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1. 发明申请

WO2015084428A1 DRIVE MECHANISM FOR DRUG DELIVERY PUMPS WITH INTEGRATED STATUS INDICATION 审中-公开
标题翻译：具有集成状态指示的药物输送泵的驱动机构
公开(公告)号：WO2015084428A1
公开(公告)日：2015-06-11
申请号：PCT/US2014/032399
申请日：2014-03-31
申请人： UNITRACT SYRINGE PTY LTD , AGARD, Ryan M.
发明人： AGARD, Ryan M. , HANSON, Ian B, , CICCARELLI, Nicholas J. , O'CONNOR, Sean M. , BOKELMAN, Kevin , BENTE IV, Paul F. , LOVE, John C. , HATCH, Christopher Edward
IPC分类号： A61M5/145 , A61M5/20
CPC分类号： A61M5/2033 , A61M5/14566 , A61M2205/58
摘要： A drive mechanism 2100, 3100 includes a housing 2130, a piston 2110 adapted to impart movement to a plunger seal 2060 within a drug container 2050, a plurality of biasing members 2106, 2122 disposed in parallel, and a retainer 2115. The biasing members 2106, 2122 are disposed to release energy to cause movement of the piston 2110 from a retracted first position to the extended second position, the piston 2110 bearing against the plunger seal 2060 to dispense medicine. The retainer 2115 is disposed to maintain the biasing members 2106, 2122 in the energized position and to release the biasing members 2106, 2122 to permit the piston 2110 to dispense the medicine. The drive mechanism 2100, 3100 may also include an end-of-dose indicator 2133, 3133 to identify at least one of when the sleeve assembly 2120, 3120 is disposed subjacent a window 2131, 3131 in the housing 2130, 3130 the relative motion of the sleeve assembly 2120, 3120 with reference to the window 2131, 3131 or another reference component, the stoppage of such motion, and the rated or change of rate of motion.
摘要翻译：驱动机构2100,3100包括壳体2130，活塞2110，适于向药物容器2050内的柱塞密封件2060施加活动，多个平行设置的偏置构件2106,2122和保持器2115.偏置构件2106 ，2122被设置为释放能量以使活塞2110从缩回的第一位置移动到延伸的第二位置，活塞2110抵靠柱塞密封件2060以分配药物。保持器2115设置成将偏置构件2106,22122保持在通电位置并且释放偏压构件2106,2122以允许活塞2110分配药物。驱动机构2100,3100还可以包括剂量终止指示器2133,33133，以识别当套筒组件2120,31220设置在壳体2130内的窗口2131,33131的下方时，3130中的至少一个，3130的相对运动套筒组件2120,31220参照窗口2131,33131或另一参考部件，停止这种运动以及运动速度的额定或改变。

2. 发明申请

WO2014116987A1 DRIVE MECHANISM FOR DRUG DELIVERY PUMPS WITH INTEGRATED STATUS INDICATION 审中-公开
标题翻译：具有集成状态指示的药物输送泵的驱动机构
公开(公告)号：WO2014116987A1
公开(公告)日：2014-07-31
申请号：PCT/US2014/013005
申请日：2014-01-24
申请人： UNITRACT SYRINGE PTY LTD , AGARD, Ryan M.
发明人： AGARD, Ryan M. , HANSON, Ian B. , CICCARELLI, Nicholas J. , O'CONNOR, Sean M. , BOKELMAN, Kevin , BENTE IV, Paul F.
IPC分类号： A61M5/145
CPC分类号： A61M5/1454 , A61M5/14566 , A61M2205/58
摘要： A drive mechanism 2100 includes a housing 2130, a piston 2110 adapted to impart movement to a plunger seal 2060 within a drug container 2050, a plurality of biasing members 2106, 2122 disposed in parallel, and a retainer 2115. The biasing members 2106, 2122 are disposed to release energy to cause movement of the piston 2110 from a retracted first position to the extended second position, the piston 2110 bearing against the plunger seal 2060 to dispense medicine. The retainer 2115 is disposed to maintain the biasing members 2106, 2122 in the energized position and to release the biasing members 2106, 2122 to permit the piston 2110 to dispense the medicine. The drive mechanism 2100 may also include an end-of-dose indicator 2133 to identify at least one of when the sleeve assembly 2120 is disposed subjacent a window 2131 in the housing 2130, the relative motion of the sleeve assembly 2120 with reference to the window 2131 or another reference component, the stoppage of such motion, and the rated or change of rate of motion.
摘要翻译：驱动机构2100包括壳体2130，活塞2110，其适于向药物容器2050内的柱塞密封件2060施加活动，多个平行设置的偏压构件2106,2212和保持器2115.偏置构件2106,2122 被设置为释放能量以使活塞2110从缩回的第一位置移动到延伸的第二位置，活塞2110抵靠柱塞密封件2060以分配药物。保持器2115设置成将偏置构件2106,22122保持在通电位置并且释放偏压构件2106,2122以允许活塞2110分配药物。驱动机构2100还可以包括剂量末端指示器2133，用于识别当套筒组件2120位于壳体2130内的窗口2131的下方时的至少一个，套筒组件2120参考窗口的相对运动 2131或其他参考组件，停止此类运动，以及运动速率的额定值或变化。

