专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2013101954A1 3-PHENYL-5-UREIDOISOTHIAZOLE-4-CARBOXIMIDE AND 3-AMINO-5-PHENYLISOTHIAZOLE DERIVATIVES AS KINASE INHIBITORS 审中-公开
标题翻译：作为激酶抑制剂的3-苯基-5-尿嘧啶-4-氧羰酰胺和3-氨基-5-苯并噻唑衍生物
公开(公告)号：WO2013101954A1
公开(公告)日：2013-07-04
申请号：PCT/US2012/071855
申请日：2012-12-27
申请人： ALLERGAN, INC. , MALONE, Thomas C. , HULL, Clarence, E., III , BORAL, Sougato , WURSTER, Julie A. , EDELMAN, Jeffrey L. , ROBINSON, Michael R.
发明人： MALONE, Thomas C. , HULL, Clarence, E., III , BORAL, Sougato , WURSTER, Julie A. , EDELMAN, Jeffrey L. , ROBINSON, Michael R.
IPC分类号： C07D417/12 , C07D295/13 , C07D275/03 , A61K31/425 , A61K31/427 , A61P35/00 , A61P3/00
CPC分类号： C07D417/12 , C07D275/03 , C07D295/13
摘要： This invention is directed to a compound of Formula I Formula I or a pharmaceutically acceptable salt thereof, wherein R, R 1 , R 2 , R 3 , n, X 1 , X 2 , L 1 , and L 2 are as defined herein. The compounds of Formula I are useful as receptor tyrosine kinase (RTK) inhibitors and can be used to treat such diseases as cancer, blood vessel proliferative disorders, fibrotic disorders, mesangial cell proliferative disorders and metabolic diseases.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐，其中R，R 1，R 2，R 3，n，X 1，X 2，L 1和L 2如本文所定义。式I化合物可用作受体酪氨酸激酶（RTK）抑制剂，可用于治疗癌症，血管增生性疾病，纤维化病症，肾小球膜细胞增殖性疾病和代谢疾病等疾病。

2. 发明申请

WO2011091205A3 INTRACAMERAL SUSTAINED RELEASE THERAPEUTIC AGENT IMPLANTS 审中-公开
标题翻译：内镜持续释放治疗代理植入物
公开(公告)号：WO2011091205A3
公开(公告)日：2012-04-19
申请号：PCT/US2011021971
申请日：2011-01-21
申请人： ALLERGAN INC , ROBINSON MICHAEL R , BURKE JAMES , SCHIFFMAN RHETT
发明人： ROBINSON MICHAEL R , BURKE JAMES , SCHIFFMAN RHETT
IPC分类号： A61K9/00 , A61K31/5575 , A61K47/34
CPC分类号： A61K9/0051 , A61K9/0024 , A61K9/1647 , A61K31/5575 , A61K47/10 , A61K47/34 , A61L27/18 , A61L27/54 , A61L27/58
摘要： Described herein are intracameral implants including at least one therapeutic agent for treatment of at least one ocular condition. The implants described herein are not anchored to the ocular tissue, but rather are held in place by currents and gravity present in the anterior chamber of an eye. The implants are preferably polymeric, biodegradable and provide sustained release of at least one therapeutic agent to both the trabecular meshwork and associated ocular tissue and the fluids within the anterior chamber of an eye.
摘要翻译：本文描述的是包括用于治疗至少一种眼部病症的至少一种治疗剂的植入物植入物。本文所述的植入物不固定在眼组织上，而是通过存在于眼前房中的电流和重力保持在适当位置。植入物优选是聚合的，可生物降解的并且提供至少一种治疗剂持续释放到小梁网和相关联的眼组织和眼睛前房内的流体。

3. 发明申请

WO2011130462A3 INTRAOCULAR PRESSURE REDUCTION WITH INTRACAMERAL BIMATOPROST IMPLANTS 审中-公开
公开(公告)号：WO2011130462A3
公开(公告)日：2011-10-20
申请号：PCT/US2011/032393
申请日：2011-04-14
申请人： ALLERGAN, INC. , HUGHES, Patrick, M. , ROBINSON, Michael, R. , BURKE, James, A.
发明人： HUGHES, Patrick, M. , ROBINSON, Michael, R. , BURKE, James, A.
IPC分类号： A61K9/70 , A61K47/34 , A61K31/557 , A61P27/02
摘要： The present invention provides a method of treating an ocular condition in an eye of a patient, comprising the step of placing a biodegradable intraocular implant in an eye of the patient, the implant comprising a prostamide and a biodegradable polymer matrix that releases drug at a rate effective to sustain release of an amount of the prostamide from the implant to provide an amount of the prostamide effective to prevent or reduce a symptom of an ocular condition of the eye, wherein said ocular condition is elevated IOP and said implant is placed in an intracameral location to dilate the outflow channels of the eye emanating from Schlemm's Canal.

