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1. 发明申请

WO2009018076A1 TUNABLY CROSSLINKED HYALURONIC ACID COMPOSITIONS 审中-公开
标题翻译： TUNABLY交联的羟丙酸组合物
公开(公告)号：WO2009018076A1
公开(公告)日：2009-02-05
申请号：PCT/US2008/070985
申请日：2008-07-24
申请人： ALLERGAN, INC. , STROUMPOULIS, Dimitrios , TEZEL, Ahmet
发明人： STROUMPOULIS, Dimitrios , TEZEL, Ahmet
IPC分类号： C08B37/08 , A61L27/20
CPC分类号： C08B37/0072 , A61L27/20 , A61L2430/34 , C08L5/08
摘要： The present invention relates to biocompatible crosslinked hyaluronic acid gel compositions, methods of their manufacture and use, and the crosslinkers used to make them. In one aspect of the invention, a polyethylene glycol crosslinking agent is described for crosslinking hyaluronic acid preferably a multifunctional one like 4-Arm Star PEG. In another aspect of the invention, crosslinking agents comprising more than two functional groups are described. These multifunctional crosslinking agents can be used on their own to crosslink hyaluronic acid, or they may be combined with bifunctional crosslinking agents in varying ratios to make hyaluronic acid of tunable mechanical strength and hardness. The present invention also discloses hyaluronic acid compositions that have been coated with polyethylene glycol and methods of their use.
摘要翻译：本发明涉及生物相容的交联透明质酸凝胶组合物，其制造和使用方法以及用于制备它们的交联剂。在本发明的一个方面，描述了用于交联透明质酸的聚乙二醇交联剂，优选为诸如4-臂星形PEG的多官能团。在本发明的另一方面，描述了包含多于两个官能团的交联剂。这些多功能交联剂可以单独使用以交联透明质酸，或者它们可以以不同比例与双功能交联剂组合以制备具有可调节的机械强度和硬度的透明质酸。本发明还公开了已经涂覆有聚乙二醇的透明质酸组合物及其使用方法。

2. 发明申请

WO2009073437A1 POLYSACCHARIDE GEL FORMULATION 审中-公开
标题翻译：多糖凝胶配方
公开(公告)号：WO2009073437A1
公开(公告)日：2009-06-11
申请号：PCT/US2008/084515
申请日：2008-11-24
申请人： ALLERGAN, INC. , STROUMPOULIS, Dimitrios , MUDD, Christopher, S. , TEZEL, Ahmet
发明人： STROUMPOULIS, Dimitrios , MUDD, Christopher, S. , TEZEL, Ahmet
IPC分类号： A61K8/60 , A61K8/73 , A61K8/04 , A61Q19/00 , A61Q19/08 , A61K9/10 , A61K31/738 , C08B37/00 , A61K9/00
CPC分类号： A61L27/26 , A61K8/042 , A61K8/492 , A61K8/60 , A61K8/602 , A61K8/676 , A61K8/678 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/736 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/727 , A61K31/728 , A61K31/737 , A61K31/738 , A61K47/183 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/42 , A61K2800/522 , A61L27/505 , A61Q19/08 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08K5/053 , C08L5/08 , C08L2205/02
摘要： Described herein are polysaccharide gel formulations including at least one inhibitor of polysaccharide degradation and methods of making the same. The methods described herein involve the steps of providing at least one polysaccharide and incorporating at least one inhibitor of degradation into the polysaccharide. In some embodiments, the incorporating step comprises 1 ) mixing the at least one inhibitor with the at least one polysaccharide at a highly hydrated state thereby encapsulating the at least one inhibitor in a polysaccharide network, and 2) dehydrating the polysaccharide network thereby controlling release kinetics or final swell ratio. In another embodiment, the incorporating step comprises 1) encapsulating at least one inhibitor into a biocompatible or biodegradable vessel and 2) combining the polysaccharide and the vessel into a gel formulation. The polysaccharide gel formulations described herein can be used for a variety of cosmetic applications.
摘要翻译：本文描述的是多糖凝胶制剂，其包括至少一种多糖降解抑制剂及其制备方法。本文描述的方法包括提供至少一种多糖并将至少一种降解抑制剂并入多糖中的步骤。在一些实施方案中，掺入步骤包括：1）以高水合状态将至少一种抑制剂与至少一种多糖混合，从而将至少一种抑制剂包封在多糖网络中，以及2）使多糖网络脱水从而控制释放动力学或最终膨胀比。在另一个实施方案中，掺入步骤包括：1）将至少一种抑制剂包封在生物相容性或可生物降解的容器中，和2）将多糖和血管结合成凝胶制剂。本文所述的多糖凝胶制剂可用于各种化妆品应用。

