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1. 发明申请

WO2005123950A2 PERFUSED THREE-DIMENSIONAL CELL/TISSUE DISEASE MODELS 审中-公开
标题翻译：丰富的三维细胞/组织疾病模型
公开(公告)号：WO2005123950A2
公开(公告)日：2005-12-29
申请号：PCT/US2005/017594
申请日：2005-05-19
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , UNIVERSITY OF PITTSBURGH , DOMANSKY, Karel , GRIFFITH, Linda, G. , TANNENBAUM, Steven, R. , WELLS, Alan
发明人： DOMANSKY, Karel , GRIFFITH, Linda, G. , TANNENBAUM, Steven, R. , WELLS, Alan
IPC分类号： C12Q1/68
CPC分类号： B01L3/502715 , B01J2219/00315 , B01J2219/00743 , B01L3/50255 , B01L3/50273 , B01L3/502738 , B01L2300/0681 , B01L2300/0829 , B01L2300/0861 , B01L2400/0481 , B01L2400/0638 , B33Y80/00 , C12M23/12 , C12M23/40 , C12M25/14 , C12M29/10
摘要： A system has been constructed that recapitulate the features of a capillary bed through normal human tissue. The system facilitates perfusion of three-dimensional (3D) cell monocultures and heterotypic cell co-cultures at the length scale of the capillary bed. A major feature is that the system can be utilized within a "multiwell plate" format amenable to highthroughput assays compatible with the type of robotics commonly used in pharmaceutical development. The system provides a means to conduct assays for toxicology and metabolism and as a model for human diseases such as hepatic diseases, including hepatitis, exposure-related pathologies, and cancer. Cancer applications include primary liver cancer as well as metastases. The system can also be used as a means of testing gene therapy approaches for treating disease and inborn genetic defects.
摘要翻译：已经构建了通过正常人体组织重现毛细血管床特征的系统。该系统有助于在毛细血管床的长度尺度上灌注三维（3D）细胞单一培养物和异型细胞共培养物。一个主要特征是该系统可以在“多孔板”格式中使用，适合与通常用于药物开发的机器人类型相容的高通量测定。该系统提供了进行毒理学和代谢测定的手段，并且作为人类疾病（如肝脏疾病，包括肝炎，暴露相关病理和癌症）的模型。癌症应用包括原发性肝癌以及转移瘤。该系统还可用作测试基因治疗方法的手段，用于治疗疾病和先天性遗传缺陷。

2. 发明申请

WO1997047821A1 WAVE ENERGY CONVERTER 审中-公开
标题翻译：波能转换器
公开(公告)号：WO1997047821A1
公开(公告)日：1997-12-18
申请号：PCT/GB1997001551
申请日：1997-06-10
申请人： APPLIED RESEARCH & TECHNOLOGY LIMITED , WELLS, Alan, Arthur
发明人： APPLIED RESEARCH & TECHNOLOGY LIMITED
IPC分类号： E02B09/08
CPC分类号： F03B13/142 , F03D9/008 , F03D9/25 , F05B2240/95 , Y02E10/32 , Y02E10/38 , Y02E10/725
摘要： A wave collector structure (51) for electrical power generation powered by wave energy comprises an outwardly extending and downwardly depending lip (105, 107) below which is situated a mouth (61, 67) of the collector. The collector further comprises side walls (75, 79) for channelling waves into the collector mouth. These side walls (75, 79) extend horizontally substantially up to or beyond the lip, partially enclosing a volume of water between the lip and side walls. The collector is placed in its desired location by sealing the mouth (61, 67) with gates (not shown) and floating the structure to its desired location. Control valves are opened to allow water into the collector to sink the structure to the sea bed (63) whereupon the gates are removed.
摘要翻译：由波浪能量发电的波发生器结构（51）包括向外延伸和向下悬垂的唇缘（105,107），下方位于收集器的口部（61,67）之下。收集器还包括用于将波浪引导到收集器口中的侧壁（75,79）。这些侧壁（75,79）水平地基本上延伸到或超过唇缘，部分地包围在唇缘和侧壁之间的一定体积的水。通过将门（61,67）与门（未示出）密封并将结构浮动到其期望的位置，将收集器放置在其期望的位置。打开控制阀以允许水进入收集器以将结构沉入海床（63），从而排除闸门。

