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1. 发明申请

WO2011103285A1 METHOD AND APPARATUS FOR REMOTELY PERFORMING HEMATOLOGIC ANALYSIS UTILIZING A TRANSMITTED IMAGE OF A CENTRIFUGED ANALYSIS TUBE 审中-公开
标题翻译：用于远程执行离散化分析管传输图像的血液分析的方法和装置
公开(公告)号：WO2011103285A1
公开(公告)日：2011-08-25
申请号：PCT/US2011/025240
申请日：2011-02-17
申请人： LEVINE, Joshua D. , LEVINE, Robert A. , WARDLAW, Stephen C. , STOUT, Craig , CLIPPER, David A.
发明人： LEVINE, Joshua D. , LEVINE, Robert A. , WARDLAW, Stephen C. , STOUT, Craig , CLIPPER, David A.
IPC分类号： B01L3/14 , G01N33/49 , G01N15/04 , G01N35/00
CPC分类号： G01N33/491 , B01L3/50215 , B01L9/065 , B01L2300/027 , B01L2300/0609 , B01L2300/0654 , B01L2300/0838 , G01N15/042 , G01N15/05 , G01N2015/045 , G01N2800/22 , G06T7/0012 , G06T2207/30024
摘要： An apparatus for and method of analyzing hematologic samples deposited within a capillary tube is provided. The method includes the steps of: a) imaging a region of sample centrifuged within a capillary tube using a first analysis device, which region is defined by substantially all of the radial width and axial length of the sample residing within the internal cavity of the tube where the float resides after centrifugation, and producing signals representative of the image; b) communicating the signals representative of the image to a second analysis device independent of, and remotely located from, the first analysis device; c) processing the signals representative of the image using the second analysis device and producing analysis data based on the signals; and d) displaying the image of the region of the sample using the second analysis device.
摘要翻译：提供了一种用于分析沉积在毛细管内的血液样品的方法和方法。该方法包括以下步骤：a）使用第一分析装置对在毛细管内离心的样品的区域进行成像，该区域由位于管内腔内的样品的基本上所有的径向宽度和轴向长度限定离心后浮子位于其中，并产生代表图像的信号; b）将表示所述图像的信号传送到与所述第一分析装置无关并且远离所述第一分析装置的第二分析装置; c）使用第二分析装置处理表示图像的信号，并基于该信号产生分析数据; 以及d）使用所述第二分析装置显示所述样品的区域的图像。

2. 发明申请

WO2011103281A1 METHOD AND APPARATUS FOR PERFORMING HEMATOLOGIC ANALYSIS USING AN ARRAY-IMAGING SYSTEM FOR IMAGING AND ANALYSIS OF A CENTRIFUGED ANALYSIS TUBE 审中-公开
标题翻译：使用阵列成像系统进行血液分析的方法和装置，用于成像分析和分析分析管
公开(公告)号：WO2011103281A1
公开(公告)日：2011-08-25
申请号：PCT/US2011/025233
申请日：2011-02-17
申请人： LEVINE, Joshua D. , LEVINE, Robert A. , WARDLAW, Stephen C. , STOUT, Craig , CLIPPER, David A.
发明人： LEVINE, Joshua D. , LEVINE, Robert A. , WARDLAW, Stephen C. , STOUT, Craig , CLIPPER, David A.
IPC分类号： B01L3/14 , G01N33/49 , G01N15/04
CPC分类号： G01N33/491 , B01L3/50215 , B01L9/065 , B01L2300/027 , B01L2300/0609 , B01L2300/0654 , B01L2300/0838 , G01N15/042 , G01N15/05 , G01N2015/045 , G01N2800/22 , G06T7/0012 , G06T2207/30024
摘要： A method and device for analyzing a hematologic sample centrifuged within a capillary tube is provided. The device includes a tube holder, a sample imaging device, a processor, and a sample data display. The sample imaging device is operable to create a digital image of the sample within a region of the tube. The region is defined by substantially all of the radial width and axial length of the sample residing within the internal cavity of the tube in the region where the float resides after centrifugation. The sample imaging device is operable to produce signals representative of the image. The processor is adapted to produce information relating to bands of interest within the image based on the signals from the sample imaging device. The sample data display is adapted to display the results therefrom and/or a digital image of the sample within the region.
摘要翻译：提供了用于分析在毛细管内离心的血液样品的方法和装置。该装置包括管座，样品成像装置，处理器和样品数据显示器。样品成像装置可操作以在管的区域内产生样品的数字图像。该区域由离心后浮子所在区域中位于管内腔内的样品的基本上所有的径向宽度和轴向长度限定。样品成像装置可操作以产生表示图像的信号。处理器适于基于来自样本成像装置的信号产生与图像内的感兴趣的频带相关的信息。样本数据显示器适于在该区域内显示样本的结果和/或数字图像。

