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1. 发明申请

WO2009018076A1 TUNABLY CROSSLINKED HYALURONIC ACID COMPOSITIONS 审中-公开
标题翻译： TUNABLY交联的羟丙酸组合物
公开(公告)号：WO2009018076A1
公开(公告)日：2009-02-05
申请号：PCT/US2008/070985
申请日：2008-07-24
申请人： ALLERGAN, INC. , STROUMPOULIS, Dimitrios , TEZEL, Ahmet
发明人： STROUMPOULIS, Dimitrios , TEZEL, Ahmet
IPC分类号： C08B37/08 , A61L27/20
CPC分类号： C08B37/0072 , A61L27/20 , A61L2430/34 , C08L5/08
摘要： The present invention relates to biocompatible crosslinked hyaluronic acid gel compositions, methods of their manufacture and use, and the crosslinkers used to make them. In one aspect of the invention, a polyethylene glycol crosslinking agent is described for crosslinking hyaluronic acid preferably a multifunctional one like 4-Arm Star PEG. In another aspect of the invention, crosslinking agents comprising more than two functional groups are described. These multifunctional crosslinking agents can be used on their own to crosslink hyaluronic acid, or they may be combined with bifunctional crosslinking agents in varying ratios to make hyaluronic acid of tunable mechanical strength and hardness. The present invention also discloses hyaluronic acid compositions that have been coated with polyethylene glycol and methods of their use.
摘要翻译：本发明涉及生物相容的交联透明质酸凝胶组合物，其制造和使用方法以及用于制备它们的交联剂。在本发明的一个方面，描述了用于交联透明质酸的聚乙二醇交联剂，优选为诸如4-臂星形PEG的多官能团。在本发明的另一方面，描述了包含多于两个官能团的交联剂。这些多功能交联剂可以单独使用以交联透明质酸，或者它们可以以不同比例与双功能交联剂组合以制备具有可调节的机械强度和硬度的透明质酸。本发明还公开了已经涂覆有聚乙二醇的透明质酸组合物及其使用方法。

2. 发明申请

WO2012054752A1 TUNABLY CROSSLINKED POLYSACCHARIDE COMPOSITIONS 审中-公开
标题翻译： TUNABLY交联多糖组合物
公开(公告)号：WO2012054752A1
公开(公告)日：2012-04-26
申请号：PCT/US2011/057137
申请日：2011-10-20
申请人： ALLERGAN, INC. , STROUMPOULIS, Dimitrios , TEZEL, Ahmet
发明人： STROUMPOULIS, Dimitrios , TEZEL, Ahmet
IPC分类号： A61L27/20 , A61L27/52 , A61L27/58
CPC分类号： A61L27/20 , A61L27/52 , A61L2400/06 , A61L2430/34 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08L5/08
摘要： The present specification generally relates to injectable dermal fillers including multifunctional polyethylene glycol-based crosslinking agents, hydrogel compositions comprising a matrix polymer crosslinked with such crosslinking agents, and methods of treating a soft tissue condition using such hydrogel compositions.
摘要翻译：本说明书通常涉及可注射的真皮填料，包括多官能聚乙二醇基交联剂，包含与这种交联剂交联的基质聚合物的水凝胶组合物，以及使用这种水凝胶组合物治疗软组织病症的方法。

3. 发明申请

WO2010132586A1 IMPLANTS AND METHODS FOR MANUFACTURING SAME 审中-公开
标题翻译：用于制造它们的植入物和方法
公开(公告)号：WO2010132586A1
公开(公告)日：2010-11-18
申请号：PCT/US2010/034578
申请日：2010-05-12
申请人： ALLERGAN, INC. , GUILLEN, Blanca , STROUMPOULIS, Dimitrios
发明人： GUILLEN, Blanca , STROUMPOULIS, Dimitrios
IPC分类号： A61F2/00 , A61L27/56
CPC分类号： A61F2/0077 , A61F2/12 , A61F2002/0086 , B29C41/003 , B29C41/08 , B29C2791/001 , B29K2105/251 , B29L2009/00 , B29L2031/7532
摘要： A implantable prosthesis having an external surface at least a portion of which is an open-cell structure is made by providing an implantable member having a surface applying a first layer (32) of elastomer to the surface, applying a first layer of particles (30) to the first layer of elastomer, applying a second layer (34) of elastomer to the first layer of particles (36), applying a second layer of particles to the second layer of elastomer, curing the layers of elastomer, and removing the particles to form an external surface at least a portion of which is an open-cell structure.
摘要翻译：具有外表面的可植入假体的至少一部分是开孔结构，通过提供具有将表面施加弹性体第一层（32）的表面的可植入构件制成，施加第一层颗粒（30 ）到第一层弹性体，将第二弹性体层（34）施加到第一层颗粒（36）上，将第二层颗粒施加到第二层弹性体上，固化弹性体层并除去颗粒以形成其至少一部分是开孔结构的外表面。

