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1. 发明申请

WO2005003723A2 METHOD FOR UNIFORM APPLICATION OF FLUID INTO A REACTIVE REAGENT AREA 审中-公开
标题翻译：将流体均匀施加到活性试剂区域的方法
公开(公告)号：WO2005003723A2
公开(公告)日：2005-01-13
申请号：PCT/US2004019374
申请日：2004-06-16
申请人： BAYER HEALTHCARE LLC , PUGIA MICHAEL J , PROFITT JAMES A , KUO HAI-HANG , BLANKENSTEIN GERT , PETERS RALF-PETER , SCHULMAN LLOYD S
发明人： PUGIA MICHAEL J , PROFITT JAMES A , KUO HAI-HANG , BLANKENSTEIN GERT , PETERS RALF-PETER , SCHULMAN LLOYD S
IPC分类号： B01L3/00 , G01N20060101 , G01N1/10 , G01N15/06 , G01N21/00 , G01N33/00 , G01N33/48 , G01N
CPC分类号： B01L3/502746 , B01L3/502723 , B01L2200/0684 , B01L2200/16 , B01L2300/0816 , B01L2400/0406 , B01L2400/0409 , B01L2400/0418 , B01L2400/0487 , B01L2400/0688 , B01L2400/086 , Y10T436/2575
摘要： Analytical results obtained with microfluidic devices are improved by providing structural features in areas containing dry supported reagents, the structural features directing the flow of a sample over the area in a predetermined uniform manner and facilitating the purging of air.
摘要翻译：利用微流体装置获得的分析结果通过在含有干燥支持的试剂的区域中提供结构特征而得到改进，所述结构特征指导样品以预定的均匀方式在区域上流动并且有利于吹扫空气。

2. 发明申请

WO2005003724A3 METHOD AND APPARATUS FOR ENTRY AND STORAGE OF SPECIMENS INTO A MICROFLUIDIC DEVICE 审中-公开
标题翻译：将样品进入和储存到微流感器件中的方法和装置
公开(公告)号：WO2005003724A3
公开(公告)日：2005-12-22
申请号：PCT/US2004019375
申请日：2004-06-16
申请人： BAYER HEALTHCARE LLC , PUGIA MICHAEL J , PROFITT JAMES A , BLANKENSTEIN GERT , PETERS RALF-PETER
发明人： PUGIA MICHAEL J , PROFITT JAMES A , BLANKENSTEIN GERT , PETERS RALF-PETER
IPC分类号： B01L3/00 , B01L3/02 , G01N15/06 , G01N35/00
CPC分类号： B01L3/502746 , B01L3/5025 , B01L3/502715 , B01L2200/027 , B01L2200/0684 , B01L2300/0806 , B01L2300/0816 , B01L2400/0406 , B01L2400/0409 , B01L2400/0478 , B01L2400/0487 , B01L2400/0688 , B01L2400/086 , Y10T436/2575
摘要： A microfluidic device for analyzing biological samples is provided with a sample inlet section including an inlet port, a capillary passageway communicating with the inlet port and with an inlet chamber. The inlet chamber includes means for uniformly distributing the sample liquid across the inlet chamber and purging the air initially contained therein.
摘要翻译：用于分析生物样品的微流体装置设置有样品入口部分，其包括入口端口，与入口端口连通的毛细通道和入口室。入口室包括用于均匀地分布样品液体穿过入口室并净化最初容纳在其中的空气的装置。

3. 发明申请

WO2004105946A3 PACKAGING OF MICROFLUIDIC DEVICES 审中-公开
标题翻译：微流体装置的包装
公开(公告)号：WO2004105946A3
公开(公告)日：2005-08-11
申请号：PCT/US2004013394
申请日：2004-04-30
申请人： BAYER HEALTHCARE LLC , PUGIA MICHAEL J , PROFITT JAMES A , SOMMER RONALD G , JUNG SUNG-KWON
发明人： PUGIA MICHAEL J , PROFITT JAMES A , SOMMER RONALD G , JUNG SUNG-KWON
IPC分类号： B01L3/00 , G01N33/48
CPC分类号： B01L3/502707 , B01L2200/142 , B01L2200/16 , B01L2300/0672 , B01L2400/0406 , B01L2400/0677 , B01L2400/0683
摘要： A microfluidic device (10) having an inlet port (12) connected to a reagent chamber (14) by a passageway (16).
摘要翻译：具有通过通道（16）连接到试剂室（14）的入口（12）的微流体装置（10）。

