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1. 发明申请

WO2004092332A3 SARS VIRUS POLYPEPTIDES 审中-公开
标题翻译： SARS病毒多糖
公开(公告)号：WO2004092332A3
公开(公告)日：2006-03-02
申请号：PCT/US2004010729
申请日：2004-04-08
申请人： CIPHERGEN BIOSYSTEMS INC , LOMAS LEE , PAK BRIAN , FU SIYU , TORNATORE PETE , VINER ROSA , WEINBERGER SCOT R , YIP TAI-TUNG
发明人： LOMAS LEE , PAK BRIAN , FU SIYU , TORNATORE PETE , VINER ROSA , WEINBERGER SCOT R , YIP TAI-TUNG
IPC分类号： C07K7/00 , A61K39/215 , C07K4/02 , C07K14/165 , C07K16/10 , C12N20060101 , C12N15/50 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/12 , A61K39/215 , C07K16/10 , C12N2770/20022 , C12N2770/20034 , G01N2333/165 , G01N2333/4721 , G01N2469/20
摘要： The present invention provides, inter alia, SARS-related polypeptides, i.e., polypeptides associated with Severe Acute Respiratory Syndrome (SARS). The present invention also provides antibodies that specifically bind SARS-related polypeptides. In addition, the present invention provides methods for detecting an infection associated with SARS.
摘要翻译：本发明尤其提供了SARS相关多肽，即与严重急性呼吸综合征（SARS）相关的多肽。本发明还提供了特异性结合SARS相关多肽的抗体。此外，本发明提供了检测与SARS有关的感染的方法。

2. 发明申请

WO2004031724A3 APPARATUS AND METHOD FOR EXPRESSION AND CAPTURE OF BIOMOLECULES AND COMPLEXES ON ADSORBENT SURFACES 审中-公开
标题翻译：生物分子和复合物在吸附表面上的表达和捕获的装置和方法
公开(公告)号：WO2004031724A3
公开(公告)日：2005-04-14
申请号：PCT/US0330760
申请日：2003-09-29
申请人： CIPHERGEN BIOSYSTEMS INC , LOMAS LEE O , BOSCHETTI EGISTO , YIP TAI-TUNG
发明人： LOMAS LEE O , BOSCHETTI EGISTO , YIP TAI-TUNG
IPC分类号： C12M1/34 , G01N20060101 , G01N33/543
CPC分类号： G01N33/54366 , B01J2219/00283 , B01J2219/00317 , B01J2219/00423 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00639 , B01J2219/00641 , B01J2219/00659 , B01J2219/00695 , B01J2219/007 , B01J2219/00725 , G01N33/54353
摘要： The present invention relates to the fields of molecular biology, combinatorial chemistry and biochemistry. Particularly, the present invention describes apparatus and methods for the detection and isolation of binding partners and activity modulators for biomolecules. The apparatus described allows for expression, capture and analysis of one or more biomolecules in a single step.
摘要翻译：本发明涉及分子生物学，组合化学和生物化学领域。特别地，本发明描述了用于检测和分离用于生物分子的结合配偶体和活性调节剂的装置和方法。所描述的装置允许在单个步骤中表达，捕获和分析一种或多种生物分子。

3. 发明申请

WO2004094460A2 POLYPEPTIDES RELATED TO NATRIURETIC PEPTIDES AND METHODS OF THEIR IDENTIFICATION AND USE 审中-公开
标题翻译：与NATRIURETIC PEPDES相关的多肽及其鉴定和使用方法
公开(公告)号：WO2004094460A2
公开(公告)日：2004-11-04
申请号：PCT/US2004012067
申请日：2004-04-19
申请人： CIPHERGEN BIOSYSTEMS INC , BIOSITE INC , BUECHLER KENNETH F , FUNG ERIC THOMAS , YIP TAI-TUNG
发明人： BUECHLER KENNETH F , FUNG ERIC THOMAS , YIP TAI-TUNG
IPC分类号： C07K20060101 , G01N33/53 , G01N33/74 , C07K
CPC分类号： G01N33/74 , G01N2500/04
摘要： The present invention relates to the identification and use of polypeptides that bind to antibodies directed to a desired polypeptide of interest. Using natriuretic peptides and their precursors, and in particular BNP, as an example, the present invention describes a number of natriuretic peptides fragments produced in biological samples, most preferably blood-derived samples, that bind to antibodies directed to BNP. Because production of such fragments is an ongoing process that may be a function of, inter alia, the elapsed time between onset of an event triggering natriuretic peptide release into the tissues and the time the sample is obtained or analyzed; the elapsed time between sample acquisition and the time the sample is analyzed; the type of tissue sample at issue; the storage conditions; the quantity of proteolytic enzymes present; etc., such fragments may be used when both designing an assay for one or more natriuretic peptides, and when performing such an assay, in order to provide an accurate prognostic or diagnostic result.
摘要翻译：本发明涉及与靶向所需感兴趣的多肽的抗体结合的多肽的鉴定和使用。使用利尿钠肽及其前体，特别是BNP作为实例，本发明描述了与生物样品中产生的许多利钠肽片段，最优选血液衍生的样品，其结合针对BNP的抗体。因为这样的片段的产生是一个持续的过程，其可以是尤其是引发利钠肽释放到组织中的事件发生之间经过的时间与获得或分析样品的时间的函数; 样品采集与样品分析时间之间的经过时间; 有关组织样本的类型; 储存条件; 存在蛋白水解酶的数量; 当设计用于一种或多种利钠肽的测定法和进行这样的测定时，可以使用这样的片段，以便提供准确的预后或诊断结果。