4. 发明申请

WO2011143206A3 POROUS MATERIALS, METHODS OF MAKING AND USES 审中-公开
标题翻译：多孔材料，制造方法和用途
公开(公告)号：WO2011143206A3
公开(公告)日：2012-05-03
申请号：PCT/US2011035910
申请日：2011-05-10
申请人： ALLERGAN INC , LIU FUTIAN , MANESIS NICHOLAS J , GORALTCHOUK ALEXEI , STROUMPOULIS DIMITRIOS
发明人： LIU FUTIAN , MANESIS NICHOLAS J , GORALTCHOUK ALEXEI , STROUMPOULIS DIMITRIOS
IPC分类号： C08J9/26 , A61F2/12 , A61L27/18 , A61L27/56
CPC分类号： A61L27/56 , A61F2/12 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/146 , A61L2430/04 , C08J9/26 , C08J2201/046 , C08J2383/04 , C08J2467/00 , C08L83/04
摘要： The present specification discloses porous materials, methods of forming such porous materials, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.
摘要翻译：本说明书公开了多孔材料，形成这种多孔材料的方法，包括这种多孔材料的生物相容性可植入装置以及制造这种生物相容性可植入装置的方法。

5. 发明申请

WO2011143206A2 POROUS MATERIALS, METHODS OF MAKING AND USES 审中-公开
标题翻译：多孔材料，制造方法和用途
公开(公告)号：WO2011143206A2
公开(公告)日：2011-11-17
申请号：PCT/US2011/035910
申请日：2011-05-10
申请人： ALLERGAN, INC. , LIU, Futian , MANESIS, Nicholas, J. , GORALTCHOUK, Alexei , STROUMPOULIS, Dimitrios
发明人： LIU, Futian , MANESIS, Nicholas, J. , GORALTCHOUK, Alexei , STROUMPOULIS, Dimitrios
IPC分类号： D04H13/00
CPC分类号： A61L27/56 , A61F2/12 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/146 , A61L2430/04 , C08J9/26 , C08J2201/046 , C08J2383/04 , C08J2467/00 , C08L83/04
摘要： The present specification discloses porous materials, methods of forming such porous materials, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.
摘要翻译：本说明书公开了多孔材料，形成这种多孔材料的方法，包括这种多孔材料的生物相容性可植入装置以及制造这种生物相容性可植入装置的方法。