4. 发明申请

WO03001213A9 TOTAL PROTEIN DETECTION METHODS AND DEVICES AT LOW PH 审中-公开
标题翻译：总蛋白检测方法和设备在低PH
公开(公告)号：WO03001213A9
公开(公告)日：2004-03-04
申请号：PCT/IB0202321
申请日：2002-06-21
申请人： BAYER HEALTHCARE LLC , PROFITT JAMES A , ORN ALEXANDER H , FARR JENNIFER
发明人： PROFITT JAMES A , ORN ALEXANDER H , FARR JENNIFER
IPC分类号： G01N21/78 , G01N33/52 , G01N33/543 , G01N33/68
CPC分类号： G01N33/6839 , G01N33/543
摘要： An assay for the determination of protein in an aqueous test fluid that comprises combining the test fluid with a buffer and a dye. The buffer is selected from citrulline, malonic acid, cyanoacetic acid, citraconic acid, methyl phosphonic acid, sarcosine, saccharin, or combinations thereof. The buffer is added in sufficient quantity to maintain the pH of the assay including the test fluid at a selected target pH range within a range of from about 2.0 to about 3.0. The dye has a pKa which enables it to operate as a protein indicator at the target pH range. The dye also has affinity for protein such that it will provide a detectable response in the presence of greater than about 15 mg/dL protein to thereby render the assay suitable for the detection of total protein in the test fluid. The buffer and dye may be absorbed in a test strip of absorbent material.
摘要翻译：用于测定水性测试流体中的蛋白质的测定法，其包括将测试流体与缓冲液和染料组合。缓冲液选自瓜氨酸，丙二酸，氰基乙酸，柠康酸，甲基膦酸，肌氨酸，糖精或其组合。以足够的量加入缓冲液，以将测定液的pH值保持在约2.0至约3.0范围内的选定目标pH范围。染料具有使其能够在目标pH范围内作为蛋白质指示剂操作的pKa。染料还对蛋白质具有亲和力，使得其在大于约15mg / dL蛋白质的存在下提供可检测的响应，从而使测定法适合于检测测试流体中的总蛋白质。缓冲液和染料可以吸收在吸收材料的测试条中。

5. 发明申请

WO03001213A2 TOTAL PROTEIN DETECTION METHODS AND DEVICES 审中-公开
标题翻译：总蛋白检测方法和设备
公开(公告)号：WO03001213A2
公开(公告)日：2003-01-03
申请号：PCT/IB0202321
申请日：2002-06-21
申请人： BAYER AG , PROFITT JAMES A , ORN ALEXANDER H , FARR JENNIFER
发明人： PROFITT JAMES A , ORN ALEXANDER H , FARR JENNIFER
IPC分类号： G01N21/78 , G01N33/52 , G01N33/543 , G01N33/68
CPC分类号： G01N33/6839 , G01N33/543
摘要： An assay for the determination of protein in an aqueous test fluid that comprises combining the test fluid with a buffer and a dye. The buffer is selected from citrulline, malonic acid, cyanoacetic acid, citraconic acid, methyl phosphonic acid, sarcosine, saccharin, or combinations thereof. The buffer is added in sufficient quantity to maintain the pH of the assay including the test fluid at a selected target pH range within a range of from about 2.0 to about 3.0. The dye has a pKa which enables it to operate as a protein indicator at the target pH range. The dye also has affinity for protein such that it will provide a detectable response in the presence of greater than about 15 mg/dL protein to thereby render the assay suitable for the detection of total protein in the test fluid. The buffer and dye may be absorbed in a test strip of absorbent material.
摘要翻译：用于测定水性测试流体中的蛋白质的测定法，其包括将测试流体与缓冲液和染料组合。缓冲液选自瓜氨酸，丙二酸，氰基乙酸，柠康酸，甲基膦酸，肌氨酸，糖精或其组合。以足够的量加入缓冲液，以将测定液的pH值保持在约2.0至约3.0范围内的选定目标pH范围。染料具有使其能够在目标pH范围内作为蛋白质指示剂操作的pKa。染料还对蛋白质具有亲和力，使得其在大于约15mg / dL蛋白质的存在下提供可检测的响应，从而使测定法适合于检测测试流体中的总蛋白质。缓冲液和染料可以吸收在吸收材料的测试条中。