3. 发明申请

WO2009117682A1 METHOD AND APPARATUS FOR DETECTING AND COUNTING PLATELETS INDIVIDUALLY AND IN AGGREGATE CLUMPS 审中-公开
标题翻译：用于检测和计数平板电脑的方法和装置
公开(公告)号：WO2009117682A1
公开(公告)日：2009-09-24
申请号：PCT/US2009/037844
申请日：2009-03-20
申请人： ABBOTT POINT OF CARE, INC. , WARDLAW, Stephen C. , LEVINE, Robert A. , LALPURIA, Niten V.
发明人： WARDLAW, Stephen C. , LEVINE, Robert A. , LALPURIA, Niten V.
IPC分类号： G01N33/50 , G01N33/49 , G01N15/02 , G01N15/14 , G01N33/80 , G01N33/58
CPC分类号： G01N33/49 , G01N15/147 , G01N15/1475 , G01N2015/0076 , G01N2015/008 , G01N2015/0084 , G01N2015/0092 , G01N2015/1486
摘要： A method for enumerating platelets within a blood sample is provided. The method includes the steps of: 1) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by a first panel and a second panel, both of which panels are transparent; 2) admixing a colorant with the sample, which colorant is operative to cause the platelets to fluoresce upon exposure to one or more predetermined first wavelengths of light; 3) illuminating at least a portion of the sample containing the platelets at the first wavelengths; 4) imaging the sample, including producing image signals indicative of fluorescent emissions from the platelets, which fluorescent emissions have an intensity; 5) identifying the platelets by their fluorescent emissions, using the image signals; 6) determining an average fluorescent emission intensity value for the individual platelets identified within the sample; 7) identifying clumps of platelets within the sample using one or more of their fluorescent emissions, area, shape, and granularity; and 8) enumerating platelets within each platelet clump using the average fluorescent emission intensity value determined for the individual platelets within the sample.
摘要翻译：提供了一种用于列举血液样品中的血小板的方法。该方法包括以下步骤：1）将样品沉积到适于静态保持样品进行分析的分析室中，所述室由第一面板和第二面板限定，两个面板都是透明的; 2）将着色剂与样品混合，所述着色剂在暴露于一个或多个预定的第一波长的光时可以使血小板发荧光; 3）以第一波长照射含有血小板的样品的至少一部分; 4）对样品进行成像，包括产生指示来自血小板的荧光发射的图像信号，该荧光发射具有强度; 5）使用图像信号通过荧光发射识别血小板; 6）确定样品内识别的各个血小板的平均荧光发射强度值; 7）使用其荧光发射，面积，形状和粒度中的一种或多种来鉴定样品中的血小板团块; 和8）使用为样品中的各个血小板确定的平均荧光发射强度值来列举每个血小板聚集体内的血小板。

4. 发明申请

WO1993005387A1 DIFFERENTIATING THE SOURCE OF OCCULT GASTROINTESTINAL BLEEDING 审中-公开
标题翻译：差异胃肠道出血的来源
公开(公告)号：WO1993005387A1
公开(公告)日：1993-03-18
申请号：PCT/US1991006593
申请日：1991-09-12
申请人： WARDLAW, Stephen, C. , LEVINE, Robert, A.
IPC分类号： G01N21/78
CPC分类号： G01N33/726 , G01N33/725 , Y10S435/805 , Y10T436/25125 , Y10T436/255
摘要： A fecal occult blood test device (1) capable of determining whether the blood found during the test originated in the upper or lower gestrointestinal track. A fecal sample (40) is applied to a test medium (20) charged to be differentially attractive to blood components originating in the upper and lower gastrointestinal track, respectively. A solvent (50) is applied to the test specimen (40) to cause differential migration of the blood components and an indicator is then applied to indicate the presence of the blood components, if any.
摘要翻译：一种粪便潜血检查装置（1），能够确定在测试期间发现的血液是否起源于上部或下部胃肠道。将粪便样品（40）施加到测试介质（20），所述测试介质（20）分别被充电以对来自上部和下部胃肠道的血液成分具有差异吸引力。将溶剂（50）施加到测试样品（40）以引起血液成分的差异迁移，然后施加指示剂以指示血液成分的存在（如果有的话）。

