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1. 发明申请

WO2011109619A3 MULTI-SHAPE PRODUCT 审中-公开
标题翻译：多种形状的产品
公开(公告)号：WO2011109619A3
公开(公告)日：2012-01-19
申请号：PCT/US2011027029
申请日：2011-03-03
申请人： UNIV SYRACUSE , MATHER PATRICK , LUO XIAOFAN
发明人： MATHER PATRICK , LUO XIAOFAN
IPC分类号： C08L63/00 , B32B5/28 , C08J5/04 , C08L63/08 , C08L101/12
CPC分类号： B29C61/0633 , B29C61/003 , Y10T428/249921 , Y10T428/269
摘要： Multi-shape products of the present disclosure comprise two components: a matrix component and a fiber component that is embedded or otherwise disposed in the matrix component. The matrix component exhibits certain shape memory properties. The fiber component interpenetrates the matrix component to facilitate fixing of the multi-shape product in various temporary shapes.
摘要翻译：本公开的多形状产品包括两个部件：嵌入或以其他方式设置在矩阵部件中的矩阵部件和纤维部件。矩阵分量表现出一定的形状记忆特性。纤维组分互穿基体组分以便于多种形状的产品以各种临时形状的固定。

2. 发明申请

WO2011019736A3 SYSTEM AND METHOD FOR CONTROLLING BACTERIAL PERSISTER CELLS WITH WEAK ELECTRIC CURRENTS 审中-公开
标题翻译：用弱电流控制细菌杀伤细胞的系统和方法
公开(公告)号：WO2011019736A3
公开(公告)日：2011-06-23
申请号：PCT/US2010045051
申请日：2010-08-10
申请人： UNIV SYRACUSE , REN DACHENG , ZHANG MI , NIEPA TAGBO , GILBERT JEREMY
发明人： REN DACHENG , ZHANG MI , NIEPA TAGBO , GILBERT JEREMY
IPC分类号： A61N1/18 , A61N1/04
CPC分类号： C12N13/00
摘要： A system and method for treating persister cells with an electrochemical process, alone or in combination with antibiotics. Weak electric currents are used to effectively eliminate persister cells and the efficacy can be further improved through synergistic effects with antibiotics. The method may be adapted for novel therapies of chronic infections and strategies to control persistent biofouling. The system has a broad spectrum applications in treating chronic and drug resistant infections, such as those caused by Pseudomonas aeruginosa, Mycobacterium tuberculosis and methicillin resistant Staphylococcus aureus, and may also be used for decontamination of medical devices.
摘要翻译：一种用电化学方法单独或与抗生素组合治疗残存细胞的系统和方法。使用弱电流有效消除残存细胞，通过与抗生素的协同作用可进一步提高疗效。该方法可适用于慢性感染的新疗法和控制持久性生物污染的策略。该系统广泛应用于治疗慢性和耐药性感染，如由铜绿假单胞菌，结核分枝杆菌和耐甲氧西林金黄色葡萄球菌引起的感染，也可用于医疗器械的净化。

3. 发明申请

WO2006076046A9 BRANCHED AND MULTI-CHAIN NUCLEIC ACID SWITCHES FOR SENSING AND SCREENING 审中-公开
标题翻译：用于感测和筛选的分支和多链式核酸开关
公开(公告)号：WO2006076046A9
公开(公告)日：2007-04-05
申请号：PCT/US2005027527
申请日：2005-08-02
申请人： UNIV SYRACUSE , BORER PHILIP N , HUDSON BRUCE S
发明人： BORER PHILIP N , HUDSON BRUCE S
IPC分类号： C12Q1/68
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/3517 , C12Q1/6818 , C12Q1/70 , C12Q1/701 , C12Q2541/101 , C12Q2525/313 , C12Q2525/205 , C12Q2525/301 , C12Q2565/301
摘要： Embodiments of the invention relate to a branched or multichain nucleic acid switch adapted to switch from a first conformation to a second conformation upon ligand binding. The switch includes a probe strand, P, which includes the ligand binding domain; a switching framework which includes a cover strand (C), and a tether that holds P and C together and a signaling apparatus. Some embodiments include a toggle strand (T) where now the tether holds P, C, T, and the signaling apparatus together. As the switch changes between the first and second conformations; the signaling apparatus reports the state of the switch. The signaling entity is typically a lumiphore and a quencher located along the switching framework. Nucleic acid switches have applications in real time assays for diverse agents including infectious agents, environmental toxins, and terrorist agents, as well as screening' methods for such agents. Further applications are found for nanoelectronics, nanofabrication and nanomachines.
摘要翻译：本发明的实施方案涉及一种支链或多链核酸开关，其适于在配体结合时从第一构象切换到第二构象。该开关包括探针链，其包括配体结合结构域; 包括盖链（C）和将P和C保持在一起的系链和信号装置的切换框架。一些实施例包括切换链（T），其中系绳将P，C，T和信令装置保持在一起。当开关在第一和第二构象之间变化时; 信令装置报告交换机的状态。信令实体通常是沿着交换框架定位的集线器和猝熄器。核酸开关可用于多种试剂的实时测定，包括感染因子，环境毒素和恐怖分子，以及筛选这些药剂的方法。发现纳米电子学，纳米制造和纳米机械的其他应用。

