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1. 发明申请

WO0218006A8 CORONARY VEINS LEAD FOR PACING OR SENSING 审中-公开
标题翻译：冠状动脉导管用于切开或感觉
公开(公告)号：WO0218006A8
公开(公告)日：2003-12-31
申请号：PCT/US0127022
申请日：2001-08-30
申请人： CARDIAC PACEMAKERS INC , WESTLUND RANDY , TOCKMAN BRUCE , WARREN JAY A , SCHEINER AVRAM , HEIL RONALD W JR , KELLEY PETER T , REPASKY CHRISTINA , BYE LYLE A , SOLTIS BRIAN D
发明人： WESTLUND RANDY , TOCKMAN BRUCE , WARREN JAY A , SCHEINER AVRAM , HEIL RONALD W JR , KELLEY PETER T , REPASKY CHRISTINA , BYE LYLE A , SOLTIS BRIAN D
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/057 , A61N2001/0585
摘要： A lead (100) for monitoring or simulating cardiac activity is provided. The lead (100) is adapted for implantation on or about the heart within the coronary vasculature and for connection to a signal generator (140). The lead is constructed and arranged so that when it is implanted, the electrodes (122) are housed in the coronary vasculature and urged into intimate contact a vessel wall (128). The lead optionally includes a tapered, flexible lead body portion that is distal to a biased portion.
摘要翻译：提供了用于监测或模拟心脏活动的导联（100）。引线（100）适于植入在冠状脉管系统内或心脏周围，并用于连接到信号发生器（140）。引线被构造和布置成使得当其被植入时，电极（122）容纳在冠状脉管系统中并被促使与血管壁（128）紧密接触。导线可选地包括在偏压部分的远侧的锥形的柔性引线主体部分。

2. 发明申请

WO2007021413A3 BIOLOGIC DEVICE FOR REGULATION OF GENE EXPRESSION 审中-公开
标题翻译：用于调节基因表达的生物学设备
公开(公告)号：WO2007021413A3
公开(公告)日：2007-04-12
申请号：PCT/US2006027209
申请日：2006-07-13
申请人： CARDIAC PACEMAKERS INC , WAGNER DARRELL O , SIH HARIS J , QU JIHONG , ROSS JEFFREY , GIROUARD STEVEN , HEIL RONALD W JR
发明人： WAGNER DARRELL O , SIH HARIS J , QU JIHONG , ROSS JEFFREY , GIROUARD STEVEN , HEIL RONALD W JR
IPC分类号： A61K48/00 , A61N1/05
CPC分类号： A61K48/0008 , A61K48/0083 , A61N1/05
摘要： A system and device are provided which include a gene regulatory system controlling expression of one or more expression cassettes present in or released by the device, by emitting one or more stimulations. An expression cassette includes a regulatable transcription control element that is responsive to the emitted stimulations linked to an open reading frame of interest. The system optionally includes a sensor to sense a parameter indicative of a need, a telemetry module to receive an external command, or a programmable device, for regulating gene expression of the open reading frame.
摘要翻译：提供了一种系统和装置，其包括通过发射一种或多种刺激来控制存在于或释放的装置中的一种或多种表达盒的表达的基因调控系统。表达盒包括可调节的转录控制元件，其响应于与感兴趣的开放阅读框架相关联的发射刺激。该系统可选地包括用于感测指示需要的参数的传感器，用于接收外部命令的遥测模块或用于调节开放阅读框的基因表达的可编程设备。

3. 发明申请

WO9930772A2 LEAD SYSTEM 审中-公开
标题翻译： LEAD系统
公开(公告)号：WO9930772A2
公开(公告)日：1999-06-24
申请号：PCT/US9826767
申请日：1998-12-17
申请人： CARDIAC PACEMAKERS INC
发明人： SCHEINER AVRAM , HSU WILLIAM , FLYNN DAVID M , ZHU QINGSHENG , HEIL JOHN E , HEIL RONALD W JR , LINDSTROM CURTIS C , BOOKER ROBERT S III , LIN YAYUN , KELLEY PETER T , WARREN JAY A , CARLSON GERRARD M , WERLEIN CAROL , JANKE AARON W , COLE MARY LEE , BARTIG JEFFREY T , GOEBEL GARY W , HEITKAMP DOUGLAS A , PETERFESO RANDALL M
IPC分类号： A61N1/05
CPC分类号： A61N1/0573
摘要： A single-pass endocardial lead electrode for implantation within a single chamber of the heart, or multiple chambers of the heart. The lead includes a first distal end electrode and a second electrode. The first and second electrodes are either passively or actively attached to the wall of the heart. The lead body also includes a curved portion which facilitates the positioning of the second electrode. The main lead body alternatively includes a recess into which an atrial lead body and an active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element can also be moved by turning the terminal pin. The lead body can also include multiple legs, each leg carrying an electrode. The lead is attached to a pulse generator for producing pulses to the multiple sites within the heart. A movement assembly for advancing a helix is also included within the legs and comprises an externally threaded collar which engages with an internally threaded housing or housing insert. The lead further includes a helical tip which has high impedance.
摘要翻译：用于植入心脏的单个腔室或心脏的多个腔室内的单程心内膜导联电极。引线包括第一远端电极和第二电极。第一和第二电极被动地或主动地附着在心脏的壁上。引线体还包括便于第二电极定位的弯曲部分。主引线主体备选地包括凹部，心房导线主体和附接到一端的主动固定元件可以从凹入位置行进到用于固定到心脏壁的位置。主动固定元件也可以通过转动端子销来移动。引线体还可以包括多个腿，每个腿携带电极。导联连接到脉冲发生器，用于向心脏内的多个部位产生脉冲。用于推进螺旋的运动组件也包括在支腿内并且包括外螺纹套环，该外螺纹套环与内螺纹外壳或外壳插入件接合。引线还包括具有高阻抗的螺旋尖端。

