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1. 发明申请

WO2007075931A2 REACTIVE HETEROCYCLIC DERIVATIVES AND METHODS FOR THEIR SYNTHESIS AND USE 审中-公开
标题翻译：反应性杂环衍生物及其合成和使用方法
公开(公告)号：WO2007075931A2
公开(公告)日：2007-07-05
申请号：PCT/US2006/048864
申请日：2006-12-22
申请人： BIOSITE INCORPORATED , NOAR, Joseph, Barry , BANASZCZYK, Mariusz, G. , MILLAN, Violeta , VALKIRS, Gunars , BUECHLER, Kenneth, F. , NOLAND, Brian
发明人： NOAR, Joseph, Barry , BANASZCZYK, Mariusz, G. , MILLAN, Violeta , VALKIRS, Gunars , BUECHLER, Kenneth, F. , NOLAND, Brian
IPC分类号： A61K31/405
CPC分类号： C07D209/18 , C07D209/08 , C07D209/14 , C07D403/12
摘要： The present invention describes molecules having a core structure that is an indole or an indolene that is modified to provide a functional moiety, and methods for their synthesis and use. Such functionalized heterocyclic derivatives may be used in a variety of assay formats.
摘要翻译：本发明描述了具有被修饰以提供功能部分的吲哚或吲哚烯的核心结构的分子，以及它们的合成和使用方法。这种官能化的杂环衍生物可以以各种测定形式使用。

2. 发明申请

WO2007028070A2 USE OF SOLUBLE FLT-1 AND ITS FRAGMENTS IN CARDIOVASCULAR CONDITIONS 审中-公开
标题翻译：可溶性FLT-1及其片段在心血管病变中的应用
公开(公告)号：WO2007028070A2
公开(公告)日：2007-03-08
申请号：PCT/US2006/034315
申请日：2006-08-29
申请人： BIOSITE, INC. , BUECHLER, Kenneth, F. , McPHERSON, Paul, H.
发明人： BUECHLER, Kenneth, F. , McPHERSON, Paul, H.
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/71 , G01N2800/32 , G01N2800/324
摘要： The present invention relates to materials and procedures for evaluating patients suffering from cardiovascular conditions, particularly acute coronary syndromes. In particular, an assay configured to measure the level of soluble FLT-1 in a patient sample, alone or in combination with one or more other markers, provides diagnostic and/or prognostic information. While applicable to diseases and conditions in which inflammation is generally manifested, the methods and compositions described herein are particularly applicable to acute coronary syndromes, including conditions selected from the group consisting of stable angina, unstable angina, non-ST-elevation non-Q wave myocardial infarction, ST-elevation non-Q wave MI, and transmural (Q-wave) MI.
摘要翻译：本发明涉及用于评价患有心血管疾病，特别是急性冠状动脉综合征的患者的材料和程序。特别地，配置成单独或与一种或多种其它标记组合测量患者样品中可溶性FLT-1水平的测定提供了诊断和/或预后信息。在适用于通常表现出炎症的疾病和病症的情况下，本文所述的方法和组合物特别适用于急性冠状动脉综合征，包括选自稳定性心绞痛，不稳定型心绞痛，非ST段抬高型非Q波心肌梗塞，ST段抬高非Q波MI，透壁（Q波）MI。

3. 发明申请

WO2004059293A3 MARKERS FOR DIFFERENTIAL DIAGNOSIS AND METHODS OF USE THEREOF 审中-公开
标题翻译：用于差异诊断的标记及其使用方法
公开(公告)号：WO2004059293A3
公开(公告)日：2005-03-31
申请号：PCT/US0341453
申请日：2003-12-23
申请人： BIOSITE INC , BUECHLER KENNETH F , MAISEL ALAN , ANDERBERG JOSEPH MICHAEL , MCPHERSON PAUL H , DAHLEN JEFFREY R , KIRCHICK HOWARD J
发明人： BUECHLER KENNETH F , MAISEL ALAN , ANDERBERG JOSEPH MICHAEL , MCPHERSON PAUL H , DAHLEN JEFFREY R , KIRCHICK HOWARD J
IPC分类号： C12Q1/68 , G01N33/68 , C12Q1/70
CPC分类号： G01N33/6887 , C12Q1/6883 , G01N2333/4737 , G01N2333/475 , G01N2333/52 , G01N2333/58 , G01N2333/9123 , G01N2333/96486 , G01N2333/974 , G01N2800/2871
摘要： The present invention provides methods for the identification and use of diagnostic markers for differential diagnosis of diseases and/or conditions. In a various aspects, the invention relates to methods and compositions able to determine the presence or absence of one, and preferably a plurality, of diseases or conditions that exhibit one or more similar or identical symptoms. Such methods and compositions can be used to provide assays and assay devices for use in determining the disease or condition underlying one or more non-specific symptoms exhibited in a clinical setting.
摘要翻译：本发明提供用于识别和使用用于疾病和/或病症鉴别诊断的诊断标记物的方法。在各个方面，本发明涉及能够确定呈现一种或多种相似或相同症状的一种，优选多种疾病或病症的存在或不存在的方法和组合物。这样的方法和组合物可用于提供用于确定临床环境中显示的一种或多种非特异性症状的疾病或病症的测定和测定装置。