4. 发明申请

WO2006102540A3 ELUCIDATION OF HIGH AFFINITY, HIGH SPECIFICITY OLIGONUCLEOTIDES AND DERIVATIZED OLIGONUCLEOTIDE SEQUENCES FOR TARGET RECOGNITION 审中-公开
标题翻译：高度亲和力，高特异性寡核苷酸和衍生化寡核苷酸序列的靶向鉴定
公开(公告)号：WO2006102540A3
公开(公告)日：2007-01-04
申请号：PCT/US2006010645
申请日：2006-03-23
申请人： UNIV SYRACUSE , HUDSON BRUCE S , BORER PHILIP N
发明人： HUDSON BRUCE S , BORER PHILIP N
IPC分类号： C07H21/02 , C07H21/04
CPC分类号： G01N33/5308 , C12Q1/6837 , G01N2333/44
摘要： A method is disclosed to obtain oligonucleotide sequences with high affinity to target molecules. By design, the oligonucleotides have a defined primary and secondary structure. The affinity for binding to target species is classified or quantified by assay measurements using physical measurements rather than being based primarily on separations. Targets include but are not limited to proteins, polymers, biological membranes including cells and organelles and small molecules.
摘要翻译：公开了获得对目标分子具有高亲和力的寡核苷酸序列的方法。通过设计，寡核苷酸具有确定的一级和二级结构。通过使用物理测量的测定测量来分类或量化与靶物种结合的亲和力，而不是主要基于分离。目标包括但不限于蛋白质，聚合物，生物膜，包括细胞和细胞器以及小分子。

5. 发明申请

WO2012170489A3 SITUATION AWARE SECURITY SYSTEM AND METHOD FOR MOBILE DEVICES 审中-公开
标题翻译：用于移动设备的情况安全系统和方法
公开(公告)号：WO2012170489A3
公开(公告)日：2013-03-21
申请号：PCT/US2012041047
申请日：2012-06-06
申请人： UNIV SYRACUSE , DU WENLIANG
发明人： DU WENLIANG
IPC分类号： H04W88/02 , G06K17/00
CPC分类号： H04W12/02 , H04W12/12
摘要： A mobile communication device can comprise a microprocessor, a memory, and one or more sensors, all coupled to a system bus. A sensor can be provided by a GPS receiving device, an accelerometer, an image sensor, a radio frequency transceiver, or a magnetic card reading device. The mobile communication device can be configured, responsive to receiving sensor data from one or more sensors, to select a corresponding security alert level. The mobile communication device can be further configured to perform at least one security-related action corresponding to the selected security alert level.
摘要翻译：移动通信设备可以包括所有耦合到系统总线的微处理器，存储器和一个或多个传感器。传感器可以由GPS接收装置，加速度计，图像传感器，射频收发器或磁卡读取装置提供。响应于从一个或多个传感器接收传感器数据，可以配置移动通信设备以选择对应的安全警报级别。移动通信设备还可以被配置为执行与所选择的安全警报级别相对应的至少一个与安全相关的动作。

