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1. 发明申请

WO2018224855A1 FILL-FINISH CARRIERS FOR DRUG CONTAINERS 审中-公开
公开(公告)号：WO2018224855A1
公开(公告)日：2018-12-13
申请号：PCT/IB2017/000836
申请日：2017-06-06
申请人： UNITRACT SYRINGE PTY LTD
发明人： DECHELETTE, Alexis Marie, Adolphe , DEVITT, Shaun, R. , JETER, Robert, G. Jr. , LAURENCE, Lawton , DESTEFANO, Mark, A.
IPC分类号： A61J1/20 , A61J1/14
摘要： A fill-finish cartridge includes a carrier, a fluid pathway connection, a needle insertion mechanism, and a drug container. The cartridges enable drug containers to be filled with pharmaceutical treatments using standard filling equipment and process systems, while maintaining the sterility and container integrity of the fluid pathway. The fill-finish cartridges of the present invention can be nested or removably housed in fill-finish trays for batch filling in standard operating processes. As such, the adaptable fill-finish cartridges of the present invention may be flexibly inserted, attached, mounted, or otherwise removably positioned in fill-finish trays. These embodiments, accordingly, may provide novel and cost-efficient assemblies and cartridges which are readily integrated into drug filling processes. Methods of assembly, manufacture, and use are also provided.

2. 发明申请

WO2018029520A1 DRUG DELIVERY DEVICE AND METHOD FOR CONNECTING A FLUID FLOWPATH 审中-公开
标题翻译：药物递送装置和用于连接流体流动通道的方法
公开(公告)号：WO2018029520A1
公开(公告)日：2018-02-15
申请号：PCT/IB2017/000937
申请日：2017-08-08
申请人： UNITRACT SYRINGE PTY LTD
发明人： DECHELETTE, Alexis Marie Adolphe , RUSSO, Robert S. , LAURENCE, Lawton , DEVITT, Shaun R.
IPC分类号： A61M5/142 , A61M5/158 , A61M5/162
摘要： Provided herein is a fluid pathway connection assembly, e.g., for connecting a fluid flowpath within a drug delivery device for delivery of a medicament to a target site. The fluid pathway connection assembly comprises a hollow needle piercing member, a sleeve fixedly engaged with the piercing member and a pierceable seal configured to sealingly engage the piercing member or the sleeve. Upon, sealing engagement, the piercing member or the sleeve and the pierceable seal form a volume within which a portion of the piercing member is disposed. The fluid pathway connection assembly is activated by relative movement between the piercing member and the pierceable seal and activation causes the piercing member to pierce the pierceable seal, thereby establishing a fluid flowpath through the pierceable seal. Upon incorporation of the assembly into a sealed fluid flowpath, the volume is isolated from the environment and maintains the sterile condition of the portion of the piercing member disposed therein. Also provided herein are drug delivery pumps and methods of operating and assembling the assemblies and pumps described herein.
摘要翻译：本文提供了流体通道连接组件，例如用于连接药物输送装置内的流体流动路径以将药物输送到目标部位。流体通道连接组件包括中空的针刺穿构件，与刺穿构件固定地接合的套筒以及构造成密封地接合刺穿构件或套筒的可刺穿的密封件。当密封接合时，刺穿构件或套筒和可刺穿密封件形成刺穿构件的一部分布置在其内的容积。流体通路连接组件通过刺穿构件和可刺穿密封件之间的相对运动而被激活，并且致动使刺穿构件刺穿可刺穿密封件，由此建立穿过可刺穿密封件的流体流动路径。在将组件结合到密封的流体流动路径中时，该体积与环境隔离并且维持布置在其中的刺穿构件的部分的无菌状态。本文还提供药物输送泵以及操作和组装这里描述的组件和泵的方法。

