predict the development of PE in the subject. The invention also provides kits and reagents to conduct assays to quantify biomarkers described herein. The invention further provides the methods of treating and/or managing PE in a subject identified as having a high risk of the development of PE.
摘要翻译：本发明涉及用于鉴定受试者具有发展PE风险高的生物标志物。本文呈现的生物标志包括miRNA，组蛋白翻译后修饰，组蛋白或DNA修饰酶的量，表达和/或活性以及基因组DNA中位点的甲基化。在某些实施方案中，与对照的血液，血清或血浆中的基因组位点CYP19A1处的增加的miR-17，H4组蛋白的乙酰化增加，HDAC5 mRNA或蛋白质的量，表达和/或活性降低或DNA甲基化增加相比较到控制对象的水平被用于预测对象中PE的发展。本发明还提供用于进行测定以定量本文所述生物标志物的试剂盒和试剂。本发明还提供了治疗和/或管理被鉴定为具有PE发展高风险的受试者中的PE的方法。

4. 发明申请

WO2017096405A1 USE OF CIRCULATING MICROPARTICLES TO STRATIFY RISK OF SPONTANEOUS PRETERM BIRTH 审中-公开
标题翻译：循环微粒子用于分层自发性前体出生的风险
公开(公告)号：WO2017096405A1
公开(公告)日：2017-06-08
申请号：PCT/US2016/065024
申请日：2016-12-05
申请人： NX PRENATAL INC.
发明人： BROHMAN, Brian, D. , ZHANG, Zhen , GOUDY, Kevin, S. , DOSS, Robert, C. , EZRIN, Alan, M. , ROSENBLATT, Kevin, Paul
IPC分类号： C40B30/00 , C40B40/10 , G01N33/68
CPC分类号： G01N33/689 , G01N2800/368 , G01N2800/50
摘要： The present disclosure relates to proteomic biomarkers of spontaneous preterm birth, proteomic biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides tools for determining whether a pregnant subject is at an increased risk for premature delivery, as well as tools for decreasing a pregnant subject's risk for premature delivery.
摘要翻译：本公开涉及自发性早产的蛋白质组生物标志物，足月生的蛋白质组生物标志物及其使用方法。具体而言，本公开提供了用于确定怀孕受试者的早产风险增加的工具，以及用于降低怀孕受试者的早产风险的工具。

5. 发明申请

WO2017059477A1 BLOOD PREPARATION AND PROFILING 审中-公开
标题翻译：血液制备和分析
公开(公告)号：WO2017059477A1
公开(公告)日：2017-04-13
申请号：PCT/AU2016/000341
申请日：2016-10-06
申请人： SANGUI BIO PTY. LTD
发明人： KARSTEN, Elisabeth , HERBERT, Ben , LIDDLE, Alan , HILL, Cameron
IPC分类号： G01N33/49 , G01N33/68
CPC分类号： G01N33/80 , G01N33/57484 , G01N2800/368
摘要： The present disclosure relates to methods for generating blood protein profiles in red blood cell-enriched blood samples. The disclosed methods represent a new and improved laboratory technique for producing a protein profile from blood, increasing protein detection.
摘要翻译：本公开涉及用于在富含红细胞的血液样品中产生血液蛋白质谱的方法。所公开的方法代表了一种新的和改进的实验室技术，用于从血液中产生蛋白质谱，增加蛋白质检测。

6. 发明申请

WO2016146647A1 BIOMARKERS FOR PREECLAMPSIA 审中-公开
标题翻译：生物标志物为前驱物
公开(公告)号：WO2016146647A1
公开(公告)日：2016-09-22
申请号：PCT/EP2016/055619
申请日：2016-03-16
申请人： A1M PHARMA AB
发明人： HANSSON, Stefan , ÅKERSTRÖM, Bo , GRAM, Magnus Göran
IPC分类号： G01N33/68
CPC分类号： G01N33/689 , C12Q2600/158 , G01N2333/4713 , G01N2333/805 , G01N2800/368 , G01N2800/50
摘要： The present invention relates to the use of hemopexin, free, non-cell bound fetal hemoglobin and alpha-1-microglobulin as markers for preeclampsia.
摘要翻译：本发明涉及血红蛋白，游离，非细胞结合的胎儿血红蛋白和α-1-微球蛋白作为先兆子痫的标记物的用途。

