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1. 发明申请

WO2011103285A1 METHOD AND APPARATUS FOR REMOTELY PERFORMING HEMATOLOGIC ANALYSIS UTILIZING A TRANSMITTED IMAGE OF A CENTRIFUGED ANALYSIS TUBE 审中-公开
标题翻译：用于远程执行离散化分析管传输图像的血液分析的方法和装置
公开(公告)号：WO2011103285A1
公开(公告)日：2011-08-25
申请号：PCT/US2011/025240
申请日：2011-02-17
申请人： LEVINE, Joshua D. , LEVINE, Robert A. , WARDLAW, Stephen C. , STOUT, Craig , CLIPPER, David A.
发明人： LEVINE, Joshua D. , LEVINE, Robert A. , WARDLAW, Stephen C. , STOUT, Craig , CLIPPER, David A.
IPC分类号： B01L3/14 , G01N33/49 , G01N15/04 , G01N35/00
CPC分类号： G01N33/491 , B01L3/50215 , B01L9/065 , B01L2300/027 , B01L2300/0609 , B01L2300/0654 , B01L2300/0838 , G01N15/042 , G01N15/05 , G01N2015/045 , G01N2800/22 , G06T7/0012 , G06T2207/30024
摘要： An apparatus for and method of analyzing hematologic samples deposited within a capillary tube is provided. The method includes the steps of: a) imaging a region of sample centrifuged within a capillary tube using a first analysis device, which region is defined by substantially all of the radial width and axial length of the sample residing within the internal cavity of the tube where the float resides after centrifugation, and producing signals representative of the image; b) communicating the signals representative of the image to a second analysis device independent of, and remotely located from, the first analysis device; c) processing the signals representative of the image using the second analysis device and producing analysis data based on the signals; and d) displaying the image of the region of the sample using the second analysis device.
摘要翻译：提供了一种用于分析沉积在毛细管内的血液样品的方法和方法。该方法包括以下步骤：a）使用第一分析装置对在毛细管内离心的样品的区域进行成像，该区域由位于管内腔内的样品的基本上所有的径向宽度和轴向长度限定离心后浮子位于其中，并产生代表图像的信号; b）将表示所述图像的信号传送到与所述第一分析装置无关并且远离所述第一分析装置的第二分析装置; c）使用第二分析装置处理表示图像的信号，并基于该信号产生分析数据; 以及d）使用所述第二分析装置显示所述样品的区域的图像。

2. 发明申请

WO2011103281A1 METHOD AND APPARATUS FOR PERFORMING HEMATOLOGIC ANALYSIS USING AN ARRAY-IMAGING SYSTEM FOR IMAGING AND ANALYSIS OF A CENTRIFUGED ANALYSIS TUBE 审中-公开
标题翻译：使用阵列成像系统进行血液分析的方法和装置，用于成像分析和分析分析管
公开(公告)号：WO2011103281A1
公开(公告)日：2011-08-25
申请号：PCT/US2011/025233
申请日：2011-02-17
申请人： LEVINE, Joshua D. , LEVINE, Robert A. , WARDLAW, Stephen C. , STOUT, Craig , CLIPPER, David A.
发明人： LEVINE, Joshua D. , LEVINE, Robert A. , WARDLAW, Stephen C. , STOUT, Craig , CLIPPER, David A.
IPC分类号： B01L3/14 , G01N33/49 , G01N15/04
CPC分类号： G01N33/491 , B01L3/50215 , B01L9/065 , B01L2300/027 , B01L2300/0609 , B01L2300/0654 , B01L2300/0838 , G01N15/042 , G01N15/05 , G01N2015/045 , G01N2800/22 , G06T7/0012 , G06T2207/30024
摘要： A method and device for analyzing a hematologic sample centrifuged within a capillary tube is provided. The device includes a tube holder, a sample imaging device, a processor, and a sample data display. The sample imaging device is operable to create a digital image of the sample within a region of the tube. The region is defined by substantially all of the radial width and axial length of the sample residing within the internal cavity of the tube in the region where the float resides after centrifugation. The sample imaging device is operable to produce signals representative of the image. The processor is adapted to produce information relating to bands of interest within the image based on the signals from the sample imaging device. The sample data display is adapted to display the results therefrom and/or a digital image of the sample within the region.
摘要翻译：提供了用于分析在毛细管内离心的血液样品的方法和装置。该装置包括管座，样品成像装置，处理器和样品数据显示器。样品成像装置可操作以在管的区域内产生样品的数字图像。该区域由离心后浮子所在区域中位于管内腔内的样品的基本上所有的径向宽度和轴向长度限定。样品成像装置可操作以产生表示图像的信号。处理器适于基于来自样本成像装置的信号产生与图像内的感兴趣的频带相关的信息。样本数据显示器适于在该区域内显示样本的结果和/或数字图像。

