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1. 发明申请

WO0218006A2 LEADS FOR PACING AND/OR SENSING THE HEART FROM WITHIN THE CORONARY VEINS 审中-公开
标题翻译：用于从冠状动脉内切开和/或感测心脏的领导
公开(公告)号：WO0218006A2
公开(公告)日：2002-03-07
申请号：PCT/US0127022
申请日：2001-08-30
申请人： CARDIAC PACEMAKERS INC , WESTLUND RANDY , TOCKMAN BRUCE , WARREN JAY A , SCHEINER AVRAM , HAIL RONALD W JR , KELLEY PETER T , REPASKY CHRISTINA , BYE LYLE A , SOLTIS BRIAN D
发明人： WESTLUND RANDY , TOCKMAN BRUCE , WARREN JAY A , SCHEINER AVRAM , HAIL RONALD W JR , KELLEY PETER T , REPASKY CHRISTINA , BYE LYLE A , SOLTIS BRIAN D
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/057 , A61N2001/0585
摘要： A lead (100) for monitoring or simulating cardiac activity is provided. The lead (100) is adapted for implantation on or about the heart within the coronary vasculature and for connection to a signal generator (140). The lead is constructed and arranged so that when it is implanted, the electrodes (122) are housed in the coronary vasculature and urged into intimate contact a vessel wall (128). The lead optionally includes a tapered, flexible lead body portion that is distal to a biased portion.
摘要翻译：提供了用于监测或模拟心脏活动的导联（100）。引线（100）适于植入在冠状脉管系统内或心脏周围，并用于连接到信号发生器（140）。引线被构造和布置成使得当其被植入时，电极（122）容纳在冠状脉管系统中并被促使与血管壁（128）紧密接触。导线可选地包括在偏压部分的远侧的锥形的柔性引线主体部分。

2. 发明申请

WO0218006A8 CORONARY VEINS LEAD FOR PACING OR SENSING 审中-公开
标题翻译：冠状动脉导管用于切开或感觉
公开(公告)号：WO0218006A8
公开(公告)日：2003-12-31
申请号：PCT/US0127022
申请日：2001-08-30
申请人： CARDIAC PACEMAKERS INC , WESTLUND RANDY , TOCKMAN BRUCE , WARREN JAY A , SCHEINER AVRAM , HEIL RONALD W JR , KELLEY PETER T , REPASKY CHRISTINA , BYE LYLE A , SOLTIS BRIAN D
发明人： WESTLUND RANDY , TOCKMAN BRUCE , WARREN JAY A , SCHEINER AVRAM , HEIL RONALD W JR , KELLEY PETER T , REPASKY CHRISTINA , BYE LYLE A , SOLTIS BRIAN D
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/057 , A61N2001/0585
摘要： A lead (100) for monitoring or simulating cardiac activity is provided. The lead (100) is adapted for implantation on or about the heart within the coronary vasculature and for connection to a signal generator (140). The lead is constructed and arranged so that when it is implanted, the electrodes (122) are housed in the coronary vasculature and urged into intimate contact a vessel wall (128). The lead optionally includes a tapered, flexible lead body portion that is distal to a biased portion.
摘要翻译：提供了用于监测或模拟心脏活动的导联（100）。引线（100）适于植入在冠状脉管系统内或心脏周围，并用于连接到信号发生器（140）。引线被构造和布置成使得当其被植入时，电极（122）容纳在冠状脉管系统中并被促使与血管壁（128）紧密接触。导线可选地包括在偏压部分的远侧的锥形的柔性引线主体部分。

3. 发明申请

WO2007053298A3 LEAD AND DELIVERY SYSTEM TO DETECT AND TREAT A MYOCARDIAL INFARCTION REGION 审中-公开
标题翻译：引导和交付系统来检测和治疗心肌梗塞区域
公开(公告)号：WO2007053298A3
公开(公告)日：2007-07-05
申请号：PCT/US2006040682
申请日：2006-10-13
申请人： CARDIAC PACEMAKERS INC , PASTORE JOSEPH M , SALO RODNEY W , HEIL JR RONALD W , WESTLUND RANDY
发明人： PASTORE JOSEPH M , SALO RODNEY W , HEIL JR RONALD W , WESTLUND RANDY
IPC分类号： A61N1/05
CPC分类号： A61N1/0587 , A61N1/059 , A61N1/3627
摘要： A method includes mounting an anchor member to a surface of a heart, the anchor member having a tension member coupled to the anchor member, advancing a lead body along the tension member, the lead body including a plurality of electrodes disposed along the lead body, identifying an MI region of the heart, positioning the plurality of electrodes at or near the MI region, affixing the tension member to the lead body to hold the electrodes in position, and delivering pulses through the plurality of electrodes to the heart.
摘要翻译：一种方法包括将锚定构件安装到心脏的表面，所述锚定构件具有联接到所述锚定构件的张紧构件，使所述引线体沿着所述张紧构件前进，所述引线主体包括沿着所述引线主体设置的多个电极，识别心脏的MI区域，将多个电极定位在MI区域处或附近，将张紧构件固定到引线体以将电极保持在适当位置，并将脉冲通过多个电极传递到心脏。