4. 发明申请

WO0009204A9 EXPANDABLE SEAL FOR USE WITH MEDICAL DEVICE AND SYSTEM 审中-公开
标题翻译：可与医疗设备和系统一起使用的可扩展密封
公开(公告)号：WO0009204A9
公开(公告)日：2001-12-06
申请号：PCT/US9918389
申请日：1999-08-12
申请人： CARDIAC PACEMAKERS INC
发明人： JANKE AARON W , HUM LARRY L , WESTLUND RANDY , HEIL RONALD W JR , TOCKMAN BRUCE
IPC分类号： A61N1/05
CPC分类号： A61N1/0573 , A61N1/0565
摘要： A seal adapted for use with medical devices is provided with a lead having a distal tip electrode. The distal tip of the lead is adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity. The lead can include a fixation helix for securing the electrode to cardiac tissue. The lead assembly can alternatively include an open lumen lead tip. A seal is provided within the lead tip assembly such that the seal is expanded to prevent or limit further entry of fluids through the lead tip. The seal includes an expandable matrix, such as a hydrogel. The seal is formed on or within the lead when the lead and the seal come into contact with a fluid and expands. The seal is also formed as a plug which is deployed through the medical device, and expands as the plug absorbs fluid. A housing incorporating the seal can also be attached to a portion of the medical device to provide the seal.
摘要翻译：适于与医疗装置一起使用的密封件设置有具有远端尖端电极的引线。引线的远端适于植入在心脏上或其周围，并用于连接到用于监测或刺激心脏活动的系统。引线可以包括用于将电极固定到心脏组织的固定螺旋。导线组件可以替代地包括开放的管腔引线端头。在引线端头组件内设置密封件，使得密封件被膨胀以防止或限制流体进一步通过引线头进入。密封件包括可膨胀基质，例如水凝胶。当铅和密封件与流体接触并膨胀时，密封件形成在引线上或内部。密封件还形成为通过医疗装置展开的塞子，并且当塞子吸收流体时膨胀。结合密封件的壳体也可以附接到医疗装置的一部分以提供密封。

5. 发明申请

WO9843697A3 LEFT VENTRICULAR ACCESS LEAD FOR HEART FAILURE PACING 审中-公开
标题翻译：左心室接触导管用于心脏衰竭
公开(公告)号：WO9843697A3
公开(公告)日：1999-02-25
申请号：PCT/US9806283
申请日：1998-01-20
申请人： CARDIAC PACEMAKERS INC
发明人： AURICCHIO ANGELO , SALO RODNEY W , TOCKMAN BRUCE A , HEIL RONALD W JR , WESTLUND RANDY , CHASTAIN STUART R
IPC分类号： A61N1/368 , A61N1/05 , A61N
CPC分类号： A61N1/056 , A61N2001/0585
摘要： An elongated monopolar or bipolar coronary vein lead having a reduced outer diameter and especially adapted to be advanced into a selected coronary vein for delivering a pacing signal to a predetermined region of a patient's heart, such as the left ventricle. A method of using the lead for pacing a patient's heart in the treatment of heart failure is also described. The method for pacing the heart includes advancing the coronary vein lead through both the coronary sinus and into a selected coronary vein of a patient's heart, connecting the lead to an electrical pacing source and applying electrical stimulation to a particular chamber of the patient's heart via the implanted lead. The lead includes a flexible tip (130) and transition ring (100) that enhances the ability to guide the lead through the coronary veins.

