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1. 发明申请

WO2009124179A1 VIRTUAL SEPARATION OF BOUND AND FREE LABEL IN A LIGAND ASSAY FOR PERFORMING IMMUNOASSAYS OF BIOLOGICAL FLUIDS, INCLUDING WHOLE BLOOD 审中-公开
标题翻译：用于执行生物流体免疫测定的配体测定中的粘合剂和免费标签的虚拟分离，包括全血
公开(公告)号：WO2009124179A1
公开(公告)日：2009-10-08
申请号：PCT/US2009/039280
申请日：2009-04-02
申请人： ABBOTT POINT OF CARE, INC. , WARDLAW, Stephen, C. , LEVINE, Robert, A.
发明人： WARDLAW, Stephen, C. , LEVINE, Robert, A.
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： G01N33/48 , G01N21/6428 , G01N33/5304 , G01N33/54373 , G01N33/54386
摘要： Detection and characterization of immunologically detected substances are performed electronically on human and animal biological fluids such as whole blood, serum, plasma, urine, milk, pleural and peritoneal fluids, and semen, which fluids are contained in a thin chamber forming a quiescent fluid sample, which chamber has at least two parallel planar walls, at least one of which is transparent.
摘要翻译：免疫检测物质的检测和表征以人和动物生物流体如全血，血清，血浆，尿，牛奶，胸膜和腹膜液以及精液电子方式进行，这些流体包含在形成静态流体样品的薄室中该室具有至少两个平行的平面壁，其中至少一个是透明的。

2. 发明申请

WO2009117664A2 METHOD AND APPARATUS FOR DETERMINING RED BLOOD CELL INDICES OF A BLOOD SAMPLE UTILIZING THE INTRINSIC PIGMENTATION OF HEMOGLOBIN CONTAINED WITHIN THE RED BLOOD CELLS 审中-公开
标题翻译：用于确定使用红细胞中含有的HEMOGLOBIN的内在色素的血液样品的红血细胞指数的方法和装置
公开(公告)号：WO2009117664A2
公开(公告)日：2009-09-24
申请号：PCT/US2009/037815
申请日：2009-03-20
申请人： ABBOTT POINT OF CARE, INC. , WARDLAW, Stephen, C. , LEVINE, Robert, A. , UNFRICHT, Darryn, W. , LALPURIA, Niten, V. , HILL, Jeremy, R.
发明人： WARDLAW, Stephen, C. , LEVINE, Robert, A. , UNFRICHT, Darryn, W. , LALPURIA, Niten, V. , HILL, Jeremy, R.
IPC分类号： G01N33/49
CPC分类号： G06T7/0012 , G01N15/05 , G01N33/49 , G01N2015/055
摘要： A method for the determination of the red blood cell indices including the volume, and hemoglobin content and concentration for individual red blood cells, as well as red blood cell population statistics, including total number of red blood cells present in the sample, and mean values for each of the aforementioned indices within a substantially undiluted blood sample is provided.
摘要翻译：用于确定红细胞指数的方法，包括体积和各个红细胞的血红蛋白含量和浓度，以及包括样品中存在的红细胞总数的红细胞群统计，以及平均值提供了基本上未稀释的血液样品中的每个上述指标。

3. 发明申请

WO2009124190A1 METHOD FOR SEROLOGIC AGGLUTINATION AND OTHER IMMUNOASSAYS PERFORMED IN A THIN FILM FLUID SAMPLE 审中-公开
标题翻译：在薄膜液体样品中进行血液动力学和其他免疫测定的方法
公开(公告)号：WO2009124190A1
公开(公告)日：2009-10-08
申请号：PCT/US2009/039303
申请日：2009-04-02
申请人： ABBOTT POINT OF CARE, INC. , WARDLAW, Stephen, C. , LEVINE, Robert, A.
发明人： WARDLAW, Stephen, C. , LEVINE, Robert, A.
IPC分类号： G01N33/543 , G01N33/58 , G01N15/14 , B01L3/00
CPC分类号： G01N33/48 , G01N21/6428 , G01N33/5304 , G01N33/54373 , G01N33/54386
摘要： A method and system for performing a serological agglutination assay in a liquid sample. The system provides a simple method for creating an in-situ sample/reagent admixture within a sample analysis chamber without the use of any precision fluid-handling components.
摘要翻译：用于在液体样品中进行血清学凝集测定的方法和系统。该系统提供了在样品分析室内创建原位样品/试剂外加剂的简单方法，而不使用任何精密的流体处理组件。