4. 发明申请

WO2011075481A1 INTRACAMERAL DEVICES FOR SUSTAINED DELIVERY 审中-公开
标题翻译：用于持续交付的内部设备
公开(公告)号：WO2011075481A1
公开(公告)日：2011-06-23
申请号：PCT/US2010/060314
申请日：2010-12-14
申请人： ALLERGAN, INC. , ROBINSON, Michael, R. , WERHNER, Orilla , NOVAKOVIC, Zoran , BURKE, James , GHEBREMESKEL, Alazar , SPADA, Lon
发明人： ROBINSON, Michael, R. , WERHNER, Orilla , NOVAKOVIC, Zoran , BURKE, James , GHEBREMESKEL, Alazar , SPADA, Lon
IPC分类号： A61F9/00 , A61F9/007 , A61K9/00
CPC分类号： A61F9/0017 , A61F9/00781 , A61K9/0051 , A61K9/0092
摘要： Described herein are intracameral drug and/or therapeutic bioactive agent delivery devices comprising a substantially cylindrical structure for at least partial placement into the anterior chamber of an eye The intracameral delivery devices have a sustained release material associated with at least a portion of the device and at least one drug and/or therapeutic bioactive agent associated with said sustained release material.
摘要翻译：本文描述的是包括用于至少部分地放置到眼睛前房中的基本圆柱形结构的腔内药物和/或治疗性生物活性剂递送装置。室内输送装置具有与装置的至少一部分相关联的持续释放材料，并且在与所述缓释材料相关的至少一种药物和/或治疗性生物活性剂。

5. 发明申请

WO2009073508A3 POLYSACCHARIDE GEL COMPOSITIONS AND METHODS FOR SUSTAINED DELIVERY OF DRUGS 审中-公开
标题翻译：多糖凝胶组合物和用于持续递送药物的方法
公开(公告)号：WO2009073508A3
公开(公告)日：2009-08-13
申请号：PCT/US2008084841
申请日：2008-11-26
申请人： ALLERGAN INC , TEZEL AHMET , ROBINSON MICHAEL R
发明人： TEZEL AHMET , ROBINSON MICHAEL R
IPC分类号： A61K8/73 , A61K9/10 , A61K31/715 , A61K47/36 , A61P27/02
CPC分类号： A61K47/4823 , A61K8/042 , A61K8/73 , A61K8/733 , A61K8/735 , A61K8/736 , A61K9/0095 , A61K31/58 , A61K31/715 , A61K47/61 , A61K47/6903
摘要： Methods of producing a biocompatible polysaccharide gel composition having sustained release properties are disclosed. Also disclosed is a biocompatible polysaccharide gel composition having sustained release properties, a method of treating a disease or condition using the present biocompatible polysaccharide gel composition, and a method of controlling rate of release of at least one target solute from the biocompatible polysaccharide gel composition. Pharmaceutical compositions which include the present biocompatible polysaccharide gel composition also are disclosed.
摘要翻译：公开了生产具有缓释性能的生物相容性多糖凝胶组合物的方法。还公开了具有持续释放性质的生物相容性多糖凝胶组合物，使用本发明的生物相容性多糖凝胶组合物治疗疾病或病症的方法，以及控制至少一种目标溶质从生物相容性多糖凝胶组合物中释放速率的方法。还公开了包含本发明的生物相容性多糖凝胶组合物的药物组合物。

