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1. 发明申请

WO2016053954A1 RIGID NEEDLE INSERTION MECHANISM FOR A DRUG DELIVERY PUMP 审中-公开
标题翻译：用于药液输送泵的刚性针插入机构
公开(公告)号：WO2016053954A1
公开(公告)日：2016-04-07
申请号：PCT/US2015/052815
申请日：2015-09-29
申请人： UNITRACT SYRINGE PTY LTD , DESTEFANO, Mark
发明人： DESTEFANO, Mark , HANSON, Ian , BENTE, Paul , LAURENCE, Lawton
IPC分类号： A61M5/158 , A61M5/142
CPC分类号： A61M5/158 , A61M5/142 , A61M5/14248 , A61M2005/14252 , A61M2005/14256 , A61M2005/1585
摘要： An insertion mechanism (200) and methods of assembly and operation of a drug pump (10) may include an insertion mechanism housing (202); a housing cap; a manifold guide (220); an insertion biasing member (210) initially held in an energized state; a retraction biasing member (216) connected to a hub (212) connected to a proximal end of a needle (214); and, optionally, a clip retainer. The retraction biasing member is held initially in an energized state between the hub and manifold guide. A manifold has a manifold body and one or more septa defining a manifold header. The retraction biasing member may be held initially in an energized state between the hub and the clip retainer. The needle is advanced by the insertion biasing member(s) from the initial configuration to an administration configuration, opening a fluid pathway from the manifold header to the target. The drug delivery pump may include an activation mechanism, a drive mechanism, a fluid pathway connection, and the insertion mechanism.
摘要翻译：插入机构（200）以及药物泵（10）的组装和操作的方法可以包括插入机构壳体（202）; 房屋帽歧管引导件（220）; 最初保持在通电状态的插入偏置构件（210）连接到连接到针（214）的近端的轮毂（212）上的回缩偏置构件（216）; 和可选的夹子保持器。回缩偏压构件最初保持在轮毂和歧管引导件之间的通电状态。歧管具有歧管主体和限定歧管歧管的一个或多个隔片。回缩偏压构件可以初始地保持在轮毂和夹子保持器之间的通电状态。针通过插入偏置构件从初始构型推进到管理构型，打开从歧管歧管到目标的流体通道。药物输送泵可以包括激活机构，驱动机构，流体通路连接和插入机构。

2. 发明申请

WO2019150145A1 ASEPTIC CONNECTIONS FOR DRUG DELIVERY DEVICES 审中-公开
公开(公告)号：WO2019150145A1
公开(公告)日：2019-08-08
申请号：PCT/IB2018/000049
申请日：2018-01-31
申请人： UNITRACT SYRINGE PTY LTD
发明人： HANSON, Ian B. , LAURENCE, Lawton , UBACH, Antonio
IPC分类号： A61M5/142 , A61M5/162 , A61M5/32 , A61M5/158 , A61J1/20
摘要： Devices and methods for establishing aseptic connections between a drug container and a fluid pathway connection for a drug pump are provided. A fluid pathway connection includes a connection hub, a piercing member, a piercing member retainer, and a drug container. The drug container includes a cap, a pierceable seal, and a barrel. The piercing member is at least partially disposed in a sterile chamber defined by the connection hub, and the connection hub is configured to be connected to the drug container while maintaining an aseptic condition of a fluid pathway from the sterile chamber to an interior of the drug container.

3. 发明申请

WO2017093803A1 SYSTEMS AND METHODS FOR CONTROLLED DRUG DELIVERY PUMPS 审中-公开
标题翻译：控制药物输送泵的系统和方法
公开(公告)号：WO2017093803A1
公开(公告)日：2017-06-08
申请号：PCT/IB2016/001835
申请日：2016-12-02
申请人： UNITRACT SYRINGE PTY LTD
发明人： LAURENCE, Lawton , HANSON, Ian, B. , BENTE, Paul, F., IV , TRZYBINSKI, Robert
IPC分类号： A61M5/142 , A61M5/172 , A61M5/315 , G06F19/00
CPC分类号： A61M5/142 , A61M5/14 , A61M5/172 , A61M5/315 , G06F19/00 , G06F19/3468
摘要： Power and control systems for a drug delivery device allow for the activation, control of, and communication with the drug delivery device. The power and control system allows for a delay between device activation, and optionally needle insertion, and commencing drug delivery. The delay may be for a predetermined time. In addition, the power and control system may communicate with one or more external sensors and devices. The inputs from the sensors and devices may automatically, or on demand, adjust the delivery parameters of the device. The power and control systems may control a drive system that delivers a fluid at a variable rate or profile, allowing for the delivery to be tailored to maximize the effectiveness of the treatment.
摘要翻译：用于药物输送装置的电力和控制系统允许激活，控制和与药物输送装置通信。电源和控制系统允许设备激活和可选的针头插入之间的延迟以及开始药物输送。延迟可能持续预定的时间。另外，电力和控制系统可以与一个或多个外部传感器和设备进行通信。来自传感器和设备的输入可以自动或根据需要调整设备的输送参数。动力和控制系统可以控制一个驱动系统，该驱动系统可以以不同的速率或轮廓输送流体，从而允许定制输送以最大化治疗的有效性。