4. 发明申请

WO2009124186A1 SELF-CALIBRATING GRADIENT DILUTION IN A CONSTITUENT ASSAY AND GRADIENT DILUTION APPARATUS PERFORMED IN A THIN FILM SAMPLE 审中-公开
标题翻译：在薄膜样品中进行的自我评估中的自校正梯度稀释和梯度稀释装置
公开(公告)号：WO2009124186A1
公开(公告)日：2009-10-08
申请号：PCT/US2009/039297
申请日：2009-04-02
申请人： ABBOTT POINT OF CARE, INC. , WARDLAW, Stephen, C. , LEVINE, Robert, A.
发明人： WARDLAW, Stephen, C. , LEVINE, Robert, A.
IPC分类号： G01N33/53
CPC分类号： G01N33/48 , G01N21/6428 , G01N33/5304 , G01N33/54373 , G01N33/54386
摘要： A method and apparatus for measuring antibody titers in a thin film sample in an automated system which does not require multiple dilutions. The system provides a simple method for creating an in-situ dilution within a sample analysis chamber without the use of any precision fluid-handling components, and further, to use the same principles to provide a wide range of sample dilutions within the chamber so as to obviate the need for additional dilution steps when dealing with samples possibly containing wide ranges of analyte concentrations.
摘要翻译：一种在不需要多次稀释的自动化系统中测量薄膜样品中抗体滴度的方法和装置。该系统提供了一种用于在样品分析室内创建原位稀释而不使用任何精密流体处理组件的简单方法，此外，使用相同的原理在腔室内提供范围广泛的样品稀释度，以便以避免在处理可能含有大范围分析物浓度的样品时需要额外的稀释步骤。

5. 发明申请

WO2009117652A1 METHOD AND APPARATUS FOR DETERMINING THE HEMATOCRIT OF A BLOOD SAMPLE UTILIZING THE INTRINSIC PIGMENTATION OF HEMOGLOBIN CONTAINED WITHIN THE RED BLOOD CELLS 审中-公开
标题翻译：用于确定使用红细胞中含有的HEMOGLOBIN的内在色素的血液样品的HEMATOCRIT的方法和装置
公开(公告)号：WO2009117652A1
公开(公告)日：2009-09-24
申请号：PCT/US2009/037796
申请日：2009-03-20
申请人： ABBOTT POINT OF CARE, INC. , LEVINE, Robert, A. , WARDLAW, Stephen, C. , UNFRICHT, Darryn, W. , LALPURIA, Niten, V.
发明人： LEVINE, Robert, A. , WARDLAW, Stephen, C. , UNFRICHT, Darryn, W. , LALPURIA, Niten, V.
IPC分类号： G01N33/49
CPC分类号： G01N33/80 , A61B5/145 , G01N15/1463 , G01N15/1475 , G01N33/48 , G01N33/49 , G01N33/721 , G01N33/86
摘要： A method for determining the hematocrit of a blood sample is provided that includes the steps of : 1) depositing the sample into an analysis chamber (10) adapted to quiescently hold the sample for analysis, the chamber defined by the interior surfaces (14, 18) of first and second panels (12, 16) and a height (20) extending there between, wherein both panels are transparent, and the height is such that at least some of the red blood cells (22) within the sample contact both interior surfaces of the panels and one or more lacunae (24) within the quiescent sample extend between the interior surfaces; 2) imaging at least a portion of the quiescent sample, which sample portion contains the red blood cells and one or more lacunae to determine an optical density of the imaged portion of the sample on a per image unit basis; 3) selecting and averaging the optical density values of the image units aligned with the red blood cells contacting the interior surfaces, and assigning an upper boundary value of 100% to the average optical density value of those image units; 4) selecting the optical density values of the image units aligned with the one or more lacunae, and assigning a lower boundary value of 0% to the optical density values of those image units; and 5) determining the hematocrit of the sample by assigning relative values to the optical density value of each image of the imaged sample portion as a function of the upper and lower boundary values, and averaging the relative values.
摘要翻译：提供了一种用于确定血液样本的血细胞比容的方法，其包括以下步骤：1）将样品沉积到适于静止保持样品进行分析的分析室（10）中，所述室由所述内表面（14,18））和第一和第二面板（12,16）之间的高度（20），其中两个面板是透明的，并且高度使得样品内的至少一些红细胞（22）与内部所述面板的表面和所述静止样品内的一个或多个空隙（24）在所述内表面之间延伸; 2）对静止样品的至少一部分进行成像，该样品部分包含红细胞和一个或多个空隙，以基于每个图像单位确定样品的成像部分的光密度; 3）选择和平均与内表面接触的红细胞对准的图像单元的光密度值，并将上限边界值分配给这些图像单元的平均光密度值; 4）选择与一个或多个空白对准的图像单元的光密度值，并为这些图像单元的光密度值分配0％的下边界值; 以及5）通过将所述成像样本部分的每个图像的光密度值分配相对值作为上边界值和下边界值的函数来确定样本的血细胞比容，并平均相对值。

