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1. 发明申请

WO2019052708A1 MAFG AS A POTENTIAL THERAPEUTIC TARGET TO RESTORE CHEMOSENSITIVITY IN PLATINUM-RESISTANT CANCER CELLS 审中-公开
公开(公告)号：WO2019052708A1
公开(公告)日：2019-03-21
申请号：PCT/EP2018/068156
申请日：2018-07-04
申请人： FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ (FIBHULP) , FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO RAMÓN Y CAJAL (FIBIOHRC) , FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PRINCESA , UNIVERSIDAD AUTÓNOMA DE MADRID
发明人： IBÁÑEZ DE CÁCERES, Inmaculada , DE CASTRO CARPEÑO, Javier , VERA PUENTE, Olga , PERNÍA ARIAS, Olga , RODRÍGUEZ ANTOLÍN, Carlos , GONZÁLEZ MUÑOZ, Víctor Manuel , MARTÍN PALMA, María Elena , SALGADO FIGUEROA, Ana María , ROSAS ALONSO, Rocío , SACRISTÁN LÓPEZ, Silvia , LEÓN MARTĺNEZ, Rafael , MICHALSKA DZIAMA, Patrycja
IPC分类号： A61K31/711 , C07K14/47 , A61K39/00 , C12Q1/6804
CPC分类号： C07K14/4703 , A61K31/711 , A61K39/001152 , A61K2039/505 , C07K14/4702 , C12Q2525/205
摘要： The present invention relates to the fields of medicine and cancer treatment. The invention more specifically relates to the use of a compound capable of decreasing or inhibiting, in vitro or ex vivo, the expression and/or activity of MAFG and thus increasing ROS-production and chemotherapy sensitivity, specifically in cancer cells resistant to platinum-based therapy. The present disclosure further relates to uses of such compounds, in particular to prepare a pharmaceutical composition to allow or improve the efficiency of a therapy of cancer in a subject in need thereof. The compound of the invention can indeed be advantageously used, in combination with at least one chemotherapeutic drug, for treating cancer, for preventing cancer metastasis, increasing overall survival and/ or for preventing cancer recurrence in a subject. The invention also discloses methods for preventing or treating cancer, cancer metastasis and/or cancer recurrence in a subject, as well as kits suitable for preparing a composition according to the present invention and/or for implementing the herein described methods.

2. 发明申请

WO2018237074A1 FUNCTIONAL LIGANDS TO TARGET MOLECULES 审中-公开
公开(公告)号：WO2018237074A1
公开(公告)日：2018-12-27
申请号：PCT/US2018/038596
申请日：2018-06-20
申请人： BASE PAIR BIOTECHNOLOGIES, INC.
发明人： JACKSON, George
IPC分类号： C12N15/10 , C12N15/115 , C12Q1/68 , C12Q1/6811
CPC分类号： C12Q1/6811 , C12N15/115 , C12N2310/16 , C12Q2525/205 , C12Q2537/143 , C12Q2563/179 , C12Q2565/531
摘要： The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as vitamin C or malaria histidine-rich protein II (HRP2).

3. 发明申请

WO2018146534A1 METHODS AND BIOSENSORS FOR TUMOR DETECTION 审中-公开
公开(公告)号：WO2018146534A1
公开(公告)日：2018-08-16
申请号：PCT/IB2017/058396
申请日：2017-12-25
申请人： AMOUZADEH TABRIZI, Mahmoud
发明人： AMOUZADEH TABRIZI, Mahmoud , SHAMSIPUR, Mojtaba , SABER, Reza , SARKAR, Saeed
IPC分类号： G01N33/50 , G01N27/26
CPC分类号： C12Q1/6886 , C12Q1/6816 , C12Q2525/205 , C12Q2565/607
摘要： Disclosed herein is a method for tumor marker detection. The method includes preparing a biosensor, forming a reference solution by adding the biosensor to a buffer solution, measuring a first fluorescence intensity of the reference solution, forming a mixture by adding a suspicious biological solution to the reference solution, measuring a second fluorescence intensity of the mixture, and detecting a presence of a tumor marker responsive to a difference between the first fluorescence intensity and the second fluorescence intensity. The biosensor preparation includes forming a functionalized nanomotor by functionalizing a nanomotor with an aptamer, forming a blocked functionalized nanomotor by blocking gaps between functionalized parts of the functionalized nanomotor with a blocking agent, and attaching a fluorescence probe to the blocked functionalized nanomotor.

