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1. 发明申请

WO2006058234A2 MEDICAL DEVICES WITH HIGHLY FLEXIBLE COATED HYPOTUBE 审中-公开
标题翻译：医疗设备与高度灵活涂层HYPOTUBE
公开(公告)号：WO2006058234A2
公开(公告)日：2006-06-01
申请号：PCT/US2005/042778
申请日：2005-11-23
申请人： BOSTON SCIENTIFIC SCIMED, INC. , OBARA, Robert, Z. , MIRIGIAN, Gregory, E. , CHAN, Huey, Quoc , ORTIZ, John, E. , GRIFFIN, Stephen
发明人： OBARA, Robert, Z. , MIRIGIAN, Gregory, E. , CHAN, Huey, Quoc , ORTIZ, John, E. , GRIFFIN, Stephen
CPC分类号： A61L29/14 , A61L29/085 , Y10T428/1321 , Y10T428/1352 , Y10T428/139 , Y10T428/2913
摘要： Hypotubes such as micromachined hypotubes can include one or more tie layers appropriate for subsequent application of a hydrophilic coating. In particular, a medical device may include a micromachined hypotube having a level of flexibility and a tie layer disposed over the hypotube such that the medical device has a level of flexibility at least substantially equivalent to the level of flexibility of the hypotube.
摘要翻译：诸如微机械海波管之类的低压管可包括适于随后施加亲水性涂层的一个或多个连接层。特别地，医疗装置可以包括具有柔性水平的微机械海波管和布置在海波管上方的连接层，使得医疗装置具有至少基本上等同于海波管柔性水平的柔性水平。

2. 发明申请

WO2005084744A1 OCCLUSION BALLOON CATHETER WITH EXTERNAL INFLATION LUMEN 审中-公开
标题翻译：具有外部充气灯的OCCLUSION BALLOON导管
公开(公告)号：WO2005084744A1
公开(公告)日：2005-09-15
申请号：PCT/US2005/006754
申请日：2005-02-28
申请人： BOSTON SCIENTIFIC SCIMED, INC. , CHAN, Huey Quoc , GRIFFIN, Stephen , LIM, Elaine
发明人： CHAN, Huey Quoc , GRIFFIN, Stephen , LIM, Elaine
IPC分类号： A61M25/10
CPC分类号： A61M25/1025 , A61M25/104 , A61M2025/1061
摘要： Catheters such as guide catheters can be configured to provide distal occlusion, while still providing sufficient interior lumen space for device delivery. Such catheters can also provide a desired level of flexibility, yet can include sufficient column support. A catheter can include an elongate shaft with a lumen, an inflatable compliant balloon disposed over the distal region of the shaft, and an external inflation component.
摘要翻译：导管如引导导管可构造为提供远端闭塞，同时仍然为装置输送提供足够的内腔空间。这样的导管也可以提供期望的柔性水平，但可以包括足够的柱支撑。导管可以包括具有内腔的细长轴，设置在轴的远侧区域上的可充气柔顺气囊和外部充气部件。

3. 发明申请

WO2006135772A2 ASSEMBLY AND METHOD FOR FORMING AN OCCLUSION IN A VASCULAR CAVITY 审中-公开
标题翻译：用于在血管腔中形成闭塞的组装和方法
公开(公告)号：WO2006135772A2
公开(公告)日：2006-12-21
申请号：PCT/US2006/022529
申请日：2006-06-09
申请人： BOSTON SCIENTIFIC SCIMED, INC. , GRIFFIN, Stephen
发明人： GRIFFIN, Stephen
IPC分类号： A61B17/12
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B90/39 , A61B2017/12063
摘要： A method and assembly for forming an occlusion within a vascular cavity. The assembly includes a catheter having an elongate shaft comprising a metallic tubular member extending from a proximal portion to a distal portion of the catheter, a delivery wire including an occlusion member detachably coupled thereto, and a power supply for providing an electrical current to initiate electrolysis at a sacrificial link between the delivery wire and the occlusion member in order to decouple the occlusion member from the delivery wire. The invention also includes a method of positioning and disposing an occlusion member within a vascular cavity using electrolysis, wherein a distal portion of the metallic tubular member serves as a first electrode and the sacrificial link serves as a second electrode. Thus, both the first electrode and the second electrode may be intravenously located proximate a vascular cavity.
摘要翻译：用于在血管腔内形成闭塞的方法和组件。组件包括具有细长轴的导管，该细长轴包括从导管的近端部分延伸到远端部分的金属管状构件，包括可拆卸地连接到其上的遮挡构件的输送线以及用于提供电流以启动电解的电源在输送线和闭塞构件之间的牺牲连接处，以便将闭塞构件与输送线分离。本发明还包括一种使用电解定位和将阻塞构件设置在血管腔内的方法，其中金属管状构件的远侧部分用作第一电极，牺牲环用作第二电极。因此，第一电极和第二电极都可以静脉内定位在血管腔附近。