6. 发明申请

WO2012094081A3 SYSTEM AND METHOD FOR IDENTIFYING AND APPLYING PERIPHERAL TREATMENT MECHANISMS FOR DISEASE 审中-公开
标题翻译：确定和应用疾病外周治疗机制的系统和方法
公开(公告)号：WO2012094081A3
公开(公告)日：2012-08-30
申请号：PCT/US2011063220
申请日：2011-12-05
申请人： UNIV SYRACUSE , KESLACY STEFAN
发明人： KESLACY STEFAN
IPC分类号： C12Q1/68 , A61K31/7088 , A61K48/00 , A61P3/00 , A61P25/28 , C12N15/85 , G01N33/15 , G01N33/50
CPC分类号： G01N33/5061 , A61K31/00 , G01N33/5023 , G01N33/6803
摘要： A method and system for the identification and application of biological targets for peripheral treatment of diseases. Existing cellular mechanisms or pathways are exploited to identify novel genes or other molecule candidates that will be used to treat disease via a peripheral treatment system. Using the method, a novel Alzheimer's disease target is identified and used to treat an animal Alzheimer's disease model via peripheral expression of that target.
摘要翻译：用于鉴定和应用疾病外周治疗的生物靶标的方法和系统。利用现有的细胞机制或途径来鉴定将用于通过外周治疗系统治疗疾病的新基因或其他候选分子。使用该方法，鉴定新型阿尔茨海默病靶标并通过该靶标的外周表达来治疗动物阿尔茨海默病模型。

7. 发明申请

WO2011133847A3 POLYHEDRAL OLIGOMERIC SILSESQUIOXANE POLYURETHANES 审中-公开
标题翻译：聚酯低聚硅氧烷聚氨酯
公开(公告)号：WO2011133847A3
公开(公告)日：2012-03-15
申请号：PCT/US2011033552
申请日：2011-04-22
申请人： UNIV SYRACUSE , MATHER PATRICK , WU JIAN , GU XINZHU
发明人： MATHER PATRICK , WU JIAN , GU XINZHU
IPC分类号： C08G18/61 , C08G18/08 , C08G18/72 , C08L75/04
CPC分类号： C08G18/771 , C08G18/3893 , C08G18/4018 , C08G18/4277 , C08G18/4833 , C08G18/61 , C08G2230/00
摘要： A multi-block thermoplastic polyurethanes system which incorporates polyhedral oligomeric silsesquioxane into conventional biodegradable thermoplastic polyurethanes built up by poly(e-caproactone) and polyethylene glycol blocks, resulting in biostability. The multi-block thermoplastic polyurethanes are synthesized from lysine-diisocyanate with poly(8-caprolactone)-diol, polyhedral oligomeric silsesquioxane-diol, and poly(ethylene glycol) using a one-step synthesis process.
摘要翻译：多嵌段热塑性聚氨酯体系，其将多面体低聚倍半硅氧烷引入由聚（ε-己内酯）和聚乙二醇嵌段构成的常规可生物降解热塑性聚氨酯中，产生生物稳定性。多嵌段热塑性聚氨酯由赖氨酸二异氰酸酯与聚（8-己内酯） - 二醇，多面体低聚倍半硅氧烷 - 二醇和聚（乙二醇）使用一步合成方法合成。

8. 发明申请

WO2014138049A3 REVERSIBLE SHAPE MEMORY POLYMERS EXHIBITING AMBIENT ACTUATION TRIGGERING 审中-公开
标题翻译：可逆形状记忆聚合物展示环境启动触发
公开(公告)号：WO2014138049A3
公开(公告)日：2015-02-26
申请号：PCT/US2014020277
申请日：2014-03-04
申请人： UNIV SYRACUSE , MATHER PATRICK T
发明人： MATHER PATRICK T
IPC分类号： C08F299/00 , C08F297/00 , C08G81/00 , C08G83/00 , C08J5/00
CPC分类号： F03G7/065 , A61L2400/16 , B29C51/002 , B29C51/10 , B29K2021/006 , C08J5/00 , C08J2300/12 , C08J2300/26
摘要： Shape memory polymers featuring reversible actuation capability under ambient stimulus for integration with apparel. One approach is to use a multiblock polymer consisting of two (or potentially more) blocks in which the one block is the crystalline switching block with relatively low melting transitions, the other block has a higher thermal transition, and the two blocks are linked together by a linker molecule. Another approach is to use a graft copolymer having high and low melting transitions where the graft copolymer has a first polymer serving as the backbone and a second polymer being grafted to or from the backbone at certain graft locations. A further approach is to use latent crosslinking of a semicrystalline polymer with reactive groups placed on the backbone. Finally, these polymers may be formed as actuators that undergo curling, twisting and even volumetric expansion.
摘要翻译：形状记忆聚合物在环境刺激下具有可逆的致动能力，与服装集成。一种方法是使用由两个（或潜在的更多）嵌段组成的多嵌段聚合物，其中一个嵌段是具有相对低的熔融转变的结晶切换嵌段，另一个嵌段具有较高的热转变，并且两个嵌段通过连接分子。另一种方法是使用具有高和低熔融转变的接枝共聚物，其中接枝共聚物具有作为主链的第一聚合物，并且在某些接枝位置处将第二聚合物接枝到骨架上或从骨架上接枝。另一种方法是使用半结晶聚合物与置于骨架上的反应性基团的潜在交联。最后，这些聚合物可以形成为经历卷曲，扭曲甚至体积膨胀的致动器。