3. 发明申请

WO2014116274A1 INTEGRATED SLIDING SEAL FLUID PATHWAY CONNECTION AND DRUG CONTAINERS FOR DRUG DELIVERY PUMPS 审中-公开
标题翻译：集成滑动密封流体路径连接和药物输送泵的药物容器
公开(公告)号：WO2014116274A1
公开(公告)日：2014-07-31
申请号：PCT/US2013/030478
申请日：2013-03-12
申请人： UNITRACT SYRINGE PTY LTD , CLEMENTE, Matthew J. , HANSON, Ian B. , BENTE IV, Paul F. , AGARD, Ryan M. , CICCARELLI, Nicholas J.
发明人： CLEMENTE, Matthew J. , HANSON, Ian B. , BENTE IV, Paul F. , AGARD, Ryan M. , CICCARELLI, Nicholas J.
IPC分类号： A61M5/158 , A61M39/18 , A61M5/142 , A61M5/315
CPC分类号： A61M39/04 , A61M5/14248 , A61M5/1452 , A61M5/158 , A61M5/3157 , A61M39/18
摘要： A fluid pathway connection (300) includes a piercing member (330), a connection hub (310), and a sliding pierceable seal (56), wherein the sliding pierceable seal (56) is configured to move from a first position, where the piercing member (330) is initially retained within a sterile cavity (311) between the connection hub (310) and the sliding pierceable seal (56), to a second position, where the pierceable seal (56) has been penetrated by the piercing member (330). A filter (309) may be utilized to enclose the sterile cavity (311) from the outside environment. The fluid pathway connection (300) may further be configured to move to a third position where one or more interconnects (61, 102) and/or one or more corresponding contacts (62, 104) are permitted to transmit a signal to the user. Such fluid pathway connections (300) may be integrated into a drug container (50) having a barrel (58) and a plunger seal (60). A drug delivery pump (10) includes such integrated fluid pathway connections (300) and drug containers (50).
摘要翻译：流体通道连接件（300）包括刺穿构件（330），连接毂（310）和可滑动的可刺穿密封件（56），其中，所述滑动可刺穿密封件（56）构造成从第一位置移动，穿刺构件（330）最初被保持在连接毂（310）和滑动可刺穿密封件（56）之间的无菌空腔（311）内的第二位置，其中可刺破密封件（56）已被刺穿构件（330）。可以使用过滤器（309）将无菌空腔（311）从外部环境封闭。流体路径连接（300）还可以被配置成移动到第三位置，其中允许一个或多个互连（61,102）和/或一个或多个对应的触点（62,104）向用户发送信号。这种流体通路连接（300）可以集成到具有桶（58）和柱塞密封件（60）的药物容器（50）中。药物输送泵（10）包括这样的集成流体通路连接（300）和药物容器（50）。