3. 发明申请

WO2016130679A2 ROTATIONALLY BIASED INSERTION MECHANISM FOR A DRUG DELIVERY PUMP 审中-公开
标题翻译：用于药物输送泵的旋转插入机构
公开(公告)号：WO2016130679A2
公开(公告)日：2016-08-18
申请号：PCT/US2016/017354
申请日：2016-02-10
申请人： UNITRACT SYRINGE PTY LTD
发明人： DESTEFANO, Mark A. , LAURENCE, Lawton , LOVE, John C. , HANSON, Ian B. , BENTE, IV, Paul F.
IPC分类号： A61M5/142 , A61M5/32 , A61M5/145 , A61M5/158
CPC分类号： A61M5/14248 , A61M5/158 , A61M5/3287 , A61M2005/14252 , A61M2005/1583 , A61M2005/1585 , A61M2205/13 , A61M2205/18 , A61M2205/44 , A61M2205/581 , A61M2205/583 , A61M2207/00
摘要： An insertion mechanism (200) for a drug pump (10, 1300) includes an insertion mechanism (200) housing (202, 1202, 2202, 3202); a sleeve (220, 1220, 2220, 3220); a rotational biasing member (210, 1210, 2210, 3210) initially held in an energized state; a retraction biasing member (216, 1216, 2216, 3216) and a hub (212, 1212, 2212, 3212) connected to a proximal end of a needle (214, 1214, 2214, 3214), wherein the retraction biasing member (216, 1216, 2216, 3216) is held initially in an energized state between the hub (212, 1212, 2212, 3212) and the sleeve (220, 1220, 2220, 3220). The needle (214, 1214, 2214, 3214) is inserted into a target tissue by the rotational biasing member (210, 1210, 2210, 3210) and interaction between the hub (212, 1212, 2212, 3212) and housing (202, 1202, 2202, 3202). Retraction of the needle (214, 1214, 2214, 3214) is caused by decompressing or de-energizing of the retraction biasing member (216, 1216, 2216, 3216). A drug delivery pump includes an activation mechanism (14), a drive mechanism (100), a sterile access connection (300), and the insertion mechanism (200). Assembly and operation methods are provided.
摘要翻译：用于药物泵（10,1300）的插入机构（200）包括插入机构（200），壳体（202,1202,2202,3202）; 套筒（220,1220,2220,3220）; 最初保持在通电状态的旋转偏压构件（210,1210,2210,3210）; 连接到针（214,1214,2214,3214）的近端的回缩偏压构件（216,1216,2216,3216）和毂（212,1212,2212,3212），其中所述回缩偏压构件（216 最初在毂（212,1212,2212,3212）和套筒（220,1220,2220,3220）之间的通电状态下被保持。针（214,1214,2214,3214）通过旋转偏置构件（210,1210,2210,3210）插入到目标组织中，并且毂（212,1212,2212,3212）和壳体（202， 1202,2202,3202）。针（214,1214,2224,3214）的缩回是通过对后退偏置构件（216,1216,2216,3216）的减压或去电来引起的。药物输送泵包括启动机构（14），驱动机构（100），无菌接入连接（300）和插入机构（200）。提供装配和操作方法。

