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1. 发明申请

WO2008122434A1 BIS-MET HISTONES 审中-公开
公开(公告)号：WO2008122434A1
公开(公告)日：2008-10-16
申请号：PCT/EP2008/002746
申请日：2008-04-07
申请人： SYMBIOTEC GESELLSCHAFT ZUR FORSCHUNG UND ENTWICKLUNG AUF DEM GEBIET DER BIOTECHNOLOGIE MBH , GROSS, Peter , JÖRNVALL, Hans , THIRY, Michel , FORMICKA-ZEPPEZAUER, Crazyna , ZEPPEZAUER, Michael
发明人： GROSS, Peter , JÖRNVALL, Hans , THIRY, Michel , FORMICKA-ZEPPEZAUER, Crazyna , ZEPPEZAUER, Michael
IPC分类号： C07K14/47 , A61K38/17 , C12P21/02 , A61K38/00
CPC分类号： C07K14/47 , A61K38/00 , Y02A50/409 , Y10T436/143333
摘要： The present invention provides a nucleic acid molecule which encodes a polypeptide consisting of two methionine residues as the first and second N-terminal amino acid residues linked via a peptide bond to a mature eukaryotic histone. The present invention furthermore relates to a vector containing said nucleic acid molecule, a host transformed with said vector, polypeptides encoded by the nucleic acid molecule and pharmaceutical and diagnostic compositions. The present invention also relates to the use of the nucleic acid molecule, vectors, hosts and the polypeptide of the invention for the preparation of a composition for the treatment of diseases. Furthermore, the present invention relates to a method of testing for the presence of the nucleic acid molecule or the polypeptide in a sample and to a kit.
摘要翻译：本发明提供了一种核酸分子，其编码由两个甲硫氨酸残基组成的多肽，作为通过肽键与成熟真核组蛋白连接的第一和第二N-末端氨基酸残基。本发明还涉及含有所述核酸分子的载体，用所述载体转化的宿主，由核酸分子编码的多肽和药物和诊断组合物。本发明还涉及本发明的核酸分子，载体，宿主和多肽在制备用于治疗疾病的组合物中的用途。此外，本发明涉及测试样品和试剂盒中核酸分子或多肽的存在的方法。

2. 发明申请

WO2007017212A3 VERWENDUNG EINES BIOLOGISCHEN WIRKSTOFFES BEI ABNORMALEN ZELLULÄREN UND VIRALEN MEMBRANPHYSIOLOGIEN 审中-公开
公开(公告)号：WO2007017212A3
公开(公告)日：2007-02-15
申请号：PCT/EP2006/007764
申请日：2006-08-04
申请人： SYMBIOTEC GESELLSCHAFT ZUR FORSCHUNG UND ENTWICKLUNG AUF DEM GEBIET DER BIOTECHNOLOGIE MBH , ZEPPEZAUER, Michael , GROSS, Peter
发明人： ZEPPEZAUER, Michael , GROSS, Peter
IPC分类号： A61K48/00 , A61P35/00
摘要： Die Erfindung betrifft einen biologischen Wirkstoff bei abnormalen zellulären und viralen Membranphysiologien in humanen und Säugetierorganismen, wobei der Wirkstoff diagnostische und/oder therapeutische Eigenschaften aufweist und wenigstens einen Bestandteil enthält oder aus ihm besteht, ausgewählt aus der Gruppe von Stoffen bestehend aus: Histonen kovalent modifizierten Histonen histonähnlichen Polypeptiden biologisch aktiven Sequenzen der Histone und histonähnlichen Polypeptiden als Mittel zur Unterbindung der Versorgung von soliden Tumoren über ihre Blutgefäße, zur Abtötung von Zellen, die von Viren befallen sind. Zur Abtötung von Tumorzellen mit gestörter Lipidasymmetrie.

