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1. 发明申请

WO2008121933A1 USING MAGNETISM TO PREPARE A MEDICAL DEVICE 审中-公开
标题翻译：使用MAGNETISM制定医疗器械
公开(公告)号：WO2008121933A1
公开(公告)日：2008-10-09
申请号：PCT/US2008/058848
申请日：2008-03-31
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ATANASOSKA, Liliana , FLANAGAN, Aiden , O'CONNOR, Timothy , MCMORROW, David , NOLAN, Robert , MALONE, Anthony , WEBER, Jan
发明人： ATANASOSKA, Liliana , FLANAGAN, Aiden , O'CONNOR, Timothy , MCMORROW, David , NOLAN, Robert , MALONE, Anthony , WEBER, Jan
IPC分类号： A61F2/82 , B05D1/00 , B05B5/00 , B05C3/09 , A61L31/10
CPC分类号： B05B5/00 , A61F2/91 , A61F2210/009 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/60 , A61L2300/62 , B05C3/09 , B05D1/18 , B05D1/32 , B05D3/207 , B05D2401/32
摘要： The present invention is directed to methods, processes, and systems for delivering therapeutic agent to a medical device (114). Under some methods, processes, and systems of the invention, particles including a magnetic material (122) and a therapeutic agent may be directed towards a medical device via magnetic attraction (132). In another embodiment particles including a magnetic material may force a therapeutic agent/solvent solution into porous matrix by using a magnetic attraction. In still another embodiment, a medical device having at least a portion thereof including a magnetic material is used to attract and adhere particles comprising magnetic material and therapeutic agent to a target surface of the medical device, wherein the particles are fused to the target surface.
摘要翻译：本发明涉及将治疗剂递送到医疗装置（114）的方法，过程和系统。在一些方法下，本发明的方法和系统可以通过磁吸引（132）将包括磁性材料（122）和治疗剂的颗粒引向医疗装置。在另一个实施方案中，包括磁性材料的颗粒可以通过使用磁吸引剂将治疗剂/溶剂溶液强制成多孔基质。在另一个实施例中，使用包括磁性材料的至少其一部分的医疗装置将包含磁性材料和治疗剂的颗粒吸附并附着到医疗装置的靶表面上，其中所述颗粒与目标表面融合。

2. 发明申请

WO2007133348A1 PARTIALLY COATED WORKPIECE AND METHOD OF MAKING SAME 审中-公开
标题翻译：部分涂层工件及其制造方法
公开(公告)号：WO2007133348A1
公开(公告)日：2007-11-22
申请号：PCT/US2007/008337
申请日：2007-04-05
申请人： BOSTON SCIENTIFIC SCIMED, INC. , NOLAN, Robert , MCMORROW, Dave , O'CONNOR, Timothy , HEANEY, Barry , FLANAGAN, Aiden , MALONE, Anthony , MCGOVERN, James
发明人： NOLAN, Robert , MCMORROW, Dave , O'CONNOR, Timothy , HEANEY, Barry , FLANAGAN, Aiden , MALONE, Anthony , MCGOVERN, James
IPC分类号： B05D1/32 , B05D7/22
CPC分类号： B05D1/32 , B05D7/22 , B05D2254/02 , B05D2254/04 , B05D2254/06 , B05D2258/00 , B05D2701/00
摘要： The present invention is directed to methods and processes for coating portions of a workpiece as well as to workpieces that have themselves been coated with one or more of these processes. Under these methods and processes a masking material may be positioned over a portion of a workpiece prior to applying coating to the workpiece. Once the coating is applied this masking may be removed to expose a portion of the workpiece that has not been coated.
摘要翻译：本发明涉及用于涂覆工件的部分以及本身已经用这些工艺中的一种或多种涂覆的工件的方法和工艺。在这些方法和工艺之前，可以在将涂层施加到工件之前将掩模材料定位在工件的一部分上方。一旦施加涂层，可以去除该掩模以暴露未被涂覆的工件的一部分。