4. 发明申请

WO2016053954A1 RIGID NEEDLE INSERTION MECHANISM FOR A DRUG DELIVERY PUMP 审中-公开
标题翻译：用于药液输送泵的刚性针插入机构
公开(公告)号：WO2016053954A1
公开(公告)日：2016-04-07
申请号：PCT/US2015/052815
申请日：2015-09-29
申请人： UNITRACT SYRINGE PTY LTD , DESTEFANO, Mark
发明人： DESTEFANO, Mark , HANSON, Ian , BENTE, Paul , LAURENCE, Lawton
IPC分类号： A61M5/158 , A61M5/142
CPC分类号： A61M5/158 , A61M5/142 , A61M5/14248 , A61M2005/14252 , A61M2005/14256 , A61M2005/1585
摘要： An insertion mechanism (200) and methods of assembly and operation of a drug pump (10) may include an insertion mechanism housing (202); a housing cap; a manifold guide (220); an insertion biasing member (210) initially held in an energized state; a retraction biasing member (216) connected to a hub (212) connected to a proximal end of a needle (214); and, optionally, a clip retainer. The retraction biasing member is held initially in an energized state between the hub and manifold guide. A manifold has a manifold body and one or more septa defining a manifold header. The retraction biasing member may be held initially in an energized state between the hub and the clip retainer. The needle is advanced by the insertion biasing member(s) from the initial configuration to an administration configuration, opening a fluid pathway from the manifold header to the target. The drug delivery pump may include an activation mechanism, a drive mechanism, a fluid pathway connection, and the insertion mechanism.
摘要翻译：插入机构（200）以及药物泵（10）的组装和操作的方法可以包括插入机构壳体（202）; 房屋帽歧管引导件（220）; 最初保持在通电状态的插入偏置构件（210）连接到连接到针（214）的近端的轮毂（212）上的回缩偏置构件（216）; 和可选的夹子保持器。回缩偏压构件最初保持在轮毂和歧管引导件之间的通电状态。歧管具有歧管主体和限定歧管歧管的一个或多个隔片。回缩偏压构件可以初始地保持在轮毂和夹子保持器之间的通电状态。针通过插入偏置构件从初始构型推进到管理构型，打开从歧管歧管到目标的流体通道。药物输送泵可以包括激活机构，驱动机构，流体通路连接和插入机构。

5. 发明申请

WO2015117131A1 EXPANDING PLUNGER RODS FOR SYRINGES 审中-公开
标题翻译：扩大钻孔枪
公开(公告)号：WO2015117131A1
公开(公告)日：2015-08-06
申请号：PCT/US2015/014255
申请日：2015-02-03
申请人： UNITRACT SYRINGE PTY LTD , HEINSBERGEN, Daniel A.
发明人： HEINSBERGEN, Daniel A. , BELL, Bryan Frederick, Jr. , RUSSO, Robert Scott , PANNEERSELVAM, Dinesh , MCKEE, Brandon J.
IPC分类号： A61M5/315 , A61M5/28 , A61M5/31
CPC分类号： A61M5/31511 , A61M5/28 , A61M5/3134 , A61M5/3135 , A61M5/31501 , A61M5/31515 , A61M2005/31518
摘要： An expanding plunger rod (100) for a syringe (50). The expanding plunger rod is configured to transition from a packaged configuration for packaging to an expanded configuration for operation. The expanding plunger rod comprises a substantially cylindrical outer sleeve (110) having a closed-off bottom end (108) and an open upper end (111). The expanding plunger includes an inner rod (114) having a lower end (138) and an upper end (140). The inner rod is slidably disposed coaxially within the outer sleeve. In the packaged configuration, the inner rod is nested within the outer sleeve. In the expanded configuration, the inner rod is disposed substantially axially above the outer sleeve, and the inner rod is configured to lock axially in place so as to prevent transition from the expanded configuration to the packaged configuration.
摘要翻译：一种用于注射器（50）的膨胀柱塞杆（100）。膨胀的柱塞杆被配置为从用于包装的封装构造转变成用于操作的扩展构型。膨胀的柱塞杆包括具有封闭的底端（108）和敞开的上端（111）的基本上圆柱形的外套筒（110）。膨胀柱塞包括具有下端（138）和上端（140）的内杆（114）。内杆可同轴地可滑动地设置在外套筒内。在封装结构中，内杆嵌套在外套管内。在扩展构造中，内杆基本上轴向设置在外套筒的上方，并且内杆构造成轴向地锁定在适当位置，以便防止从膨胀构型向包装构型的转变。