4. 发明申请

WO2014036308A2 CONTROLLED DELIVERY DRIVE MECHANISMS FOR DRUG DELIVERY PUMPS 审中-公开
标题翻译：用于药物输送泵的受控输送驱动机构
公开(公告)号：WO2014036308A2
公开(公告)日：2014-03-06
申请号：PCT/US2013/057367
申请日：2013-08-29
申请人： UNITRACT SYRINGE PTY LTD , HANSON, Ian B.
发明人： HANSON, Ian B. , BEAVER, Scott , BENTE IV, Paul F. , BOKELMAN, Kevin , MAJETTE, Mark
IPC分类号： A61M5/145
CPC分类号： A61M5/1454 , A61M5/1452 , A61M5/14546 , A61M5/14566 , A61M5/16804 , A61M2005/14208 , A61M2202/0007 , A61M2205/3334
摘要： A controlled delivery drive mechanism includes a drug container having a barrel and a plunger seal; a drive housing within which at least initially partially resides a piston having an interface surface and a drive rack; and a power spring. The piston is configured to contact and axially translate the plunger seal within barrel. The mechanism may be configured to convert rotational movement of a drive pinion to axial translation of the drive rack, or to convert axial force of a linear power spring into torsional motion of a drive pinion. A regulating mechanism meters the drive pinion such that the piston is axially translated at a controlled rate. The drug container may contain a drug fluid within a drug chamber for drug delivery at a controlled rate. The regulating mechanism may be an escapement regulating mechanism. A drug delivery pump includes such controlled delivery drive mechanisms.
摘要翻译：受控传送驱动机构包括具有筒体和柱塞密封件的药物容器; 驱动器壳体，其中至少最初部分地驻留有具有界面表面的活塞和驱动齿条; 和动力弹簧。活塞构造成使柱塞密封件在筒内接触并轴向平移。该机构可以被配置为将驱动小齿轮的旋转运动转换成驱动齿条的轴向平移，或者将线性动力弹簧的轴向力转换成驱动小齿轮的扭转运动。调节机构计量驱动小齿轮，使得活塞以受控的速度轴向平移。药物容器可以在药物室内含有药物流体，用于以受控的速率进行药物递送。调节机构可以是擒纵机构。药物输送泵包括这种受控输送驱动机构。

5. 发明申请

WO2014036285A3 VARIABLE RATE CONTROLLED DELIVERY DRIVE MECHANISMS FOR DRUG DELIVERY PUMPS 审中-公开
公开(公告)号：WO2014036285A3
公开(公告)日：2014-03-06
申请号：PCT/US2013/057327
申请日：2013-08-29
申请人： UNITRACT SYRINGE PTY LTD , BENTE IV, Paul F.
发明人： BENTE IV, Paul F. , HANSON, Ian B. , MANDES, Vincent E. , O'CONNOR, Sean M.
IPC分类号： A61M5/145
摘要： A variable rate controlled delivery drive mechanism includes a drive mechanism housing, at least partially within which initially resides a biasing member positioned in an initially energized state within an inner cavity of a piston. The drive mechanism may include a gear drive having one or more screws and one or more corresponding nuts. The piston contacts a plunger seal and is configured to axially translate the plunger seal, by force asserted upon it from the biasing member, from a first position to a second position within a drug container for drug delivery. The biasing member is metered from free expansion from its energized state by the gear drive and a gear assembly mechanism having a motor. A drug delivery pump utilizes such variable rate controlled delivery mechanisms. A status reader configured to recognize one or more corresponding status triggers is utilized to provide feedback to a user.

6. 发明申请

WO2014116998A2 FLUID RESTRICTION MECHANISMS FOR DRUG DELIVERY PUMPS 审中-公开
标题翻译：用于药物输送泵的流体限制机构
公开(公告)号：WO2014116998A2
公开(公告)日：2014-07-31
申请号：PCT/US2014/013019
申请日：2014-01-24
申请人： UNITRACT SYRINGE PTY LTD , O'CONNOR, Sean M.
发明人： O'CONNOR, Sean M. , HANSON, Ian B. , BENTE IV, Paul F. , CLEMENTE, Matthew J.
IPC分类号： A61M5/14
CPC分类号： A61M5/16813 , A61M5/141 , A61M5/14248 , A61M5/1452 , A61M5/1454 , A61M5/16822 , A61M2205/13
摘要： A replaceable fluid restriction mechanism 500, 1500 includes: an aperture 520A residing adjacent to a fluid pathway connection and configured to permit flow of a drug fluid through the aperture 520A when the fluid pathway connection is open; an entry point 520B of a fluid channel 520C configured such that the flow of drug fluid can travel through aperture 520A to the entry point 520B and through the fluid channel 520C to an exit point 520D; and an outlet aperture 514 of a port 512 through which the flow of drug fluid may travel after exiting the exit point 520D, wherein a fluid conduit 30 is connected to the fluid restriction mechanism at the outlet aperture. A configurable fluid restriction mechanism 500, 1500 includes a plurality of fluid channels 520C, 521C, 522C, 523C, selectable to align with the entry point 520B and an exit point 520D of the fluid restriction mechanism.
摘要翻译：可替换的流体限制机构500,1500包括：邻近流体通路连接并且构造成允许药物流体在流体通路连接打开时通过孔520A流动的孔520A; 流体通道520C的入口点520B被配置为使得药物流体的流动可以通过孔520A行进到入口点520B并且通过流体通道520C行进到出口点520D; 以及端口512的出口孔514，药物流体的流动可以在离开出口点520D之后行进，其中流体导管30在出口孔处连接到流体限制机构。可配置流体限制机构500,1500包括多个流体通道520C，521C，522C，523C，其可选择地与流体限制机构的入口点520B和出口点520D对准。

