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1. 发明申请

WO2019110559A1 SPRING STRAINING MECHANISM FOR TORSION SPRING BASED DEVICE 审中-公开
公开(公告)号：WO2019110559A1
公开(公告)日：2019-06-13
申请号：PCT/EP2018/083430
申请日：2018-12-04
申请人： NOVO NORDISK A/S
发明人： JENSEN, Nicolai, Michael , SIGURDARSON, Nökkvi, Steinn
IPC分类号： A61M5/20
CPC分类号： A61M5/2033 , A61M5/2448 , A61M5/31583 , A61M2005/2013 , A61M2005/202
摘要： The present invention concerns a drug delivery device (1) comprising: a housing (2) extending along a main axis, a torsion spring (5) comprising a first spring end (4) arranged stationarily with respect to the housing (2) and a second spring end (6) capable of rotation about the main axis, a rotatable shaft (80) extending along the main axis, the rotatable shaft (80) having a non-self-locking thread (81) and being axially fixed with respect to the housing (2), a spring end retainer (82) to which the second spring end (6) is attached, the spring end retainer (82) being rotationally fixed relative to the rotatable shaft (80), and a nut member (45) engaged with the non-self-locking thread (81), the nut member (45) being axially movable by translation relative to the housing (2) to thereby travel the non-self-locking thread (81) between a first position in which the torsion spring (5) is in a relaxed state and a second position in which the torsion spring (5) is in a strained state.

2. 发明申请

WO2019096913A1 MIXING AND/OR RECONSTITUTION SYSTEM AND RESPECTIVE METHOD 审中-公开
公开(公告)号：WO2019096913A1
公开(公告)日：2019-05-23
申请号：PCT/EP2018/081386
申请日：2018-11-15
申请人： SANOFI
发明人： SCHABBACH, Michael , KADEREIT, Dieter , HEIBERGER, Andrea , GEIGER, Claus , HARVEY, Charlotte Emma , HUANG, Congyi , FREARSON, Timothy Charles , NORMAN, Alexander David
IPC分类号： A61M5/19 , A61M5/315
CPC分类号： A61M5/31596 , A61J1/2096 , A61M5/1782 , A61M5/19 , A61M5/20 , A61M5/2053 , A61M5/2066 , A61M5/2448 , A61M5/445 , A61M2005/2013 , A61M2005/2474 , A61M2005/3128 , A61M2005/31598 , A61M2005/3267 , A61M2205/0272 , A61M2209/04
摘要： The invention refers to a mixing and/or reconstitution system which reduces the possibility of user error and provides a well mixed and/or reconstituted drug in a short time comprising -a device (200), for example a cartridge, a syringe or an autoinjector, containing a first material within a first chamber (205), a housing (201) and a plunger (207), wherein the plunger (207) comprises a second chamber (209) containing a second material, wherein one of the first and the second material is a fluid, and a movable element (210) with an electric, magnetic or paramagnetic characteristic, wherein the second chamber (209) is initially closed, -a base unit (250) comprising an recess (265) for accommodation of the device (200), a control unit (270), and an electromagnetic unit (260) which is adapted to produce an electromagnetic field penetrating the recess (265), wherein the control unit (270) electrically operates the electromagnetic unit (260), wherein the base unit (250) is adapted such that after accommodation of the device (200) within the recess (265) and after user activation of the base unit (250) the control unit (270) operates the electromagnetic unit (260) such that the element (210) contained in the second chamber (209) moves in a direction of the device (200) determined by the electromagnetic field and thereby opens a path providing a fluid communication between the first chamber (205) and the second chamber (209). The invention also refers to a respective device (200) and a respective mixing and/or reconstitution method.