4. 发明申请

WO2004009798A3 PROTEIN INTERACTION DIFFERENCE MAPPING 审中-公开
公开(公告)号：WO2004009798A3
公开(公告)日：2004-01-29
申请号：PCT/US2003/023320
申请日：2003-07-23
申请人： CIPHERGEN BIOSYSTEMS, INC. , RICH, William , BOSCHETTI, Egisto , LOMAS, Lee, O. , YIP, Tai-Tung
发明人： RICH, William , BOSCHETTI, Egisto , LOMAS, Lee, O. , YIP, Tai-Tung
IPC分类号： G01N33/543
摘要： This invention provides methods and materials for mapping interaction characteristics between components of a multicomponent biological complex. The methods involve capturing a multicomponent complex on a solid support and washing the support with a series of elution washes forming a gradient of solute concentrations, and determining whether a particular elution wash eluted a particular component.

5. 发明申请

WO2004097368A3 IMPROVED IMMUNOASSAYS 审中-公开
标题翻译：改善免疫力
公开(公告)号：WO2004097368A3
公开(公告)日：2005-06-30
申请号：PCT/US2004011843
申请日：2004-04-16
申请人： CIPHERGEN BIOSYSTEMS INC , YIP TAI-TUNG , FUNG ERIC THOMAS
发明人： YIP TAI-TUNG , FUNG ERIC THOMAS
IPC分类号： G01N20060101 , G01N33/53 , G01N33/68 , G06F19/00
CPC分类号： G01N33/6851 , G06F19/18 , G06F19/24
摘要： Methods for discriminating between related proteins and other analytes in a sample and for correlating protein expression with disease states.
摘要翻译：用于区分样品中相关蛋白质和其他分析物以及将蛋白质表达与疾病状态相关联的方法。

6. 发明申请

WO2004061410A3 SERUM BIOMARKERS IN LUNG CANCER 审中-公开
公开(公告)号：WO2004061410A3
公开(公告)日：2004-07-22
申请号：PCT/US2003/037090
申请日：2003-12-16
申请人： CIPHERGEN BIOSYSTEMS, INC. , QUEEN ELIZABETH HOSPITAL , YIP, Timothy, Tak, Chun , CHO, Chi, Shing , AU, Siu, Kie , YIP, Tai-Tung , YIP, Christine, L. , YIP, Victor, F.
发明人： YIP, Timothy, Tak, Chun , CHO, Chi, Shing , AU, Siu, Kie , YIP, Tai-Tung , YIP, Christine, L. , YIP, Victor, F.
IPC分类号： C12Q1/00
摘要： Certain biomarkers and biomarker combinations are useful in a qualifying lung cancer status in a subject. A diagnostic methodology employing these biomarkers and combinations can detect whether a subject has lung cancer.

7. 发明申请

WO2003058198A2 HUMAN BREAST CANCER BIOMARKERS 审中-公开
标题翻译：人乳腺癌生物标志物
公开(公告)号：WO2003058198A2
公开(公告)日：2003-07-17
申请号：PCT/US2002/041614
申请日：2002-12-23
申请人： CIPHERGEN BIOSYSTEMS, INC. , YIP, Tai-Tung , YIP, Christine
发明人： YIP, Tai-Tung , YIP, Christine
IPC分类号： G01N
CPC分类号： G01N33/57415
摘要： The invention provides markers, methods and kits that can be used as an aid for breast cancer diagnosis using markers that are differentially present in the samples of breast cancer patients and a control ( e.g. , women in whom breast cancer is undetectable).
摘要翻译：本发明提供了标记，方法和试剂盒，其可以用作乳腺癌诊断的辅助，其使用在乳腺癌患者的样品中差异存在的标记，以及对照（例如，其中乳腺癌的妇女是不可检测的）。

