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1. 发明申请

WO2005035558A2 PISCIRICKETTSIA SALMONIS ANTIGENS AND USE THEREOF 审中-公开
标题翻译： PISCIRICKETTSIA SALMONIS抗原及其用途
公开(公告)号：WO2005035558A2
公开(公告)日：2005-04-21
申请号：PCT/IB2004/003339
申请日：2004-10-01
申请人： THIRY, Michel , DHEUR, Ingrid
发明人： THIRY, Michel , DHEUR, Ingrid
IPC分类号： C07K14/29
CPC分类号： C07K14/195 , A61K39/00
摘要： The present invention discloses novel proteins, e.g., antigens, from Piscirickettsia salmonis. The present invention further discloses nucleic acids that encode these proteins. The present invention also discloses the use of the proteins, e.g., antigens, and nucleic acids to prepare vaccines against salmonid rickettsial septicemia (SRS). The present invention further provides recombinant Yersinia ruckeri cells to be used to construct vaccines against SRS. The present invention also discloses vaccines that can be used to protect fish from Piscirickettsia salmonis, as well as other pathogens. In addition, the present invention discloses methods of using the vaccines of the present invention to protect fish from SRS as well as from other pathogenic diseases.
摘要翻译：本发明公开了来自鲑鱼沙门氏菌（Pisciricketetia salmonis）的新蛋白质，例如抗原。本发明进一步公开了编码这些蛋白质的核酸。本发明还公开了蛋白质例如抗原和核酸用于制备针对鲑鱼立克次体败血症（SRS）的疫苗的用途。本发明进一步提供了用于构建针对SRS的疫苗的重组耶尔森氏菌耶尔森菌（Yersinia ruckeri）细胞。本发明还公开了可用于保护来自鱼类沙门氏菌（Pisciricketetia salmonis）的鱼以及其他病原体的疫苗。另外，本发明公开了使用本发明的疫苗来保护鱼类免受SRS以及其他致病性疾病的方法。

2. 发明申请

WO1990004028A1 RECOMBINANT POLYPEPTIDES OF THE HEMORRAGIC SEPTICEMY VIRUS OF FISH 审中-公开
标题翻译：鱼类HEMORRAGIC分裂病毒的重组多聚体
公开(公告)号：WO1990004028A1
公开(公告)日：1990-04-19
申请号：PCT/EP1989001228
申请日：1989-10-12
申请人： EUROGENTEC S.A. , RENARD, André , THIRY, Michel
发明人： EUROGENTEC S.A.
IPC分类号： C12N15/47
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C07K2319/033 , C12N9/88 , C12N2760/20022
摘要： The invention relates to new amino acid sequences comprising particularly all or part of the amino acid chain represented in figures III and IIIcontinued. These amino acids sequences may be used as active principle of a vaccine against viral hemorragic septicemy of fish.

3. 发明申请

WO2008122434A8 BIS-MET HISTONES 审中-公开
公开(公告)号：WO2008122434A8
公开(公告)日：2010-10-21
申请号：PCT/EP2008002746
申请日：2008-04-07
申请人： SYMBIOTEC GMBH , GROSS PETER , JOERNVALL HANS , THIRY MICHEL , FORMICKA-ZEPPEZAUER GRAZYNA , ZEPPEZAUER MICHAEL
发明人： GROSS PETER , JOERNVALL HANS , THIRY MICHEL , FORMICKA-ZEPPEZAUER GRAZYNA , ZEPPEZAUER MICHAEL
IPC分类号： C07K14/47 , A61K38/00 , A61K38/17 , C12P21/02
CPC分类号： C07K14/47 , A61K38/00 , Y10T436/143333
摘要： The present invention provides a nucleic acid molecule which encodes a polypeptide consisting of two methionine residues as the first and second N-terminal amino acid residues linked via a peptide bond to a mature eukaryotic histone. The present invention furthermore relates to a vector containing said nucleic acid molecule, a host transformed with said vector, polypeptides encoded by the nucleic acid molecule and pharmaceutical and diagnostic compositions. The present invention also relates to the use of the nucleic acid molecule, vectors, hosts and the polypeptide of the invention for the preparation of a composition for the treatment of diseases. Furthermore, the present invention relates to a method of testing for the presence of the nucleic acid molecule or the polypeptide in a sample and to a kit.
摘要翻译：本发明提供了一种核酸分子，其编码由两个甲硫氨酸残基组成的多肽，作为通过肽键与成熟真核组蛋白连接的第一和第二N-末端氨基酸残基。本发明还涉及含有所述核酸分子的载体，用所述载体转化的宿主，由核酸分子编码的多肽和药物和诊断组合物。本发明还涉及本发明的核酸分子，载体，宿主和多肽在制备用于治疗疾病的组合物中的用途。此外，本发明涉及测试样品和试剂盒中核酸分子或多肽的存在的方法。