4. 发明申请

WO2018112350A1 MOLECULAR FUSES FOR REAL-TIME, LABEL-FREE, MULTIPLEXED IMAGING OF RNAS IN LIVING CELLS 审中-公开
公开(公告)号：WO2018112350A1
公开(公告)日：2018-06-21
申请号：PCT/US2017/066684
申请日：2017-12-15
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
发明人： GREEN, Alexander
IPC分类号： C12N15/115 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6841 , G01N33/5308 , G01N33/542 , C12Q2525/205 , C12Q2525/301 , C12Q2565/133
摘要： Provided herein are imaging probes and systems and methods employing such imaging probes for real-time, label-free, multiplexed imaging of RNAs in living cells. More particularly, aptamer-based sensors ("aptasensors") and molecular fuses comprising multiple aptasensors are genetically encoded imaging probes comprising RNA-target binding sequence and an intramolecular reconfiguration sequence. The probe is configured such that binding of a RNA target by the RNA-target binding sequence triggers the intramolecular reconfiguration sequence to reconfigure such that an optically detectable output is generated by the probe.

5. 发明申请

WO2017044494A1 HIGH-THROUGHPUT SPLIT APTAMER SCREENING ASSAY 审中-公开
标题翻译：高分子分离APTAMER筛选测定
公开(公告)号：WO2017044494A1
公开(公告)日：2017-03-16
申请号：PCT/US2016/050564
申请日：2016-09-07
申请人： BELLBROOK LABS
发明人： KUMAR, Meera , LOWERY, Robert, G.
IPC分类号： C12N15/115 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6804 , G01N33/5308 , C12Q2525/205 , C12Q2561/119 , C12Q2563/103 , C12Q2563/107 , C12Q2565/101 , C12Q2561/107
摘要： Methods and materials for development of high-throughput screening assays using split aptamers are provided by this invention.
摘要翻译：通过本发明提供用于开发使用裂合适体的高通量筛选测定法的方法和材料。

6. 发明申请

WO2017005265A1 INTRAVENOUS BAG 审中-公开
标题翻译： INTRAVENO袋子
公开(公告)号：WO2017005265A1
公开(公告)日：2017-01-12
申请号：PCT/DK2016/050191
申请日：2016-06-16
申请人： DYRSBORG, Dorte
发明人： DYRSBORG, Dorte
IPC分类号： A61J1/10 , A61J1/14 , A61J1/20
CPC分类号： A61J1/10 , A61J1/1475 , A61J1/2024 , A61J1/2031 , A61J1/2093 , C12N15/1068 , C12Q1/6832 , C12Q2525/205 , C12Q2531/113 , C12Q2537/143 , C12Q2545/114 , C12Q2563/179
摘要： An intravenous (IV) bag for providing IV fluid to a patient is disclosed. The IV bag (2) comprises a first compartment (6) separated from a second compartment (4) by means of a wall member (20). The IV bag (2) comprises an outlet port (12) provided in the lower end of the IV bag (2) for dispensing the IV bag (2). The IV bag (2) comprises an activation member (8f 8', 8") configured to establish fluid connection between the first compartment (6) and the second compartment (4). The activation member (8, 8f, 8") may be a push button or a rotatable button.
摘要翻译：公开了一种用于向患者提供IV流体的静脉内（IV）袋。 IV袋（2）包括通过壁构件（20）与第二隔室（4）分离的第一隔室（6）。 IV袋（2）包括设置在IV袋（2）的下端中用于分配IV袋（2）的出口（12）。 IV袋（2）包括构造成在第一隔室（6）和第二隔室（4）之间建立流体连接的致动构件（8f 8'，8“），启动构件（8,8f，8”）可以作为按钮或可旋转按钮。