3. 发明申请

WO2010101901A2 SELF-BUFFERING MEDICAL IMPLANTS 审中-公开
标题翻译：自助医疗植入物
公开(公告)号：WO2010101901A2
公开(公告)日：2010-09-10
申请号：PCT/US2010/025896
申请日：2010-03-02
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ATANASOSKA, Liliana , SHIPPY, James, Lee, III , HOLMAN, Tom , ARNEY, Michael, S. , SCHOENLE, Victor , GENOVESE, Frank , FENG, James Q. , FLANAGAN, Aiden , WEBER, Jan
发明人： ATANASOSKA, Liliana , SHIPPY, James, Lee, III , HOLMAN, Tom , ARNEY, Michael, S. , SCHOENLE, Victor , GENOVESE, Frank , FENG, James Q. , FLANAGAN, Aiden , WEBER, Jan
IPC分类号： A61L27/04
CPC分类号： A61L31/148 , A61L27/34 , A61L27/446 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/128 , A61L31/16 , A61L2300/416 , A61L2300/604 , A61L2400/12 , A61L2420/04 , C08L67/04
摘要： A medical implant includes a bioerodible portion that includes a bioerodible polymer and a bioerodible metal. The bioerodible polymer matrix degrades under physiological conditions to form acidic degradation products. The bioerodible metal degrades under physiological conditions to form basic degradation products. The acidic degradation products and the basic degradation products buffer at least a portion of the medical implant. In one aspect, the bioerodible portion includes a bioerodible polymer matrix and a bioerodible metal within the bioerodible polymer matrix. In another aspect, the medical implant can include a body, a plurality of discrete deposits of the bioerodible polymer on the body, and a plurality of discrete deposits of the bioerodible metal on the body.
摘要翻译：医疗植入物包括生物腐蚀性部分，其包括生物可蚀解聚合物和生物腐蚀性金属。生物可蚀解聚合物基质在生理条件下降解形成酸性降解产物。生物腐蚀金属在生理条件下降解形成碱性降解产物。酸性降解产物和碱性降解产物缓冲至少一部分医用植入物。在一个方面，生物可蚀解部分包括生物可腐蚀聚合物基质和生物可腐蚀的聚合物基质内的生物可腐蚀金属。在另一方面，医疗植入物可以包括主体，身体上的生物可蚀解聚合物的多个离散沉积物，以及身体上的生物可腐蚀金属的多个离散沉积物。

4. 发明申请

WO2008106223A1 COATED MEDICAL DEVICES FOR ABLUMINAL DRUG DELIVERY 审中-公开
标题翻译：用于药物输送的涂层医疗装置
公开(公告)号：WO2008106223A1
公开(公告)日：2008-09-04
申请号：PCT/US2008/002713
申请日：2008-02-29
申请人： BOSTON SCIENTIFIC SCIMED, INC. , McMORROW, David , HEANEY, Barry , MALONE, Anthony , FLANAGAN, Aiden , O'CONNOR, Tim
发明人： McMORROW, David , HEANEY, Barry , MALONE, Anthony , FLANAGAN, Aiden , O'CONNOR, Tim
IPC分类号： A61F2/90
CPC分类号： A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2230/0013 , A61F2250/0036 , A61F2250/0068 , B33Y80/00
摘要： The invention relates generally to an implantable medical device for delivering a therapeutic agent to the body tissue of a patient, and a method for making such a medical device. In particular, the invention pertains to an implantable stent, such as an intravascular stent, having a coating comprising an inorganic or ceramic oxide, metal or inert carbon and a plurality of reservoirs in such material that contain a therapeutic agent.
摘要翻译：本发明一般涉及用于将治疗剂递送到患者的身体组织的可植入医疗装置，以及用于制造这种医疗装置的方法。特别地，本发明涉及可植入支架，例如血管内支架，其具有包含无机或陶瓷氧化物，金属或惰性碳的涂层以及包含治疗剂的这种材料中的多个储存器。

5. 发明申请

WO2007133419A3 PARTIALLY COATED WORKPIECES AND METHOD AND SYSTEM FOR MAKING THE SAME 审中-公开
公开(公告)号：WO2007133419A3
公开(公告)日：2007-11-22
申请号：PCT/US2007/010184
申请日：2007-04-27
申请人： BOSTON SCIENTIFIC SCIMED, INC. , MALONE, Anthony , MCMORROW, Dave , HEANEY, Barry , O'CONNOR, Timothy , FLANAGAN, Aiden
发明人： MALONE, Anthony , MCMORROW, Dave , HEANEY, Barry , O'CONNOR, Timothy , FLANAGAN, Aiden
IPC分类号： B05D1/00 , B05D1/32
摘要： The present invention is directed to methods, processes, and systems for coating portions of a workpiece as well as to workpieces that have themselves been coated in accord with the invention. Under these methods and processes of the invention, a workpiece may be rotated to drive coating away from a non-target surface. In some embodiments, surfaces of the workpiece may be pre-treated. Still further, in accord with the embodiments of the present invention, the workpiece may be positioned in a treatment chamber. In still other embodiments, the workpiece may be an implantable medical device and the coating may include a therapeutic.