4. 发明申请

WO2018224855A1 FILL-FINISH CARRIERS FOR DRUG CONTAINERS 审中-公开
公开(公告)号：WO2018224855A1
公开(公告)日：2018-12-13
申请号：PCT/IB2017/000836
申请日：2017-06-06
申请人： UNITRACT SYRINGE PTY LTD
发明人： DECHELETTE, Alexis Marie, Adolphe , DEVITT, Shaun, R. , JETER, Robert, G. Jr. , LAURENCE, Lawton , DESTEFANO, Mark, A.
IPC分类号： A61J1/20 , A61J1/14
摘要： A fill-finish cartridge includes a carrier, a fluid pathway connection, a needle insertion mechanism, and a drug container. The cartridges enable drug containers to be filled with pharmaceutical treatments using standard filling equipment and process systems, while maintaining the sterility and container integrity of the fluid pathway. The fill-finish cartridges of the present invention can be nested or removably housed in fill-finish trays for batch filling in standard operating processes. As such, the adaptable fill-finish cartridges of the present invention may be flexibly inserted, attached, mounted, or otherwise removably positioned in fill-finish trays. These embodiments, accordingly, may provide novel and cost-efficient assemblies and cartridges which are readily integrated into drug filling processes. Methods of assembly, manufacture, and use are also provided.

5. 发明申请

WO2018029520A1 DRUG DELIVERY DEVICE AND METHOD FOR CONNECTING A FLUID FLOWPATH 审中-公开
标题翻译：药物递送装置和用于连接流体流动通道的方法
公开(公告)号：WO2018029520A1
公开(公告)日：2018-02-15
申请号：PCT/IB2017/000937
申请日：2017-08-08
申请人： UNITRACT SYRINGE PTY LTD
发明人： DECHELETTE, Alexis Marie Adolphe , RUSSO, Robert S. , LAURENCE, Lawton , DEVITT, Shaun R.
IPC分类号： A61M5/142 , A61M5/158 , A61M5/162
摘要： Provided herein is a fluid pathway connection assembly, e.g., for connecting a fluid flowpath within a drug delivery device for delivery of a medicament to a target site. The fluid pathway connection assembly comprises a hollow needle piercing member, a sleeve fixedly engaged with the piercing member and a pierceable seal configured to sealingly engage the piercing member or the sleeve. Upon, sealing engagement, the piercing member or the sleeve and the pierceable seal form a volume within which a portion of the piercing member is disposed. The fluid pathway connection assembly is activated by relative movement between the piercing member and the pierceable seal and activation causes the piercing member to pierce the pierceable seal, thereby establishing a fluid flowpath through the pierceable seal. Upon incorporation of the assembly into a sealed fluid flowpath, the volume is isolated from the environment and maintains the sterile condition of the portion of the piercing member disposed therein. Also provided herein are drug delivery pumps and methods of operating and assembling the assemblies and pumps described herein.
摘要翻译：本文提供了流体通道连接组件，例如用于连接药物输送装置内的流体流动路径以将药物输送到目标部位。流体通道连接组件包括中空的针刺穿构件，与刺穿构件固定地接合的套筒以及构造成密封地接合刺穿构件或套筒的可刺穿的密封件。当密封接合时，刺穿构件或套筒和可刺穿密封件形成刺穿构件的一部分布置在其内的容积。流体通路连接组件通过刺穿构件和可刺穿密封件之间的相对运动而被激活，并且致动使刺穿构件刺穿可刺穿密封件，由此建立穿过可刺穿密封件的流体流动路径。在将组件结合到密封的流体流动路径中时，该体积与环境隔离并且维持布置在其中的刺穿构件的部分的无菌状态。本文还提供药物输送泵以及操作和组装这里描述的组件和泵的方法。