3. 发明申请

WO2010085691A1 THERMOELECTRIC MANAGEMENT UNIT 审中-公开
标题翻译：热电管理单元
公开(公告)号：WO2010085691A1
公开(公告)日：2010-07-29
申请号：PCT/US2010/021863
申请日：2010-01-22
申请人： HOFFMAN ENCLOSURES INC. , RAWSKI, John, Myron , LARSON, Larry, Allen , DICKMANN, Jason, William , GUITART, Pedro, Ramon , RICKE, Joseph , HANSON, William , WELLS, Alan
发明人： RAWSKI, John, Myron , LARSON, Larry, Allen , DICKMANN, Jason, William , GUITART, Pedro, Ramon , RICKE, Joseph , HANSON, William , WELLS, Alan
IPC分类号： F25B21/02
CPC分类号： F25B21/04 , F25B2321/0211 , F25B2321/0212 , F25B2321/023 , G06F1/206 , H05K7/20163
摘要： Embodiments of the invention provide a thermal management unit including a housing, at least one fan, a plurality of thermoelectric modules, at least one heat sink assembly coupled to the plurality of thermoelectric modules, and controller providing power to the plurality of thermoelectric modules. The thermal management unit also includes a printed circuit board incorporating the plurality of thermoelectric modules and electrically connecting the plurality of thermoelectric modules to the controller. The printed circuit board separates an ambient side of the thermal management unit and an enclosure side of the thermal management unit.
摘要翻译：本发明的实施例提供一种热管理单元，其包括壳体，至少一个风扇，多个热电模块，耦合到多个热电模块的至少一个散热器组件，以及向多个热电模块提供电力的控制器。热管理单元还包括结合有多个热电模块并将多个热电模块电连接到控制器的印刷电路板。印刷电路板分离热管理单元的环境侧和热管理单元的外壳侧。

4. 发明申请

WO9218704A3 Wave energy converter 审中-公开
标题翻译：波能量转换器
公开(公告)号：WO9218704A3
公开(公告)日：1992-10-29
申请号：PCT/GB9200711
申请日：1992-04-16
申请人： APPLIED RES & TECHNOLOGY LTD , WELLS ALAN ARTHUR
发明人： WELLS ALAN ARTHUR
IPC分类号： E02B3/04 , E02B9/08 , E02D23/16 , F03B13/14 , F03B13/24
CPC分类号： F03B13/142 , E02B3/04 , E02B9/08 , E02D23/16 , Y02E10/32 , Y02E10/38
摘要： In a method and apparatus for anchoring a structure such as a wave collector (213), sediment (237) is pumped from the sea bed (215) into the base (221) of the structure. Hydraulic tuning of a wave energy converter collector, an advantageous rotor structure and a means of smoothing wave-to-electricity energy conversion are also described and claimed.

5. 发明申请

WO2013032853A1 ACTIVATORS OF CXCR3 FOR THE TREATMENT OF ANGIOPATHIES OF THE EYE 审中-公开
标题翻译： CXCR3的激活剂用于治疗眼睛的血管病变
公开(公告)号：WO2013032853A1
公开(公告)日：2013-03-07
申请号：PCT/US2012/052049
申请日：2012-08-23
申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , WELLS, Alan, H. , YATES-BINDER, Cecelia, C. , SCHUMAN, Joel, S.
发明人： WELLS, Alan, H. , YATES-BINDER, Cecelia, C. , SCHUMAN, Joel, S.
IPC分类号： A61P27/02 , A61K38/19
CPC分类号： A61K38/195 , A61K9/0048 , A61K38/217
摘要： The present disclosure describes methods of treating angiogenic disorders of the eye, such as macular degeneration, restenosis following glaucoma treatment or diabetic retinopathy, by administering an activator of CXCR3. In some embodiments, the activator of CXCR3 is IP-10 or a fragment or variant thereof, such as a fragment comprising or consisting of the C-terminal a-helix of IP-10. In other embodiments, the activator of CXCR3 is PF4 or a fragment or variant thereof.
摘要翻译：本公开内容描述了通过施用CXCR3的活化剂来治疗眼睛的血管生成疾病如黄斑变性，青光眼治疗后的再狭窄或糖尿病性视网膜病变的方法。在一些实施方案中，CXCR3的活化剂是IP-10或其片段或变体，例如包含IP-10的C-末端α-螺旋或由其构成的片段。在其它实施方案中，CXCR3的活化剂是PF4或其片段或变体。