6. 发明申请

WO2009126505A1 METHOD OF DETECTING VERY LOW LEVELS OF ANALYTE WITHIN A THIN FILM FLUID SAMPLE CONTAINED IN A THIN THICKNESS CHAMBER 审中-公开
标题翻译：检测在薄膜室中含有薄膜流体样品中分析仪的极低水平的方法
公开(公告)号：WO2009126505A1
公开(公告)日：2009-10-15
申请号：PCT/US2009/039283
申请日：2009-04-02
申请人： ABBOTT POINT OF CARE, INC. , WARDLAW, Stephen, C. , LEVINE, Robert, A.
发明人： WARDLAW, Stephen, C. , LEVINE, Robert, A.
IPC分类号： G01N33/543 , G01N33/58
CPC分类号： G01N33/588 , B82Y15/00 , G01N33/54366
摘要： A method and apparatus for the detection and quantification of very low levels of a target analyte using an imaging system is provided. In the case of some analytes such as certain hormones, for example TSH, their levels may be as low as several tens of thousands of molecules per micro liter. These extremely low levels can be measured by using the present invention to count the individual molecules of analyte. The invention also has the advantage of being a primary quantitative method, which is one which needs no standardization.
摘要翻译：提供了使用成像系统检测和定量非常低水平的目标分析物的方法和装置。在某些分析物如某些激素（例如TSH）的情况下，其水平可能低至每微升几万个分子。通过使用本发明来计数分析物的各个分子，可以测量这些极低的水平。本发明还具有作为不需要标准化的主要定量方法的优点。