9. 发明申请

WO2012003279A3 BIOENGINEERED PROTEIN PORES 审中-公开
标题翻译：生物蛋白质原料
公开(公告)号：WO2012003279A3
公开(公告)日：2012-04-05
申请号：PCT/US2011042532
申请日：2011-06-30
申请人： UNIV SYRACUSE , MOVILEANU LIVIU , MOHAMMAD MOHAMMAD M
发明人： MOVILEANU LIVIU , MOHAMMAD MOHAMMAD M
IPC分类号： C12N15/31 , C07K14/245 , G01N33/68
CPC分类号： C07K14/245
摘要： A mutant Escherichia coli ß-barrel monomeric protein pore bioengineered to remove a lumen- occluding domain and modify some of its extracellular domains. The modified protein, FhuA ?/C?4L, forms a highly conductive pore as compared to other known pores and is capable of sensing large polypeptides and discriminating between modified protein analytes.
摘要翻译：突变体大肠杆菌β-桶单体蛋白孔生物工程去除内腔封闭结构域并修饰其一些细胞外结构域。与其他已知的孔相比，修饰的蛋白质FhuAα/ C 4L形成高导电性孔，并且能够感测大多肽并区分修饰的蛋白质分析物。

10. 发明申请

WO2008101200A3 INTEGRATED MULTISTAGE SUPERCRITICAL TECHNOLOGY TO PRODUCE HIGH QUALITY VEGETABLE OILS AND BIOFUELS 审中-公开
标题翻译：集成多级超临界技术生产高品质植物油和生物燃料
公开(公告)号：WO2008101200A3
公开(公告)日：2008-10-23
申请号：PCT/US2008054141
申请日：2008-02-15
申请人： UNIV SYRACUSE , ANITESCU GHEORGHE , TAVLARIDES LAWRENCE L
发明人： ANITESCU GHEORGHE , TAVLARIDES LAWRENCE L
IPC分类号： C10L1/14
CPC分类号： C10L1/02 , C10G2300/1011 , C10L1/026 , C11C3/00 , Y02E50/13 , Y02P30/20
摘要： The present invention relates to a power generation system, which includes a source of a seed oil, a source of alcohol, and a reactor in communication with the source of seed oil and the source of alcohol. The reactor produces a biofuel product. The system has a power source that operates on a biofuel energy source to produce heated exhaust. The power source is in communication with the reactor to utilize a portion of the biofuel product as its biofuel energy source. The system has a heat transfer mechanism that transfers heat from the exhaust manifold to the reactor. The power source also converts mechanical power into electrical power. Also disclosed is a system that involves extraction of oil from an oilseed product. A method of extracting oil from an oilseed product, a method of making a transesterified seed oil, and a method of making a biofuel are also disclosed, as are products obtained thereby.
摘要翻译：本发明涉及一种发电系统，其包括种子油源，醇源以及与种子油源和醇源通信的反应器。该反应器生产生物燃料产品。该系统有一个电源，可以在生物燃料能源上运行以产生加热排气。动力源与反应器连通以利用一部分生物燃料产品作为其生物燃料能源。该系统具有将热量从排气歧管传递到反应器的传热机构。电源还将机械动力转化为电力。还公开了涉及从油籽产品中提取油的系统。还公开了从油籽产品中提取油的方法，制备酯交换的种子油的方法以及制备生物燃料的方法，以及由此获得的产品。

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