3. 发明申请

WO2009117682A1 METHOD AND APPARATUS FOR DETECTING AND COUNTING PLATELETS INDIVIDUALLY AND IN AGGREGATE CLUMPS 审中-公开
标题翻译：用于检测和计数平板电脑的方法和装置
公开(公告)号：WO2009117682A1
公开(公告)日：2009-09-24
申请号：PCT/US2009/037844
申请日：2009-03-20
申请人： ABBOTT POINT OF CARE, INC. , WARDLAW, Stephen C. , LEVINE, Robert A. , LALPURIA, Niten V.
发明人： WARDLAW, Stephen C. , LEVINE, Robert A. , LALPURIA, Niten V.
IPC分类号： G01N33/50 , G01N33/49 , G01N15/02 , G01N15/14 , G01N33/80 , G01N33/58
CPC分类号： G01N33/49 , G01N15/147 , G01N15/1475 , G01N2015/0076 , G01N2015/008 , G01N2015/0084 , G01N2015/0092 , G01N2015/1486
摘要： A method for enumerating platelets within a blood sample is provided. The method includes the steps of: 1) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by a first panel and a second panel, both of which panels are transparent; 2) admixing a colorant with the sample, which colorant is operative to cause the platelets to fluoresce upon exposure to one or more predetermined first wavelengths of light; 3) illuminating at least a portion of the sample containing the platelets at the first wavelengths; 4) imaging the sample, including producing image signals indicative of fluorescent emissions from the platelets, which fluorescent emissions have an intensity; 5) identifying the platelets by their fluorescent emissions, using the image signals; 6) determining an average fluorescent emission intensity value for the individual platelets identified within the sample; 7) identifying clumps of platelets within the sample using one or more of their fluorescent emissions, area, shape, and granularity; and 8) enumerating platelets within each platelet clump using the average fluorescent emission intensity value determined for the individual platelets within the sample.
摘要翻译：提供了一种用于列举血液样品中的血小板的方法。该方法包括以下步骤：1）将样品沉积到适于静态保持样品进行分析的分析室中，所述室由第一面板和第二面板限定，两个面板都是透明的; 2）将着色剂与样品混合，所述着色剂在暴露于一个或多个预定的第一波长的光时可以使血小板发荧光; 3）以第一波长照射含有血小板的样品的至少一部分; 4）对样品进行成像，包括产生指示来自血小板的荧光发射的图像信号，该荧光发射具有强度; 5）使用图像信号通过荧光发射识别血小板; 6）确定样品内识别的各个血小板的平均荧光发射强度值; 7）使用其荧光发射，面积，形状和粒度中的一种或多种来鉴定样品中的血小板团块; 和8）使用为样品中的各个血小板确定的平均荧光发射强度值来列举每个血小板聚集体内的血小板。