3. 发明申请

WO0110901A9 ANTIMICROBIAL HISTONE H1 COMPOSITIONS, KITS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗生素HISTONE H1组合物，用途及其使用方法
公开(公告)号：WO0110901A9
公开(公告)日：2002-09-12
申请号：PCT/US0021747
申请日：2000-08-09
申请人： CLASS REINER , ZEPPEZAUER MICHAEL , SYMBIOTEC GMBH , PHILADELPHIA HEALTH & EDUCATIO
发明人： CLASS REINER , ZEPPEZAUER MICHAEL
IPC分类号： A61F13/15 , A01N63/00 , A23K1/17 , A61F13/02 , A61F13/20 , A61F13/472 , A61K8/00 , A61K8/41 , A61K8/42 , A61K8/49 , A61K8/64 , A61K8/73 , A61K8/96 , A61K31/165 , A61K31/43 , A61K31/496 , A61K31/65 , A61K31/7036 , A61K31/7048 , A61K31/727 , A61K38/00 , A61K38/16 , A61K38/17 , A61K38/46 , A61K39/02 , A61K39/39 , A61P31/00 , A61P31/04 , A61P39/02 , A61Q1/00 , A61Q1/02 , A61Q1/04 , A61Q11/00 , A61Q15/00 , C07K14/47
CPC分类号： A61K39/02 , A23K20/195 , A61K38/1709 , A61K39/39 , A61K2039/55516 , Y10S930/19 , A61K2300/00
摘要： The invention includes antibiotic pharmaceutical compositions comprising eukaryotic histone H1 protein and methods of using eukaryotic histone H1 protein to kill or to inhibit the growth of microorganisms, including, but not limited to, human pathogenic bacteria. The invention further includes a eukaryotic histone H1-containing animal feed and methods of improving growth of an animal by supplying the feed to the animal. The invention still further includes a kit comprising a eukaryotic histone H1-containing antibiotic pharmaceutical composition and an instructional material which describes the use of the composition. In addition, the invention includes a vaccine comprising a eukaryotic histone H1 protein and a method of vaccinating an animal using the vaccine.
摘要翻译：本发明包括包含真核组蛋白H1蛋白的抗生素药物组合物和使用真核组蛋白H1蛋白来杀死或抑制微生物生长的方法，包括但不限于人类致病菌。本发明还包括含有真核生物组蛋白H1的动物饲料和通过向动物供应饲料来改善动物生长的方法。本发明还包括一种包含含有真核生物组蛋白H1的抗生素药物组合物的试剂盒和描述该组合物的用途的说明材料。此外，本发明包括包含真核组蛋白H1蛋白的疫苗和使用疫苗接种动物的方法。

4. 发明申请

WO1985003003A1 BIOLOGICALLY ACTIVE SUBSTANCE WITH HORMONAL PROPERTIES, PRODUCTION PROCESS THEREOF AND UTILIZATION OF HISTONES FOR MEDICAL PURPOSES 审中-公开
标题翻译：生物活性物质，具有异常性质，其生产过程及其用于医疗用途的组合物
公开(公告)号：WO1985003003A1
公开(公告)日：1985-07-18
申请号：PCT/DE1985000004
申请日：1985-01-10
申请人： RUSCH, Volker , REICHHART, Robert , ZEPPEZAUER, Michael , JÖRNVALL, Hans
IPC分类号： A61K37/24
CPC分类号： A61K39/39 , A61K35/26 , A61K38/00 , C07K14/47 , C07K14/575 , G01N33/6875 , Y10S514/885
摘要： Biologically active substance with standardizable hormonal activity, containing in a physiological medium at least one histone, particularly at least one histone H2 or an active area of said histone with immune system immunostimulating and/or endocrinological properties. Utilization of histones and/or segments of histones for producing such a preparation for medical purposes. Said histones may be extracted from biological starting materials, for example calf thymus. Since H2A and H2B histones of oxen and humans are identical, ox histones may also be used for such a preparation for human medical purposes. The preparation according to the present invention may also contain only the variable evolution segments or part of at least one H2 histone. The invention is based on the fact that the biologically active area of an immunostimulating or endocrinologically active histone is located in the variable evolution histone segment. The preparation according to the present invention may also be used in immunotherapy.
摘要翻译：在生物培养基中含有至少一种组蛋白，特别是至少一种组蛋白H2或具有免疫系统免疫刺激和/或内分泌特性的所述组蛋白的活性区域的生物活性物质。利用组蛋白和/或组蛋白片段制备用于医疗目的的制剂。所述组蛋白可以从生物起始材料例如小牛胸腺提取。由于牛和人的H2A和H2B组蛋白是相同的，因此，ox组蛋白也可用于人类医学目的的这种制备。根据本发明的制剂还可以仅含有可变进化段或至少一种H2组蛋白的一部分。本发明基于以下事实：免疫刺激或内分泌活性组蛋白的生物活性区域位于可变进化组蛋白片段中。根据本发明的制剂也可用于免疫治疗。

5. 发明申请

WO2006119912A3 USE OF HISTONES FOR THERAPEUTIC PURPOSES 审中-公开
标题翻译：利用治疗目的组蛋白
公开(公告)号：WO2006119912A3
公开(公告)日：2007-04-12
申请号：PCT/EP2006004167
申请日：2006-05-04
申请人： SYMBIOTEC GMBH GES FUER FORSCH , ZEPPEZAUER MICHAEL , REINER CLASS
发明人： ZEPPEZAUER MICHAEL , REINER CLASS
IPC分类号： A61K38/17 , A61P7/00
CPC分类号： A61K38/1709
摘要： The invention relates to the use of at least one human recombinant histone, especially at least one histone H1 subtype, and/or a therapeutic histone fraction as a basis for the treatment of thrombocytopenia.
摘要翻译：本发明涉及一种使用至少一个人类重组组蛋白; 特别是至少一种组蛋白H1亚型，和/或治疗有效Histonabschnittes作为用于血小板减少症的治疗性治疗的基础。