4. 发明申请

WO2005035558A3 PISCIRICKETTSIA SALMONIS ANTIGENS AND USE THEREOF 审中-公开
标题翻译： PISCIRICKETTSIA SALMONIS抗体及其用途
公开(公告)号：WO2005035558A3
公开(公告)日：2005-10-13
申请号：PCT/IB2004003339
申请日：2004-10-01
申请人： THIRY MICHEL , DHEUR INGRID
发明人： THIRY MICHEL , DHEUR INGRID
IPC分类号： A61K39/00 , A61K39/02 , A61K39/295 , C07K14/195 , C07K14/29 , C07K16/12 , C12N15/31
CPC分类号： C07K14/195 , A61K39/00
摘要： The present invention discloses novel proteins, e.g., antigens, from Piscirickettsia salmonis. The present invention further discloses nucleic acids that encode these proteins. The present invention also discloses the use of the proteins, e.g., antigens, and nucleic acids to prepare vaccines against salmonid rickettsial septicemia (SRS). The present invention further provides recombinant Yersinia ruckeri cells to be used to construct vaccines against SRS. The present invention also discloses vaccines that can be used to protect fish from Piscirickettsia salmonis, as well as other pathogens. In addition, the present invention discloses methods of using the vaccines of the present invention to protect fish from SRS as well as from other pathogenic diseases.
摘要翻译：本发明公开了来自沙门氏菌的新型蛋白质，例如抗原。本发明还公开了编码这些蛋白质的核酸。本发明还公开了蛋白质例如抗原和核酸用于制备针对鲑鱼立克次体败血症（SRS）的疫苗的用途。本发明还提供了用于构建针对SRS的疫苗的重组Yersinia ruckeri细胞。本发明还公开了可用于保护鱼类从沙门氏菌和其他病原体中获得的疫苗。此外，本发明公开了使用本发明的疫苗来保护鱼类免受SRS以及其它病原性疾病的方法。

5. 发明申请

WO2005049638A3 AMNIOTIC-DERIVED PEPTIDE AND USES THEREOF 审中-公开
公开(公告)号：WO2005049638A3
公开(公告)日：2005-06-02
申请号：PCT/US2004/037800
申请日：2004-11-12
申请人： LAJOR BIOTECH, INC. , BAKHUTASHVILI, Vladimir , HALLER, Jordan, D. , BAKHUTASHVILI, Ivane , BAKHUTASHVILI, Alexander , NICOLETTI, Ferdinando , THIRY, Michel , PONCIN, Alain
发明人： BAKHUTASHVILI, Vladimir , HALLER, Jordan, D. , BAKHUTASHVILI, Ivane , BAKHUTASHVILI, Alexander , NICOLETTI, Ferdinando , THIRY, Michel , PONCIN, Alain
IPC分类号： A61K38/08 , A61K38/00 , A61K38/02 , A61K38/19 , A61K35/54 , C07K7/04 , C07K2/00
摘要： The present invention relates to the method(s) of synthesis of and the therapeutic and cosmetic applications of biologically active peptides for improving the appearance of skin, for hastening wound healing and for treating and/or preventing the progression of various conditions, injuries and diseases, including but not limited to viral hepatitis B and C, herpes zoster ganglioneuritis, diabetic peripheral polyneuropathy, nephrotic syndrome, juvenile rheumatoid arthritis, rheumatoid arthritis, psoriatic arthritis, bronchial asthma, respiratory infection, breast cancer, epilepsy, psoriasis, atherosclerosis and other forms of vascular obstructions, myocardial infarction, HIV and SARS infection, brain cell malfunction due to ischemia and trauma, pathologic consequences of ischemia-reperfusion, rejection reaction following organ transplantation, chemical and drug intoxication including but not limited to anesthetic, alcohol and morphine, cancer, type 1 diabetes mellitus, multiple sclerosis, septic shock (Gram negative sepsis), Parkinson's disease, type 2 diabetes mellitus, Alzheimer's disease, amyotrophic lateral sclerosis, hyperthyroidism, Guillain-Barre syndrome, systematic lupus erythematosus, parasitic infections, especially leishmaniasis, and other collagen diseases, and diseases in which apoptosis occurs.