3. 发明申请

WO2019096908A1 DEVICE AND MIXING AND/OR RECONSTITUTION METHOD 审中-公开
公开(公告)号：WO2019096908A1
公开(公告)日：2019-05-23
申请号：PCT/EP2018/081375
申请日：2018-11-15
申请人： SANOFI
发明人： SCHABBACH, Michael , GEIGER, Claus , HEIBERGER, Andrea , KADEREIT, Dieter , HARVEY, Charlotte Emma , HUANG, Congyi , FREARSON, Timothy Charles , NORMAN, Alexander David
IPC分类号： A61M5/20 , A61J1/20 , A61M5/19
CPC分类号： A61M5/19 , A61J1/1406 , A61J1/16 , A61J1/201 , A61J1/2093 , A61J1/2096 , A61J2205/60 , A61M5/1782 , A61M5/2053 , A61M5/2066 , A61M5/2448 , A61M5/31596 , A61M5/445 , A61M2005/2013 , A61M2005/2474 , A61M2005/3128 , A61M2005/31598 , A61M2005/3267 , A61M2205/0272 , A61M2209/045
摘要： The invention refers to a device (100, 500, 510), for example a cartridge, a syringe or an autoinjector, which reduces the possibility of user error and provides an easy and automatic operation during mixing and/or reconstitution, comprising: - a first chamber (105, 505) within the housing, wherein the first chamber (105, 505) contains a first material, - a second chamber (109, 509) comprising a first piston (112, 512) and a second piston (111, 511), wherein the first piston (112, 512) and the second piston (111, 511) are axially moveable within the second chamber (109, 509), and - a second fluid material initially contained within the second chamber (109, 509) between the first piston (112, 512) and the second piston (111, 511 ), wherein the device is adapted such that activation of the device (100, 500, 510) causes movement one of the first piston (112, 512) and the second piston (111, 511 ) in an axial direction of the device thereby - moving the other one of the first piston (112, 512) and the second piston (111, 511 ) into the same axial direction of the device, - opening a fluid communication path between the second chamber (109, 509) and the first chamber (105, 505) and - expelling the second material from the second chamber (109, 509) into the first chamber (105, 505) via the fluid communication path. The invention is further directed to a respective mixing and/or reconstitution method.

4. 发明申请

WO2018085318A2 SELF-CONTAINED SYRINGE FOR DISSOLUTION AND ADMINISTRATION OF DRUGS 审中-公开
标题翻译：自带注射器，用于溶解和管理药物
公开(公告)号：WO2018085318A2
公开(公告)日：2018-05-11
申请号：PCT/US2017/059432
申请日：2017-11-01
申请人： HANSS, Basil, G. , NGUYEN, Dac
发明人： HANSS, Basil, G. , NGUYEN, Dac
IPC分类号： A61M5/31
CPC分类号： A61M5/31596 , A61M5/2448 , A61M5/31 , A61M5/31515 , A61M2005/3128
摘要： The invention provides a mixing syringe adapted for the storage of a two- component medicament in unmixed form. One of the components is a liquid, which is maintained in a separate, collapsible compartment until just prior to administration, while the other component, which may be solid or liquid, is stored within the syringe body. The act of partially withdrawing the plunger from the syringe creates a partial vacuum within the syringe body, and atmospheric pressure forces the liquid from the collapsible compartment through a one-way valve and into the syringe body. The combined medicament is then injected by use of the syringe in the usual manner.
摘要翻译：本发明提供了一种适用于以未混合形式存储双组分药物的混合注射器。其中一种成分是液体，其直到给药之前一直保持在单独的可收缩隔室中，而另一种可以是固体或液体的成分储存在注射器主体内。从注射器部分地抽出柱塞的动作在注射器本体内产生部分真空，并且大气压力迫使液体从可收缩隔室通过单向阀进入注射器本体。然后以通常的方式使用注射器注射组合药物。