6. 发明申请

WO2009073508A2 POLYSACCHARIDE GEL COMPOSITIONS AND METHODS FOR SUSTAINED DELIVERY OF DRUGS 审中-公开
标题翻译：多糖凝胶组合物和用于持续输送药物的方法
公开(公告)号：WO2009073508A2
公开(公告)日：2009-06-11
申请号：PCT/US2008/084841
申请日：2008-11-26
申请人： ALLERGAN, INC. , TEZEL, Ahmet , ROBINSON, Michael, R.
发明人： TEZEL, Ahmet , ROBINSON, Michael, R.
IPC分类号： C08B37/00 , C08B37/10 , C08B37/08 , C08B37/04 , A61K47/36 , A61K31/58 , A61K8/73 , A61K9/10 , A61K31/715 , A61P27/02
CPC分类号： A61K47/4823 , A61K8/042 , A61K8/73 , A61K8/733 , A61K8/735 , A61K8/736 , A61K9/0095 , A61K31/58 , A61K31/715 , A61K47/61 , A61K47/6903
摘要： Methods of producing a biocompatible polysaccharide gel composition having sustained release properties are disclosed. Also disclosed is a biocompatible polysaccharide gel composition having sustained release properties, a method of treating a disease or condition using the present biocompatible polysaccharide gel composition, and a method of controlling rate of release of at least one target solute from the biocompatible polysaccharide gel composition. Pharmaceutical compositions which include the present biocompatible polysaccharide gel composition also are disclosed.
摘要翻译：公开了具有持续释放特性的生物相容性多糖凝胶组合物的制备方法。还公开了具有持续释放性质的生物相容性多糖凝胶组合物，使用本生物相容性多糖凝胶组合物治疗疾病或病症的方法，以及从生物相容性多糖凝胶组合物中控制至少一种靶溶质释放速率的方法。还公开了包含本发明的生物相容性多糖凝胶组合物的药物组合物。

7. 发明申请

WO2008070402A3 INTRAOCULAR DRUG DELIVERY SYSTEMS 审中-公开
公开(公告)号：WO2008070402A3
公开(公告)日：2008-06-12
申请号：PCT/US2007/084224
申请日：2007-11-09
申请人： ALLERGAN, INC. , ROBINSON, Michael, R. , BLANDA, Wendy, M. , HUGHES, Patrick, M. , RUIZ, Guadalupe , ORILLA, Werhner, C. , WHITCUP, Scott, M. , LIN, Joan-En , WELTY, Devin, F.
发明人： ROBINSON, Michael, R. , BLANDA, Wendy, M. , HUGHES, Patrick, M. , RUIZ, Guadalupe , ORILLA, Werhner, C. , WHITCUP, Scott, M. , LIN, Joan-En , WELTY, Devin, F.
IPC分类号： A61F2/14 , A61K9/00 , A61K9/10 , A61K9/16 , A61K9/50 , A61K31/557 , A61K31/565 , A61K47/34 , A61K47/48
摘要： Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants such as microsheres provide an extended release of an active agent at a therapeutically effective amount for a period of time between 10 days and one year or longer. The active is selected from estradiols such as 2-methoxyestradiol or alpha 2. adrenergic agonists such as brimonidine and its derivates or prostagladin analogis.

8. 发明申请

WO2008019267A3 OCULAR IMPLANT DELIVERY ASSEMBLIES WITH DISTAL CAPS 审中-公开
标题翻译： OCULAR IMPLANT交付组件与远端CAPS
公开(公告)号：WO2008019267A3
公开(公告)日：2008-04-03
申请号：PCT/US2007074937
申请日：2007-08-01
申请人： ALLERGAN INC , TROGDEN JOHN T , LYONS ROBERT T , CHANG JAMES N , ROBINSON MICHAEL R , ORILLA WERHNER C
发明人： TROGDEN JOHN T , LYONS ROBERT T , CHANG JAMES N , ROBINSON MICHAEL R , ORILLA WERHNER C
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： Ocular implant delivery assemblies (10) are provided which include a cannula (12) having a lumen (14) extending therethrough, a proximal end (16), a proximal end opening (18), a distal end (22), a distal end opening (24), and a lumen extending through the cannula. A cap (32) is provided having a closed distal end, being in contact with the outer wall of the cannula, and covering the distal end (22a) and the distal end opening of the cannula, the cap being structured to allow the distal end and the distal end opening of the cannula to pass through the cap as the cannula is passed into an eye. An ocular implant (40) is located in the lumen. The implant may be sealed in the cannula without the addition of a liquid carrier or it may be contained in a liquid carrier medium in the cannula. The implant may be made up of a number of microparticles having different compositions or different forms. The assembly also includes a sleeve (48) located on the proximal end of the cannula and suitable for coupling the assembly to a syringe containing a pushing gel.
摘要翻译：提供了眼部植入物递送组件（10），其包括具有延伸穿过其中的内腔（14）的插管（12），近端（16），近端开口（18），远端（22），远端开口（24）和延伸穿过套管的内腔。盖（32）设置有封闭的远端，与套管的外壁相接触，并且覆盖套管的远端（22a）和远端开口，帽被构造成允许远端并且套管的远端开口在插管穿过眼睛时通过帽。眼部植入物（40）位于内腔中。植入物可以密封在套管中而不加入液体载体，或者其可以包含在插管中的液体载体介质中。植入物可以由具有不同组成或不同形式的许多微粒组成。组件还包括位于套管的近端上的套筒（48），并且适于将组件耦合到包含推压凝胶的注射器。