6. 发明申请

WO2016130679A2 ROTATIONALLY BIASED INSERTION MECHANISM FOR A DRUG DELIVERY PUMP 审中-公开
标题翻译：用于药物输送泵的旋转插入机构
公开(公告)号：WO2016130679A2
公开(公告)日：2016-08-18
申请号：PCT/US2016/017354
申请日：2016-02-10
申请人： UNITRACT SYRINGE PTY LTD
发明人： DESTEFANO, Mark A. , LAURENCE, Lawton , LOVE, John C. , HANSON, Ian B. , BENTE, IV, Paul F.
IPC分类号： A61M5/142 , A61M5/32 , A61M5/145 , A61M5/158
CPC分类号： A61M5/14248 , A61M5/158 , A61M5/3287 , A61M2005/14252 , A61M2005/1583 , A61M2005/1585 , A61M2205/13 , A61M2205/18 , A61M2205/44 , A61M2205/581 , A61M2205/583 , A61M2207/00
摘要： An insertion mechanism (200) for a drug pump (10, 1300) includes an insertion mechanism (200) housing (202, 1202, 2202, 3202); a sleeve (220, 1220, 2220, 3220); a rotational biasing member (210, 1210, 2210, 3210) initially held in an energized state; a retraction biasing member (216, 1216, 2216, 3216) and a hub (212, 1212, 2212, 3212) connected to a proximal end of a needle (214, 1214, 2214, 3214), wherein the retraction biasing member (216, 1216, 2216, 3216) is held initially in an energized state between the hub (212, 1212, 2212, 3212) and the sleeve (220, 1220, 2220, 3220). The needle (214, 1214, 2214, 3214) is inserted into a target tissue by the rotational biasing member (210, 1210, 2210, 3210) and interaction between the hub (212, 1212, 2212, 3212) and housing (202, 1202, 2202, 3202). Retraction of the needle (214, 1214, 2214, 3214) is caused by decompressing or de-energizing of the retraction biasing member (216, 1216, 2216, 3216). A drug delivery pump includes an activation mechanism (14), a drive mechanism (100), a sterile access connection (300), and the insertion mechanism (200). Assembly and operation methods are provided.
摘要翻译：用于药物泵（10,1300）的插入机构（200）包括插入机构（200），壳体（202,1202,2202,3202）; 套筒（220,1220,2220,3220）; 最初保持在通电状态的旋转偏压构件（210,1210,2210,3210）; 连接到针（214,1214,2214,3214）的近端的回缩偏压构件（216,1216,2216,3216）和毂（212,1212,2212,3212），其中所述回缩偏压构件（216 最初在毂（212,1212,2212,3212）和套筒（220,1220,2220,3220）之间的通电状态下被保持。针（214,1214,2214,3214）通过旋转偏置构件（210,1210,2210,3210）插入到目标组织中，并且毂（212,1212,2212,3212）和壳体（202， 1202,2202,3202）。针（214,1214,2224,3214）的缩回是通过对后退偏置构件（216,1216,2216,3216）的减压或去电来引起的。药物输送泵包括启动机构（14），驱动机构（100），无菌接入连接（300）和插入机构（200）。提供装配和操作方法。

7. 发明申请

WO2016145094A2 DRIVE MECHANISMS FOR DRUG DELIVERY PUMPS 审中-公开
标题翻译：药物输送泵的驱动机构
公开(公告)号：WO2016145094A2
公开(公告)日：2016-09-15
申请号：PCT/US2016/021585
申请日：2016-03-09
申请人： UNITRACT SYRINGE PTY LTD , HANSON, Ian B.
发明人： HANSON, Ian B. , LAURENCE, Lawton , BENTE, IV, Paul F. , DESTEFANO, Mark A. , DARDANI, Ian P.
IPC分类号： A61M5/145 , A61M5/168 , A61M5/172 , A61M5/142 , A61M5/162 , A61M5/158
CPC分类号： A61M5/1454 , A61M5/14216 , A61M5/145 , A61M5/1452 , A61M5/14566 , A61M5/158 , A61M5/162 , A61M5/168 , A61M5/16804 , A61M5/1684 , A61M5/1685 , A61M5/16877 , A61M5/1723 , A61M2005/1402 , A61M2005/14208 , A61M2005/14506 , A61M2005/1585 , A61M2205/18 , A61M2205/276 , A61M2205/33 , A61M2205/3334 , A61M2205/3584 , A61M2205/50 , A61M2205/581 , A61M2205/582 , A61M2205/583
摘要： A drive mechanism (100) for use with a drug container (50) in a drug pump, the drug container (50) having a barrel (58) and a plunger seal (60), including a tether, an electrical actuator (101) and a gear interface. Rotation of the gear interface is controlled by the actuator (101). A gear assembly rotationally engages with the gear interface. The gear assembly includes a main gear and a regulating mechanism. Release of the tether is metered by the gear assembly through the regulating mechanism. A piston (110, 1110, 2110) is connected to the tether and is disposed in the barrel (58) and configured to translate axially within the container. A biasing member is disposed at least partially within the barrel (58) and is retained in an energized state between the piston (110, 1110, 2110) and drive housing, wherein the release of the tether controls the free expansion of the biasing member from its energized state and the axial translation of the piston (110, 1110, 2110).
摘要翻译：一种用于与药物泵中的药物容器（50）一起使用的驱动机构（100），所述药物容器（50）具有筒体（58）和柱塞密封件（60），所述驱动机构包括系绳，电动致动器（101）和齿轮接口。齿轮接口的旋转由致动器（101）控制。齿轮组件与齿轮接口旋转啮合。齿轮组件包括主齿轮和调节机构。系绳的释放通过调节机构由齿轮组件计量。活塞（110,1110,2110）连接到系绳并设置在筒体（58）中并构造成在容器内轴向平移。偏压构件至少部分地设置在筒体（58）内并且保持在活塞（110,1110,2110）与驱动壳体之间的激励状态，其中系绳的释放控制偏压构件的自由膨胀其通电状态和活塞（110,1110,2110）的轴向平移。