5. 发明申请

WO2017066885A1 VORRICHTUNG ZUR VERABREICHUNG EINES WIRKSTOFFS UND VERFAHREN ZUR BEDIENUNG DIESER VORRICHTUNG 审中-公开
标题翻译：设备为活跃操作此设备进行管理和方法
公开(公告)号：WO2017066885A1
公开(公告)日：2017-04-27
申请号：PCT/CH2016/000129
申请日：2016-10-04
申请人： TECPHARMA LICENSING AG
发明人： SCHENKER, Susanne , STREIT, Ursina
IPC分类号： A61M5/19 , A61M5/20 , A61M5/24 , A61M5/28 , A61M5/31 , A61M5/315
CPC分类号： A61M5/19 , A61M5/2066 , A61M5/2448 , A61M5/284 , A61M5/3146 , A61M5/3148 , A61M5/31501 , A61M5/31511 , A61M5/31586 , A61M5/31596 , A61M2005/2451 , A61M2005/2488 , A61M2005/31518
摘要： Vorrichtung zur Verabreichung eines Wirkstoffs umfassend -eine Mehrkammerkarpule (4) mit einem Bypass {7) in einer Wandung (8) der Mehrkammerkarpule (4) und mit wenigstens einer ersten Kammer (9) mit einem festen Wirkstoff und einer zweiten Kammer (10) mit einer Lösungsflüssigkeit für den Wirkstoff, wobei die zweite Kammer (10) durch einen in der Mehrkammerkarpule (4) distal angeordneten ersten (5) und einen in der Mehrkammerkarpule (4) proximal angeordneten zweiten Stopfen (6) begrenzt ist, -ein Abmischelement (1, 1', 1"), welches relativ zu dem Gehäuse (11, 11', 11") um eine Drehachse drehbar gelagert ist und zum Abmischen des Wirkstoffes und der Lösungsflüssigkeit in eine Drehrichtung um die Drehachse drehbar ist, -und eine Rasteinrichtung, welche derart an der Vorrichtung vorgesehen ist, dass nach dem Abmischvorgang eine axiale Verschiebung eines distalen Endes des zweiten Stopfens (6) relativ zu der Wandung (8) der Mehrkammerkarpule (4) über ein distales Ende des Bypasses (6) in die proximale Richtung blockiert ist.
摘要翻译：
一种用于在壁与旁路{7）施用含有-a Mehrkammerkarpule（4）的药物装置（8）的Mehrkammerkarpule（4）和具有至少一个第一腔室（9）与固体活性物质和第二腔室（10）具有L＆ouml; sungsfl导航用途液体F导航用途r为活性物质，其中，所述第二室（10）在Mehrkammerkarpule远侧设置有（4）的第一（5）和一个在Mehrkammerkarpule（4）的近端布置的第二止动件（6）是有限的，-a Abmischelement（1，1”，QUOT 1），其相对于所述壳体BEAR使用（11，11' ，QUOT 11）可旋转地安装围绕旋转轴线和用于所述活性物质的混合和 L＆ouml; sungsfl导航用途是LIQUID旋转在绕旋转轴的旋转方向，-and其中提供这样的装置上的锁定装置是，在混合过程中，所述第二端塞的远端的轴向位移（6）（相对于壁8后）的multichamberka （4）经由旁路（6）的远端在近侧方向上被阻塞。

6. 发明申请

WO2017005590A1 SYRINGE FOR MIXING TWO COMPONENTS AND FOR RETAINING A VACUUM IN A STORAGE CONDITION 审中-公开
标题翻译：用于混合两个组件和用于在存储条件下保留真空的SYRINGE
公开(公告)号：WO2017005590A1
公开(公告)日：2017-01-12
申请号：PCT/EP2016/065260
申请日：2016-06-30
申请人： FERROSAN MEDICAL DEVICES A/S
发明人： LARSEN, Kristian , ELLE, Lise Sjørup , JENSEN, Thomas Ingemann
IPC分类号： A61M5/20 , A61M5/315 , A61M5/24 , A61M5/28
CPC分类号： A61M5/2066 , A61M5/2448 , A61M5/2459 , A61M5/284 , A61M5/31596 , A61M2005/2086 , A61M2005/31598
摘要： The present disclosure relates to a syringe for mixing two substances which have been retained separately inside the syringe, for instance in a storage condition.In particular the present disclosure relates to a syringe for 1) retaining a dry composition in a vacuum, and 2)mixing the dry composition with an aqueous medium to form a flowable substance. One embodiment relates to a syringe for retaining and mixing first and second substances comprising: a barrel comprising a sealable and/or closable distal outlet and a vacuum chamber for holding a first substance, a plunger incorporating a reservoir chamber for holding a second substance and configured to be axially displaced through a proximal end of the barrel, a membrane separating the vacuum chamber and the reservoir chamber, and a pointed member, such as one or more needles, for penetrating the membrane.
摘要翻译：本公开涉及一种注射器，用于混合在注射器内分开保留的两种物质，例如在储存条件下。特别地，本公开涉及一种注射器，用于1）在真空中保持干燥组合物，以及2）将干燥组合物与水性介质混合以形成可流动物质。一个实施例涉及用于保持和混合第一和第二物质的注射器，包括：包括可密封和/或可封闭的远端出口的桶，以及用于保持第一物质的真空室，包括用于保持第二物质的储存室的柱塞，通过筒的近端轴向移位，分离真空室和储存室的膜，以及用于穿透膜的尖形构件，例如一个或多个针。