4. 发明申请

WO2017123296A1 PERFORMING ONE OR MORE ANALYSES ON A THIN LAYER OF BIOLOGIC FLUID USING OPTICALLY RESPONSIVE CHEMICAL SENSORS 审中-公开
标题翻译：使用光学化学传感器在生物流体薄层上进行一个或多个分析
公开(公告)号：WO2017123296A1
公开(公告)日：2017-07-20
申请号：PCT/US2016/056965
申请日：2016-10-14
申请人： LEVINE, Robert A. , WARDLAW, Stephen C.
发明人： LEVINE, Robert A. , WARDLAW, Stephen C.
IPC分类号： G01N15/14 , G01N21/29 , G01N21/76 , G01N21/77 , G01N33/00 , G01N33/48
CPC分类号： G01N33/487 , G01N21/6428 , G01N21/6489 , G01N21/77 , G01N21/78 , G01N33/48 , G01N2021/6434 , G01N2021/7786
摘要： A method and apparatus for analyzing a biologic fluid sample for at least one target analyte is provided. The method includes providing an analysis chamber having at least one optically responsive chemical sensor (ORCS), sample and calibration fluid regions, and at least one fluid separator that separates the sample and calibration fluid regions. A first portion of each sensor is disposed in the sample fluid region and a second portion of each sensor is disposed in the calibration fluid region. The ORCS is configured to optically respond in the presence of the target analyte and when interrogated with one or more predetermined wavelengths oflight. The method further includes disposing at least one calibration fluid having target analyte in a known or ascertainable concentration in the calibration fluid region, and disposing the biologic fluid sample in the sample fluid region. The sample is analyzed using a first optical response from the first portion of the ORCS and a second optical response from the second portion of the ORCS.
摘要翻译：提供了用于分析至少一种目标分析物的生物流体样品的方法和设备。该方法包括提供具有至少一个光学响应化学传感器（ORCS），样本和校准流体区域的分析室以及分离样本和校准流体区域的至少一个流体分离器。每个传感器的第一部分布置在样本流体区域中，并且每个传感器的第二部分布置在校准流体区域中。 ORCS被配置为在存在目标分析物时以及在用一个或多个预定波长的光进行询问时进行光学响应。该方法还包括将具有目标分析物的至少一种校准流体以已知或可确定的浓度设置在校准流体区域中，并且将生物流体样品设置在样品流体区域中。使用来自ORCS的第一部分的第一光学响应和来自ORCS的第二部分的第二光学响应来分析样本。

5. 发明申请

WO2012012800A3 A METHOD AND APPARATUS FOR DETECTING THE PRESENCE OF ANISOTROPIC CRYSTALS AND HEMOZOIN PRODUCING PARASITES IN LIQUID BLOOD 审中-公开
公开(公告)号：WO2012012800A3
公开(公告)日：2012-01-26
申请号：PCT/US2011/045224
申请日：2011-07-25
申请人： ABBOTT POINT OF CARE, INC. , LEVINE, Robert A. , UNFRICHT, Darryn W. , WARDLAW, Stephen C. , PORTS, Benjamin
发明人： LEVINE, Robert A. , UNFRICHT, Darryn W. , WARDLAW, Stephen C. , PORTS, Benjamin
IPC分类号： G01N33/49 , G01N21/21 , G01N21/23 , G01N21/64
摘要： An apparatus and method for detecting the presence of anisotropic crystals within a biologic fluid sample is provided. The method includes the steps of: a) disposing the sample within a sample chamber in a sample layer having a height not greater than about fifteen microns (15μ); b) disposing the sample layer within the sample chamber between a polarizing filter and an analyzing filter; c) disposing the polarizing filter, sample chamber, and analyzing filter in a configuration relative to a light source such that polarized light passes through the sample, and subsequently impinges on the analyzing filter; and d) wherein polar orientations of the polarizing filter and the analyzing filter are such that the polarized light will not pass through the analyzing filter, and light passing through an anisotropic crystal disposed within the sample will pass through the analyzing filter and appear as a point of light.