6. 发明申请

WO2004049095A2 BETAINE COMPOSITIONS 审中-公开
标题翻译： BETAINE组合物
公开(公告)号：WO2004049095A2
公开(公告)日：2004-06-10
申请号：PCT/IB2002/004923
申请日：2002-11-25
申请人： MESSADEK, Jallal , ENNAMANY, Rachid , THIRY, Michel
发明人： MESSADEK, Jallal , ENNAMANY, Rachid , THIRY, Michel
IPC分类号： G06F
CPC分类号： A61K9/209 , A61K31/205 , A61K31/60 , A61K2300/00
摘要： This invention relates to the pharmaceutical combination comprising at least: a first compound selected among the group consisting of acetylsalicylic acid, salicylic acid, pharmaceutical derivatives thereof, and a second compound selected from the group consisting of lipidic betaines, betaines lipids, betaines of Formula (CH 3 ) 3 N + (CH 2 ) n COO - with n an integer from 1 to 5, pharmaceutically acceptable salts thereof, esters thereof, precursors thereof, and mixtures thereof, with the provision that said second compound is different from the first compound and in an amount by weight at least three times the amount of first compound.
摘要翻译：本发明涉及至少包含选自乙酰水杨酸，水杨酸及其药物衍生物的第一化合物和选自脂质甜菜碱，甜菜碱脂质，式（β）的甜菜碱的第二化合物的药物组合物，其中n为1至5的整数，其药学上可接受的盐，其酯，其前体及其混合物，其中所述第二化合物与第一化合物不同，重量比为第一化合物的量的至少三倍。

7. 发明申请

WO2008122434A1 BIS-MET HISTONES 审中-公开
公开(公告)号：WO2008122434A1
公开(公告)日：2008-10-16
申请号：PCT/EP2008/002746
申请日：2008-04-07
申请人： SYMBIOTEC GESELLSCHAFT ZUR FORSCHUNG UND ENTWICKLUNG AUF DEM GEBIET DER BIOTECHNOLOGIE MBH , GROSS, Peter , JÖRNVALL, Hans , THIRY, Michel , FORMICKA-ZEPPEZAUER, Crazyna , ZEPPEZAUER, Michael
发明人： GROSS, Peter , JÖRNVALL, Hans , THIRY, Michel , FORMICKA-ZEPPEZAUER, Crazyna , ZEPPEZAUER, Michael
IPC分类号： C07K14/47 , A61K38/17 , C12P21/02 , A61K38/00
CPC分类号： C07K14/47 , A61K38/00 , Y02A50/409 , Y10T436/143333
摘要： The present invention provides a nucleic acid molecule which encodes a polypeptide consisting of two methionine residues as the first and second N-terminal amino acid residues linked via a peptide bond to a mature eukaryotic histone. The present invention furthermore relates to a vector containing said nucleic acid molecule, a host transformed with said vector, polypeptides encoded by the nucleic acid molecule and pharmaceutical and diagnostic compositions. The present invention also relates to the use of the nucleic acid molecule, vectors, hosts and the polypeptide of the invention for the preparation of a composition for the treatment of diseases. Furthermore, the present invention relates to a method of testing for the presence of the nucleic acid molecule or the polypeptide in a sample and to a kit.
摘要翻译：本发明提供了一种核酸分子，其编码由两个甲硫氨酸残基组成的多肽，作为通过肽键与成熟真核组蛋白连接的第一和第二N-末端氨基酸残基。本发明还涉及含有所述核酸分子的载体，用所述载体转化的宿主，由核酸分子编码的多肽和药物和诊断组合物。本发明还涉及本发明的核酸分子，载体，宿主和多肽在制备用于治疗疾病的组合物中的用途。此外，本发明涉及测试样品和试剂盒中核酸分子或多肽的存在的方法。