4. 发明申请

WO2007050718A1 ELONGATE MEDICAL DEVICE WITH CONTINUOUS REINFORCEMENT MEMBER 审中-公开
标题翻译：具有连续加固成员的ELONGATE医疗设备
公开(公告)号：WO2007050718A1
公开(公告)日：2007-05-03
申请号：PCT/US2006/041712
申请日：2006-10-25
申请人： BOSTON SCIENTIFIC SCIMED, INC. , GRIFFIN, Stephen , LIM, Elaine , CHAN, Huey Quoc
发明人： GRIFFIN, Stephen , LIM, Elaine , CHAN, Huey Quoc
IPC分类号： A61M25/00
CPC分类号： A61M25/0013 , A61M25/0045 , A61M25/0051 , A61M25/0053 , A61M25/0054 , A61M2025/006
摘要： An elongate medical device including an inner elongate member, a reinforcing member, and an outer tubular member is described. The reinforcing member may be a helically wound continuous wire including a first portion having a first cross-sectional profile, a second portion having a second cross-sectional profile, and a transition region located between the first portion and the second portion. The first cross-sectional profile may be different from the second cross-sectional profile. In some embodiments, the first cross-sectional profile may be circular or non-circular and the second cross-sectional profile may be circular or non-circular.
摘要翻译：描述了包括内部细长构件，加强构件和外部管状构件的细长医疗装置。加强构件可以是螺旋缠绕的连续线，包括具有第一横截面轮廓的第一部分，具有第二横截面轮廓的第二部分和位于第一部分和第二部分之间的过渡区域。第一截面轮廓可以不同于第二横截面轮廓。在一些实施例中，第一横截面轮廓可以是圆形或非圆形，并且第二横截面轮廓可以是圆形或非圆形。

5. 发明申请

WO2006065517A1 CATHETER HAVING AN ULTRA SOFT TIP AND METHODS FOR MAKING THE SAME 审中-公开
标题翻译：具有超软提示的导管及其制造方法
公开(公告)号：WO2006065517A1
公开(公告)日：2006-06-22
申请号：PCT/US2005/043017
申请日：2005-11-29
申请人： BOSTON SCIENTIFIC SCIMED, INC. , GRIFFIN, Stephen , CHAN, Huey Quoc , LIM, Elaine , JANSEN, Lex Philip , TASSONI, Anthony F., Jr.
发明人： GRIFFIN, Stephen , CHAN, Huey Quoc , LIM, Elaine , JANSEN, Lex Philip , TASSONI, Anthony F., Jr.
IPC分类号： A61M25/10 , A61M25/00
CPC分类号： A61M25/10 , A61M25/0069 , A61M2025/1093 , Y10T29/49826
摘要： An intravascular balloon catheter (10) having an ultra soft tip. The catheter includes a braided reinforcement member (70) extending substantially the length of the elongate shaft (60). A balloon (50) is disposed at the distal end of the elongate shaft. An ultra soft tip is formed from a distal portion of balloon material extending distal of the distal end of the elongate shaft.
摘要翻译：具有超软尖端的血管内气囊导管（10）。导管包括基本上延伸的细长轴（60）的长度延伸的编织加强件（70）。气球（50）设置在细长轴的远端。超软尖端由从细长轴远端延伸的球囊材料的远端部分形成。