6. 发明申请

WO2015084428A1 DRIVE MECHANISM FOR DRUG DELIVERY PUMPS WITH INTEGRATED STATUS INDICATION 审中-公开
标题翻译：具有集成状态指示的药物输送泵的驱动机构
公开(公告)号：WO2015084428A1
公开(公告)日：2015-06-11
申请号：PCT/US2014/032399
申请日：2014-03-31
申请人： UNITRACT SYRINGE PTY LTD , AGARD, Ryan M.
发明人： AGARD, Ryan M. , HANSON, Ian B, , CICCARELLI, Nicholas J. , O'CONNOR, Sean M. , BOKELMAN, Kevin , BENTE IV, Paul F. , LOVE, John C. , HATCH, Christopher Edward
IPC分类号： A61M5/145 , A61M5/20
CPC分类号： A61M5/2033 , A61M5/14566 , A61M2205/58
摘要： A drive mechanism 2100, 3100 includes a housing 2130, a piston 2110 adapted to impart movement to a plunger seal 2060 within a drug container 2050, a plurality of biasing members 2106, 2122 disposed in parallel, and a retainer 2115. The biasing members 2106, 2122 are disposed to release energy to cause movement of the piston 2110 from a retracted first position to the extended second position, the piston 2110 bearing against the plunger seal 2060 to dispense medicine. The retainer 2115 is disposed to maintain the biasing members 2106, 2122 in the energized position and to release the biasing members 2106, 2122 to permit the piston 2110 to dispense the medicine. The drive mechanism 2100, 3100 may also include an end-of-dose indicator 2133, 3133 to identify at least one of when the sleeve assembly 2120, 3120 is disposed subjacent a window 2131, 3131 in the housing 2130, 3130 the relative motion of the sleeve assembly 2120, 3120 with reference to the window 2131, 3131 or another reference component, the stoppage of such motion, and the rated or change of rate of motion.
摘要翻译：驱动机构2100,3100包括壳体2130，活塞2110，适于向药物容器2050内的柱塞密封件2060施加活动，多个平行设置的偏置构件2106,2122和保持器2115.偏置构件2106 ，2122被设置为释放能量以使活塞2110从缩回的第一位置移动到延伸的第二位置，活塞2110抵靠柱塞密封件2060以分配药物。保持器2115设置成将偏置构件2106,22122保持在通电位置并且释放偏压构件2106,2122以允许活塞2110分配药物。驱动机构2100,3100还可以包括剂量终止指示器2133,33133，以识别当套筒组件2120,31220设置在壳体2130内的窗口2131,33131的下方时，3130中的至少一个，3130的相对运动套筒组件2120,31220参照窗口2131,33131或另一参考部件，停止这种运动以及运动速度的额定或改变。

7. 发明申请

WO2015021236A3 RETAINER FOR RETRACTABLE NEEDLE ASSEMBLIES AND SYRINGES 审中-公开
标题翻译：可伸缩针头组件和注射器的固定器
公开(公告)号：WO2015021236A3
公开(公告)日：2015-05-14
申请号：PCT/US2014050066
申请日：2014-08-07
申请人： UNITRACT SYRINGE PTY LTD , JOHNSON JEFFREY M
发明人： JOHNSON JEFFREY M , BOKELMAN KEVIN , GUPTA JYOTI , MCKEE BRANDON J
IPC分类号： A61M5/32
CPC分类号： A61M5/3221 , A61M5/1782 , A61M5/3234 , A61M2005/3106 , A61M2005/3142 , A61M2005/323 , A61M2005/3231 , A61M2005/3241
摘要： A retainer 220 for a needle assembly 200 of a retractable syringe 1000 that includes a plunger assembly 400 and a barrel 100 having a mounting member 110. The needle assembly 200 includes a retractable needle 210, a needle hub 230, and a retainer 220. The retractable needle 210 is engageable by the plunger assembly 400 to facilitate retraction thereof. The needle hub 230 is mountable to the mounting member 110 of the barrel 100. The retainer 220 includes a body 225 and at least one retaining member 221 that extends distally from the body 225. The retaining member 221 includes an inwardly projecting lateral projection 224 to engage the retractable needle 210 and thereby prevent inadvertent proximal movement of said retractable needle 210 prior to retraction. A retractable needle assembly 200 includes the retainer 220, and a retractable syringe includes the retractable needle assembly 200 including the retainer 220. A syringe kit 90 includes a retractable syringe, a plurality of retractable needle assemblies 200, and a vial adapter 2000.
摘要翻译：用于可缩回注射器1000的针组件200的保持器220包括柱塞组件400和具有安装构件110的针筒100.针组件200包括可缩回针210，针座230和保持器220. 可伸缩针头210可与柱塞组件400接合以促进其缩回。针毂230可安装到筒100的安装构件110上。保持器220包括主体225和从主体225向远侧延伸的至少一个保持构件221.保持构件221包括向内突出的侧向突起224到接合可缩回的针头210并由此防止缩回之前的所述可缩回的针头210的无意的近侧移动。可缩回的针组件200包括保持器220，并且可缩回的注射器包括包括保持器220的可缩回的针组件200.注射器套件90包括可缩回的注射器，多个可缩回的针组件200以及小瓶适配器2000。