8. 发明申请

WO9859360A9 RETENTATE CHROMATOGRAPHY AND PROTEIN CHIP ARRAYS WITH APPLICATIONS IN BIOLOGY AND MEDICINE 审中-公开
标题翻译：再生色素和蛋白质芯片阵列与生物医学应用
公开(公告)号：WO9859360A9
公开(公告)日：1999-04-15
申请号：PCT/US9812843
申请日：1998-06-19
申请人： CIPHERGEN BIOSYSTEMS INC , HUTCHENS T WILLIAM , YIP TAI TUNG
发明人： HUTCHENS T WILLIAM , YIP TAI-TUNG
IPC分类号： G01N33/52 , A61K49/00 , B01D15/38 , B01J20/281 , B01J20/286 , B01J20/32 , C12M1/34 , C12M1/42 , C12N15/09 , C12Q1/00 , C12Q1/68 , C40B30/04 , C40B40/10 , G01N27/62 , G01N27/64 , G01N30/00 , G01N30/02 , G01N30/46 , G01N30/90 , G01N30/95 , G01N33/15 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/531 , G01N33/538 , G01N33/543 , G01N33/566 , G01N33/68 , G01N37/00 , G06F19/00 , H01J49/04 , H01J49/26
CPC分类号： C40B30/04 , B01D15/1878 , B01D15/305 , B01D15/3809 , B01J20/281 , B01J20/286 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3265 , B01J20/3274 , B01J20/3289 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2220/54 , C12Q1/00 , C40B40/10 , G01N30/00 , G01N30/02 , G01N30/461 , G01N30/463 , G01N30/466 , G01N30/48 , G01N30/482 , G01N30/90 , G01N30/95 , G01N33/531 , G01N33/538 , G01N33/543 , G01N33/54306 , G01N33/54353 , G01N33/54373 , G01N33/54393 , G01N33/566 , G01N33/6803 , G01N33/6845 , G01N33/6851 , G01N2030/008 , G01N2030/009 , Y02A90/26 , Y10S422/906 , Y10S435/803 , Y10S435/81 , Y10S435/814 , Y10S435/815 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/808 , Y10S436/809 , Y10S436/811 , Y10S436/813 , Y10S436/824 , Y10S436/825 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , B01D15/363 , B01D15/322 , B01D15/327 , B01D15/3804 , B01D15/362 , B01D15/38 , B01D15/26
摘要： This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectively conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
摘要翻译：本发明提供了用于分析样品中分析物的滞留层析方法。所述方法包括在多种不同选择性条件下将分析物吸附到基底上，并通过解吸光谱法检测保留在底物上的分析物。这些方法在生物学和医学中是有用的，包括临床诊断和药物发现。

9. 发明申请

WO2008121340A1 METHODS FOR DIAGNOSING OVARIAN CANCER 审中-公开
标题翻译：诊断卵巢癌的方法
公开(公告)号：WO2008121340A1
公开(公告)日：2008-10-09
申请号：PCT/US2008/004089
申请日：2008-03-27
申请人： VERMILLION, INC. , SAHLGRENSKA ACADEMY AT GOETEBORG UNIVERSITY , FUNG, Eric, Thomas , YIP, Tai-Tung , PODUST, Vladimir , BRANNSTROM, Mats , SUNDFELDT, Karin , KRISTJANSDOTTIR, Bjorg
发明人： FUNG, Eric, Thomas , YIP, Tai-Tung , PODUST, Vladimir , BRANNSTROM, Mats , SUNDFELDT, Karin , KRISTJANSDOTTIR, Bjorg
IPC分类号： G01N33/53 , C07K1/00
CPC分类号： G01N33/57449 , C07K1/1077 , G01N33/6848
摘要： The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer, ovarian cancer of low malignant potential, benign ovarian disease or other malignant condition. The biomarkers can be detected by SELDI mass spectrometry, immunoassay, or other means.
摘要翻译：本发明提供了可用于评估患者卵巢癌状态的基于蛋白质的生物标志物和生物标志物组合。特别地，本发明的生物标志物可用于将受试者样品分类为卵巢癌，低恶性潜能的卵巢癌，良性卵巢疾病或其他恶性病症。生物标志物可以通过SELDI质谱，免疫分析法或其他手段检测。

10. 发明申请

WO2005121758A1 BIOMARKERS FOR PERIPHERAL ARTERY DISEASE 审中-公开
标题翻译：外周动脉疾病的生物标志物
公开(公告)号：WO2005121758A1
公开(公告)日：2005-12-22
申请号：PCT/US2005/018728
申请日：2005-05-26
申请人： CIPHERGEN BIOSYSTEMS, INC. , FUNG, Eric T. , COOKE, John P. , MENG, Xiao-Ying , YIP, Tai-Tung , ZHANG, Fujun
发明人： FUNG, Eric T. , COOKE, John P. , MENG, Xiao-Ying , YIP, Tai-Tung , ZHANG, Fujun
IPC分类号： G01N24/00
CPC分类号： G01N33/6893 , G01N2800/32 , G01N2800/324
摘要： This invention provides biomarkers whose concentrations in blood plasma are associated with the presence or absence of PAD in the patient from whom the plasma sample is taken. The invention also provides biomarkers for distinguishing between PAD patients who are long claudicators and PAD patients who are not. In addition, the invention provides methods for identifying additional biomarkers, methods for detecting the biomarkers in patients, and methods for identifying agents, including pharmaceutical agents, which interact with the biomarkers and are useful for preventing or treating PAD in patients.
摘要翻译：本发明提供了血浆中的浓度与患有血浆样品的患者中存在或不存在PAD有关的生物标志物。本发明还提供用于区分长跛行者的PAD患者和不是PAD患者的生物标志物。此外，本发明提供了用于鉴定另外的生物标志物的方法，用于检测患者中生物标志物的方法，以及用于鉴定与生物标志物相互作用并可用于预防或治疗患者中PAD的药剂（包括药剂）的方法。

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