7. 发明申请

WO2016123110A1 MECHANICAL PEN FOR REMOVABLY RETAINING CAPSULES WITH COMPOUNDS, AND APPLICATORS FOR THE COMPOUNDS 审中-公开
标题翻译：用于具有化合物的可拆卸保持胶囊的机械笔和化合物的应用者
公开(公告)号：WO2016123110A1
公开(公告)日：2016-08-04
申请号：PCT/US2016/014933
申请日：2016-01-26
申请人： TAPOCIK, Bryan
发明人： TAPOCIK, Bryan
IPC分类号： A61C5/06
CPC分类号： A61C5/62 , A61C19/066 , A61M5/19 , A61M5/2033 , A61M5/2448 , A61M5/31581 , A61M2005/2414
摘要： The present invention involves the field of numerous types of compounds including tooth whitening compounds and in particular, to specific apparatus which are used to retain tooth whitening compounds and then dispense them either into a dental tray where the tray is placed over the patient's teeth for a period of time or the tooth whitening compound is directly applied to the patient's teeth by the dentist or the dental assistant. More broadly described, the present invention includes compound and applicators used to dispense the compounds including tooth whitening compounds, dental bonding and filling compounds, adhesives, finely ground powder, jells, creams and paints.
摘要翻译：本发明涉及多种类型的化合物领域，包括牙齿美白化合物，特别是涉及用于保留牙齿美白化合物的具体装置，然后将其分配到牙托中，其中托盘放置在患者牙齿上以用于一段时间或牙齿美白化合物由牙医或牙科助手直接施用于患者的牙齿。更广泛地描述，本发明包括用于分配化合物的化合物和施用器，包括牙齿美白化合物，牙科粘合剂和填充化合物，粘合剂，细磨粉末，胶凝剂，霜剂和油漆。

8. 发明申请

WO2016102446A1 SYRINGE FOR RETAINING AND MIXING FIRST AND SECOND SUBSTANCES 审中-公开
标题翻译：用于保留和混合第一和第二物质的注射器
公开(公告)号：WO2016102446A1
公开(公告)日：2016-06-30
申请号：PCT/EP2015/080761
申请日：2015-12-21
申请人： FERROSAN MEDICAL DEVICES A/S
发明人： LARSEN, Kristian
IPC分类号： A61M5/19 , A61M5/24 , A61M5/315
CPC分类号： A61M5/19 , A61B2017/00495 , A61M5/2448 , A61M5/31501 , A61M5/31511 , A61M5/31596 , A61M2005/3128
摘要： The present disclosure relates to a syringe for retaining and/or mixing two substances which have been retained separately inside the syringe.In particular the present disclosure relates to a syringe for 1) retaining a dry composition in a vacuum, and 2) mixing the dry composition with an aqueous medium to form a flowable substance. One embodiment relates to a syringe for mixing first and second substances comprising a barrel comprising a vacuum chamber for holding a first substance, a plunger incorporating a reservoir chamber for holding a second substance and configured to be axially displaced in the vacuum chamber, and a valve for controlling and/or establishing a fluid connection between the vacuum chamber and the reservoir chamber.
摘要翻译：本公开内容涉及一种用于保持和/或混合在注射器内分开保留和/或混合的两种物质的注射器。特别地，本公开涉及一种注射器，其用于1）将干燥组合物保持在真空中，以及2）组合物与水性介质形成可流动物质。一个实施例涉及一种用于混合第一和第二物质的注射器，其包括：包括用于保持第一物质的真空室的桶;包括用于保持第二物质并被构造成在真空室中轴向移位的储存室的柱塞;以及阀用于控制和/或建立真空室和储存室之间的流体连接。

9. 发明申请

WO2016094387A2 VERSATILE SYRINGE PLATFORM 审中-公开
公开(公告)号：WO2016094387A2
公开(公告)日：2016-06-16
申请号：PCT/US2015/064464
申请日：2015-12-08
申请人： GENENTECH, INC. , F. HOFFMANN-LA ROCHE AG
发明人： VEDRINE, Lionel , ROE, Steven N. , PATEL, Mukund
IPC分类号： H04L12/803
CPC分类号： A61M5/31513 , A61F9/0017 , A61M5/2033 , A61M5/24 , A61M5/2448 , A61M5/2459 , A61M5/3137 , A61M5/3145 , A61M5/3146 , A61M5/31505 , A61M5/31528 , A61M5/31573 , A61M5/31581 , A61M5/31586 , A61M5/31596 , A61M5/3202 , A61M5/3298 , A61M5/36 , A61M2005/2451 , A61M2005/31508 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2207/00 , B29C45/16 , B29L2031/7544
摘要： Apparatus and methods for medicament delivery. The apparatus may include, and the methods may involve, a delivery device for delivering a target amount of the medicament from a distal end of the device. The device may include a rod for moving a plunger that discharges the medicament from the distal end. The device may avoid or reduce deformation of the plunger during the discharge. The plunger motion may be stopped by detent that interacts with the rod. The apparatus and the methods may provide an operator indication of progress of stages of operation. The device may feature triggers corresponding to stages of medicament displacement from the device, such as pre-delivery stages, including priming.
摘要翻译：用于药物输送的装置和方法该装置可以包括并且该方法可以包括用于从装置的远端递送目标量的药物的递送装置。该装置可以包括用于移动从远端排出药物的柱塞的杆。该装置可以避免或减少放电期间柱塞的变形。柱塞运动可以通过与杆相互作用的制动器来停止。装置和方法可以提供操作者对操作阶段的进展的指示。该装置可以具有对应于来自装置的药物置换阶段的触发器，例如预输送阶段，包括起动。