4. 发明申请

WO2005019819A1 METHODS AND COMPOSITIONS FOR MEASURING BIOLOGICALLY ACTIVE NATRIURETIC PEPTIDES AND FOR IMPROVING THEIR THERAPEUTIC POTENTIAL 审中-公开
标题翻译：用于测量生物活性胃肠肽并改善其治疗潜力的方法和组合物
公开(公告)号：WO2005019819A1
公开(公告)日：2005-03-03
申请号：PCT/US2004/026984
申请日：2004-08-19
申请人： BIOSITE, INC. , BUECHLER, Kenneth, F. , WHITTAKER, Michael , REYNOLDS, Mark , SCOTT, Christopher, A.
发明人： BUECHLER, Kenneth, F. , WHITTAKER, Michael , REYNOLDS, Mark , SCOTT, Christopher, A.
IPC分类号： G01N33/53
CPC分类号： C07K16/26 , A61K38/2242 , C07K2317/55 , G01N33/74 , G01N2333/58 , A61K2300/00
摘要： The present invention describes compositions and methods designed to determine the presence or amount of biologically active natriuretic peptides, or their fragments, in a sample. The degradation of natriuretic peptides is an ongoing process that may be a function of, inter alia , the elapsed time between onset of an event triggering natriuretic peptide release into the tissues and the time the sample is obtained or analyzed; the quantity of proteolytic enzymes present; etc. This degradation can produce circulating amounts of natriuretic peptides having reduced or lost biological function. The present invention provides, inter alia , assays designed to accurately measure biologically active natriuretic peptides, and compositions to inhibit a previously unknown pathway for degradation of natriuretic peptides.
摘要翻译：本发明描述了设计用于确定样品中生物活性利钠肽或其片段的存在或量的组合物和方法。利尿钠肽的降解是一个持续的过程，其可以是尤其是引发利钠肽释放到组织中的事件的发作时间和获得或分析样品的时间之间经过的时间的函数; 存在蛋白水解酶的数量; 这种降解可以产生具有降低或丧失的生物功能的循环量的利尿钠肽。本发明尤其提供了设计用于精确测量生物活性钠尿肽的分析物和抑制先前未知的利钠肽降解途径的组合物。

5. 发明申请

WO2004094460A3 POLYPEPTIDES RELATED TO NATRIURETIC PEPTIDES AND METHODS OF THEIR IDENTIFICATION AND USE 审中-公开
公开(公告)号：WO2004094460A3
公开(公告)日：2004-11-04
申请号：PCT/US2004/012067
申请日：2004-04-19
申请人： CIPHERGEN BIOSYSTEMS, INC. , BIOSITE, INC. , BUECHLER, Kenneth, F. , FUNG, Eric, Thomas , YIP, Tai-Tung
发明人： BUECHLER, Kenneth, F. , FUNG, Eric, Thomas , YIP, Tai-Tung
IPC分类号： G01N33/53
摘要： The present invention relates to the identification and use of polypeptides that bind to antibodies directed to a desired polypeptide of interest. Using natriuretic peptides and their precursors, and in particular BNP, as an example, the present invention describes a number of natriuretic peptides fragments produced in biological samples, most preferably blood-derived samples, that bind to antibodies directed to BNP. Because production of such fragments is an ongoing process that may be a function of, inter alia, the elapsed time between onset of an event triggering natriuretic peptide release into the tissues and the time the sample is obtained or analyzed; the elapsed time between sample acquisition and the time the sample is analyzed; the type of tissue sample at issue; the storage conditions; the quantity of proteolytic enzymes present; etc., such fragments may be used when both designing an assay for one or more natriuretic peptides, and when performing such an assay, in order to provide an accurate prognostic or diagnostic result.