7. 发明申请

WO2013040032A1 STERILE FLUID PATHWAY CONNECTION TO DRUG CONTAINERS FOR DRUG DELIVERY PUMPS 审中-公开
标题翻译：无效液体路径连接药物输送泵的药液容器
公开(公告)号：WO2013040032A1
公开(公告)日：2013-03-21
申请号：PCT/US2012/054861
申请日：2012-09-12
申请人： UNITRACT SYRINGE PTY LTD , O'CONNOR, Sean M. , HANSON, Ian B. , BENTE IV, Paul F. , RAMASWAMY, Rajan , CODD, Daniel S. , BEAVER, Scott W. , BOKELMAN, Kevin L. , LOVE, John C.
发明人： O'CONNOR, Sean M. , HANSON, Ian B. , BENTE IV, Paul F. , RAMASWAMY, Rajan , CODD, Daniel S. , BEAVER, Scott W. , BOKELMAN, Kevin L. , LOVE, John C.
IPC分类号： A61M5/168 , A61M5/158 , A61M5/142 , A61M5/145 , A61M39/10 , A61M39/26
CPC分类号： A61M5/14248 , A61M5/1452 , A61M5/162 , A61M5/16813 , A61M5/16877 , A61M2005/1581
摘要： A user-initiated fluid pathway connection 300 includes: a connection hub 310, a piercing member 330, a sterile sleeve 320, and a drug container 50 having a cap 52, a pierceable seal 56, a barrel 58, and a plunger seal 60, wherein the piercing member 330 is initially retained within the sterile sleeve 320 between the connection hub 310 and the pierceable seal 56 of the drug container 50. The connection hub 3310 may include an internal aperture 3310D within the connection hub 3310 which functions as a flow restrictor and wherein a piercing member 3330 is connected to one end of the internal aperture 3310D and a fluid conduit 3030 is connected to another end of the internal aperture 3310D. A drug delivery pump 10 with integrated sterility maintenance features includes a housing 12, upon which an activation mechanism 14, an insertion mechanism 200, a fluid pathway connection 300 as described above, a power and control system 400, and a drive mechanism 100 connected to a drug container 50 are mounted. Methods of assembly and operation are also provided.
摘要翻译：用户启动的流体通道连接件300包括：连接毂310，刺穿构件330，无菌套管320和具有帽52，可刺破密封件56，筒体58和柱塞密封件60的药物容器50，其中穿刺构件330初始地保持在连接毂310和药物容器50的可刺穿密封件56之间的无菌套筒320内。连接毂3310可以包括连接毂3310内的内部孔3310D，其用作限流器并且其中刺穿构件3330连接到内孔3310D的一端，并且流体导管3030连接到内孔3310D的另一端。具有集成的无菌维护特征的药物输送泵10包括外壳12，如上所述的启动机构14，插入机构200，流体通路连接300，电力和控制系统400以及驱动机构100连接到安装药物容器50。还提供了组装和操作的方法。

8. 发明申请

WO2019092469A1 HANDHELD DRUG DELIVERY DEVICE 审中-公开
公开(公告)号：WO2019092469A1
公开(公告)日：2019-05-16
申请号：PCT/IB2017/001371
申请日：2017-11-09
申请人： UNITRACT SYRINGE PTY LTD
发明人： KING, Andrew, N. , HANSON, Ian, B. , BENTE IV, Paul F.
IPC分类号： A61M5/20 , A61M5/24
摘要： Handheld drug delivery devices for injection of a medicament into a target location are disclosed herein. The drug delivery devices of the present disclosure include drive mechanisms, needle insertion mechanisms, and fluid pathway connectors. These components may be arranged within a housing. The arrangement of these components may provide an easy to use device that is capable of delivering volumes larger than traditionally injected using syringes. Translation of a drug container of the device may cause connection of a fluid pathway from the drug container for delivery of a medicament to a target location.