6. 发明申请

WO1994009272A1 COMBINED WIND AND WAVE POWER GENERATOR 审中-公开
标题翻译：组合式风力发电机组
公开(公告)号：WO1994009272A1
公开(公告)日：1994-04-28
申请号：PCT/GB1993002072
申请日：1993-10-06
申请人： APPLIED RESEARCH & TECHNOLOGY LIMITED , WELLS, Alan, Arthur
发明人： APPLIED RESEARCH & TECHNOLOGY LIMITED
IPC分类号： F03B13/14
CPC分类号： F03D9/008 , F02C1/02 , F03B13/142 , F03D3/04 , F03D13/25 , F05B2240/212 , F05B2240/93 , Y02E10/32 , Y02E10/38 , Y02E10/727 , Y02E10/74
摘要： Combined wind turbine and oscillating water column device with unidirectional rotation air turbine of the Darius type (79), both supported by the same offshore toroidal, polyhedral or quasi-spherical structure, anchored or otherwise fixed to the sea bed.
摘要翻译：具有Darius型（79）的单向旋转式空气涡轮的组合式风力涡轮机和振荡水柱装置，均由相同的海上环形多面体或准球形结构支撑，锚固或以其他方式固定在海床上。

7. 发明申请

WO1992022740A1 ELECTRICITY GENERATOR 审中-公开
标题翻译：电力发电机
公开(公告)号：WO1992022740A1
公开(公告)日：1992-12-23
申请号：PCT/GB1992001050
申请日：1992-06-11
申请人： HASER COMPANY LIMITED , WELLS, Alan, Arthur
发明人： HASER COMPANY LIMITED
IPC分类号： F02G03/00
CPC分类号： F02C3/00 , F01D1/30
摘要： A device (1) for generating electricity comprises a resonance tube (3) and a pulse combustor (9) for causing oscillations in a gas in the resonance tube (3). The device has a rotor (17) with an associated electrical generator unit (15) remote from the pulse combustor (9). The oscillations in the gas cause the rotor (17) to rotate and drive the electrical generator unit (15).
摘要翻译：用于产生电力的装置（1）包括用于引起谐振管（3）中的气体中的振荡的共振管（3）和脉冲燃烧器（9）。该装置具有转子（17），其具有远离脉冲燃烧器（9）的相关联的发电机单元（15）。气体中的振荡导致转子（17）旋转并驱动发电机单元（15）。

8. 发明申请

WO2021009603A1 A METHOD, SYSTEM, APP OR KIT OF PARTS FOR TEACHING MUSICAL RHYTHM, IN PARTICULAR PERCUSSION 审中-公开
公开(公告)号：WO2021009603A1
公开(公告)日：2021-01-21
申请号：PCT/IB2020/056203
申请日：2020-06-30
申请人： WELLS, Alan , WELLS, Neil
发明人： WELLS, Neil
IPC分类号： G09B15/00 , G09B5/06
摘要： Musical rhythm, is taught using a sequenced rhythm pattern, wherein a user's strike within a time window around each note maintains suppression of audible output. If a strike falls outside the time window, output resumes. Fig 2 shows a smartphone/tablet app. Pad 13 is struck in harmony with a rhythmic pattern on display 1. Means 3 to 11 adjust app parameters. Means 2 control rhythm. A display preferably shows current and past states of the system during a session (e.g. metronome suppressed, metronome non-suppressed, strike detected in time window, strikes outside time window), as well as time remaining in the current session, as either a 'clock' or 'pie chart' type, or rectilinear 'bar' type, the 'time remaining' segment of the display being progressively replaced by sections e.g. of differing colour or texture corresponding to the current state, with the 'time past' segments displaying the past states.