4. 发明申请

WO2008100392A3 IMPLANTABLE MEDICAL DEVICE WITH FIXATION MECHANISM 审中-公开
标题翻译：具有固定机构的可植入医疗器械
公开(公告)号：WO2008100392A3
公开(公告)日：2009-04-16
申请号：PCT/US2008001512
申请日：2008-02-05
申请人： CARDIAC PACEMAKERS INC , LIBBUS IMAD , WESTLUND RANDY
发明人： LIBBUS IMAD , WESTLUND RANDY
IPC分类号： A61N1/36
CPC分类号： A61N1/0558 , A61N1/36114 , A61N1/372 , A61N1/37205 , A61N1/3756
摘要： Miniature implantable medical devices each include a fixation mechanism to prevent the device from migrating in the body of a patient after implantation. The fixation mechanism is activated after the device is positioned in the body. In one embodiment, the miniature implantable medical devices each include a circuit to deliver neurostimulation. In one embodiment, the fixation mechanism includes one or more externally activated anchoring devices each configured to switch from a substantially non-anchoring state to a substantially anchoring state in response to an externally applied energy. In another embodiment, implantable medical devices are magnetically attracted to each other to prevent the devices from migrating in the body after implantation.
摘要翻译：微型可植入医疗装置各自包括固定机构，以防止装置在植入后在患者体内迁移。在装置定位在体内后，固定机构被激活。在一个实施例中，微型可植入医疗装置各自包括用于递送神经刺激的电路。在一个实施例中，固定机构包括一个或多个外部激活的锚固装置，其各自被配置为响应于外部施加的能量而从基本上非锚定状态转换到基本锚定状态。在另一个实施例中，可植入医疗装置彼此磁吸引以防止装置在植入后在体内迁移。

5. 发明申请

WO2007146517A3 SYSTEM FOR NEURAL STIMULATION VIA LYMPHATIC VESSEL 审中-公开
标题翻译：通过淋巴管进行神经刺激的系统
公开(公告)号：WO2007146517A3
公开(公告)日：2008-05-02
申请号：PCT/US2007068617
申请日：2007-05-10
申请人： CARDIAC PACEMAKERS INC , SHUROS ALLAN , WESTLUND RANDY , CAPARSO ANTHONY V
发明人： SHUROS ALLAN , WESTLUND RANDY , CAPARSO ANTHONY V
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/36114
摘要： An implantable neural stimulation system includes an implantable medical device having a neural stimulation circuit and at least one implantable lead configured to allow one or more stimulation electrodes to be placed in one or more lymphatic vessels of a patient, such as the patient's thoracic duct and/or vessels branching from the thoracic duct. Neural stimulation pulses are delivered from the implantable medical device to one or more target regions adjacent to the thoracic duct or the vessels branching from the thoracic duct through the one or more stimulation electrodes.
摘要翻译：可植入神经刺激系统包括具有神经刺激电路的可植入医疗装置和至少一个可植入引线，其被配置为允许将一个或多个刺激电极放置在患者的一个或多个淋巴管中，例如患者的胸导管和/ 或从胸导管分支的血管。神经刺激脉冲从可植入医疗装置传送到与胸导管相邻的一个或多个目标区域或通过一个或多个刺激电极从胸导管分支的血管。

