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1. 发明申请

WO2023272344A1 SLEEP APNOEA DIAGNOSTIC 审中-公开
公开(公告)号：WO2023272344A1
公开(公告)日：2023-01-05
申请号：PCT/AU2022/050662
申请日：2022-06-28
申请人： THE HEART RESEARCH INSTITUTE, LTD , THE UNIVERSITY OF SYDNEY
发明人： FARNHAM, Melissa , CISTULLI, Peter
IPC分类号： G01N33/68 , G01N33/74 , G01N33/94 , A61P11/04 , G01N33/543
摘要： The present disclosure relates to sleep apnoea and methods of diagnosing, treating and monitoring sleep apnoea.

2. 发明申请

WO2022153316A1 DEVICES AND METHODS FOR DIAGNOSISING THYROID MEDICAL CONDITIONS 审中-公开
公开(公告)号：WO2022153316A1
公开(公告)日：2022-07-21
申请号：PCT/IL2022/050067
申请日：2022-01-17
申请人： B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY , MOR RESEARCH APPLICATIONS LTD.
发明人： MARKS, Robert , YOEL, Uri , AXELROD, Tim , ANGEL, Sagi , KUSHMARO, Ariel
IPC分类号： G01N33/574 , G01N33/543 , G01N33/74 , B01L3/00
摘要： Disclosed is a device including at least 4 sections with a unique layout which includes a surface functionalized with an agent having specific binding affinity to a target molecule, and which allows flow. Disclosed are also a kit and a method for determining and quantifying the presence of a biomarker of a thyroid medical condition in a sample.

3. 发明申请

WO2022117604A1 DETECTION OF AN ANALYTE OF INTEREST BY CROSS SPRAY ESI MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2022117604A1
公开(公告)日：2022-06-09
申请号：PCT/EP2021/083681
申请日：2021-12-01
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： KARACA, Samir , PIRKL, Nicole , REMPT, Martin
IPC分类号： G01N33/68 , G01N33/74 , C07C315/00
摘要： The present invention relates to a method, a diagnostic system, a dopant and the use thereof for the enhancement of detection of an analyte of interest by Cross Spray ESI mass spectrometry. The dopant is preferably a sulfone. The method involves two electrospray ionization sources for a two analytical flow streams in a gaseous form or aerosol. The second flow stream comprises a dopant or a derivatization reagent. The the first and the second analytical flow stream are intermixed and the presence or the level of an analyte of interest in the sample is determined with improved sensitivity using mass spectrometry.

4. 发明申请

WO2022103282A1 NOVEL STEROID HORMONE LIGAND ASSAYS 审中-公开
公开(公告)号：WO2022103282A1
公开(公告)日：2022-05-19
申请号：PCT/NZ2021/050201
申请日：2021-11-12
申请人： INSITUGEN LIMITED
发明人： HEATHER, Alison Kay
IPC分类号： C12Q1/6897 , G01N33/74
摘要： The present invention is concerned with the detection of ligands which bind to and activate steroid hormone receptors. Specifically, the present invention provides test kits and assay methods for the selective identification of steroid hormone receptor ligands from a test sample. Importantly, the test kits and assay methods described herein are cell-free, and do not require expensive-to-manufacture nuclear extracts for their performance. Instead, the test kits and assay methods described herein employ single polypeptide polymerases, such as T7 RNA polymerase, linked to a reporter construct. Activity of the enzyme is inhibited, rather than activated, by ligand-bound steroid hormone receptor complexes which only form in the presence of a target ligand. Accordingly, a measured change in a physical property of the reporter construct (e.g. fluorescence output) may be used to determine the presence of a target ligand in a sample under investigation.

5. 发明申请

WO2022100263A1 抗AMH的抗体、检测AMH的试剂和试剂盒审中-公开
公开(公告)号：WO2022100263A1
公开(公告)日：2022-05-19
申请号：PCT/CN2021/117806
申请日：2021-09-10
申请人：东莞市朋志生物科技有限公司
发明人：崔鹏 , 何志强 , 孟媛 , 钟冬梅 , 叶庆妮 , 陈晓倩 , 王晨 , 范凌云
IPC分类号： C07K16/26 , C12N15/13 , C12P21/02 , G01N33/74
摘要：一种抗AMH的抗体、检测AMH的试剂和试剂盒，涉及抗体技术领域。抗AMH的抗体包括重链互补决定区和轻链互补决定区。该抗体对抗AMH的亲和力较好，使用该抗体检测AMH具有更好的灵敏度和特异性。为AMH的检测提供了更多以及性能更佳的抗体选择。