6. 发明申请

WO2011100191A1 IMPLANTABLE INJECTION PORT 审中-公开
标题翻译：可注射口
公开(公告)号：WO2011100191A1
公开(公告)日：2011-08-18
申请号：PCT/US2011/023894
申请日：2011-02-07
申请人： ALLERGAN, INC. , HARDERS, James A. , RAVEN, Joseph S. , STROUMPOULIS, Dimitrios , TRILOKEKAR, Nikhil S.
发明人： HARDERS, James A. , RAVEN, Joseph S. , STROUMPOULIS, Dimitrios , TRILOKEKAR, Nikhil S.
IPC分类号： A61F5/00
CPC分类号： A61F5/0056 , A61F5/003 , A61F5/0043 , A61M39/0208 , A61M39/04 , A61M2039/0223
摘要： An implantable injection port facilitates filling and/or draining an inflatable portion of a gastric band. In an embodiment, the port comprises a movable cap that causes anchor wires to extend from anchor devices in order to implant the injection port in the tissue of a patient. In another embodiment, the port comprises a handle that rotates to implant curved anchors into the tissue of a patient. In yet another embodiment, a cap is configured to move towards a base of the port in order to cause the curved anchors to rotate into the tissue of a patient. The cap may also rotate with respect to the base in order to lock the cap and the anchors in position. Further, surfaces of the injection port may be textured to increase adhesiveness to the patient's tissue during installation and to facilitate simpler installation.
摘要翻译：可植入注射口有助于填充和/或排出胃带的可充气部分。在一个实施例中，端口包括可移动盖，其使锚线从锚定装置延伸以便将注射端口植入患者的组织中。在另一个实施例中，端口包括旋转的手柄，以将弯曲的锚固件植入患者的组织中。在另一个实施例中，帽构造成朝向端口的基部移动，以便使弯曲的锚固件旋转到患者的组织中。盖子也可以相对于基座旋转，以便将盖子和锚固件锁定就位。此外，注射端口的表面可以被纹理化以在安装期间增加对患者组织的粘附性并且便于更简单的安装。

7. 发明申请

WO2011143219A1 POROUS MATERIALS, METHODS OF MAKING AND USES 审中-公开
标题翻译：多孔材料，制造方法和用途
公开(公告)号：WO2011143219A1
公开(公告)日：2011-11-17
申请号：PCT/US2011/035923
申请日：2011-05-10
申请人： ALLERGAN, INC. , LIU, Futian , MANESIS, Nicholas J. , GORALTCHOUK, Alexei , STROUMPOULIS, Dimitrios
发明人： LIU, Futian , MANESIS, Nicholas J. , GORALTCHOUK, Alexei , STROUMPOULIS, Dimitrios
IPC分类号： A61L27/18 , A61L27/50 , A61L27/56 , A61L27/58
CPC分类号： A61L27/18 , A61L27/16 , A61L27/50 , A61L27/56 , A61L2430/04 , Y10T156/10 , C08L83/04 , C08L53/02 , C08L23/22
摘要： The present specification discloses porous materials, methods of forming such porous materials, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.
摘要翻译：本说明书公开了多孔材料，形成这种多孔材料的方法，包含这种多孔材料的生物相容性可植入装置以及制造这种生物相容性可植入装置的方法。

8. 发明申请

WO2011100452A1 REMOTELY ADJUSTABLE GASTRIC BANDING SYSTEM 审中-公开
标题翻译：远程可调节的带式系统
公开(公告)号：WO2011100452A1
公开(公告)日：2011-08-18
申请号：PCT/US2011/024379
申请日：2011-02-10
申请人： ALLERGAN, INC. , STROUMPOULIS, Dimitrios
发明人： STROUMPOULIS, Dimitrios
IPC分类号： A61F5/00
CPC分类号： A61F5/0056 , A61F5/005 , A61F5/0053 , A61F5/0059
摘要： An implantable device comprises a reservoir that contains a fluid for filling an inflatable portion of a gastric band. A device is coupled to the reservoir and includes stored potential energy having a first state and a second state. The first state represents a higher level of potential energy and the second state represents a lower level of potential energy. The implantable device further comprises a filling valve coupled between the reservoir and the gastric band, and the filling valve is configured to be opened in response to a first telemetric signal. The stored potential energy decreases from the first state to the second state when the filling valve is open, and a filling amount of the fluid moves from the reservoir to the gastric band when the stored potential energy decreases from the first state to the second state.
摘要翻译：可植入装置包括储存器，其容纳用于填充胃带的可充气部分的流体。一个装置耦合到贮存器并且包括具有第一状态和第二状态的存储的势能。第一状态代表较高水平的势能，第二状态代表较低水平的势能。可植入装置还包括联接在储存器和胃带之间的填充阀，并且填充阀被配置为响应于第一遥测信号而打开。当填充阀打开时，储存的势能从第一状态减少到第二状态，并且当存储的势能从第一状态降低到第二状态时，流体的填充量从储存器移动到胃束带。