8. 发明申请

WO2006037383A1 PISCIRICKETTSIA SALMONIS ANTIGENS AND USE THEREOF 审中-公开
标题翻译： PISCIRICKETTSIA SALMONIS抗体及其用途
公开(公告)号：WO2006037383A1
公开(公告)日：2006-04-13
申请号：PCT/EP2005/003615
申请日：2005-04-05
申请人： THIRY, Michel , DHEUR, Ingrid
发明人： THIRY, Michel , DHEUR, Ingrid
IPC分类号： C07K14/29 , C12N15/31 , C07K16/12 , A61K39/02 , A61K39/295
CPC分类号： C07K14/29 , A61K39/0233 , A61K2039/523 , A61K2039/552 , A61K2039/55566
摘要： The present invention discloses novel proteins, e.g., antigens, from Piscirickettsia salmonis. The present invention further discloses nucleic acids that encode these proteins. The present invention also discloses the use of the proteins, e.g., antigens, and nucleic acids to prepare vaccines against salmonid rickettsial septicemia (SRS). The present invention further provides recombinant Yersinia ruckeri cells to be used to construct vaccines against SRS. The present invention also discloses vaccines that to can be used to protect fish from Piscirickettsia salmonis, as well as other pathogens. In addition, the present invention discloses methods of using the vaccines of the present invention to protect fish from SRS as well as from other pathogenic diseases.
摘要翻译：本发明公开了新的蛋白质，例如抗原

9. 发明申请

WO2005049638A2 AMNIOTIC-DERIVED PEPTIDE AND USES THEREOF 审中-公开
标题翻译：生物衍生肽及其用途
公开(公告)号：WO2005049638A2
公开(公告)日：2005-06-02
申请号：PCT/US2004037800
申请日：2004-11-12
申请人： LAJOR BIOTECH INC , BAKHUTASHVILI VLADIMIR , HALLER JORDAN D , BAKHUTASHVILI IVANE , BAKHUTASHVILI ALEXANDER , NICOLETTI FERDINANDO , THIRY MICHEL , PONCIN ALAIN
发明人： BAKHUTASHVILI VLADIMIR , HALLER JORDAN D , BAKHUTASHVILI IVANE , BAKHUTASHVILI ALEXANDER , NICOLETTI FERDINANDO , THIRY MICHEL , PONCIN ALAIN
IPC分类号： C07K20060101 , C07K7/06 , C07K
CPC分类号： C07K14/555 , A61K38/00 , C07K7/06
摘要： The present invention relates to the method(s) of synthesis of and the therapeutic and cosmetic applications of biologically active peptides for improving the appearance of skin, for hastening wound healing and for treating and/or preventing the progression of various conditions, injuries and diseases, including but not limited to viral hepatitis B and C, herpes zoster ganglioneuritis, diabetic peripheral polyneuropathy, nephrotic syndrome, juvenile rheumatoid arthritis, rheumatoid arthritis, psoriatic arthritis, bronchial asthma, respiratory infection, breast cancer, epilepsy, psoriasis, atherosclerosis and other forms of vascular obstructions, myocardial infarction, HIV and SARS infection, brain cell malfunction due to ischemia and trauma, pathologic consequences of ischemia-reperfusion, rejection reaction following organ transplantation, chemical and drug intoxication including but not limited to anesthetic, alcohol and morphine, cancer, type 1 diabetes mellitus, multiple sclerosis, septic shock (Gram negative sepsis), Parkinson's disease, type 2 diabetes mellitus, Alzheimer's disease, amyotrophic lateral sclerosis, hyperthyroidism, Guillain-Barre syndrome, systematic lupus erythematosus, parasitic infections, especially leishmaniasis, and other collagen diseases, and diseases in which apoptosis occurs.
摘要翻译：本发明涉及用于改善皮肤外观，促进伤口愈合和治疗和/或预防各种病症，损伤和疾病进展的生物活性肽的合成方法和治疗和美容应用的方法包括但不限于病毒性乙型和丙型肝炎，带状疱疹性神经节炎，糖尿病性周围多发性神经病，肾病综合征，幼年类风湿性关节炎，类风湿性关节炎，牛皮癣关节炎，支气管哮喘，呼吸道感染，乳腺癌，癫痫，牛皮癣，动脉粥样硬化等形式血管阻塞，心肌梗死，HIV和SARS感染，由缺血和创伤引起的脑细胞功能障碍，缺血再灌注的病理学后果，器官移植后的排斥反应，化学和药物中毒，包括但不限于麻醉，酒精和吗啡，癌症，1型糖尿病，多发性硬化，脓毒性休克（革兰阴性败血症），帕金森病，2型糖尿病，阿尔茨海默病，肌萎缩性侧索硬化，甲状腺功能亢进，吉兰巴利综合征，系统性红斑狼疮，寄生虫感染，尤其是利什曼病等胶原病，发生。