6. 发明申请

WO2006062757A1 CATHETER INCLUDING A COMPLIANT BALLOON 审中-公开
标题翻译：导管包括合适的气球
公开(公告)号：WO2006062757A1
公开(公告)日：2006-06-15
申请号：PCT/US2005/043019
申请日：2005-11-29
申请人： BOSTON SCIENTIFIC SCIMED, INC. , GRIFFIN, Stephen , CHAN, Huey Quoc , LIM, Elaine , TO, Nhan Hue
发明人： GRIFFIN, Stephen , CHAN, Huey Quoc , LIM, Elaine , TO, Nhan Hue
IPC分类号： A61M25/00 , A61M25/10 , A61B17/22
CPC分类号： A61M25/1002 , A61B17/22032 , A61M25/0054 , A61M25/0105 , A61M25/10
摘要： A catheter (10) having an elongate shaft including a plurality of apertures disposed along at least a length of the shaft to facilitate bending. The catheter (10) includes an inflatable balloon (20), wherein a subset of the plurality of apertures (100) provides fluid communication from an inflation lumen (80) to the inflatable balloon (20).
摘要翻译：一种具有细长轴的导管（10），其包括沿轴的至少一段长度设置的多个孔，以便于弯曲。导管（10）包括一个可充气气球（20），其中多个孔（100）的一个子集提供从充气腔（80）到可膨胀球囊（20）的流体连通。

7. 发明申请

WO2006060312A1 SELECTIVELY FLEXIBLE CATHETER AND METHOD OF USE 审中-公开
标题翻译：选择灵活的导管和使用方法
公开(公告)号：WO2006060312A1
公开(公告)日：2006-06-08
申请号：PCT/US2005/042914
申请日：2005-11-29
申请人： BOSTON SCIENTIFIC SCIMED, INC. , GRIFFIN, Stephen
发明人： GRIFFIN, Stephen
IPC分类号： A61M25/00
CPC分类号： A61M25/0054 , A61M25/005 , A61M25/0053 , A61M2025/0064 , A61M2205/0266 , A61M2205/36
摘要： Catheter assembly including an elongate shaft comprising a thermoplastic polymer such as a thermoplastic shape memory polymer having a pre-selected glass transition temperature (Tg) and a means for heating the thermoplastic polymer, wherein the thermoplastic polymer is in a rubbery state at temperatures above the glass transition temperature and is in a glassy state at temperatures below the glass transition temperature. The elongate shaft may be selectively heated and cooled to provide sufficient flexibility and retention during a medical procedure.
摘要翻译：导管组件包括细长轴，其包括热塑性聚合物，例如具有预先选择的玻璃化转变温度（Tg）的热塑性形状记忆聚合物和用于加热热塑性聚合物的装置，其中热塑性聚合物在高于玻璃化转变温度，并且在低于玻璃化转变温度的温度下处于玻璃态。细长轴可以被选择性地加热和冷却，以在医疗过程中提供足够的灵活性和保持力。

8. 发明申请

WO2016019028A1 HYPOTUBE CONSTRUCTION 审中-公开
标题翻译： HYPOTUBE建筑
公开(公告)号：WO2016019028A1
公开(公告)日：2016-02-04
申请号：PCT/US2015/042676
申请日：2015-07-29
申请人： SULLIVAN, Gregory , GRIFFIN, Stephen
发明人： SULLIVAN, Gregory , GRIFFIN, Stephen
IPC分类号： A61B17/94 , A61L29/14 , B32B1/08
CPC分类号： A61M25/0054 , A61F2/958 , A61L29/085 , A61L29/14 , A61L2400/10 , A61M25/0013 , A61M25/0045 , A61M25/0051 , A61M25/0053 , A61M25/09 , A61M25/10 , A61M2025/0046 , A61M2025/0047 , B32B1/08 , B32B15/08 , B32B15/18 , B32B27/08 , B32B27/281 , B32B27/32 , B32B27/322 , B32B27/34 , B32B27/40 , B32B2255/10 , B32B2255/26 , B32B2535/00 , C08L77/00 , C08L75/04 , C08L77/12
摘要： A medical device such as a catheter may have an elongate shaft that includes a hypotube having a cut formed therein. The elongate shaft may define a lumen that extends within the elongate shaft. A polymer may be disposed over at least a portion of the hypotube. A medical device may include a cut hypotube having a constant pitch and may be configured to reversibly and temporarily alter the pitch of at least a portion of the cut hypotube. In some cases, the medical device may be configured to reversibly and/or temporarily alter a compressive strength of at least a portion of the cut hypotube.
摘要翻译：诸如导管的医疗装置可以具有细长轴，其包括形成在其中的切口的海波管。细长轴可以限定在细长轴内延伸的内腔。聚合物可以设置在海波波的至少一部分上。医疗装置可以包括具有恒定节距的切割海波管，并且可以被配置为可逆地和临时地改变切割海波管的至少一部分的俯仰。在一些情况下，医疗装置可以构造成可逆地和/或暂时地改变切割海波管的至少一部分的抗压强度。