6. 发明申请

WO0108745A9 REMOVABLE CAP FOR TISSUE-INSERTABLE CONNECTIONS 审中-公开
标题翻译：用于组织无关连接的可拆卸盖
公开(公告)号：WO0108745A9
公开(公告)日：2002-08-01
申请号：PCT/US0040510
申请日：2000-07-28
申请人： CARDIAC PACEMAKERS INC
发明人： HEIL RONALD W JR , LEY GREGORY R , SKINNER DWIGHT , HUM LARRY L
IPC分类号： A61N1/05
CPC分类号： A61N1/0573
摘要： A helical element for insertion into tissue comprises a helical element having an insertion end, a protruding end and an open central area within the wire, rods, filaments, cables or the like that form the helix. The helical element has at least its insertion end covered by a cap of a water-soluble or water-dispersible composition. The cap is provided with a surface shape in a cross-section in which surface variations are present in the cross-section which create a surface orientation where a line from the center of the cross-section can intersect the surface, and a line perpendicular to said radius at a point of intersection with said surface forms four quadrants, three of said quadrants containing water-soluble or water-dispersible cap material. There is either a hollow area within the composition within the open central area or the material is more porous than the remaining material. The helical element preferably comprises an electrical lead, such as a positive endocardial lead, with an electrode at the protruding or distal end of the lead. The helical element may comprise any biocompatible material with sufficient structural integrity to provide a secure attachment to a tissue in a patient. Where the helical element is also to provide an active (electrically active) function, the composition of the helical element should also be electrically conductive.
摘要翻译：用于插入组织的螺旋元件包括螺旋形元件，其具有插入端，突出端和形成螺旋线的线，杆，细丝，电缆等内的开口中心区域。螺旋元件的至少其插入端被水溶性或水分散性组合物的盖子覆盖。该盖在横截面中具有表面形状，其中在横截面中存在表面变化，其形成表面取向，其中横截面中心的线可以与表面相交，并且垂直于在与所述表面的交点处的所述半径形成四个象限，所述象限中的三个包含水溶性或水分散性盖材料。组合物中的中空区域在开放的中心区域内，或者材料比剩余的材料多孔。螺旋元件优选地包括电引线，例如正心内膜引线，在引线的突出或远端具有电极。螺旋元件可以包括具有足够的结构完整性的任何生物相容性材料，以提供对患者组织的牢固连接。当螺旋元件也提供活性（电活性）功能时，螺旋元件的组成也应当是导电的。

7. 发明申请

WO0128609A3 DRUG DELIVERY SYSTEM FOR IMPLANTABLE CARDIAC DEVICE 审中-公开
标题翻译：用于可植入心脏装置的药物递送系统
公开(公告)号：WO0128609A3
公开(公告)日：2001-11-01
申请号：PCT/US0041214
申请日：2000-10-18
申请人： CARDIAC PACEMAKERS INC
发明人： SCHEINER AVRAM , HERNER MARK , HEIL RONALD W JR , GIROUARD STEVEN D
IPC分类号： A61N1/30 , A61N1/362 , A61B5/00 , A61N1/39
CPC分类号： A61N1/30 , A61N1/3621 , Y10S128/12 , Y10S128/13
摘要： A drug delivery system incorporated into a cardiac device (Fig. 1) for delivering a dose (133) of a drug to a patient upon detection of a particular medical condition. The cardiac device may be, for example, an implantable cardioverter/defibrillator, cardiac pacemaker, or combination device that communicates via a radio frequency link (40, 140) with a drug delivery device (Fig. 2). The drug delivery device is preferably an electrically modulated transdermal drug delivery device for delivering the drug transdermally in accordance with a signal received from the cardiac device.
摘要翻译：一种药物递送系统，其结合到心脏装置（图1）中，用于在检测到特定医疗状况时将药物的剂量（133）递送给患者。心脏装置可以是例如通过射频链路（40,140）与药物递送装置（图2）进行通信的可植入式心律转复器/除颤器，心脏起搏器或组合装置。药物递送装置优选是经电调制的透皮药物递送装置，用于根据从心脏装置接收的信号透皮地递送药物。

8. 发明申请

WO0013665A9 CONTROLLED RELEASE DRUG DELIVERY 审中-公开
标题翻译：控制释放药物递送
公开(公告)号：WO0013665A9
公开(公告)日：2000-08-10
申请号：PCT/US9920681
申请日：1999-09-09
申请人： CARDIAC PACEMAKERS INC
发明人： HEIL RONALD W JR , KENKNIGHT BRUCE H
IPC分类号： A61K9/22 , A61K9/00 , A61K9/48 , A61K47/34 , A61K31/165 , A61K31/57 , A61P9/06
CPC分类号： A61K9/0024
摘要： Biologically active materials are provided in a cylindrical carrier medium with better control over the rate of delivery and length of time of delivery by providing a carrier having dissolved or dispersed therein at least two compounds having a common biologically active nucleus, but with different solubility parameters. Thecombination of the two different variants of the same drug with different solubility parameters provides the material with control over the rate of release of the compounds (by varying the proportions of the variants) and most importantly, extending the useful life of the device by enabling release of effective levels of the compounds over a longer period of time. The cylindrical carrier medium, comprised of silicone, further includes a tail, a skirt, or a rate-limiting membrane.
摘要翻译：生物活性材料提供在圆柱形载体介质中，通过提供具有溶解或分散在其中的至少两种具有共同的生物活性核，但具有不同溶解度参数的化合物的载体，可以更好地控制输送速率和输送时间。具有不同溶解度参数的相同药物的两种不同变体的组合提供了材料对化合物释放速率的控制（通过改变变体的比例），最重要的是通过启用释放来延长器件的使用寿命的化合物在较长时间内的有效水平。由硅树脂构成的圆柱形载体介质还包括尾部，裙部或速率限制膜。

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