5. 发明申请

WO2010148135A3 HARVESTING TARGET MATERIALS FROM CENTRIFUGED SUSPENSIONS 审中-公开
标题翻译：从离心悬架收集目标材料
公开(公告)号：WO2010148135A3
公开(公告)日：2011-04-28
申请号：PCT/US2010038887
申请日：2010-06-16
申请人： LEVINE ROBERT A , WARDLAW STEPHEN C
发明人： LEVINE ROBERT A , WARDLAW STEPHEN C
IPC分类号： G01N33/483 , C12M1/10 , G01N1/14 , G01N1/28 , G01N35/10
CPC分类号： G01N33/491 , Y10T436/25 , Y10T436/25375
摘要： Embodiments of the present invention are directed to harvesting a target material from a suspension using a tube and float system. A suspension suspected of containing a target material is combined with a solution having one or more labels that distinguish the target material from other materials in the suspension. The tube, float, and suspension are centrifuged to separate various materials in the suspension according to associated specific gravities. The float expands the axial length of the target material layer and displaces the target material to a narrow space between the float and the inner wall of the tube. The space is illuminated with light that causes the labels to emit light identifying the location of the target material within the tube. One or more openings can then be formed in the tube at or near the point where the target material is located and the target material harvested.
摘要翻译：本发明的实施方案涉及使用管和浮子系统从悬浮液中收获目标材料。怀疑含有目标材料的悬浮液与具有一种或多种将目标材料与悬浮液中的其它材料区分开的标签的溶液合并。将管，浮子和悬浮液离心以根据相关的比重分离悬浮液中的各种材料。浮子膨胀目标材料层的轴向长度，并将目标材料移位到浮子和管内壁之间的狭窄空间。该空间用光照亮，导致标签发光以识别管内的目标材料的位置。然后可以在管中或靶附近所处的点附近形成一个或多个开口，并收集目标材料。

6. 发明申请

WO2010115026A1 METHOD AND DEVICE FOR TRANSFERRING BIOLOGIC FLUID SAMPLES 审中-公开
标题翻译：用于转移生物流体样品的方法和装置
公开(公告)号：WO2010115026A1
公开(公告)日：2010-10-07
申请号：PCT/US2010/029664
申请日：2010-04-01
申请人： ABBOTT POINT OF CARE, INC. , WARDLAW, Stephen, C.
发明人： WARDLAW, Stephen, C.
IPC分类号： B01L3/02 , A61M5/178 , G01N1/10
CPC分类号： B01L3/0217 , B01L2200/141 , B01L2300/0672 , G01N35/1079 , Y10T436/2575
摘要： A biologic fluid sample transfer device (10) and method is provided. The device includes an outer casing (12) and a lance (14). The outer casing has a tip (18) with an exterior surface and a bore (26) extending lengthwise through the tip and out to the exterior surface of the tip to form an aperture (30) in the exterior surface. The lance has a length extending between an operating end (32) and a sample end (34). The lance includes a seal segment (38) contiguous with the sample end. The seal segment extends a distance lengthwise and has a constant cross-sectional geometry. The transfer device is selectively disposable in an empty volume position and a sample volume position by relative lengthwise movement between the outer casing and the lance. In the empty volume position, the sample end extends outside of the- aperture. In the sample volume position, the sample end of the lance is disposed within the bore a distance away from the aperture. The seal segment of the lance forms an interference fit with the bore, which interference fit is operable to create a seal between the seal segment and the bore.
摘要翻译：提供生物流体样品转移装置（10）和方法。该装置包括外壳（12）和喷枪（14）。外壳具有一个具有外表面的尖端（18）和一个纵向延伸穿过尖端的孔（26），并在外表面上形成一个孔（30）。喷枪具有在操作端（32）和样品端（34）之间延伸的长度。喷枪包括与样品端连续的密封段（38）。密封段沿长度方向延伸一段距离，具有恒定的横截面几何形状。传送装置通过在外壳和喷枪之间的相对长度方向的移动而选择性地处于空的体积位置和样本容积位置。在空的体积位置，样品端延伸到孔的外侧。在样品体积位置，喷枪的样品端设置在距离孔径一定距离的孔内。喷枪的密封段与孔形成过盈配合，该过盈配合可操作以在密封段和孔之间形成密封。