9. 发明申请

WO2015188013A1 METHOD AND SYSTEM FOR CONSISTENT, REPEATABLE, AND SAFE CRYOSPRAY TREATMENT OF AIRWAY TISSUE 审中-公开
标题翻译：航空组织的一致性，可重复性和安全性结晶治疗的方法和系统
公开(公告)号：WO2015188013A1
公开(公告)日：2015-12-10
申请号：PCT/US2015/034301
申请日：2015-06-04
申请人： CSA MEDICAL, INC. , MANERS, Wendelin , SHEETS, Ellen , CORDERO, Rafael , DAVIDSON, Marc , FAN, Wei , SHERRILL, David , HANLEY, Brian, M. , SARLI, Amy , GRIFFIN, Stephen , HAWKE, Heather, V.
发明人： MANERS, Wendelin , SHEETS, Ellen , CORDERO, Rafael , DAVIDSON, Marc , FAN, Wei , SHERRILL, David , HANLEY, Brian, M. , SARLI, Amy , GRIFFIN, Stephen , HAWKE, Heather, V.
IPC分类号： A61B18/02 , F25D31/00
CPC分类号： A61B18/0218 , A61B90/98 , A61B2018/00041 , A61B2018/00172 , A61B2018/00541 , A61B2018/00577 , A61B2018/00642 , A61B2018/00714 , A61B2018/00744 , A61B2018/00761 , A61B2018/00791 , A61B2018/00863 , A61B2018/00988 , A61B2018/0212 , A61B2018/0231
摘要： A method and system for automated and semi-automated predictable, consistent, safe, effective, and lumen-specific and patient-specific cryospray treatment of airway tissue in which treatment duration is automatically set by the system following entry of patient information and treatment location information into the system by the user, and treatment spray is automatically stopped by the system when the automatically selected treatment duration has been achieved as determined by the system.
摘要翻译：用于气道组织的自动化和半自动可预测，一致，安全，有效和流明特异性和患者特异性冷冻喷雾治疗的方法和系统，其中治疗持续时间由患者信息和治疗位置信息输入之后由系统自动设定使用者进入系统时，系统确定自动选择的治疗时间后，系统会自动停止治疗喷雾。

10. 发明申请

WO2004005333A1 USE OF HEPATITIS C VIRUS (HCV) P7 PROTEIN 审中-公开
标题翻译： HEPATITIS C病毒（HCV）P7蛋白的使用
公开(公告)号：WO2004005333A1
公开(公告)日：2004-01-15
申请号：PCT/GB2003/002937
申请日：2003-07-07
申请人： UNIVERSITY OF LEEDS , ROWLANDS, David , GRIFFIN, Stephen
发明人： ROWLANDS, David , GRIFFIN, Stephen
IPC分类号： C07K14/18
CPC分类号： C07K14/005 , C12N2770/24222 , G01N33/6872 , G01N2500/00
摘要： The present invention relates to the use of hepatitis C virus (HCV) p7 protein, and particularly but not exclusively, to its use in rationalised drug design and as a screen for antiviral therapeutic agents.
摘要翻译：本发明涉及丙型肝炎病毒（HCV）p7蛋白的用途，特别是但不排他地用于合理化的药物设计和作为抗病毒治疗剂的筛选。

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