7. 发明申请

WO2010115026A1 METHOD AND DEVICE FOR TRANSFERRING BIOLOGIC FLUID SAMPLES 审中-公开
标题翻译：用于转移生物流体样品的方法和装置
公开(公告)号：WO2010115026A1
公开(公告)日：2010-10-07
申请号：PCT/US2010/029664
申请日：2010-04-01
申请人： ABBOTT POINT OF CARE, INC. , WARDLAW, Stephen, C.
发明人： WARDLAW, Stephen, C.
IPC分类号： B01L3/02 , A61M5/178 , G01N1/10
CPC分类号： B01L3/0217 , B01L2200/141 , B01L2300/0672 , G01N35/1079 , Y10T436/2575
摘要： A biologic fluid sample transfer device (10) and method is provided. The device includes an outer casing (12) and a lance (14). The outer casing has a tip (18) with an exterior surface and a bore (26) extending lengthwise through the tip and out to the exterior surface of the tip to form an aperture (30) in the exterior surface. The lance has a length extending between an operating end (32) and a sample end (34). The lance includes a seal segment (38) contiguous with the sample end. The seal segment extends a distance lengthwise and has a constant cross-sectional geometry. The transfer device is selectively disposable in an empty volume position and a sample volume position by relative lengthwise movement between the outer casing and the lance. In the empty volume position, the sample end extends outside of the- aperture. In the sample volume position, the sample end of the lance is disposed within the bore a distance away from the aperture. The seal segment of the lance forms an interference fit with the bore, which interference fit is operable to create a seal between the seal segment and the bore.
摘要翻译：提供生物流体样品转移装置（10）和方法。该装置包括外壳（12）和喷枪（14）。外壳具有一个具有外表面的尖端（18）和一个纵向延伸穿过尖端的孔（26），并在外表面上形成一个孔（30）。喷枪具有在操作端（32）和样品端（34）之间延伸的长度。喷枪包括与样品端连续的密封段（38）。密封段沿长度方向延伸一段距离，具有恒定的横截面几何形状。传送装置通过在外壳和喷枪之间的相对长度方向的移动而选择性地处于空的体积位置和样本容积位置。在空的体积位置，样品端延伸到孔的外侧。在样品体积位置，喷枪的样品端设置在距离孔径一定距离的孔内。喷枪的密封段与孔形成过盈配合，该过盈配合可操作以在密封段和孔之间形成密封。

8. 发明申请

WO2009126800A1 METHOD FOR MEASURING THE AREA OF A SAMPLE DISPOSED WITHIN AN ANALYSIS CHAMBER 审中-公开
标题翻译：用于测量在分析室中处理的样品的区域的方法
公开(公告)号：WO2009126800A1
公开(公告)日：2009-10-15
申请号：PCT/US2009/040057
申请日：2009-04-09
申请人： ABBOTT POINT OF CARE, INC. , LALPURIA, Niten, V. , WARDLAW, Stephen, C.
发明人： LALPURIA, Niten, V. , WARDLAW, Stephen, C.
IPC分类号： G01N15/14 , G06T7/00 , G06T7/60
CPC分类号： G01N21/17 , G01N15/05 , G01N2015/055 , G06T7/0012 , G06T7/62 , G06T2207/10056 , G06T2207/10064 , G06T2207/30024 , Y10T436/11
摘要： A method for determining the area of an analysis chamber covered by a biologic fluid sample quiescently residing within the chamber is provided. The chamber has a first panel with an interior surface, and a second panel with an interior surface, both of which panels are transparent. The method includes the steps of: a) illuminating the sample residing within the analysis chamber at one or more wavelengths operable to highlight interfaces between the sample and air, and to highlight a constituent within the sample; b) imaging the sample along the one or more wavelengths, and producing image signals representative of the interaction of the one or more wavelengths with the sample; c) determining a location of at least one interface between the sample and air, using the image signals; d) determining a location of one or more constituents within the sample relative to the at least one sample-air interface using the image signals; and e) determining an area of the chamber containing the sample, using the location of the one or more constituents and the at least one sample-air interface.
摘要翻译：提供了一种用于确定由静止在腔室内的生物流体样品覆盖的分析室的面积的方法。该室具有带内表面的第一面板和具有内表面的第二面板，两个面板都是透明的。该方法包括以下步骤：a）以可操作以突出样品和空气之间的界面的一个或多个波长照亮驻留在分析室内的样品，并突出显示样品内的成分; b）沿着一个或多个波长对样本进行成像，并产生表示一个或多个波长与样本的相互作用的图像信号; c）使用图像信号确定样品和空气之间的至少一个界面的位置; d）使用所述图像信号，相对于所述至少一个采样空气接口确定所述样本内的一个或多个成分的位置; 以及e）使用所述一个或多个成分和所述至少一个样品 - 空气界面的位置来确定包含所述样品的所述室的面积。