7. 发明申请

WO2016209900A1 DEVICE AND METHODS TO DETECT BIOMARKERS USING OLOGONUCLEOTIDES 审中-公开
标题翻译：使用OLOGONUCLEOTIDES检测生物标记的设备和方法
公开(公告)号：WO2016209900A1
公开(公告)日：2016-12-29
申请号：PCT/US2016/038668
申请日：2016-06-22
申请人： POC MEDICAL SYSTEMS, INC.
发明人： CUPPOLETTI, Andrea , SAXENA, Sanjeev , BURTON, Louis, Eugene
IPC分类号： G01N33/543 , C12Q1/68 , B01L3/00
CPC分类号： C12Q1/6811 , B01L3/5027 , C12N2310/16 , C12N2310/3519 , C12Q1/6806 , C12Q1/6834 , C12Q1/686 , C12Q2600/158 , G01N33/54366 , C12Q2523/32 , C12Q2525/205 , C12Q2565/625 , C12Q2565/629
摘要： Devices for detecting targets in a sample and methods for detecting such targets are discussed. The targets may be biomarkers associated with a disease or other health condition. The devices may contain a disc including a plurality of microfluidic channels each extending in a radial direction of the disc, the microfluidic channels containing a plurality of capture molecules specific to at least one target. The capture molecules may include an aptamer and/or an oligonucleotide capable of hybridizing to the target. The methods may include introducing a fluid sample into one or more microfluidic channels of a disc, rotating the disc, such that the fluid sample flows radially outward through the microfluidic channel(s) to combine with capture molecules in the disc, and detecting a signal from the disc indicative of a presence of the target.
摘要翻译：讨论了用于检测样本中的目标的装置和用于检测这些目标的方法。靶标可能是与疾病或其他健康状况相关的生物标志物。所述装置可以包含盘，其包括沿盘的径向方向延伸的多个微流体通道，所述微流体通道包含特定于至少一个靶的多个捕获分子。捕获分子可以包含能够与靶杂交的适体和/或寡核苷酸。所述方法可以包括将流体样品引入盘的一个或多个微流体通道中，使盘旋转，使得流体样品径向向外流过微流体通道以与盘中的捕获分子结合，并检测信号从盘表示目标的存在。

8. 发明申请

WO2016207436A1 BRANCHED PROXIMITY HYBRIDIZATION ASSAY 审中-公开
标题翻译：分支接近度杂交测定
公开(公告)号：WO2016207436A1
公开(公告)日：2016-12-29
申请号：PCT/EP2016/064864
申请日：2016-06-27
申请人： ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG , MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
发明人： CAVALLARI, Marco , YANG, Jianying , RETH, Michael
IPC分类号： C12Q1/68 , G01N33/68
CPC分类号： C12Q1/682 , C12N2310/50 , C12Q2525/161 , C12Q2525/197 , C12Q2525/205 , C12Q2525/313 , C12Q2543/10 , C12Q2565/102 , G01N33/6845
摘要： The invention relates to a method for detecting the proximity of at least two biomolecules using branched DNA technology. The assay is called branched proximity hybridization assay.
摘要翻译：本发明涉及使用支链DNA技术检测至少两种生物分子的接近度的方法。该测定称为支化邻近杂交测定。