8. 发明申请

WO2015047758A2 AUTOMATIC SELF-DISPENSING ACCURATE DOSE DRUG DELIVERY SYRINGES 审中-公开
标题翻译：自动自动分配精确剂量药物输送
公开(公告)号：WO2015047758A2
公开(公告)日：2015-04-02
申请号：PCT/US2014/055486
申请日：2014-09-12
申请人： UNITRACT SYRINGE PTY LTD , SHETTY, Gautam N.
发明人： SHETTY, Gautam N. , CASTAGNA, Lou
IPC分类号： A61M5/28
CPC分类号： A61M5/31583 , A61M5/20 , A61M5/2033 , A61M5/31515 , A61M5/31551 , A61M5/31553 , A61M5/31575 , A61M5/3234 , A61M5/482 , A61M2005/202 , A61M2005/3114 , A61M2005/3139 , A61M2005/3152 , A61M2207/00
摘要： An automatic accurate dose syringe includes a barrel, a plunger seal, a barrel adapter assembly having a barrel tip and a needle, and a dose control mechanism having a plunger having a coarse pitch screw on its exterior surface, a housing having a corresponding coarse pitch guide along the interior surface of the housing, a screw having a fine pitch screw which interfaces with a fine pitch nut of an adapter, wherein the plunger has an internal annular space within which screw at least partially resides. The syringe further includes a locking mechanism, an activation button, and a biasing member such as a compression and/or a torsional spring. The components are configured such that actuation of the activation button by the user manipulates the locking mechanism to permit the biasing member to move from an initial energized state to a lower energy state, thereby automating drug delivery from the syringe.
摘要翻译：自动精确剂量注射器包括筒体，柱塞密封件，具有筒尖和针头的筒适配器组件，以及剂量控制机构，其具有在其外表面上具有粗螺旋螺旋的柱塞，具有相应粗节距沿着壳体的内表面引导，具有与适配器的精细节距螺母相接合的细间距螺钉的螺钉，其中柱塞具有至少部分地位于其中的内部环形空间。注射器还包括锁定机构，启动按钮和诸如压缩和/或扭转弹簧的偏置构件。构件被构造成使得使用者的致动按钮的操作操纵锁定机构以允许偏压构件从初始通电状态移动到较低能量状态，从而使从注射器自动进行药物递送。