8. 发明申请

WO2016141082A1 DEVICE AND METHOD FOR MAKING ASEPTIC CONNECTIONS 审中-公开
标题翻译：用于制造自由连接的装置和方法
公开(公告)号：WO2016141082A1
公开(公告)日：2016-09-09
申请号：PCT/US2016/020486
申请日：2016-03-02
申请人： UNITRACT SYRINGE PTY LTD , CLEMENTE, Matthew J.
发明人： CLEMENTE, Matthew J. , HANSON, Ian B. , LAURENCE, Lawton , UBACH, Antonio , RAMASWAMY, Rajan , CODD, Daniel S. , BEAVER, Scott , BOKELMAN, Kevin L. , FELDMAN, Danielle
IPC分类号： A61M5/142 , A61M5/32 , A61M5/158 , A61M39/18 , A61J1/14 , A61M5/34 , A61M5/145 , A61M5/24
CPC分类号： A61M5/162 , A61J1/1406 , A61J1/201 , A61J1/2051 , A61M5/1413 , A61M5/142 , A61M5/14248 , A61M5/1456 , A61M5/158 , A61M5/1626 , A61M5/32 , A61M39/18 , A61M2005/14252 , A61M2005/1585 , A61M2005/2474 , A61M2005/341 , A61M2205/0216 , A61M2205/18 , A61M2205/581 , A61M2205/587
摘要： The present invention provides devices and methods for establishing aseptic connections between two or more components or subassemblies. The devices may be used in medical devices such as drug delivery pumps (10). In some embodiments, a connection is made between a drug container (50, 1050, 2050) and a fluid pathway connection assembly (300, 1300, 2300). The fluid pathway connection assembly may include a connection hub (312, 1312, 2312), a piercing member (316, 1316, 2316), and a piercing member retainer (314, 1314, 2314). The assembly may further include a first film (318, 1318, 2318) covering a cavity (312A, 1312A, 2312A), thereby maintaining the aseptic condition of the cavity. The drug container may hold a fluid drug and include a pierceable seal (326, 1326, 2326). A second film (322, 1322, 2322) may cover a recess (328, 1328, 2328) formed by the seal and thereby maintain the aseptic condition of the interior of the chamber. The piercing member may be caused to pierce the first and second film and the pierceable seal to open a fluid pathway for delivery of the fluid drug through the fluid pathway connection assembly.
摘要翻译：本发明提供了用于在两个或多个部件或子组件之间建立无菌连接的装置和方法。这些装置可以用于诸如药物输送泵（10）的医疗装置中。在一些实施例中，在药物容器（50,1050,2050）和流体通路连接组件（300,1300,2300）之间形成连接。流体路径连接组件可以包括连接毂（312,1312,2312），刺穿构件（316,1316,2316）和穿孔构件保持架（314,1314,2134）。组件还可以包括覆盖空腔（312A，1312A，2312A）的第一膜（318,1318,2318），从而保持空腔的无菌状态。药物容器可以容纳流体药物并且包括可刺破的密封件（326,1326,2326）。第二膜（322,1322,2322）可以覆盖由密封件形成的凹部（328,1328,2328），从而保持腔室内部的无菌状态。穿刺构件可以被刺穿第一和第二膜和可刺破的密封件以打开流体通道，用于将流体药物输送通过流体通路连接组件。

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