6. 发明申请

WO2004094459A2 POLYPEPTIDES RELATED TO NATRIURETIC PEPTIDES AND METHODS OF THEIR IDENTIFICATION AND USE 审中-公开
标题翻译：与利钠肽有关的多肽及其鉴定和使用方法
公开(公告)号：WO2004094459A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/012024
申请日：2004-04-15
申请人： BIOSITE INCORPORATED , BUECHLER, Kenneth, F.
发明人： BUECHLER, Kenneth, F.
IPC分类号： C07K
CPC分类号： C07K16/26 , G01N33/573 , G01N33/6887 , G01N33/6893 , G01N2333/58 , G01N2333/96486 , G01N2800/324 , G01N2800/325
摘要： The present invention relates to the identification and use of polypeptides that bind to antibodies directed to a desired polypeptide of interest. Using natriuretic peptides and their precursors, and in particular BNP, as an example, the present invention describes a number of natriuretic peptides fragments produced in biological samples, most preferably blood-derived samples, that bind to antibodies directed to BNP. Because production of such fragments is an ongoing process that may be a function of, inter alia, the elapsed time between onset of an event triggering natriuretic peptide release into the tissues and the time the sample is obtained or analyzed; the elapsed time between sample acquisition and the time the sample is analyzed; the type of tissue sample at issue; the storage conditions; the quantity of proteolytic enzymes present; etc., such fragments may be used when both designing an assay for one or more natriuretic peptides, and when performing such an assay, in order to provide an accurate prognostic or diagnostic result.
摘要翻译：本发明涉及鉴定和使用结合针对所需目标多肽的抗体的多肽。作为实例，使用利尿钠肽及其前体，特别是BNP，本发明描述了在生物样品中产生的许多利钠肽片段，最优选血源性样品，其与针对BNP的抗体结合。因为这种片段的产生是一个持续的过程，其可能是尤其是从触发利钠肽释放到组织中的事件开始到样品获得或分析的时间之间的经过时间的函数; 样品采集和样品分析时间之间的时间间隔; 问题组织样本的类型; 储存条件; 存在的蛋白水解酶的量; 当设计一种或多种利尿钠肽的测定和进行这样的测定时，为了提供准确的预后或诊断结果，可以使用这样的片段。

7. 发明申请

WO2002083913A1 USE OF B-TYPE NATRIURETIC PEPTIDE AS A PROGNOSTIC INDICATOR IN ACUTE CORONARY SYNDROMES 审中-公开
标题翻译：在急性冠状动脉综合征中使用B型鼻塞肽作为预防指标
公开(公告)号：WO2002083913A1
公开(公告)日：2002-10-24
申请号：PCT/US2002/011441
申请日：2002-04-11
申请人： BIOSITE DIAGNOSTICS, INC. , DAHLEN, Jeffrey, R. , VALKIRS, Gunars, E. , BUECHLER, Kenneth, F.
发明人： DAHLEN, Jeffrey, R. , VALKIRS, Gunars, E. , BUECHLER, Kenneth, F.
IPC分类号： C12P19/34
CPC分类号： G01N33/6887 , G01N33/6893 , G01N2333/58 , G01N2800/324
摘要： The present invention relates to materials and procedures for evaluating the prognosis of patients suffering from acute coronary syndromes. In particular, the level of BNP, or a marker related to BNP, in a patient sample, alone or in combination with one or more other prognostic markers, provides prognostic information useful for predicting near-term morbidity and/or mortality across the entire spectrum of acute coronary syndromes, including unstable angina, non-ST-elevation non-Q wave myocardial infarction, ST-elevation non-Q wave MI, and transmural (Q-wave) MI.
摘要翻译：本发明涉及用于评估患有急性冠状动脉综合征的患者的预后的材料和程序。特别地，在患者样品中单独或与一种或多种其他预后标志物组合的BNP或与BNP相关的标志物的水平提供了可用于预测整个频谱中的近期发病率和/或死亡率的预后信息急性冠状动脉综合征，包括不稳定型心绞痛，非ST段抬高型非Q波心肌梗死，ST段抬高型非Q波心肌梗死和透壁（Q波）MI。