6. 发明申请

WO2005044079A3 APPARATUS AND METHOD FOR ENDOSCOPIC CARDIAC MAPPING AND LEAD PLACEMENT 审中-公开
标题翻译：用于内镜心脏图谱和导管放置的装置和方法
公开(公告)号：WO2005044079A3
公开(公告)日：2006-02-02
申请号：PCT/US2004034538
申请日：2004-10-19
申请人： ORIGIN MEDSYSTEMS INC , CHIN ALBERT K , DAVIS JOHN , WESTLUND RANDY
发明人： CHIN ALBERT K , DAVIS JOHN , WESTLUND RANDY
IPC分类号： A61B20060101 , A61B1/01 , A61B17/00 , A61B17/06 , A61B17/22 , A61B17/30 , A61B17/32 , A61B17/34 , A61B18/00 , A61B18/14 , A61B19/00 , A61N1/05
CPC分类号： A61B17/3421 , A61B1/00094 , A61B17/00008 , A61B17/320068 , A61B17/3403 , A61B17/3417 , A61B17/3468 , A61B17/3478 , A61B18/1482 , A61B90/11 , A61B90/39 , A61B2017/00243 , A61B2017/00247 , A61B2017/061 , A61B2017/22077 , A61B2017/306 , A61B2017/308 , A61B2017/320044 , A61B2017/3445 , A61B2017/3488 , A61B2018/00291 , A61B2018/00392 , A61B2018/00982 , A61B2090/036 , A61B2090/062
摘要： Apparatus and surgical methods establish temporary suction attachment to a target site on the surface of a beating heart for analyzing electrical signals or hemodynamic responses to applied signals at the target sites for enhancing the accuracy of placement of cardiac electrodes at selected sites and for enhancing accurate placement of a surgical instrument maintained in alignment with the suction attachment. A suction port on the distal end of a supporting cannula carries surface-contacting electrodes and provides suction attachment to facilitate temporary positioning of the electrodes in contact with tissue at the target site, and a clamping and release mechanism to facilitate anchoring a cardiac electrode on the moving surface of a beating heart at a selected site. Analyses of sensed signals or responses to applied signals at target sites promote epicardial mapping of a patient's heart for determining optimum sites at which to attach cardiac electrodes.
摘要翻译：装置和手术方法建立临时抽吸附着到跳动心脏表面上的目标部位，用于分析电信号或对目标部位施加的信号的血液动力学反应，以提高心脏电极在选定部位的放置准确度，并提高精确放置保持与抽吸附件对齐的手术器械。在支撑套管的远端上的吸入口携带表面接触电极并且提供吸附附件，以便于电极与目标部位的组织接触的临时定位，以及夹持和释放机构，以便于将心电极固定在跳动心脏在选定的地点的移动表面。感测信号的分析或对目标位置的应用信号的响应促进患者心脏的心外膜映射，以确定附着心脏电极的最佳位置。

7. 发明申请

WO0009204A9 EXPANDABLE SEAL FOR USE WITH MEDICAL DEVICE AND SYSTEM 审中-公开
标题翻译：可与医疗设备和系统一起使用的可扩展密封
公开(公告)号：WO0009204A9
公开(公告)日：2001-12-06
申请号：PCT/US9918389
申请日：1999-08-12
申请人： CARDIAC PACEMAKERS INC
发明人： JANKE AARON W , HUM LARRY L , WESTLUND RANDY , HEIL RONALD W JR , TOCKMAN BRUCE
IPC分类号： A61N1/05
CPC分类号： A61N1/0573 , A61N1/0565
摘要： A seal adapted for use with medical devices is provided with a lead having a distal tip electrode. The distal tip of the lead is adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity. The lead can include a fixation helix for securing the electrode to cardiac tissue. The lead assembly can alternatively include an open lumen lead tip. A seal is provided within the lead tip assembly such that the seal is expanded to prevent or limit further entry of fluids through the lead tip. The seal includes an expandable matrix, such as a hydrogel. The seal is formed on or within the lead when the lead and the seal come into contact with a fluid and expands. The seal is also formed as a plug which is deployed through the medical device, and expands as the plug absorbs fluid. A housing incorporating the seal can also be attached to a portion of the medical device to provide the seal.
摘要翻译：适于与医疗装置一起使用的密封件设置有具有远端尖端电极的引线。引线的远端适于植入在心脏上或其周围，并用于连接到用于监测或刺激心脏活动的系统。引线可以包括用于将电极固定到心脏组织的固定螺旋。导线组件可以替代地包括开放的管腔引线端头。在引线端头组件内设置密封件，使得密封件被膨胀以防止或限制流体进一步通过引线头进入。密封件包括可膨胀基质，例如水凝胶。当铅和密封件与流体接触并膨胀时，密封件形成在引线上或内部。密封件还形成为通过医疗装置展开的塞子，并且当塞子吸收流体时膨胀。结合密封件的壳体也可以附接到医疗装置的一部分以提供密封。