9. 发明申请

WO2013033467A2 DRIVE MECHANISM FOR DRUG DELIVERY PUMPS WITH INTEGRATED STATUS INDICATION 审中-公开
标题翻译：具有综合状态指示的药物递送泵的驱动机构
公开(公告)号：WO2013033467A2
公开(公告)日：2013-03-07
申请号：PCT/US2012/053241
申请日：2012-08-30
申请人： UNITRACT SYRINGE PTY LTD , O'CONNOR, Sean M. , BOKELMAN, Kevin , HANSON, Ian B. , BENTE IV, Paul F.
发明人： O'CONNOR, Sean M. , BOKELMAN, Kevin , HANSON, Ian B. , BENTE IV, Paul F.
IPC分类号： A61M5/145
CPC分类号： A61M5/172 , A61M5/1452 , A61M5/14566 , A61M2005/14506 , A61M2205/58
摘要： A drive mechanism (100) having integrated status indication includes a drive housing (130), a status switch interconnect (132), a drive biasing member (122), a piston (110), and a drug container (50) having a cap (52), a pierceable seal (56), a barrel (58), and a plunger seal (60), wherein the drive biasing member (122) is configured to bear upon an interface surface (110C) of the piston (110). Drive mechanism (100) may include an incremental status stem (650) having a stem interconnect (652), wherein the stem (650) resides within the drive housing (630) and the piston (610), and wherein the stem (650) has an interconnect which engages one or more contacts on the piston (610) to provide incremental feedback. A drug delivery pump (10) with integrated status indication includes a housing (12) and an assembly platform (20), upon which an activation mechanism (14), an insertion mechanism (200), a fluid pathway connection (300), a power and control system (400), and the drive mechanism (100) having a drug container (50) may be mounted.
摘要翻译：具有集成状态指示的驱动机构（100）包括驱动外壳（130），状态开关互连（132），驱动偏置构件（122），活塞（110）和（52），可刺穿的密封件（56），筒（58）和柱塞密封件（60）的药物容器（50），其中所述驱动偏置构件（122）构造成承载界面表面 110C）。驱动机构100可以包括具有阀杆互连652的增量状态阀杆650，其中阀杆650位于驱动器壳体630和活塞610内，具有接合活塞（610）上的一个或多个触点以提供增量反馈的互连。具有集成状态指示的药物输送泵（10）包括壳体（12）和组装平台（20），在该组装平台上设置有激活机构（14），插入机构（200），流体路径连接（300），动力和控制系统（400）以及具有药物容器（50）的驱动机构（100）可以被安装。

10. 发明申请

WO2013033421A3 INSERTION MECHANISM FOR A DRUG DELIVERY PUMP 审中-公开
公开(公告)号：WO2013033421A3
公开(公告)日：2013-03-07
申请号：PCT/US2012/053174
申请日：2012-08-30
申请人： UNITRACT SYRINGE PTY LTD , O'CONNOR, Sean M. , DECKER, Robert , SHETTY, Gautam N. , DESTEFANO, Mark A. , HANSON, Ian B. , BENTE IV, Paul F.
发明人： O'CONNOR, Sean M. , DECKER, Robert , SHETTY, Gautam N. , DESTEFANO, Mark A. , HANSON, Ian B. , BENTE IV, Paul F.
IPC分类号： A61M5/158
摘要： An insertion mechanism (200) for a drug pump (10) includes an insertion mechanism housing (202); a manifold guide (220); an insertion biasing member (210) initially held in an energized state; a retraction biasing member (216) and a hub (212) connected to a proximal end of a needle (214), wherein the retraction biasing member (216) is held initially in an energized state between the hub (212) and the manifold guide (220); and a manifold (240) having a septum (230) and a cannula (234), wherein the annular space between the septum (230) and the cannula (234) defines a manifold header (242). The needle (214) and cannula (234) are inserted into the body of a user by the insertion biasing member(s) (210), after which only the needle (214) is retracted. Retraction of the needle (214) may open a fluid pathway from the manifold header (242) to the body through the cannula (234). A drug delivery pump (10) includes an activation mechanism (12), a drive mechanism (100), a fluid pathway connection (300), and the insertion mechanism 200. Assembly and operation methods are provided.

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