8. 发明申请

WO2007140188A3 USE OF NATRIURETIC PEPTIDES AS DIAGNOSTIC AND PROGNOSTIC INDICATORS IN VASCULAR DISEASES 审中-公开
标题翻译：在血管疾病中作为诊断和预后指标使用NATRIURETIC PEPTIDES
公开(公告)号：WO2007140188A3
公开(公告)日：2008-07-10
申请号：PCT/US2007069475
申请日：2007-05-22
申请人： BIOSITE INC , BUECHLER KENNETH F
发明人： BUECHLER KENNETH F
IPC分类号： C07K16/40 , A61K39/395
CPC分类号： G01N33/6893 , G01N2800/323
摘要： The present invention relates to methods for the diagnosis and evaluation of subclinical atherosclerosis. In particular, patient test samples are analyzed for the presence and amount of one or more natriuretic peptides. A variety of additional markers are disclosed for assembling a panel of markers for such diagnosis and evaluation.
摘要翻译：本发明涉及亚临床动脉粥样硬化的诊断和评估方法。特别地，分析患者测试样品中一种或多种利尿钠肽的存在和量。公开了用于组装用于这种诊断和评估的一组标记物的各种附加标记物。

9. 发明申请

WO2007041623A3 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND/OR PROGNOSIS IN SYSTEMIC INFLAMMATORY RESPONSE SYNDROMES 审中-公开
公开(公告)号：WO2007041623A3
公开(公告)日：2007-04-12
申请号：PCT/US2006/038755
申请日：2006-10-03
申请人： BIOSITE INCORPORATED , BUECHLER, Kenneth, F. , ANDERBERG, Joseph, M. , MCPHERSON, Paul, H.
发明人： BUECHLER, Kenneth, F. , ANDERBERG, Joseph, M. , MCPHERSON, Paul, H.
IPC分类号： G01N33/53 , G01N33/50
摘要： Provided are methods and compositions for symptom-based differential diagnosis, prognosis and determination of treatment regimens in subjects In particular, the methods and compositions provided are selected to rule in or out SIRS, or for differentiating sepsis, severe sepsis, septic shock and/or MODS from each other and/or from non-infectious SIRS.

10. 发明申请

WO2004094459A3 POLYPEPTIDES RELATED TO NATRIURETIC PEPTIDES AND METHODS OF THEIR IDENTIFICATION AND USE 审中-公开
标题翻译：与利钠肽有关的多肽及其鉴定和使用方法
公开(公告)号：WO2004094459A3
公开(公告)日：2004-12-16
申请号：PCT/US2004012024
申请日：2004-04-15
申请人： BIOSITE INC , BUECHLER KENNETH F
发明人： BUECHLER KENNETH F
IPC分类号： C07K20060101 , C07K16/26 , G01N33/53 , G01N33/573 , G01N33/68
CPC分类号： C07K16/26 , G01N33/573 , G01N33/6887 , G01N33/6893 , G01N2333/58 , G01N2333/96486 , G01N2800/324 , G01N2800/325
摘要： The present invention relates to the identification and use of polypeptides that bind to antibodies directed to a desired polypeptide of interest. Using natriuretic peptides and their precursors, and in particular BNP, as an example, the present invention describes a number of natriuretic peptides fragments produced in biological samples, most preferably blood-derived samples, that bind to antibodies directed to BNP. Because production of such fragments is an ongoing process that may be a function of, inter alia, the elapsed time between onset of an event triggering natriuretic peptide release into the tissues and the time the sample is obtained or analyzed; the elapsed time between sample acquisition and the time the sample is analyzed; the type of tissue sample at issue; the storage conditions; the quantity of proteolytic enzymes present; etc., such fragments may be used when both designing an assay for one or more natriuretic peptides, and when performing such an assay, in order to provide an accurate prognostic or diagnostic result.
摘要翻译：本发明涉及鉴定和使用结合针对所需目标多肽的抗体的多肽。作为实例，使用利尿钠肽及其前体，特别是BNP，本发明描述了在生物样品中产生的许多利钠肽片段，最优选血源性样品，其与针对BNP的抗体结合。因为这种片段的产生是一个持续的过程，其可能是尤其是从触发利钠肽释放到组织中的事件开始到样品获得或分析的时间之间的经过时间的函数; 样品采集和样品分析时间之间的时间间隔; 问题组织样本的类型; 储存条件; 存在的蛋白水解酶的量; 当设计一种或多种利尿钠肽的测定和进行这种测定时，可以使用这种片段以提供准确的预后或诊断结果。

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