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1. 发明申请

WO2005049638A2 AMNIOTIC-DERIVED PEPTIDE AND USES THEREOF 审中-公开
标题翻译：生物衍生肽及其用途
公开(公告)号：WO2005049638A2
公开(公告)日：2005-06-02
申请号：PCT/US2004037800
申请日：2004-11-12
申请人： LAJOR BIOTECH INC , BAKHUTASHVILI VLADIMIR , HALLER JORDAN D , BAKHUTASHVILI IVANE , BAKHUTASHVILI ALEXANDER , NICOLETTI FERDINANDO , THIRY MICHEL , PONCIN ALAIN
发明人： BAKHUTASHVILI VLADIMIR , HALLER JORDAN D , BAKHUTASHVILI IVANE , BAKHUTASHVILI ALEXANDER , NICOLETTI FERDINANDO , THIRY MICHEL , PONCIN ALAIN
IPC分类号： C07K20060101 , C07K7/06 , C07K
CPC分类号： C07K14/555 , A61K38/00 , C07K7/06
摘要： The present invention relates to the method(s) of synthesis of and the therapeutic and cosmetic applications of biologically active peptides for improving the appearance of skin, for hastening wound healing and for treating and/or preventing the progression of various conditions, injuries and diseases, including but not limited to viral hepatitis B and C, herpes zoster ganglioneuritis, diabetic peripheral polyneuropathy, nephrotic syndrome, juvenile rheumatoid arthritis, rheumatoid arthritis, psoriatic arthritis, bronchial asthma, respiratory infection, breast cancer, epilepsy, psoriasis, atherosclerosis and other forms of vascular obstructions, myocardial infarction, HIV and SARS infection, brain cell malfunction due to ischemia and trauma, pathologic consequences of ischemia-reperfusion, rejection reaction following organ transplantation, chemical and drug intoxication including but not limited to anesthetic, alcohol and morphine, cancer, type 1 diabetes mellitus, multiple sclerosis, septic shock (Gram negative sepsis), Parkinson's disease, type 2 diabetes mellitus, Alzheimer's disease, amyotrophic lateral sclerosis, hyperthyroidism, Guillain-Barre syndrome, systematic lupus erythematosus, parasitic infections, especially leishmaniasis, and other collagen diseases, and diseases in which apoptosis occurs.
摘要翻译：本发明涉及用于改善皮肤外观，促进伤口愈合和治疗和/或预防各种病症，损伤和疾病进展的生物活性肽的合成方法和治疗和美容应用的方法包括但不限于病毒性乙型和丙型肝炎，带状疱疹性神经节炎，糖尿病性周围多发性神经病，肾病综合征，幼年类风湿性关节炎，类风湿性关节炎，牛皮癣关节炎，支气管哮喘，呼吸道感染，乳腺癌，癫痫，牛皮癣，动脉粥样硬化等形式血管阻塞，心肌梗死，HIV和SARS感染，由缺血和创伤引起的脑细胞功能障碍，缺血再灌注的病理学后果，器官移植后的排斥反应，化学和药物中毒，包括但不限于麻醉，酒精和吗啡，癌症，1型糖尿病，多发性硬化，脓毒性休克（革兰阴性败血症），帕金森病，2型糖尿病，阿尔茨海默病，肌萎缩性侧索硬化，甲状腺功能亢进，吉兰巴利综合征，系统性红斑狼疮，寄生虫感染，尤其是利什曼病等胶原病，发生。

2. 发明申请

WO0220613A2 PROCESS FOR THE PURIFICATION OF EPI-HNE PROTEINS 审中-公开
标题翻译：用于纯化EPI-HNE蛋白的方法
公开(公告)号：WO0220613A2
公开(公告)日：2002-03-14
申请号：PCT/EP0110727
申请日：2001-08-30
申请人： DEBIOPHARM SA , PONCIN ALAIN , SAUDUBRAY FRANCOIS , BOKMAN ANNE
发明人： PONCIN ALAIN , SAUDUBRAY FRANCOIS , BOKMAN ANNE
IPC分类号： C07K14/81
CPC分类号： C07K14/8114
摘要： The present invention concerns a process for the purification of EPI-HNE proteins, from the culture medium of a host strain for the expression of said proteins, comprising the steps of: (a) passing a derived part of the culture medium over an expanded bed of cationic exchange adsorbent or a mechanically and chemically inert micromembrane, in order to recover an eluate, (b) optionally conducting chromatographic separation of proteins, according to their hydrophobicity, on the resulting eluate, (c) passing the resulting eluate over a cationic exchange column, (d) optionally filtering the resulting medium such as to obtain a sterile filtrate, and optionally further comprising the step of (e) causing precipitation of EPI-HNE in a crystallised form and recovering the protein crystals.
摘要翻译：本发明涉及从用于表达所述蛋白质的宿主菌株的培养基中纯化EPI-HNE蛋白的方法，包括以下步骤：（a）将衍生的部分培养基通过扩展床的阳离子交换吸附剂或机械和化学惰性微膜，以回收洗脱液，（b）根据其疏水性，任意进行蛋白质色谱分离所得洗脱液，（c）将所得洗脱液通过阳离子交换柱，（d）任选地过滤得到的培养基，以获得无菌滤液，任选地还包括（e）使结晶形式的EPI-HNE沉淀并回收蛋白质晶体的步骤。

3. 发明申请

WO0236158A8 SUSPENSION OF AN EPI-HNE PROTEIN, PROCESS OF PREPARATION THEREOF, DRY POWDER AEROSOL DERIVED THEREFROM, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID SUSPENSION OR AEROSOL, AND THEIR USES 审中-公开
标题翻译： EPI-HNE蛋白质的悬浮液，其制备方法，其中衍生的干粉剂，含有所述悬浮剂或空气动力学的药物组合物及其用途
公开(公告)号：WO0236158A8
公开(公告)日：2004-03-04
申请号：PCT/EP0112983
申请日：2001-10-26
申请人： DEBIOPHARM SA , PONCIN ALAIN , SAUDUBRAY FRANCOIS , BOKMAN ANNE
发明人： PONCIN ALAIN , SAUDUBRAY FRANCOIS , BOKMAN ANNE
IPC分类号： A61K9/107 , A61K9/00 , A61K9/12 , A61K9/14 , A61K38/00 , A61K38/16 , A61K38/17 , A61K38/43 , A61K38/55 , A61K38/57 , A61P11/00
CPC分类号： A61K9/0078 , A61K38/57
摘要： The present invention concerns a suspension of crystallized particles of an EPI-hNE protein, methods for preparing said suspension, a dry powder aerosol derived from said suspension, an inhalable pharmaceutical formulation comprising said suspension or said dry powder aerosol, and the use of said inhalable pharmaceutical formulation in the treatment of various pathological conditions.
摘要翻译：本发明涉及EPI-hNE蛋白质的结晶颗粒的悬浮液，制备所述悬浮液的方法，源自所述悬浮液的干燥粉末气溶胶，包含所述悬浮液或所述干粉气溶胶的可吸入药物制剂，以及使用所述可吸入药物制剂治疗各种病理状况。

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