3. 发明申请

WO2011059909A1 POLYSACCHARIDE GEL FORMULATION HAVING MULTI-STAGE BIOACTIVE AGENT DELIVERY 审中-公开
标题翻译：具有多阶段生物交换剂的多糖凝胶配方
公开(公告)号：WO2011059909A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/055801
申请日：2010-11-08
申请人： ALLERGAN, INC. , STROUMPOULIS, Dimitrios , LESLIE, Dustin B. , MUDD, Christopher S. , TEZEL, Ahmet
发明人： STROUMPOULIS, Dimitrios , LESLIE, Dustin B. , MUDD, Christopher S. , TEZEL, Ahmet
IPC分类号： A61K8/60 , A61K8/73 , A61K8/04 , A61K8/34 , A61K9/10 , A61K47/36 , A61K47/10 , A61K47/26 , A61K31/728 , A61K31/738
CPC分类号： A61K8/042 , A61K8/492 , A61K8/60 , A61K8/602 , A61K8/676 , A61K8/678 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/736 , A61K9/0024 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/727 , A61K31/728 , A61K31/737 , A61K31/738 , A61K47/12 , A61K47/36 , A61K2800/522 , A61Q19/08 , C08B37/0072 , C08J3/075 , C08J3/12 , C08J3/128 , C08J3/24 , C08J2351/02 , C08K5/0025 , C08L1/02 , C08L5/04 , C08L5/08 , C08L5/10
摘要： Described herein are polysaccharide gel formulations including at least one inhibitor of polysaccharide degradation and methods of making the same. The methods described herein involve the steps of providing at least one polysaccharide and incorporating at least one inhibitor of degradation into the polysaccharide.
摘要翻译：本文描述的是多糖凝胶制剂，其包括至少一种多糖降解抑制剂及其制备方法。本文描述的方法包括提供至少一种多糖并将至少一种降解抑制剂并入多糖中的步骤。

4. 发明申请

WO2012054752A1 TUNABLY CROSSLINKED POLYSACCHARIDE COMPOSITIONS 审中-公开
标题翻译： TUNABLY交联多糖组合物
公开(公告)号：WO2012054752A1
公开(公告)日：2012-04-26
申请号：PCT/US2011/057137
申请日：2011-10-20
申请人： ALLERGAN, INC. , STROUMPOULIS, Dimitrios , TEZEL, Ahmet
发明人： STROUMPOULIS, Dimitrios , TEZEL, Ahmet
IPC分类号： A61L27/20 , A61L27/52 , A61L27/58
CPC分类号： A61L27/20 , A61L27/52 , A61L2400/06 , A61L2430/34 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08L5/08
摘要： The present specification generally relates to injectable dermal fillers including multifunctional polyethylene glycol-based crosslinking agents, hydrogel compositions comprising a matrix polymer crosslinked with such crosslinking agents, and methods of treating a soft tissue condition using such hydrogel compositions.
摘要翻译：本说明书通常涉及可注射的真皮填料，包括多官能聚乙二醇基交联剂，包含与这种交联剂交联的基质聚合物的水凝胶组合物，以及使用这种水凝胶组合物治疗软组织病症的方法。

5. 发明申请

WO2011146713A1 MODULAR INJECTION DEVICE 审中-公开
标题翻译：模块化注射装置
公开(公告)号：WO2011146713A1
公开(公告)日：2011-11-24
申请号：PCT/US2011/037147
申请日：2011-05-19
申请人： ALLERGAN, INC. , MUDD, Christopher S. , TEZEL, Ahmet , QIU, Shaohui , POWERS, Lee F.
发明人： MUDD, Christopher S. , TEZEL, Ahmet , QIU, Shaohui , POWERS, Lee F.
IPC分类号： A61M5/142 , A61M5/145 , A61M5/20
CPC分类号： A61M5/20 , A61M5/1413 , A61M5/14244 , A61M5/14546 , A61M5/14566 , A61M5/3129 , A61M2005/2407 , A61M2005/2496 , A61M2005/3125 , A61M2005/3126 , A61M2205/14 , A61M2205/3334 , A61M2205/586 , A61M2205/8206 , A61M2205/8268 , A61M2209/086 , A61M2209/088
摘要： A modular injection device for administration of dermal filler compositions is provided. The injection device may include a handheld injector unit including a drive unit, the drive unit configured to apply an extrusion force to a fluid; a control unit remote from the injector unit, the control unit configured to control the drive unit; and a cable configured to connect the control unit to the injector unit.
摘要翻译：提供了用于施用皮肤填充剂组合物的模块化注射装置。注射装置可以包括手动注射器单元，其包括驱动单元，该驱动单元被配置为向流体施加挤压力; 远离所述喷射器单元的控制单元，所述控制单元被配置为控制所述驱动单元; 以及配置成将控制单元连接到喷射器单元的电缆。