7. 发明申请

WO2015082545A1 METHOD FOR THE SELECTIVE DETERMINATION OF PLACENTAL GROWTH FACTOR 2 审中-公开
标题翻译：选择性确定生物生长因子的方法2
公开(公告)号：WO2015082545A1
公开(公告)日：2015-06-11
申请号：PCT/EP2014/076413
申请日：2014-12-03
申请人： CÉZANNE S.A.S.
发明人： DEMIRDJIAN, Gaïané , ESPINASSE, Delphine
IPC分类号： G01N33/68
CPC分类号： G01N33/74 , C07K16/22 , C07K2317/14 , G01N33/689 , G01N2800/368
摘要： The present invention relates to an immunoassay method for placental growth factor 2 (PlGF- 2) detection in pregnant subjects. Furthermore the invention relates to the use of said method for the diagnosis, prognosis, risk assessment and therapy control of prenatal disorders comprising the determination of the level of PlGF-2 in said pregnant subjects.
摘要翻译：本发明涉及孕妇胎盘生长因子2（PlGF-2）检测的免疫测定方法。此外，本发明涉及所述方法用于产前障碍的诊断，预后，风险评估和治疗控制的用途，包括测定所述怀孕受试者中PlGF-2的水平。

8. 发明申请

WO2015040190A1 DIAGNOSIS OF FOETAL DISTRESS 审中-公开
标题翻译：诊断胎儿区
公开(公告)号：WO2015040190A1
公开(公告)日：2015-03-26
申请号：PCT/EP2014/070053
申请日：2014-09-19
申请人： SALURATE LIMITED
发明人： MAGUIRE, Patrick Martin
IPC分类号： G01N33/50 , G01N33/53
CPC分类号： G01N33/487 , G01N33/50 , G01N33/5308 , G01N2800/36 , G01N2800/368
摘要： A method of diagnosing or monitoring foetal distress comprises measuring uric acid levels in saliva in samples obtained from the expectant mother. The method provides a warning sign for complications in pregnancy such as HELLP syndrome, eclampsia, gestational diabetes, gestational hypertension, premature amniorrhexis, placenta accreta and intrauterine growth restriction. The diagnosis can be carried out on patients free from pre-eclampsia or eclampsia.
摘要翻译：诊断或监测胎儿窘迫的方法包括测量从预期母亲获得的样品中唾液中的尿酸水平。该方法为HELLP综合征，子痫，妊娠糖尿病，妊娠期高血压，早产儿早产，胎盘增生和子宫内生长受限等怀孕并发症提供警示。可以对没有先兆子痫或子痫的患者进行诊断。

9. 发明申请

WO2015017900A1 AN ANTIBODY THERAPY FOR AMYLOID BETA DISEASE 审中-公开
标题翻译： AMYLOID BETA疾病的抗体治疗
公开(公告)号：WO2015017900A1
公开(公告)日：2015-02-12
申请号：PCT/AU2014/050172
申请日：2014-08-05
申请人： ST. VINCENT'S INSTITUTE OF MEDICAL RESEARCH
发明人： MILES, Luke Anthony , PARKER, Michael William , NERO, Tracy Leah
IPC分类号： C07K16/18 , A61K39/395 , A61P25/28
CPC分类号： C07K16/18 , C07K2299/00 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , G01N33/689 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/368
摘要： The present disclosure relates generally to a protocol to treat or prevent diseases or conditions associated with pathological forms of amyloid beta (Aβ), including Alzheimer's disease. Enabled herein is a reagent for use in the treatment and prophylaxis of Aβ-associated pathological conditions.
摘要翻译：本公开一般涉及治疗或预防与淀粉样蛋白β（A＆bgr）的病理形式（包括阿尔茨海默氏病）相关的疾病或病症的方案。本文使用的是用于治疗和预防与疾病相关的病理状况的试剂。

10. 发明申请

WO2014153232A2 METHODS AND COMPOSITIONS FOR DIAGNOSING PREECLAMPSIA 审中-公开
标题翻译：方法和组合物诊断前列腺炎
公开(公告)号：WO2014153232A2
公开(公告)日：2014-09-25
申请号：PCT/US2014/029741
申请日：2014-03-14
申请人： ORGAN-I, INC.
发明人： ROEDDER, Sike , ABDULLAH, Isha , SARWAL, Minnie, M.
IPC分类号： G01N33/53
CPC分类号： G01N33/689 , C07K14/00 , G01N33/564 , G01N2800/368 , G01N2800/60
摘要： Provided herein are methods, compositions, and kits for using binding agents to detect the presence of PEE proteins and/or PEE autoantibodies in a biological sample from a pregnant woman. Such methods and compositions are useful for predicting the onset of preeclampsia, monitoring the progression of preeclampsia, monitoring the regression of preeclampsia, assessing efficacy of treatment for preeclampsia, identifying a sub-population of patients who should be treated for preeclampsia and/or identifying a sub-population of patients who should be monitored for preeclampsia symptoms.
摘要翻译：本文提供了使用结合剂检测来自孕妇的生物样品中PEE蛋白和/或PEE自身抗体的存在的方法，组合物和试剂盒。这些方法和组合物可用于预测先兆子痫的发作，监测先兆子痫的发展，监测先兆子痫的消退，评估治疗先兆子痫的功效，鉴定应该治疗先兆子痫患者的亚群和/或鉴定应监测先兆子痫症状的亚群患者。

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