6. 发明申请

WO2004061413A3 METHOD AND APPARATUS FOR SEPARATION OF PARTICLES IN A MICROFLUIDIC DEVICE 审中-公开
标题翻译：用于在微流体装置中分离颗粒的方法和装置
公开(公告)号：WO2004061413A3
公开(公告)日：2004-09-23
申请号：PCT/US0339375
申请日：2003-12-11
申请人： BAYER HEALTHCARE LLC
发明人： PUGIA MICHAEL J , PROFITT JAMES A , SCHULMAN LLOYD S , BLANKENSTEIN GERT , PETERS RALF-PETER
IPC分类号： B01D21/26 , B01L3/00 , G01N33/49 , G01N9/30
CPC分类号： B01L3/502753 , B01D21/262 , B01D2221/10 , B01L3/502723 , B01L2200/0668 , B01L2300/0816 , B01L2300/161 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , B01L2400/088 , G01N33/491 , Y10T436/111666
摘要： A microfluidic device provides separation of particles in a liquid sample, particularly, separation of a sample of whole blood into its components for further analysis. Separation into red blood cells and plasma occurs within a few seconds after the blood sample has been transferred from a sample well (12) into a separation chamber (14) with the application of centrifugal force of less than one up to about five times gravity. With the application of greater force measurement of hematocrit is possible.
摘要翻译：微流体装置提供液体样品中的颗粒的分离，特别是将全血样品分离成其组分用于进一步分析。在血液样品从样品井（12）转移到分离室（14）中后，在几分钟内分离出红细胞和血浆，施加离心力小于1至多约5倍的离心力。随着应用更大的力测量血细胞比容是可能的。

7. 发明申请

WO2004061414A3 METHOD AND APPARATUS FOR SPLITTING OF SPECIMENS INTO MULTIPLE CHANNELS OF A MICROFLUIDIC DEVICE 审中-公开
标题翻译：用于将样本分割成微流体设备的多个通道的方法和设备
公开(公告)号：WO2004061414A3
公开(公告)日：2004-10-07
申请号：PCT/US0339377
申请日：2003-12-11
申请人： BAYER HEALTHCARE LLC
发明人： PUGIA MICHAEL J , PROFITT JAMES A , BLANKENSTEIN GERT , PETERS RALF-PETER
IPC分类号： B01L3/00 , C12M1/34 , G01N20060101
CPC分类号： B01L3/5027 , B01L3/5025 , B01L3/50273 , B01L2200/0605 , B01L2200/0684 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688
摘要： A microliter liquid sample, particularly a biological sample, is analyzed in a device employing centrifugal and capillary forces. The sample is moved by capillary forces into one or more metering wells which define the amount of said sample to be analyzed in subsequent steps. The defined amount of the sample is transferred from the metering wells to one or more conditioning and reagent wells for measuring the amount of an analyte contained in each metered amount of the sample.
摘要翻译：在采用离心力和毛细管力的装置中分析微升液体样品，特别是生物样品。样品通过毛细作用力移动到一个或多个计量孔中，该计量孔确定了在后续步骤中待分析的所述样品的量。将限定量的样品从计量孔转移到一个或多个调节孔和试剂孔，用于测量每个计量量的样品中含有的分析物的量。

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