10. 发明申请

WO9113987A3 CDNA CODING FOR THE GENE N OF THE VIRAL HAEMORRHAGIC SEPTICAEMIA VIRUS AND UTILIZATIONS THEREOF 审中-公开
标题翻译：病毒性肝炎病毒病毒基因组的CDNA编码及其利用
公开(公告)号：WO9113987A3
公开(公告)日：2004-04-29
申请号：PCT/FR9100198
申请日：1991-03-12
申请人： AGRONOMIQUE INST NAT RECH , BERNARD JACQUELINE , LECOQ-XHONNEUX FLORENCE , THIRY MICHEL , DE KINKELIN PIERRE
发明人： BERNARD JACQUELINE , LECOQ-XHONNEUX FLORENCE , THIRY MICHEL , DE KINKELIN PIERRE
IPC分类号： A61K39/00 , C07K14/145 , C12N15/47 , A61K39/205 , C07K13/00 , C12Q1/68 , G01N33/569
CPC分类号： C07K14/005 , A61K39/00 , C12N2760/20022
摘要： Nucleotidic sequences from the viral haemorrhagic septicaemia (VHS) virus, transcription products of the genomic RNA of said virus, use of said sequences as probes or triggers and for the expression of the nucleoprotein N and/or its fragments, plasmides useful for said expression and use of the expressed nucleoprotein and/or its fragments as an immunogenic agent, especially for the prevention of viral haemorrhagic septicaemia. Application of said sequences to the detection of viral haemorrhagic septicaemia and the obtaining of genetically modified animals. The nucleotidic sequence from the genomic RNA of the VHS virus comprises the coding gene for the nucleoprotein N, corresponds to the messenger RNA and comprises about 1346 nucleotides.
摘要翻译：来自病毒性出血性败血病（VHS）病毒的核苷酸序列，所述病毒的基因组RNA的转录产物，使用所述序列作为探针或触发因子，并用于表达核蛋白N和/或其片段，可用于所述表达的质粒和使用表达的核蛋白和/或其片段作为免疫原性试剂，特别是用于预防病毒性出血性败血症。所述序列用于检测病毒性出血性败血症和获得转基因动物。来自VHS病毒的基因组RNA的核苷酸序列包含核蛋白N的编码基因，对应于信使RNA并且包含约1346个核苷酸。

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