9. 发明申请

WO2011084504A1 SYRINGE COMPRISING TWO PLUNGERS WITH LOCKING MEANS 审中-公开
标题翻译：包装两个枕头的锁紧装置
公开(公告)号：WO2011084504A1
公开(公告)日：2011-07-14
申请号：PCT/US2010/060553
申请日：2010-12-15
申请人： ALLERGAN, INC. , STROUMPOULIS, Dimitrios , MUDD, Christopher, S.
发明人： STROUMPOULIS, Dimitrios , MUDD, Christopher, S.
IPC分类号： A61M5/19 , A61M5/315 , A61F2/00
CPC分类号： A61M5/31501 , A61M5/19 , A61M5/31511 , A61M5/3158 , A61M5/31596 , A61M2005/31508 , A61M2005/31598
摘要： The syringe includes a syringe body (101) with a fluid chamber and with an extrusion opening (104) at the proximal end (401); a dividing wall disposed within the fluid chamber, defining a first fluid chamber (302) and a second fluid chamber (303), the first fluid chamber and the second fluid chamber in communication with the extrusion opening; a first plunger (102) disposed in a distal end of the first chamber, the first plunger including a first locking mechanism (402) configured to prevent the first plunger from sliding away from the proximal end of the syringe body, when the first plunger is in a first initial position and the second plunger is being depressed; and a second plunger disposed in a distal end of the second chamber, the second plunger including a second locking mechanism (402) configured to prevent the second plunger from sliding away from the proximal end of the syringe body when the second plunger is in a second initial position and the first plunger is being depressed.
摘要翻译：注射器包括具有流体室的注射器主体（101）和在近端（401）处的挤出开口（104）; 分隔壁，其设置在所述流体室内，限定第一流体室（302）和第二流体室（303），所述第一流体室和所述第二流体室与所述挤出口连通; 设置在所述第一腔室的远端中的第一柱塞（102），所述第一柱塞包括第一锁定机构（402），所述第一锁定机构构造成当所述第一柱塞为所述第一柱塞时，防止所述第一柱塞从所述注射器主体的近端滑离; 在第一初始位置和第二柱塞被压下; 以及设置在所述第二腔室的远端中的第二柱塞，所述第二柱塞包括第二锁定机构（402），所述第二锁定机构构造成当所述第二柱塞处于第二柱塞时，所述第二锁定机构被构造成防止所述第二柱塞从所述注射器主体的近端滑离初始位置和第一柱塞被压下。

10. 发明申请

WO2011059909A1 POLYSACCHARIDE GEL FORMULATION HAVING MULTI-STAGE BIOACTIVE AGENT DELIVERY 审中-公开
标题翻译：具有多阶段生物交换剂的多糖凝胶配方
公开(公告)号：WO2011059909A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/055801
申请日：2010-11-08
申请人： ALLERGAN, INC. , STROUMPOULIS, Dimitrios , LESLIE, Dustin B. , MUDD, Christopher S. , TEZEL, Ahmet
发明人： STROUMPOULIS, Dimitrios , LESLIE, Dustin B. , MUDD, Christopher S. , TEZEL, Ahmet
IPC分类号： A61K8/60 , A61K8/73 , A61K8/04 , A61K8/34 , A61K9/10 , A61K47/36 , A61K47/10 , A61K47/26 , A61K31/728 , A61K31/738
CPC分类号： A61K8/042 , A61K8/492 , A61K8/60 , A61K8/602 , A61K8/676 , A61K8/678 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/736 , A61K9/0024 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/727 , A61K31/728 , A61K31/737 , A61K31/738 , A61K47/12 , A61K47/36 , A61K2800/522 , A61Q19/08 , C08B37/0072 , C08J3/075 , C08J3/12 , C08J3/128 , C08J3/24 , C08J2351/02 , C08K5/0025 , C08L1/02 , C08L5/04 , C08L5/08 , C08L5/10
摘要： Described herein are polysaccharide gel formulations including at least one inhibitor of polysaccharide degradation and methods of making the same. The methods described herein involve the steps of providing at least one polysaccharide and incorporating at least one inhibitor of degradation into the polysaccharide.
摘要翻译：本文描述的是多糖凝胶制剂，其包括至少一种多糖降解抑制剂及其制备方法。本文描述的方法包括提供至少一种多糖并将至少一种降解抑制剂并入多糖中的步骤。

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