10. 发明申请

WO2016062563A1 DUAL-CHAMBER SYRINGE 审中-公开
标题翻译：双室搅拌机
公开(公告)号：WO2016062563A1
公开(公告)日：2016-04-28
申请号：PCT/EP2015/073441
申请日：2015-10-09
申请人： SULZER MIXPAC AG
发明人： ETTLIN, Josef
IPC分类号： A61M5/28 , A61M5/315 , A61C5/06 , A61M5/24
CPC分类号： A61M5/31596 , A61M5/2448 , A61M5/283 , A61M5/284 , A61M5/32 , A61M2005/2451 , A61M2005/31598
摘要： Syringe (10) for discharging two components comprises a housing (12)d, a piston (20) at least partly inside said housing and axially moveable relative thereto between a first and a second position, a hollow cylindrical container (22) at least partly inside said housing, surrounding said piston and axially moveable relative to said piston between a first and a second position, a first compartment (24) defined within said housing between the distal end of said piston assuming its first position and the distal end of said housing for receiving a first component (28), a second compartment (30) defined within said container assuming its first position between the proximal end of said container and the proximal end of said piston for receiving a second component (36), an axially extending passage (38) in the interior of said piston and in communication with said first compartment and a radial opening (40) of said piston in the region of the proximal end of said piston, sealing means (52) for preventing communication between said second compartment and said radial opening of said piston when the container assumes its first position, and releasable retaining means (44) for retaining said piston in its first position until said container has reached its second position. The syringe is further adapted so that communication between said second compartment and said radial opening of said piston is established after initiation of the movement of said container out of its first position towards its second position relative to said piston, thereby transferring said second component from said second compartment into the radial opening and through the axial passage of the piston into said first compartment, said retaining means are released by said container reaching its second position, and with the further movement of said container into said housing and the simultaneous movement of the released piston out of its first position towards its second position, the two mixed components are pressed out of said first compartment.
摘要翻译：用于排出两个部件的注射器（10）包括壳体（12），至少部分地位于所述壳体内的活塞（20），并且可在第一和第二位置之间相对于其间轴向移动;中空圆柱形容器（22），至少部分在所述壳体的内部，围绕所述活塞并且在第一和第二位置之间相对于所述活塞轴向移动;第一隔室（24），其限定在所述壳体内，所述第一隔室（24）在所述活塞的远端位于所述活塞的第一位置和所述壳体的远端之间用于接收第一部件（28），限定在所述容器内的第二隔室（30），其假定其位于所述容器的近端和所述活塞的近端之间的第一位置，用于容纳第二部件（36），轴向延伸的通道（38）在所述活塞的内部并与所述第一隔室连通并且在所述活塞的近端区域中的所述活塞的径向开口（40），密封装置（52），用于当所述容器处于其第一位置时，防止所述第二隔室和所述活塞的所述径向开口之间的连通;以及可释放保持装置（44），用于将所述活塞保持在其第一位置，直到所述容器已经达到其第二位置。注射器进一步适于使得所述第二隔室与所述活塞的所述径向开口之间的连通在所述容器从其第一位置移动到相对于所述活塞的第二位置开始之后建立，从而将所述第二部件从所述第二隔室进入径向开口并且通过活塞的轴向通道进入所述第一隔室，所述保持装置被所述容器释放到其第二位置，并且随着所述容器进一步移动到所述壳体中并且同时移动所释放的活塞从其第一位置朝向其第二位置，两个混合部件被压出所述第一隔室。

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