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1. 发明申请

WO2005035558A2 PISCIRICKETTSIA SALMONIS ANTIGENS AND USE THEREOF 审中-公开
标题翻译： PISCIRICKETTSIA SALMONIS抗原及其用途
公开(公告)号：WO2005035558A2
公开(公告)日：2005-04-21
申请号：PCT/IB2004/003339
申请日：2004-10-01
申请人： THIRY, Michel , DHEUR, Ingrid
发明人： THIRY, Michel , DHEUR, Ingrid
IPC分类号： C07K14/29
CPC分类号： C07K14/195 , A61K39/00
摘要： The present invention discloses novel proteins, e.g., antigens, from Piscirickettsia salmonis. The present invention further discloses nucleic acids that encode these proteins. The present invention also discloses the use of the proteins, e.g., antigens, and nucleic acids to prepare vaccines against salmonid rickettsial septicemia (SRS). The present invention further provides recombinant Yersinia ruckeri cells to be used to construct vaccines against SRS. The present invention also discloses vaccines that can be used to protect fish from Piscirickettsia salmonis, as well as other pathogens. In addition, the present invention discloses methods of using the vaccines of the present invention to protect fish from SRS as well as from other pathogenic diseases.
摘要翻译：本发明公开了来自鲑鱼沙门氏菌（Pisciricketetia salmonis）的新蛋白质，例如抗原。本发明进一步公开了编码这些蛋白质的核酸。本发明还公开了蛋白质例如抗原和核酸用于制备针对鲑鱼立克次体败血症（SRS）的疫苗的用途。本发明进一步提供了用于构建针对SRS的疫苗的重组耶尔森氏菌耶尔森菌（Yersinia ruckeri）细胞。本发明还公开了可用于保护来自鱼类沙门氏菌（Pisciricketetia salmonis）的鱼以及其他病原体的疫苗。另外，本发明公开了使用本发明的疫苗来保护鱼类免受SRS以及其他致病性疾病的方法。

2. 发明申请

WO2006037383A1 PISCIRICKETTSIA SALMONIS ANTIGENS AND USE THEREOF 审中-公开
标题翻译： PISCIRICKETTSIA SALMONIS抗体及其用途
公开(公告)号：WO2006037383A1
公开(公告)日：2006-04-13
申请号：PCT/EP2005/003615
申请日：2005-04-05
申请人： THIRY, Michel , DHEUR, Ingrid
发明人： THIRY, Michel , DHEUR, Ingrid
IPC分类号： C07K14/29 , C12N15/31 , C07K16/12 , A61K39/02 , A61K39/295
CPC分类号： C07K14/29 , A61K39/0233 , A61K2039/523 , A61K2039/552 , A61K2039/55566
摘要： The present invention discloses novel proteins, e.g., antigens, from Piscirickettsia salmonis. The present invention further discloses nucleic acids that encode these proteins. The present invention also discloses the use of the proteins, e.g., antigens, and nucleic acids to prepare vaccines against salmonid rickettsial septicemia (SRS). The present invention further provides recombinant Yersinia ruckeri cells to be used to construct vaccines against SRS. The present invention also discloses vaccines that to can be used to protect fish from Piscirickettsia salmonis, as well as other pathogens. In addition, the present invention discloses methods of using the vaccines of the present invention to protect fish from SRS as well as from other pathogenic diseases.
摘要翻译：本发明公开了新的蛋白质，例如抗原

3. 发明申请

WO2005049638A3 AMNIOTIC-DERIVED PEPTIDE AND USES THEREOF 审中-公开
公开(公告)号：WO2005049638A3
公开(公告)日：2005-06-02
申请号：PCT/US2004/037800
申请日：2004-11-12
申请人： LAJOR BIOTECH, INC. , BAKHUTASHVILI, Vladimir , HALLER, Jordan, D. , BAKHUTASHVILI, Ivane , BAKHUTASHVILI, Alexander , NICOLETTI, Ferdinando , THIRY, Michel , PONCIN, Alain
发明人： BAKHUTASHVILI, Vladimir , HALLER, Jordan, D. , BAKHUTASHVILI, Ivane , BAKHUTASHVILI, Alexander , NICOLETTI, Ferdinando , THIRY, Michel , PONCIN, Alain
IPC分类号： A61K38/08 , A61K38/00 , A61K38/02 , A61K38/19 , A61K35/54 , C07K7/04 , C07K2/00
摘要： The present invention relates to the method(s) of synthesis of and the therapeutic and cosmetic applications of biologically active peptides for improving the appearance of skin, for hastening wound healing and for treating and/or preventing the progression of various conditions, injuries and diseases, including but not limited to viral hepatitis B and C, herpes zoster ganglioneuritis, diabetic peripheral polyneuropathy, nephrotic syndrome, juvenile rheumatoid arthritis, rheumatoid arthritis, psoriatic arthritis, bronchial asthma, respiratory infection, breast cancer, epilepsy, psoriasis, atherosclerosis and other forms of vascular obstructions, myocardial infarction, HIV and SARS infection, brain cell malfunction due to ischemia and trauma, pathologic consequences of ischemia-reperfusion, rejection reaction following organ transplantation, chemical and drug intoxication including but not limited to anesthetic, alcohol and morphine, cancer, type 1 diabetes mellitus, multiple sclerosis, septic shock (Gram negative sepsis), Parkinson's disease, type 2 diabetes mellitus, Alzheimer's disease, amyotrophic lateral sclerosis, hyperthyroidism, Guillain-Barre syndrome, systematic lupus erythematosus, parasitic infections, especially leishmaniasis, and other collagen diseases, and diseases in which apoptosis occurs.