9. 发明申请

WO2009117678A1 METHOD AND APPARATUS FOR DETERMINING A FOCAL POSITION OF AN IMAGING DEVICE ADAPTED TO IMAGE A BIOLOGIC SAMPLE 审中-公开
标题翻译：用于确定适用于图像生物样品的成像装置的焦点位置的方法和装置
公开(公告)号：WO2009117678A1
公开(公告)日：2009-09-24
申请号：PCT/US2009/037839
申请日：2009-03-20
申请人： ABBOTT POINT OF CARE, INC. , WARDLAW, Stephen, C. , LALPURIA, Niten, V. , UNFRICHT, Darryn, W.
发明人： WARDLAW, Stephen, C. , LALPURIA, Niten, V. , UNFRICHT, Darryn, W.
IPC分类号： G02B21/24 , H04N5/232
CPC分类号： G02B21/241
摘要： A method and apparatus for focusing a device for imaging a biologic sample is provided. A method aspect of the disclosure includes the steps of: 1) disposing lenslets within a field of a biologic sample, which lenslets have a height, and have a refractive index and which refractive index is different from that of the sample, wherein one or both of the imaging device and the sample are relatively locatable so a focal position of the imaging device can be moved along the height of the lenslets; 2) imaging at least a portion of the sample including a plurality of lenslets using transmittance at one or more predetermined wavelengths; 3) determining an average light transmittance intensity of the sample at the wavelengths; 4) determining an average light transmittance intensity of a region of each lenslet at the wavelengths; and 5) determining the focal position of the imaging device using the average light transmittance intensity of the sample and the average light transmittance intensity of the region of the lenslets.
摘要翻译：提供了用于聚焦用于对生物样品进行成像的装置的方法和装置。本公开的方法方面包括以下步骤：1）在生物样品的场内设置小透镜，哪些小透镜具有高度，并且具有折射率并且折射率不同于样品的折射率，其中一个或两个成像装置和样品相对定位，使得成像装置的焦点位置可以沿着小透镜的高度移动; 2）使用一个或多个预定波长的透射率对包含多个小透镜的样品的至少一部分进行成像; 3）确定样品在波长处的平均光透射强度; 4）确定每个小透镜在该波长处的区域的平均透光强度; 以及5）使用样品的平均光透射强度和小透镜区域的平均光透射强度来确定成像装置的焦点位置。

10. 发明申请

WO2005118140A1 SPECIMEN ANALYSIS TUBE 审中-公开
标题翻译：样品分析管
公开(公告)号：WO2005118140A1
公开(公告)日：2005-12-15
申请号：PCT/US2005/017310
申请日：2005-05-17
申请人： WARDLAW, Stephen, C. , LEVINE, Robert, A.
发明人： WARDLAW, Stephen, C. , LEVINE, Robert, A.
IPC分类号： B01L3/00
CPC分类号： B01L3/5021 , A61B5/150022 , A61B5/150213 , A61B5/150343 , A61B5/150351 , A61B5/150755 , B01L2300/0838 , B01L2400/0406 , Y10T436/2575
摘要： A method and apparatus for analyzing a fluid sample. More particularly, this relates to a specimen analysis tube (2) for containing the specimen (12) sample and to a method of drawing the specimen sample (12) into the tube (2) by capillary action. When the sample (12) is drawn into the tube (2), air is expelled from the tube (2) in the direction which is counter to the flow of the sample (12) into the tube (2). The tube (2) can be U-shaped or it can be linear and can be disposed in a closed-ended holder (22) that is operative to vent air from the tube (2) in a direction which is counter to the direction of flow of the sample into the tube (2).
摘要翻译：一种用于分析流体样品的方法和装置。更具体地，涉及用于容纳样本（12）样本的样本分析管（2）和通过毛细管作用将样本样品（12）拉入管（2）的方法。当样品（12）被吸入管（2）中时，空气从与样品（12）的流动相反的方向从管（2）排出到管（2）中。管（2）可以是U形的，或者它可以是线性的，并且可以设置在闭合端的保持器（22）中，该保持器可操作以沿着与管（2）的方向相反的方向从管（2）排出空气样品流入管（2）。

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