8. 发明申请

WO9843697A3 LEFT VENTRICULAR ACCESS LEAD FOR HEART FAILURE PACING 审中-公开
标题翻译：左心室接触导管用于心脏衰竭
公开(公告)号：WO9843697A3
公开(公告)日：1999-02-25
申请号：PCT/US9806283
申请日：1998-01-20
申请人： CARDIAC PACEMAKERS INC
发明人： AURICCHIO ANGELO , SALO RODNEY W , TOCKMAN BRUCE A , HEIL RONALD W JR , WESTLUND RANDY , CHASTAIN STUART R
IPC分类号： A61N1/368 , A61N1/05 , A61N
CPC分类号： A61N1/056 , A61N2001/0585
摘要： An elongated monopolar or bipolar coronary vein lead having a reduced outer diameter and especially adapted to be advanced into a selected coronary vein for delivering a pacing signal to a predetermined region of a patient's heart, such as the left ventricle. A method of using the lead for pacing a patient's heart in the treatment of heart failure is also described. The method for pacing the heart includes advancing the coronary vein lead through both the coronary sinus and into a selected coronary vein of a patient's heart, connecting the lead to an electrical pacing source and applying electrical stimulation to a particular chamber of the patient's heart via the implanted lead. The lead includes a flexible tip (130) and transition ring (100) that enhances the ability to guide the lead through the coronary veins.

9. 发明申请

WO2004067086A3 MEDICAL ELECTRICAL LEAD EMPLOYING LOAD BEARING SLEEVE 审中-公开
标题翻译：医用电子导线采用负载轴套
公开(公告)号：WO2004067086A3
公开(公告)日：2004-12-09
申请号：PCT/US2004002148
申请日：2004-01-27
申请人： CARDIAC PACEMAKERS INC
发明人： WESTLUND RANDY , KRISHNAN MOHAN , SCHEINER AVRAM
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N2001/0578 , A61N2001/0585
摘要： A medical electrical lead employs a load bearing sleeve arrangement. A medical electrical lead includes an outer sleeve, having proximal and distal ends, and is formed of a first material. At least one electrical conductor is situated within the outer sleeve and extends between the proximal and distal ends of the outer sleeve. At least one electrode is electrically coupled to the electrical conductor. A load bearing sleeve extends between the proximal and distal ends of the outer sleeve. The load bearing sleeve is formed of a second material different from the first maternal. The load bearing sleeve offers resistance to axial loading forces applied to the lead. The load bearing sleeve can be coextensive with the outer sleeve or extend along at least the majority of the length of the outer sleeve.
摘要翻译：医用电导线采用承载套筒布置。医用电引线包括具有近端和远端的外套筒，并且由第一材料形成。至少一个电导体位于外套筒内并且在外套筒的近端和远端之间延伸。至少一个电极电耦合到电导体。承载套筒在外套筒的近端和远端之间延伸。承载套筒由与第一母体不同的第二材料形成。承载套筒抵抗施加在引线上的轴向负载力。承载套筒可以与外套筒共同延伸或者至少沿外套筒的大部分长度延伸。

10. 发明申请

WO2004018029A3 CORONARY VEIN NAVIGATOR 审中-公开
标题翻译：冠状动脉导管
公开(公告)号：WO2004018029A3
公开(公告)日：2004-06-03
申请号：PCT/US0326359
申请日：2003-08-22
申请人： CARDIAC PACEMAKERS INC
发明人： TOCKMAN BRUCE , HALL JEFFREY A , WESTLUND RANDY
IPC分类号： A61M25/01 , A61M25/09 , A61N1/05 , A61M25/00
CPC分类号： A61M25/0147 , A61M25/0152 , A61N2001/0585
摘要： A system and method for navigating coronary vasculature involves use of a guide catheter system (70) which includes a guide catheter (72), a navigator catheter (74) longitudinally displaceable within the guide catheter, and a deflection arrangement provided at a distal end of the navigator catheter. The guide catheter is advanced to at least a patient's coronary sinus ostium, and the navigator catheter is extended from the guide catheter to a location proximate or within an angled vein distal to the coronary sinus ostium. Using the deflection arrangement, a guide wire (76) passing through the navigation catheter is directed into the angled vein. A lead having an open lumen is advanced over the guide wire to direct the lead to an implant site within the angled vein.
摘要翻译：用于导航冠状动脉脉管系统的系统和方法涉及使用导向导管系统（70），其包括导向导管（72），可在引导导管内纵向移位的导航导管（74），以及设置在导管导航导管。引导导管前进到至少一个患者的冠状窦口，并且导管导管从引导导管延伸到远离冠状窦口的倾斜静脉附近的位置。使用偏转装置，穿过导航导管的导丝（76）被引导到成角度的静脉中。具有开口腔的引线在引导线上前进，以将引线引导到成角度静脉内的植入部位。

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