7. 发明申请

WO2009124179A1 VIRTUAL SEPARATION OF BOUND AND FREE LABEL IN A LIGAND ASSAY FOR PERFORMING IMMUNOASSAYS OF BIOLOGICAL FLUIDS, INCLUDING WHOLE BLOOD 审中-公开
标题翻译：用于执行生物流体免疫测定的配体测定中的粘合剂和免费标签的虚拟分离，包括全血
公开(公告)号：WO2009124179A1
公开(公告)日：2009-10-08
申请号：PCT/US2009/039280
申请日：2009-04-02
申请人： ABBOTT POINT OF CARE, INC. , WARDLAW, Stephen, C. , LEVINE, Robert, A.
发明人： WARDLAW, Stephen, C. , LEVINE, Robert, A.
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： G01N33/48 , G01N21/6428 , G01N33/5304 , G01N33/54373 , G01N33/54386
摘要： Detection and characterization of immunologically detected substances are performed electronically on human and animal biological fluids such as whole blood, serum, plasma, urine, milk, pleural and peritoneal fluids, and semen, which fluids are contained in a thin chamber forming a quiescent fluid sample, which chamber has at least two parallel planar walls, at least one of which is transparent.
摘要翻译：免疫检测物质的检测和表征以人和动物生物流体如全血，血清，血浆，尿，牛奶，胸膜和腹膜液以及精液电子方式进行，这些流体包含在形成静态流体样品的薄室中该室具有至少两个平行的平面壁，其中至少一个是透明的。

8. 发明申请

WO1995023026A1 APPARATUS AND METHOD FOR QUANTIFICATION OF BIOLOGICAL MATERIAL IN A LIQUID SAMPLE 审中-公开
标题翻译：用于定量液体样品中生物材料的装置和方法
公开(公告)号：WO1995023026A1
公开(公告)日：1995-08-31
申请号：PCT/US1995002255
申请日：1995-02-22
申请人： IDEXX LABORATORIES, INC. , WARDLAW, Stephen, C.
发明人： IDEXX LABORATORIES, INC. , NAQUI, Ali , PIERSON, Mark, W. , WESCHLER, Thomas, R. , FINNERTY, Michael, P. , CARPENTER, Charles, R.
IPC分类号： B01L03/00
CPC分类号： B01L3/5085 , B01L3/505 , B65D75/324 , C12Q1/04 , G01N2333/245 , Y10S435/81 , Y10S435/975
摘要： An article (A) adapted for holding a liquid sample for quantification of biological material in the liquid sample. The article includes a bag having an upper surface sheet (1) and a lower surface sheet (2) enclosing a volume therebetween. The bag has an upper opening through which the liquid sample can be poured into the volume in the bag. The bag also has a plurality of partitions (9) configured to separate one or more portions (3) of adequate sample in the bag. Also provided is a passage through which a liquid sample can be distributed throughout the volume in the bag. The bag is made of material which can be caused to form discrete non-permeable compartments for holding separate aliquots of the liquid sample.
摘要翻译：一种用于容纳用于定量液体样品中生物材料的液体样品的物品（A）。该物品包括具有上表面片（1）和在其间包围体积的下表面片（2）的袋。该袋具有上部开口，液体样品可以通过该上部开口倒入袋中的体积中。该袋还具有多个分隔件（9），其构造成分离袋中充足样品的一个或多个部分（3）。还提供了一种通道，液体样品可通过该通道分布在袋中的整个体积中。袋子由材料制成，可以形成离散的不可渗透隔室，用于保持液体样品的单独等分试样。