9. 发明申请

WO2008019267A2 OCULAR IMPLANT DELIVERY ASSEMBLIES WITH DISTAL CAPS 审中-公开
标题翻译： OCULAR IMPLANT交付组件与远端CAPS
公开(公告)号：WO2008019267A2
公开(公告)日：2008-02-14
申请号：PCT/US2007/074937
申请日：2007-08-01
申请人： ALLERGAN, INC. , TROGDEN, John T. , LYONS, Robert T. , CHANG, James N. , ROBINSON, Michael R. , ORILLA, Werhner C.
发明人： TROGDEN, John T. , LYONS, Robert T. , CHANG, James N. , ROBINSON, Michael R. , ORILLA, Werhner C.
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： Ocular implant delivery assemblies are provided which include a cannula having a lumen extending therethrough, a proximal end, a proximal end opening, a distal end, a distal end opening, and a lumen extending through the cannula. A cap is provided having a closed distal end, being in contact with the outer wall of the cannula, and covering the distal end and the distal end opening of the cannula, the cap being structured to allow the distal end and the distal end opening of the cannula to pass through the cap as the cannula is passed into an eye. An ocular implant is located in the lumen. The implant may be sealed in the cannula without the addition of a liquid carrier or it may be contained in a liquid carrier medium in the cannula. The implant may be made up of a number of microparticles having different compositions or different forms. The assembly also includes a sleeve located on the proximal end of the cannula and suitable for coupling the assembly to a syringe containing a pushing gel.
摘要翻译：提供了眼部植入物递送组件，其包括具有延伸穿过其中的内腔的套管，近端，近端开口，远端，远端开口和延伸穿过套管的内腔。提供具有封闭的远端的盖，其与套管的外壁接触并且覆盖套管的远端和远端开口，帽被构造成允许远端和远端开口当套管穿过眼睛时，套管穿过帽子。眼内植入物位于内腔中。植入物可以密封在套管中而不加入液体载体，或者其可以包含在插管中的液体载体介质中。植入物可以由具有不同组成或不同形式的许多微粒组成。组件还包括位于套管的近端上的套筒，并且适于将组件耦合到包含推动凝胶的注射器。

10. 发明申请

WO2008019265A2 OCULAR IMPLANT DELIVERY ASSEMBLIES 审中-公开
标题翻译： OCULAR IMPLANT交付组件
公开(公告)号：WO2008019265A2
公开(公告)日：2008-02-14
申请号：PCT/US2007/074930
申请日：2007-08-01
申请人： ALLERGAN, INC. , TROGDEN, John, T. , LYONS, Robert, T. , CHANG, James, N. , ROBINSON, Michael, R.
发明人： TROGDEN, John, T. , LYONS, Robert, T. , CHANG, James, N. , ROBINSON, Michael, R.
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： Ocular implant delivery assemblies are provided which include a cannula having a lumen extending therethrough, a proximal end, a proximal end opening, a distal end, a distal end opening, and a lumen extending through the cannula. A removable distal closure element is provided for closing the distal end opening, and a removable proximal closure element is provided for closing the proximal end opening. An ocular implant is located in the lumen. The implant may be sealed in the cannula without the addition of a liquid carrier or it may be contained in a liquid carrier medium in the cannula. The implant may be made up of a number of microparticles having different compositions or different forms. The assembly also includes a sleeve located on the proximal end of the cannula and suitable for coupling the assembly to a syringe containing a pushing gel.
摘要翻译：提供了眼部植入物递送组件，其包括具有延伸穿过其中的内腔的套管，近端，近端开口，远端，远端开口和延伸穿过套管的内腔。提供可移除的远端闭合元件用于封闭远端开口，并且提供可移除的近端闭合元件用于封闭近端开口。眼内植入物位于内腔中。植入物可以密封在套管中而不加入液体载体，或者其可以包含在插管中的液体载体介质中。植入物可以由具有不同组成或不同形式的许多微粒组成。组件还包括位于套管的近端上的套筒，并且适于将组件耦合到包含推动凝胶的注射器。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式