9. 发明申请

WO2016205940A1 BIOSENSOR COMPRISING TANDEM REACTIONS OF STRUCTURE SWITCHING, NUCLEOLYTIC DIGESTION AND AMPLIFICATION OF A NUCLEIC ACID ASSEMBLY 审中-公开
标题翻译：生物传感器包含结构开关的TANDEM反应，核酸组装的核化消除和放大
公开(公告)号：WO2016205940A1
公开(公告)日：2016-12-29
申请号：PCT/CA2016/050731
申请日：2016-06-22
申请人： MCMASTER UNIVERSITY
发明人： LI, Yingfu , BRENNAN, John , LIU, Meng
IPC分类号： C12Q1/68 , C12M1/34 , C40B30/04 , G01N33/48
CPC分类号： C12Q1/6853 , C12Q1/6811 , C12Q1/6825 , C12Q2525/205 , C12Q2525/307 , C12Q2531/125
摘要： The present application relates to a biosensor for detecting analytes, various kits and methods of use thereof. In particular, the biosensor's mode of operation is based on binding of analytes to a nucleic acid sequence which triggers rolling circle amplification and detection of the amplified product as the indicator of the presence of the analytes.
摘要翻译：本申请涉及用于检测分析物的生物传感器，各种试剂盒及其使用方法。特别地，生物传感器的操作模式是基于分析物与引发滚环扩增和扩增产物检测作为分析物存在指标的核酸序列的结合。

10. 发明申请

WO2016187284A1 METHODS AND COMPOSITION FOR DETERMINING PH 审中-公开
标题翻译：用于测定PH的方法和组合物
公开(公告)号：WO2016187284A1
公开(公告)日：2016-11-24
申请号：PCT/US2016/033050
申请日：2016-05-18
申请人： THE UNIVERSITY OF CHICAGO
发明人： KRISHNAM, Yamuna , HALDER, Saheli
IPC分类号： C12N15/85 , C12N15/113
CPC分类号： C12N15/113 , A01K2207/05 , A01K2227/703 , A01K2267/0306 , A01K2267/0362 , C12N15/111 , C12N2310/14 , C12N2310/3517 , C12Q1/68 , C12Q1/6816 , C12Q1/6825 , G01N33/84 , C12Q2525/205 , C12Q2527/119 , C12Q2565/1015
摘要： Described herein are nucleic acid molecules and complexes useful as i-switch pH reporters that have increased sensitivities as a pH reporter and have alternate pH reporting capacity ranges. Aspects of the disclosure relate to a method for determining pH comprising providing a nucleic acid complex comprising: a first single-stranded nucleic acid molecule comprising the sequence C n XC n YC n ZC n (SEQ ID NO. 6) wherein C is cytosine; X, Y and Z are each one or more of adenine, thymine, guanine, or combinations thereof; and n is greater than or equal to 2; and wherein at least 2 cytosine residues of the first single-stranded nucleic acid molecule are modified; and a second single-stranded nucleic acid molecule that is partially or fully complementary to the first single-stranded molecule, wherein a first label is conjugated to the first single-stranded nucleic acid molecule or the second single-stranded nucleic acid molecule; and wherein the first label is capable of producing a signal, wherein the intensity of the signal varies as a function of the conformation of the nucleic acid complex; and measuring the intensity of the signal and determining the pH from the measured signal.
摘要翻译：本文描述的是可用作i-转换pH报告者的核酸分子和复合物，其具有作为pH报告基因的增加的敏感性并且具有交替的pH报告能力范围。本公开的方面涉及一种用于测定pH的方法，包括提供核酸复合物，其包含：包含序列CnXCnYCnZCn（SEQ ID NO.6）的第一单链核酸分子，其中C是胞嘧啶; X，Y和Z各自为腺嘌呤，胸腺嘧啶，鸟嘌呤或其组合中的一种或多种; 并且n大于或等于2; 并且其中所述第一单链核酸分子的至少2个胞嘧啶残基被修饰; 和与第一单链分子部分或完全互补的第二单链核酸分子，其中第一标记与第一单链核酸分子或第二单链核酸分子缀合; 并且其中所述第一标记能够产生信号，其中所述信号的强度作为所述核酸复合物的构象的函数而变化; 并测量信号的强度并根据测得的信号测定pH值。

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