9. 发明申请

WO2005123950A3 PERFUSED THREE-DIMENSIONAL CELL/TISSUE DISEASE MODELS 审中-公开
标题翻译：丰富的三维细胞/组织疾病模型
公开(公告)号：WO2005123950A3
公开(公告)日：2006-04-13
申请号：PCT/US2005017594
申请日：2005-05-19
申请人： MASSACHUSETTS INST TECHNOLOGY , UNIV PITTSBURGH , DOMANSKY KAREL , GRIFFITH LINDA G , TANNENBAUM STEVEN R , WELLS ALAN
发明人： DOMANSKY KAREL , GRIFFITH LINDA G , TANNENBAUM STEVEN R , WELLS ALAN
IPC分类号： B01L3/00 , C12M1/00 , C12M1/32 , C12M1/34 , C12Q1/68 , C12M1/12 , C12M1/22
CPC分类号： B01L3/502715 , B01J2219/00315 , B01J2219/00743 , B01L3/50255 , B01L3/50273 , B01L3/502738 , B01L2300/0681 , B01L2300/0829 , B01L2300/0861 , B01L2400/0481 , B01L2400/0638 , B33Y80/00 , C12M23/12 , C12M23/40 , C12M25/14 , C12M29/10
摘要： A system has been constructed that recapitulate the features of a capillary bed through normal human tissue. The system facilitates perfusion of three-dimensional (3D) cell monocultures and heterotypic cell co-cultures at the length scale of the capillary bed. A major feature is that the system can be utilized within a "multiwell plate" format amenable to highthroughput assays compatible with the type of robotics commonly used in pharmaceutical development. The system provides a means to conduct assays for toxicology and metabolism and as a model for human diseases such as hepatic diseases, including hepatitis, exposure-related pathologies, and cancer. Cancer applications include primary liver cancer as well as metastases. The system can also be used as a means of testing gene therapy approaches for treating disease and inborn genetic defects.
摘要翻译：已经构建了通过正常人体组织重现毛细血管床特征的系统。该系统便于在毛细血管床的长度尺度上灌注三维（3D）细胞单一培养物和异型细胞共培养物。一个主要特征是该系统可以在“多孔板”格式中使用，适合与通常用于制药开发的机器人类型兼容的高通量测定。该系统提供了进行毒理学和代谢测定的手段，并且作为人类疾病（如肝脏疾病，包括肝炎，暴露相关病理和癌症）的模型。癌症应用包括原发性肝癌以及转移瘤。该系统也可用作检测基因治疗方法以治疗疾病和先天性遗传缺陷的手段。

10. 发明申请

WO1992018704A2 WAVE ENERGY CONVERTER 审中-公开
标题翻译：波能转换器
公开(公告)号：WO1992018704A2
公开(公告)日：1992-10-29
申请号：PCT/GB1992000711
申请日：1992-04-16
申请人： APPLIED RESEARCH & TECHNOLOGY LIMITED , WELLS, Alan, Arthur
发明人： APPLIED RESEARCH & TECHNOLOGY LIMITED
IPC分类号： E02D23/16
CPC分类号： F03B13/142 , E02B3/04 , E02B9/08 , E02D23/16 , Y02E10/32 , Y02E10/38
摘要： In a method and apparatus for anchoring a structure such as a wave collector (213), sediment (237) is pumped from the sea bed (215) into the base (221) of the structure. Hydraulic tuning of a wave energy converter collector, an advantageous rotor structure and a means of smoothing wave-to-electricity energy conversion are also described and claimed.
摘要翻译：在用于锚定诸如波浪收集器（213）的结构的方法和装置中，将沉积物（237）从海床（215）泵送到结构的基座（221）中。还描述和要求保护波能量转换器收集器的液压调谐，有利的转子结构和平滑波电能转换的手段。

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