6. 发明申请

WO2011116305A1 METHOD AND APPARATUS FOR OPTICALLY DETERMINING AT LEAST ONE HEMOGLOBIN RELATED PARAMETER OF A WHOLE BLOOD SAMPLE 审中-公开
标题翻译：用于光学测定至少一种HEMOGLOBIN相关参数的全血样品的方法和装置
公开(公告)号：WO2011116305A1
公开(公告)日：2011-09-22
申请号：PCT/US2011/029031
申请日：2011-03-18
申请人： ABBOTT POINT OF CARE, INC. , DAVIS, Graham , WARDLAW, Stephen C. , LEVINE, Robert A. , UNFRICHT, Darryn W. , LALPURIA, Niten V. , MITSIS, Paul G.
发明人： DAVIS, Graham , WARDLAW, Stephen C. , LEVINE, Robert A. , UNFRICHT, Darryn W. , LALPURIA, Niten V. , MITSIS, Paul G.
IPC分类号： G01N15/14 , G01N33/49
CPC分类号： G01N33/726 , G01N15/1475 , G01N2015/0073
摘要： A method and apparatus for determining at least one hemoglobin related parameter of a whole blood sample is provided. The method includes the steps of: a) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by an interior surface of a first panel, and an interior surface of a second panel, and the chamber has a height extending between the interior surfaces of the panels, wherein the chamber is configured to increase the oxygenation state of the sample to a substantially oxygenated state within a predetermined amount of time after entry into the chamber; b) imaging the at least one red blood cell contacting the interior surfaces, and producing image signals; c) determining an optical density of at least a portion of the imaged red blood cell contacting both interior surfaces; and d) determining the at least one hemoglobin related parameter of the red blood cell contacting the interior surfaces, using the determined optical density and a molar extinction coefficient for oxygenated hemoglobin.
摘要翻译：提供了一种用于确定全血样品的至少一种血红蛋白相关参数的方法和装置。该方法包括以下步骤：a）将样品沉积到适于静态保持样品进行分析的分析室中，所述室由第一面板的内表面和第二面板的内表面限定，并且所述室具有在所述面板的内表面之间延伸的高度，其中所述腔被配置为在进入所述腔室之后的预定量的时间内将所述样品的氧合状态增加到基本上氧合状态; b）对与内表面接触的至少一个红细胞进行成像，并产生图像信号; c）确定接触两个内表面的成像红细胞的至少一部分的光密度; 以及d）使用确定的光密度和氧合血红蛋白的摩尔消光系数来确定与内表面接触的红细胞的至少一种血红蛋白相关参数。

7. 发明申请

WO2010115024A1 DETECTION OF INFECTIOUS DISEASE IN A HUMAN OR ANIMAL BY MEASURING SPECIFIC PHAGOCYTOSIS IN A THIN FILM SAMPLE OF THEIR ANTICOAGULATED BLOOD 审中-公开
标题翻译：通过在其抗凝血液薄膜中测定特异性PHAGOCYTOSIS来检测人类或动物中的感染性疾病
公开(公告)号：WO2010115024A1
公开(公告)日：2010-10-07
申请号：PCT/US2010/029662
申请日：2010-04-01
申请人： ABBOTT POINT OF CARE, INC. , LEVINE, Robert A. , WARDLAW, Stephen C.
发明人： LEVINE, Robert A. , WARDLAW, Stephen C.
IPC分类号： C12Q1/04 , G01N33/50 , G01N33/543 , G01N33/569 , G01N15/14
CPC分类号： G01N33/56911 , C12Q1/04 , G01N15/1475 , G01N33/5094 , G01N33/5432 , G01N2015/008 , Y02A50/57
摘要： A method for performing a target analyte assay of a thin film anticoagulated blood sample, wherein the target analyte is the presence or absence of specific phagocytosis and/or binding of particles coated with a particular antigen or antigens by white blood cells present in the anticoagulated blood sample, wherein the particles are coated with the particular antigen or antigens, which antigens are similar or identical to antigens expressed by a defined pathogenic infectious agent of interest.
摘要翻译：一种用于进行薄膜抗凝血液样品的目标分析物测定的方法，其中所述目标分析物是存在或不存在特定的吞噬作用和/或通过存在于抗凝血液中的白细胞与特定抗原或抗原结合的颗粒的结合样品，其中所述颗粒用特定的抗原或抗原包被，所述抗原与所定义的感兴趣感染性感染物表达的抗原相似或相同。

8. 发明申请

WO2012142450A3 QUALITY CONTROL METHOD AND APPARATUS FOR AUTOMATED ANALYSES OF BIOLOGIC FLUID SAMPLE 审中-公开
公开(公告)号：WO2012142450A3
公开(公告)日：2012-10-18
申请号：PCT/US2012/033576
申请日：2012-04-13
申请人： WARDLAW, Stephen C. , LEVINE, Robert A.
发明人： WARDLAW, Stephen C. , LEVINE, Robert A.
IPC分类号： F21S8/08 , G01N33/48 , G01N33/49 , G01N33/50 , G01N33/53 , G01N35/00 , G06F19/00 , G06Q10/00
摘要： An apparatus and method for analyzing a biologic sample is provided. The apparatus includes a capillary tube, a machine readable identity tag, and an analysis device. The tube is operable to hold the biologic sample. The machine readable identity tag is disposed on the tube, and indicates a production source of the tube. The analysis device is operable to analyze the biologic sample. The analysis device includes a reader adapted to read the identity tag, and the analysis device is operable to authenticate the tube based on the identity tag read from the tube.