6. 发明申请

WO2009158145A2 INJECTION DEVICE FOR SOFT-TISSUE AUGMENTATION FILLERS, BIOACTIVE AGENTS AND OTHER BIOCOMPATIBLE MATERIALS IN LIQUID OR GEL FORM 审中-公开
标题翻译：用于软组织填充填料，生物剂和液体或凝胶形式中的其他生物成分材料的注射装置
公开(公告)号：WO2009158145A2
公开(公告)日：2009-12-30
申请号：PCT/US2009/045831
申请日：2009-06-01
申请人： ALLERGAN, INC. , MUDD, Christopher, S. , TEZEL, Ahmet
发明人： MUDD, Christopher, S. , TEZEL, Ahmet
IPC分类号： A61M5/20
CPC分类号： A61M5/2053 , A61B5/150129 , A61M5/19 , A61M5/20 , A61M5/24 , A61M5/2448 , A61M5/31575 , A61M5/422 , A61M5/427 , A61M5/46 , A61M39/24 , A61M2005/2006 , A61M2005/2411 , A61M2005/3125 , A61M2005/3126 , A61M2005/3128 , A61M2005/31588 , A61M2202/0007 , A61M2202/049 , A61M2202/09 , A61M2202/20 , A61M2205/19 , A61M2205/3569 , A61M2205/36 , A61M2205/3606 , A61M2205/502 , A61M2205/52 , A61M2205/586 , A61M2205/587 , A61M2205/6045 , A61M2205/6063 , A61M2205/8206 , A61M2205/8212 , A61M2205/8237 , A61M2205/8243 , A61M2210/04
摘要： Described herein are injection devices capable of automatically injecting substances into the soft tissue of a patient. The devices can inject low to high viscosity materials at predetermined, user selected injection rates, allowing the operator more control than a traditional syringe. The devices can allow mixing of more than one substance and/or reconstitution of a solid substance for injection. The injection devices described herein can allow the operator to easily inject one or more low to high viscosity liquid or gel soft-tissue augmentation fillers, one or more drugs, one or more other biocompatible materials, or combinations thereof.
摘要翻译：这里描述的是能够将物质自动注射到患者的软组织中的注射装置。这些装置可以以预定的用户选择的注射速率注入低至高粘度的材料，使得操作者比传统注射器更加控制。该装置可以允许多于一种物质的混合和/或用于注射的固体物质的重建。本文所述的注射装置可以允许操作者容易地注入一种或多种低至高粘度液体或凝胶软组织增强填料，一种或多种药物，一种或多种其它生物相容性材料或其组合。

7. 发明申请

WO2012154948A1 NEEDLE GUARD TO PROTECT ACCESS PORT TUBING 审中-公开
标题翻译：针头保护接入口管
公开(公告)号：WO2012154948A1
公开(公告)日：2012-11-15
申请号：PCT/US2012/037305
申请日：2012-05-10
申请人： ALLERGAN, INC. , CHITRE, Kaustubh S. , HONARYAR, Babak , TEZEL, Ahmet , MANESIS, Nicholas J.
发明人： CHITRE, Kaustubh S. , HONARYAR, Babak , TEZEL, Ahmet , MANESIS, Nicholas J.
IPC分类号： A61F5/00 , A41D19/015 , A41H1/02 , F41H5/04
CPC分类号： A61F2/12 , A61B90/02 , A61F5/0043 , A61F5/0056 , A61F2250/0003 , A61F2250/0004
摘要： A device for the treatment of the obesity (406) comprising an access part (404) a tube (402) and a needle guard assembly, suitable to protect the tube leading from the implantable access port. The needle guard assembly may include a first composite guard and a second composite guard, each composite guard including an arrangement of puncture resistant members and a flexible substrate having a first side on which the puncture resistant members are positioned. The needle guard assembly may comprise a sleeve extending over an end of the tube.
摘要翻译：一种用于治疗肥胖症的装置（406），其包括适于保护从可植入进入口导出的管的管（402）和针保护组件的通路部分（404）。针护罩组件可以包括第一复合防护件和第二复合防护件，每个复合防护罩包括防穿刺构件的布置和具有第一侧的柔性基底，防刺构件被定位在其上。针护罩组件可以包括在管的一端延伸的套筒。