6. 发明申请

WO2009158276A2 MEDICAL DEVICES CONTAINING THERAPEUTIC AGENTS 审中-公开
标题翻译：含有治疗药物的医疗器械
公开(公告)号：WO2009158276A2
公开(公告)日：2009-12-30
申请号：PCT/US2009/047899
申请日：2009-06-19
申请人： BOSTON SCIENTIFIC SCIMED, INC. , CLARKE, John , O'CONNOR, Tim , O'BRIEN, Barry, J. , MCMORROW, David , WEBER, Jan , FLANAGAN, Aiden
发明人： CLARKE, John , O'CONNOR, Tim , O'BRIEN, Barry, J. , MCMORROW, David , WEBER, Jan , FLANAGAN, Aiden
IPC分类号： A61L31/02 , A61L31/08 , A61L31/14 , A61L31/16
CPC分类号： A61L31/16 , A61F2/82 , A61F2250/0014 , A61F2250/0025 , A61F2250/0026 , A61F2250/0037 , A61F2250/0067 , A61L27/30 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/082 , A61L31/146 , A61L2300/416 , A61L2300/63
摘要： The present invention pertains to implantable or insertable medical devices which comprise a substrate and one or more therapeutic-agent-containing regions contain one or more therapeutic agents. In various aspects of the invention, one or more characteristics of such therapeutic-agent-containing regions are controlled. Further aspects of the invention relate to methods of forming such devices and to methods of using such devices.
摘要翻译：本发明涉及可植入或可插入的医疗装置，其包括底物和含有一种或多种治疗剂的一种或多种含治疗剂的区域。在本发明的各个方面，控制这种含治疗剂的区域的一个或多个特征。本发明的其它方面涉及形成这种装置的方法以及使用这种装置的方法。

7. 发明申请

WO2009042667A3 MEDICAL DEVICES HAVING A METAL PARTICULATE COMPOSITION FOR CONTROLLED DIFFUSION 审中-公开
公开(公告)号：WO2009042667A3
公开(公告)日：2009-04-02
申请号：PCT/US2008/077496
申请日：2008-09-24
申请人： BOSTON SCIENTIFIC SCIMED, INC. , CLARKE, John , MCMORROW, David , FLANAGAN, Aiden , O'CONNOR, Tim , WEBER, Jan , O'BRIEN, Barry, J.
发明人： CLARKE, John , MCMORROW, David , FLANAGAN, Aiden , O'CONNOR, Tim , WEBER, Jan , O'BRIEN, Barry, J.
IPC分类号： A61L31/02 , A61L31/14 , A61L31/16
摘要： An implantable or insertable medical device is provided which includes as components: (a) a substrate component comprising a depression that is at least partially filled with a therapeutic agent-containing material that comprises a first therapeutic agent, and (b) a particulate composition disposed in the depression such that it regulates transport of chemical species between the depression and the exterior of the device upon implantation or insertion of the device into a subject.

8. 发明申请

WO2008140482A2 MEDICAL DEVICES HAVING COATINGS FOR CONTROLLED THERAPEUTIC AGENT DELIVERY 审中-公开
标题翻译：具有用于受控治疗药物递送的涂层的医疗装置
公开(公告)号：WO2008140482A2
公开(公告)日：2008-11-20
申请号：PCT/US2007/023601
申请日：2007-11-09
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WEBER, Jan , FLANAGAN, Aiden , O'CONNOR, Tim , O'BRIEN, Barry, J. , CLARKE, John , MCMORROW, David
发明人： WEBER, Jan , FLANAGAN, Aiden , O'CONNOR, Tim , O'BRIEN, Barry, J. , CLARKE, John , MCMORROW, David
IPC分类号： A61F2/82 , A61L31/08
CPC分类号： A61F2/06 , A61F2250/0068 , A61L27/30 , A61L27/54 , A61L31/082 , A61L31/16 , A61L2300/00 , A61L2400/12 , A61N1/05
摘要： According to an aspect of the invention, medical devices are provided, which include a nanoparticle-derived inorganic layer disposed over a least a portion of structure that includes a substrate, and optionally, a therapeutic-agent-containing layer disposed over at least a portion of the substrate. In some embodiments, the inorganic layer is a nanoporous inorganic layer. Other aspects of the invention comprise methods for forming such medical device.
摘要翻译：根据本发明的一个方面，提供了医疗装置，其包括设置在包括基底的结构的至少一部分上的纳米颗粒衍生的无机层，以及任选地，设置在至少一部分上的治疗剂含有层的基底。在一些实施方案中，无机层是纳米多孔无机层。本发明的其它方面包括用于形成这种医疗装置的方法。