9. 发明申请

WO2010148135A2 HARVESTING TARGET MATERIALS FROM CENTRIFUGED SUSPENSIONS 审中-公开
标题翻译：从离心悬挂中收集目标材料
公开(公告)号：WO2010148135A2
公开(公告)日：2010-12-23
申请号：PCT/US2010/038887
申请日：2010-06-16
申请人： LEVINE, Robert A. , WARDLAW, Stephen C.
发明人： LEVINE, Robert A. , WARDLAW, Stephen C.
IPC分类号： G01N33/483 , G01N1/28 , G01N35/10 , C12M1/10 , G01N1/14
CPC分类号： G01N33/491 , Y10T436/25 , Y10T436/25375
摘要： Embodiments of the present invention are directed to harvesting a target material from a suspension using a tube and float system. A suspension suspected of containing a target material is combined with a solution having one or more labels that distinguish the target material from other materials in the suspension. The tube, float, and suspension are centrifuged to separate various materials in the suspension according to associated specific gravities. The float expands the axial length of the target material layer and displaces the target material to a narrow space between the float and the inner wall of the tube. The space is illuminated with light that causes the labels to emit light identifying the location of the target material within the tube. One or more openings can then be formed in the tube at or near the point where the target material is located and the target material harvested.
摘要翻译：本发明的实施方案涉及使用管和浮子系统从悬浮液中收获目标材料。怀疑含有目标材料的悬浮液与具有一种或多种将目标材料与悬浮液中的其他材料区分开的标签的溶液合并。将管，浮子和悬浮液离心以根据相关的比重分离悬浮液中的各种材料。浮子膨胀目标材料层的轴向长度，并将目标材料移位到浮子和管内壁之间的狭窄空间。该空间用光照亮，导致标签发光，以识别目标材料在管内的位置。然后可以在管中或在目标材料所在的点处或附近形成一个或多个开口，并且收集目标材料。

10. 发明申请

WO2010118028A1 METHOD OF TREATING AND PREVENTING NEURO-OLFACTORY TRIGGERED OR AGGRAVATED ILLNESSES OR RELATED CONDITIONS 审中-公开
标题翻译：治疗和预防神经损伤或激素受体或相关病症的方法
公开(公告)号：WO2010118028A1
公开(公告)日：2010-10-14
申请号：PCT/US2010/030097
申请日：2010-04-06
申请人： LEVINE, Joshua D. , LEVINE, Robert A.
发明人： LEVINE, Joshua D. , LEVINE, Robert A.
IPC分类号： A61K31/715 , A61K38/14
CPC分类号： A61K31/715 , A61K9/0043 , A61K9/107 , A61K9/12 , A61K9/127 , A61K31/00
摘要： A method for treating at least one of neuro-olfactory triggered illnesses, and related conditions within a subject is provided. The method includes the steps of: a) providing a composition that includes one or more agents adapted to induce a level of anosmia/hyposmia in the subject, which level of anosmia/hyposmia is sufficient to substantially decrease olfactory sensory stimulation within the subject and a neurologic response to the stimulation that is one or both of triggering and aggravating the illness or condition; and b) applying the composition to a nasopharynx region of the subject.
摘要翻译：提供了治疗受试者中的神经 - 嗅觉触发疾病和相关病况中的至少一种的方法。该方法包括以下步骤：a）提供一种组合物，其包含一种或多种适于在受试者中诱导一定程度的厌食/低血压的药剂，所述水平的厌食/低血压足以显着降低受试者内的嗅觉感觉刺激，对刺激的神经反应是触发和加重疾病或病症的一种或两种; 和b）将组合物施用于受试者的鼻咽区域。

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