8. 发明申请

WO2010065649A1 INJECTION DEVICE 审中-公开
标题翻译：注射装置
公开(公告)号：WO2010065649A1
公开(公告)日：2010-06-10
申请号：PCT/US2009/066427
申请日：2009-12-02
申请人： ALLERGAN, INC. , TEZEL, Ahmet , MCNERNEY, Kevin , MUDD, Christopher, S. , STORIE, Blake, R. , MANDAROUX, Bastien
发明人： TEZEL, Ahmet , MCNERNEY, Kevin , MUDD, Christopher, S. , STORIE, Blake, R. , MANDAROUX, Bastien
IPC分类号： A61M5/34
CPC分类号： A61M5/347 , A61M5/3293 , A61M2210/04
摘要： An injection device (10) includes a syringe (12) having a body (14) with a piston (18) disposed therein with an open end along with a viscous fluid disposed in the body for injection by the piston. A needle assembly (26) is provided which includes a cannula (30) having a luer connection engageable with the syringe distal end with the luer connector including a hub. Mating engagement is provided by way of internal threads at the syringe distal end and external treads of a hub with a pitch sufficient to prevent detachment of the hub from the syringe distal end during ejection of the viscous fluid. In addition, a stepped cavity, disposed in the hub, further prevents detachment of the hub from the syringe distal end during ejection of the viscous fluid.
摘要翻译：注射装置（10）包括具有本体（14）的注射器（12），其具有设置在其中的活塞（18），开口端与设置在主体中用于由活塞注射的粘性流体连接。提供一种针组件（26），其包括套管（30），所述套管具有可与注射器远端接合的鲁尔连接件，鲁尔连接器包括轮毂。配合接合通过注射器远端的内螺纹和具有足以防止在排出粘性流体期间将轮毂从注射器远端分离的间距的毂的外胎面提供。此外，设置在轮毂中的阶梯式空腔进一步防止在排出粘性流体期间轮毂从注射器远端脱离。

9. 发明申请

WO2011028370A1 SYSTEM INCLUDING ACCESS PORT AND APPLICATOR TOOL 审中-公开
标题翻译：系统包括进出口和应用工具
公开(公告)号：WO2011028370A1
公开(公告)日：2011-03-10
申请号：PCT/US2010/044957
申请日：2010-08-10
申请人： ALLERGAN, INC. , OLROYD, Craig , MUDD, Christopher , TEZEL, Ahmet , TURNER, Kris
发明人： OLROYD, Craig , MUDD, Christopher , TEZEL, Ahmet , TURNER, Kris
IPC分类号： A61F5/00 , A61M39/02
CPC分类号： A61F5/0056 , A61B17/064 , A61M39/0208 , A61M39/04 , A61M2039/0223 , A61M2210/1053
摘要： The present invention provides a system for attaching a fluid access port to a patient. The system generally comprises an implantable access port and a tool for attaching an access port to a patient. The implantable access port may include a plurality of anchor assemblies composed of two different materials. In addition, a mesh member may be attached to the base of the access port to facilitate implantation of the access port into a patient's body. The tool may have a rotatable actuator head, and may engage the access port in various orientations.
摘要翻译：本发明提供了一种用于将流体进入口附接到患者的系统。该系统通常包括可植入进入端口和用于将进入端口附接到患者的工具。可植入进入口可以包括由两种不同材料组成的多个锚固组件。此外，网状构件可以附接到入口的基部，以便于将进入口植入患者体内。工具可以具有可旋转的致动器头部，并且可以以各种取向接合进入端口。

10. 发明申请

WO2009073508A2 POLYSACCHARIDE GEL COMPOSITIONS AND METHODS FOR SUSTAINED DELIVERY OF DRUGS 审中-公开
标题翻译：多糖凝胶组合物和用于持续输送药物的方法
公开(公告)号：WO2009073508A2
公开(公告)日：2009-06-11
申请号：PCT/US2008/084841
申请日：2008-11-26
申请人： ALLERGAN, INC. , TEZEL, Ahmet , ROBINSON, Michael, R.
发明人： TEZEL, Ahmet , ROBINSON, Michael, R.
IPC分类号： C08B37/00 , C08B37/10 , C08B37/08 , C08B37/04 , A61K47/36 , A61K31/58 , A61K8/73 , A61K9/10 , A61K31/715 , A61P27/02
CPC分类号： A61K47/4823 , A61K8/042 , A61K8/73 , A61K8/733 , A61K8/735 , A61K8/736 , A61K9/0095 , A61K31/58 , A61K31/715 , A61K47/61 , A61K47/6903
摘要： Methods of producing a biocompatible polysaccharide gel composition having sustained release properties are disclosed. Also disclosed is a biocompatible polysaccharide gel composition having sustained release properties, a method of treating a disease or condition using the present biocompatible polysaccharide gel composition, and a method of controlling rate of release of at least one target solute from the biocompatible polysaccharide gel composition. Pharmaceutical compositions which include the present biocompatible polysaccharide gel composition also are disclosed.
摘要翻译：公开了具有持续释放特性的生物相容性多糖凝胶组合物的制备方法。还公开了具有持续释放性质的生物相容性多糖凝胶组合物，使用本生物相容性多糖凝胶组合物治疗疾病或病症的方法，以及从生物相容性多糖凝胶组合物中控制至少一种靶溶质释放速率的方法。还公开了包含本发明的生物相容性多糖凝胶组合物的药物组合物。

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