9. 发明申请

WO2015027174A1 INTEGRATED PIERCEABLE SEAL FLUID PATHWAY CONNECTION AND DRUG CONTAINERS FOR DRUG DELIVERY PUMPS 审中-公开
标题翻译：集成式密封流体路径连接和药物输送泵的药物容器
公开(公告)号：WO2015027174A1
公开(公告)日：2015-02-26
申请号：PCT/US2014/052329
申请日：2014-08-22
申请人： UNITRACT SYRINGE PTY LTD , CLEMENTE, Matthew J. , HANSON, Ian B. , BENTE, Paul F.
发明人： CLEMENTE, Matthew J. , HANSON, Ian B. , BENTE, Paul F.
IPC分类号： A61M5/142 , A61M39/04
CPC分类号： A61M5/14224 , A61M5/14244 , A61M5/14248 , A61M5/14566 , A61M39/10 , A61M39/18 , A61M2039/1072
摘要： A sterile fluid pathway connector includes a piercing member, a connector hub, and a pierceable seal; wherein at least a portion of the pierceable seal is configured to move from a first position in which the piercing member is retained within a sterile cavity between the pierceable seal and the connector hub, to a second position in which the pierceable seal has been penetrated by the piercing member. A filter may be utilized to enclose the sterile cavity from the outside environment. Such fluid pathway connections may be integrated into a fluid container having a barrel and a plunger seal. The components of the fluid pathway connector may further be capable of transmitting a signal to the user upon completion of fluid delivery, for example, upon contact between the plunger seal and the pierceable seal. A fluid delivery pump includes such integrated fluid pathway connectors and fluid containers.
摘要翻译：无菌流体通道连接器包括刺穿构件，连接器毂和可刺破密封件; 其中所述可刺破密封件的至少一部分被构造成从所述穿孔构件保持在所述可刺破密封件和所述连接器毂之间的无菌空腔内的第一位置移动到所述可刺破密封件已经被穿透的第二位置穿孔成员。可以使用过滤器来从外部环境封闭无菌腔。这种流体通道连接可以集成到具有筒体和柱塞密封件的流体容器中。流体通路连接器的部件还可以在流体输送完成时例如在柱塞密封件和可刺穿密封件之间接触时将信号传递给使用者。流体输送泵包括这种集成流体通路连接器和流体容器。

10. 发明申请

WO2015021236A2 RETAINER FOR RETRACTABLE NEEDLE ASSEMBLIES AND SYRINGES 审中-公开
标题翻译：可伸缩针头组件和注射器的固定器
公开(公告)号：WO2015021236A2
公开(公告)日：2015-02-12
申请号：PCT/US2014/050066
申请日：2014-08-07
申请人： UNITRACT SYRINGE PTY LTD , JOHNSON, Jeffrey M.
发明人： JOHNSON, Jeffrey M. , BOKELMAN, Kevin , GUPTA, Jyoti , MCKEE, Brandon J.
IPC分类号： A61M5/32
CPC分类号： A61M5/3221 , A61M5/1782 , A61M5/3234 , A61M2005/3106 , A61M2005/3142 , A61M2005/323 , A61M2005/3231 , A61M2005/3241
摘要： A retainer 220 for a needle assembly 200 of a retractable syringe 1000 that includes a plunger assembly 400 and a barrel 100 having a mounting member 110. The needle assembly 200 includes a retractable needle 210, a needle hub 230, and a retainer 220. The retractable needle 210 is engageable by the plunger assembly 400 to facilitate retraction thereof. The needle hub 230 is mountable to the mounting member 110 of the barrel 100. The retainer 220 includes a body 225 and at least one retaining member 221 that extends distally from the body 225. The retaining member 221 includes an inwardly projecting lateral projection 224 to engage the retractable needle 210 and thereby prevent inadvertent proximal movement of said retractable needle 210 prior to retraction. A retractable needle assembly 200 includes the retainer 220, and a retractable syringe includes the retractable needle assembly 200 including the retainer 220. A syringe kit 90 includes a retractable syringe, a plurality of retractable needle assemblies 200, and a vial adapter 2000.
摘要翻译：用于可缩回注射器1000的针组件200的保持器220包括柱塞组件400和具有安装构件110的针筒100.针组件200包括可缩回针头210，针头针头 230和保持器220.可收缩针210可与柱塞组件400接合以促进其回缩。针毂230可安装到筒100的安装构件110上。保持器220包括主体225和从主体225向远侧延伸的至少一个保持构件221.保持构件221包括向内突出的侧向突起224到接合可缩回的针头210并由此防止缩回之前的所述可缩回的针头210的无意的近侧移动。可伸缩针头组件200包括保持器220，并且可伸缩注射器包括可缩回针头组件200，其包括保持器220.注射器套件90包括可缩回注射器，多个可缩回针头组件200和小瓶适配器2000。 p>

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