9. 发明申请

WO2011008534A1 IMPLANTABLE SELF-POWERED BIODEGRADABLE MEDICAL DEVICE TO TREAT OR PREVENT REPERFUSION INJURY 审中-公开
标题翻译：可植入式自动生物可降解医疗设备治疗或预防再灌注损伤
公开(公告)号：WO2011008534A1
公开(公告)日：2011-01-20
申请号：PCT/US2010/040362
申请日：2010-06-29
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ATANASOSKA, Liliana , FLANAGAN, Aiden , DAVIS, Liza J. , HARRISON, Kent , SOGARD, David J.
发明人： ATANASOSKA, Liliana , FLANAGAN, Aiden , DAVIS, Liza J. , HARRISON, Kent , SOGARD, David J.
IPC分类号： A61M31/00 , A61N1/30
CPC分类号： A61M5/14276
摘要： In one embodiment, the present disclosure provides a biodegradable, self-powered medical device for preventing or reducing reperfusion injury, comprising a galvanic cell, the galvanic cell comprising: a first biodegradable electrode member; and a second biodegradable electrode member comprising a biodegradable conductive polymer and an electrode-releasable therapeutic agent, wherein the galvanic cell generates an electric force sufficient to cause the electrode-releasable therapeutic agent to be released from the biodegradable conductive polymer and elute to a target location. The device may further include a reservoir material containing a burst-release therapeutic agent.
摘要翻译：在一个实施方案中，本公开提供了一种用于预防或减少再灌注损伤的可生物降解的自供电医疗装置，包括原电池，所述原电池包括：第一可生物降解的电极构件; 以及包含可生物降解的导电聚合物和电极可释放的治疗剂的第二可生物降解的电极构件，其中所述原电池产生足以使所述电极可释放的治疗剂从所述可生物降解的导电聚合物释放并洗脱至目标位置的电力。该装置还可以包括含有爆发释放治疗剂的贮存器材料。

10. 发明申请

WO2010129184A2 MAGNETIC PARTICLES FOR DELIVERING THERAPEUTIC AGENT TO A TARGET LOCATION 审中-公开
标题翻译：用于将治疗药物递送至目标位置的磁性颗粒
公开(公告)号：WO2010129184A2
公开(公告)日：2010-11-11
申请号：PCT/US2010/032035
申请日：2010-04-22
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FLANAGAN, Aiden , HARRISON, Kent , ATANASOSKA, Liliana , SOGARD, David J. , DAVIS, Liza J.
发明人： FLANAGAN, Aiden , HARRISON, Kent , ATANASOSKA, Liliana , SOGARD, David J. , DAVIS, Liza J.
IPC分类号： A61K9/00
CPC分类号： A61K9/0009 , A61K9/1676 , A61K9/501 , A61K9/5094 , A61K9/5115
摘要： A system for delivering therapeutic agent to a target location in a body in accordance with one embodiment is provided comprising a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, and a magnetic device for attracting the magnetic particles to a target location. The magnetic particles may be delivered by a catheter into a blood vessel upstream from the target location so that they travel toward the target location. A method for delivering therapeutic agent to a target location in a body in accordance with another embodiment comprises providing a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, placing a magnetic device in a position to attract the magnetic particles to a target location, and allowing the magnetic particles to infuse the target location by the attraction of the magnetic particles to the magnetic device. The therapeutic agent may comprises a therapeutic agent for preventing or treating reperfusion injury, and the step of providing the plurality of magnetic particles may comprise delivering the plurality of magnetic particles through a blood vessel.
摘要翻译：提供了根据一个实施例的用于将治疗剂递送到身体中的目标位置的系统，其包括多个磁性颗粒，每个携带治疗剂的磁性颗粒和用于将磁性颗粒吸引到目标位置的磁性装置。磁性颗粒可以通过导管输送到目标位置上游的血管中，使得它们朝向目标位置行进。根据另一实施例的用于将治疗剂递送到身体中的目标位置的方法包括提供多个磁性颗粒，每个磁性颗粒携带治疗剂，将磁性装置放置在将磁性颗粒吸引到目标位置的位置，并且允许磁性颗粒通过磁性颗粒吸引到磁性装置来注入目标位置。治疗剂可以包括用于预防或治疗再灌注损伤的治疗剂，并且提供多个磁性颗粒的步骤可以包括通过血管递送多个磁性颗粒。

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