6. 发明申请

WO2021127376A1 TREATMENT OF, AND DIFFERENTIAL DIAGNOSIS BETWEEN, ACTH-DEPENDENT CUSHING'S SYNDROME AND ACTH-INDEPENDENT CUSHING'S SYNDROME 审中-公开
公开(公告)号：WO2021127376A1
公开(公告)日：2021-06-24
申请号：PCT/US2020/065916
申请日：2020-12-18
申请人： CORCEPT THERAPEUTICS INCORPORATED
发明人： MORAITIS, Andreas G. , BELANOFF, Joseph
IPC分类号： A61K31/567 , A61K31/513 , A61K31/4738 , A61P5/38 , G01N33/74
摘要： Methods for treating and differential diagnosis between ACTH-Dependent and ACTH-Independent Cushing's syndrome are disclosed, in which a glucocorticoid receptor antagonist (GRA) is administered to a Cushing's syndrome patient with a basal ACTH level less than about 25 pg/mL. If i) the patient's blood ACTH and ii) the patient's blood cortisol, or adrenal hormone, or adrenal pre-hormone levels rise, or if the ACTH:cortisol ratio increases, then ACTH-Dependent Cushing's syndrome is diagnosed. If those levels do not rise, or if the ACTH:cortisol ratio decreases, then ACTH-Independent Cushing's syndrome is diagnosed. In some instances, the patient is recovering from surgery to remove an ACTH secreting tumor, and the method described herein is used to determine if the tumor resection was successful or complete. The GRA may be mifepristone, or a non-steroidal GRA having a heteroaryl-ketone fused azadecalin backbone, an octahydro fused azadecalin backbone, a cyclohexyl pyrimidine backbone, or a fused azadecalin backbone.

7. 发明申请

WO2021007671A1 URINALYSIS TEST STRIP FOR OVER-THE-COUNTER USE 审中-公开
公开(公告)号：WO2021007671A1
公开(公告)日：2021-01-21
申请号：PCT/CA2020/050985
申请日：2020-07-15
申请人： YOUCOUNT INC. , DECHEV, Teodora , DECHEV, Nikolai , FRASER, Ian
发明人： DECHEV, Teodora , DECHEV, Nikolai , FRASER, Ian
IPC分类号： G01N33/50 , C12Q1/00 , C12Q1/26 , C12Q1/34 , C12Q1/48 , C12Q1/533 , G01N33/543 , G01N33/558 , G01N33/66 , G01N33/74 , G01N33/94
摘要： A test strip for urinalysis is provided, the test strip including a reagent pad for detecting a concentration of a selected analyte, the reagent pad attached to the test strip and comprising a substrate and an analyte detection system retained thereon, the analyte detection system including a plurality of components necessary for detection of the selected analyte, wherein at least one of the plurality of components is a variable component, the variable component immobilized on the substrate at a plurality of amounts on the reagent pad.

8. 发明申请

WO2020251460A1 SYSTEM FOR DETERMINING VALIDITY OF A LATERAL FLOW TEST RESULT 审中-公开
公开(公告)号：WO2020251460A1
公开(公告)日：2020-12-17
申请号：PCT/SE2020/050586
申请日：2020-06-09
申请人： DELAVAL HOLDING AB
发明人： DALLERUP RASMUSSEN, Claus , TRIER HALD, Jonas
IPC分类号： G01N33/558 , G01N33/74 , G01N21/84
摘要： A system (10) for determining validity of a result of a lateral flow test, comprising a lateral flow stick (180a, 180b, 180c). The lateral flow stick (180a, 180b, 180c) comprises: a sample pad (310); a conjugate pad (315) comprising antibody treated gold particles; a porous membrane (320) for receiving a capillary flow of the milk sample. The porous membrane (320) comprises: a test line (360) treated with a progesterone reference which binds antibody treated gold particles of the milk sample and thereby brings the test line (360) to change colour tint when exposed for milk comprising a progesterone level lower than a threshold limit; and a control line (370) treated with an antibody reference which binds antibody, and thereby brings the control line (370) to change colour tint when exposed for milk comprising antibody treated gold particles. The system also comprises a sensor (210) and a control unit (150), configured to obtain a reference colour tint (380) of the control line (370); determine a current colour tint of the control line (370), based on the image captured by the sensor (210) during the ongoing lateral flow test; compare the reference colour tint (380) of the control line (370) with the current colour tint of the control line (370); and indicate validity of the lateral flow test on the lateral flow stick (180a, 180b, 180c), based on the made comparison.

9. 发明申请

WO2020148363A1 ORAL COMPOSITION COMPRISING SACCHARIDES FOR THE DIAGNOSIS OF INSULIN DYSREGULATION IN EQUINES AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2020148363A1
公开(公告)日：2020-07-23
申请号：PCT/EP2020/050968
申请日：2020-01-16
申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH
发明人： REICHE, Dania, Birte , HOEJVANG-NIELSEN, Leif , SONNTAG, Johanna, Sigrid, Nelly
IPC分类号： G01N33/68 , G01N33/74 , A23K20/00 , A23K50/20 , A23L33/125
摘要： The invention relates to novel palatable, well-tolerated, accurate, oral glycemic challenge compositions comprising saccharides and methods for use in equines to diagnose insulin dysregulation.

10. 发明申请

WO2020136096A1 SELENIUM BINDING PROTEIN 1 DETECTION FROM BODY FLUIDS FOR DIAGNOSIS OF PERACUTE TISSUE DAMAGE 审中-公开
公开(公告)号：WO2020136096A1
公开(公告)日：2020-07-02
申请号：PCT/EP2019/086474
申请日：2019-12-19
申请人： BERYSOL GMBH
发明人： SCHOMBURG, Lutz , KUEHN, Eike Christian
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/68 , G01N33/74
摘要： The present invention refers to an immunoassay for determining the amount of selenium binding protein 1 (SELENBP1) in the body liquid of an individual suspected of suffering from peracute tissue damage and detecting pathologically elevated levels of SELENBP1, the diagnostic use of this immunoassay and a kit for the performance of a diagnostic assay comprising an antibody against SELENBP1.

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