4. 发明申请

WO2004049095A2 BETAINE COMPOSITIONS 审中-公开
标题翻译： BETAINE组合物
公开(公告)号：WO2004049095A2
公开(公告)日：2004-06-10
申请号：PCT/IB2002/004923
申请日：2002-11-25
申请人： MESSADEK, Jallal , ENNAMANY, Rachid , THIRY, Michel
发明人： MESSADEK, Jallal , ENNAMANY, Rachid , THIRY, Michel
IPC分类号： G06F
CPC分类号： A61K9/209 , A61K31/205 , A61K31/60 , A61K2300/00
摘要： This invention relates to the pharmaceutical combination comprising at least: a first compound selected among the group consisting of acetylsalicylic acid, salicylic acid, pharmaceutical derivatives thereof, and a second compound selected from the group consisting of lipidic betaines, betaines lipids, betaines of Formula (CH 3 ) 3 N + (CH 2 ) n COO - with n an integer from 1 to 5, pharmaceutically acceptable salts thereof, esters thereof, precursors thereof, and mixtures thereof, with the provision that said second compound is different from the first compound and in an amount by weight at least three times the amount of first compound.
摘要翻译：本发明涉及至少包含选自乙酰水杨酸，水杨酸及其药物衍生物的第一化合物和选自脂质甜菜碱，甜菜碱脂质，式（β）的甜菜碱的第二化合物的药物组合物，其中n为1至5的整数，其药学上可接受的盐，其酯，其前体及其混合物，其中所述第二化合物与第一化合物不同，重量比为第一化合物的量的至少三倍。

5. 发明申请

WO2008122434A1 BIS-MET HISTONES 审中-公开
公开(公告)号：WO2008122434A1
公开(公告)日：2008-10-16
申请号：PCT/EP2008/002746
申请日：2008-04-07
申请人： SYMBIOTEC GESELLSCHAFT ZUR FORSCHUNG UND ENTWICKLUNG AUF DEM GEBIET DER BIOTECHNOLOGIE MBH , GROSS, Peter , JÖRNVALL, Hans , THIRY, Michel , FORMICKA-ZEPPEZAUER, Crazyna , ZEPPEZAUER, Michael
发明人： GROSS, Peter , JÖRNVALL, Hans , THIRY, Michel , FORMICKA-ZEPPEZAUER, Crazyna , ZEPPEZAUER, Michael
IPC分类号： C07K14/47 , A61K38/17 , C12P21/02 , A61K38/00
CPC分类号： C07K14/47 , A61K38/00 , Y02A50/409 , Y10T436/143333
摘要： The present invention provides a nucleic acid molecule which encodes a polypeptide consisting of two methionine residues as the first and second N-terminal amino acid residues linked via a peptide bond to a mature eukaryotic histone. The present invention furthermore relates to a vector containing said nucleic acid molecule, a host transformed with said vector, polypeptides encoded by the nucleic acid molecule and pharmaceutical and diagnostic compositions. The present invention also relates to the use of the nucleic acid molecule, vectors, hosts and the polypeptide of the invention for the preparation of a composition for the treatment of diseases. Furthermore, the present invention relates to a method of testing for the presence of the nucleic acid molecule or the polypeptide in a sample and to a kit.
摘要翻译：本发明提供了一种核酸分子，其编码由两个甲硫氨酸残基组成的多肽，作为通过肽键与成熟真核组蛋白连接的第一和第二N-末端氨基酸残基。本发明还涉及含有所述核酸分子的载体，用所述载体转化的宿主，由核酸分子编码的多肽和药物和诊断组合物。本发明还涉及本发明的核酸分子，载体，宿主和多肽在制备用于治疗疾病的组合物中的用途。此外，本发明涉及测试样品和试剂盒中核酸分子或多肽的存在的方法。

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