9. 发明申请

WO2017123296A1 PERFORMING ONE OR MORE ANALYSES ON A THIN LAYER OF BIOLOGIC FLUID USING OPTICALLY RESPONSIVE CHEMICAL SENSORS 审中-公开
标题翻译：使用光学化学传感器在生物流体薄层上进行一个或多个分析
公开(公告)号：WO2017123296A1
公开(公告)日：2017-07-20
申请号：PCT/US2016/056965
申请日：2016-10-14
申请人： LEVINE, Robert A. , WARDLAW, Stephen C.
发明人： LEVINE, Robert A. , WARDLAW, Stephen C.
IPC分类号： G01N15/14 , G01N21/29 , G01N21/76 , G01N21/77 , G01N33/00 , G01N33/48
CPC分类号： G01N33/487 , G01N21/6428 , G01N21/6489 , G01N21/77 , G01N21/78 , G01N33/48 , G01N2021/6434 , G01N2021/7786
摘要： A method and apparatus for analyzing a biologic fluid sample for at least one target analyte is provided. The method includes providing an analysis chamber having at least one optically responsive chemical sensor (ORCS), sample and calibration fluid regions, and at least one fluid separator that separates the sample and calibration fluid regions. A first portion of each sensor is disposed in the sample fluid region and a second portion of each sensor is disposed in the calibration fluid region. The ORCS is configured to optically respond in the presence of the target analyte and when interrogated with one or more predetermined wavelengths oflight. The method further includes disposing at least one calibration fluid having target analyte in a known or ascertainable concentration in the calibration fluid region, and disposing the biologic fluid sample in the sample fluid region. The sample is analyzed using a first optical response from the first portion of the ORCS and a second optical response from the second portion of the ORCS.
摘要翻译：提供了用于分析至少一种目标分析物的生物流体样品的方法和设备。该方法包括提供具有至少一个光学响应化学传感器（ORCS），样本和校准流体区域的分析室以及分离样本和校准流体区域的至少一个流体分离器。每个传感器的第一部分布置在样本流体区域中，并且每个传感器的第二部分布置在校准流体区域中。 ORCS被配置为在存在目标分析物时以及在用一个或多个预定波长的光进行询问时进行光学响应。该方法还包括将具有目标分析物的至少一种校准流体以已知或可确定的浓度设置在校准流体区域中，并且将生物流体样品设置在样品流体区域中。使用来自ORCS的第一部分的第一光学响应和来自ORCS的第二部分的第二光学响应来分析样本。

10. 发明申请

WO2012142450A2 QUALITY CONTROL METHOD AND APPARATUS FOR AUTOMATED ANALYSES OF BIOLOGIC FLUID SAMPLE 审中-公开
标题翻译：生物流体样品自动分析的质量控制方法和装置
公开(公告)号：WO2012142450A2
公开(公告)日：2012-10-18
申请号：PCT/US2012033576
申请日：2012-04-13
申请人： WARDLAW STEPHEN C , LEVINE ROBERT A
发明人： WARDLAW STEPHEN C , LEVINE ROBERT A
IPC分类号： G06F3/048
CPC分类号： G01N35/00613 , B01L3/508 , B01L3/545 , B01L2300/021 , G01N2035/00851
摘要： An apparatus and method for analyzing a biologic sample is provided. The apparatus includes a capillary tube, a machine readable identity tag, and an analysis device. The tube is operable to hold the biologic sample. The machine readable identity tag is disposed on the tube, and indicates a production source of the tube. The analysis device is operable to analyze the biologic sample. The analysis device includes a reader adapted to read the identity tag, and the analysis device is operable to authenticate the tube based on the identity tag read from the tube.
摘要翻译：提供了用于分析生物样品的装置和方法。该装置包括毛细管，机器可读身份标签和分析装置。管可操作以保持生物样品。机器可读身份标签设置在管上，并指示管的生产源。分析装置可操作以分析生物样品。分析装置包括适于读取身份标签的读取器，并且分析装置可操作以基于从管中读取的身份标签来认证管。

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