6. 发明申请

WO2007017212A2 USE OF AN ACTIVE BIOLOGICAL SUBSTANCE IN ABNORMAL CELLULAR AND VIRAL MEMBRANE PHYSIOLOGIES 审中-公开
标题翻译：生物活性物质的异常细胞和病毒膜生理机能使用
公开(公告)号：WO2007017212A2
公开(公告)日：2007-02-15
申请号：PCT/EP2006007764
申请日：2006-08-04
申请人： SYMBIOTEC GMBH , ZEPPEZAUER MICHAEL , GROSS PETER
发明人： ZEPPEZAUER MICHAEL , GROSS PETER
IPC分类号： A61K48/00 , A61P35/00
CPC分类号： A61K38/1709 , A61K49/0056 , G01N33/5091 , G01N2800/52
摘要： An active biological substance is disclosed for use in abnormal cellular and viral membrane physiologies in human and mammal organisms. The active substance has diagnostic and/or therapeutic properties and contains or consists of at least one component selected from the group of substances including: histones, covalently modified histones, histone-like polypeptides, biologically active histone sequences and histone-like polypeptides as agents for stopping the supply to solid tumours over their blood vessels, for killing cells infected by virus and for killing tumour cells with disturbed lipid asymmetry.
摘要翻译：本发明涉及在人类和哺乳动物生物体异常细胞和病毒膜生理机能，其中活性成分的诊断和/或治疗性质的生物活性剂和含有至少一种组分或由它，从以下组成的组的物质选自：组蛋白共价修饰的组蛋白组蛋白生物活性的多肽的组蛋白和组蛋白样多肽经由他们的血管停止实体瘤的供给的装置的序列 - 杀由病毒感染的细胞。杀死肿瘤细胞与不安脂质不对称。

7. 发明申请

WO2003044054A3 PEPTIDES FOR THE PRODUCTION OF PREPARATIONS FOR THE DIAGNOSIS AND THERAPY OF AUTOIMMUN DISEASES 审中-公开
公开(公告)号：WO2003044054A3
公开(公告)日：2003-05-30
申请号：PCT/EP2002/012955
申请日：2002-11-19
申请人： SYMBIOTEC GESELLSCHAFT ZUR ERFORSCHUNG UND ENTWICKLUNG AUF DEM GEBIETE DER BIOTECHNOLOGY MBH , ZEPPEZAUER, Michael , SCHÖNBERGER, Arno , CEBECAUER, Ladislav
发明人： ZEPPEZAUER, Michael , SCHÖNBERGER, Arno , CEBECAUER, Ladislav
IPC分类号： C07K14/47
摘要： Peptides are proposed with antigenic or immunogenic determinants, which result from autoantibodies in the body fluids of patients, who are suffering from autoimmun diseases, in particular diseases of the rheumatic group as systemic lupus erythematosus (SLE), rheumatoid arthritis or systemic sclerosis. In the case of the peptides it is preferably a question of the C terminus of bovine histone H1 with the sequence section 187-211 or corresponding human histon-H1-peptides of the sub-types H1.1, H1.2, H1.3, H1.4, H1.5 and H1.a and the N termini of histone H2B with the sequence section 1-35 and 36-76, which are capable of cross reactions with the autoantibodies (anti-histone-antibodies). The invention furthermore provides ways of forming monoclonal antibodies and antiidiotypical antibodies, which are directed against autoantibodies. The diagnosis of autoimmun peptides and diseases is possible in accordance with the invention with a high degree of certainty and the monoclonal antibodies directed against the autoantibodies are suitable for the production of medicaments for the therapy of said diseases.

8. 发明申请

WO2001010901A3 ANTIMICROBIAL HISTONE H1 COMPOSITIONS, KITS, AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2001010901A3
公开(公告)日：2001-02-15
申请号：PCT/US2000/021747
申请日：2000-08-09
申请人： SYMBIOTEC GMBH , PHILADELPHIA HEALTH AND EDUCATION CORPORATION , CLASS, Reiner , ZEPPEZAUER, Michael
发明人： CLASS, Reiner , ZEPPEZAUER, Michael
IPC分类号： A61K38/17
摘要： The invention includes antibiotic pharmaceutical compositions comprising eukaryotic histone H1 protein and methods of using eukaryotic histone H1 protein to kill or to inhibit the growth of microorganisms, including, but not limited to, human pathogenic bacteria. The invention further includes a eukaryotic histone H1-containing animal feed and methods of improving growth of an animal by supplying the feed to the animal. The invention still further includes a kit comprising a eukaryotic histone H1-containing antibiotic pharmaceutical composition and an instructional material which describes the use of the composition. In addition, the invention includes a vaccine comprising a eukaryotic histone H1 protein and a method of vaccinating an animal using the vaccine.

9. 发明申请

WO1995015332A1 TRANSMEMBRANOUS ACTIVE AGENT USED TO DISRUPT DNA BIOSYNTHESIS 审中-公开
标题翻译：膜连续有源干扰DNA生物合成
公开(公告)号：WO1995015332A1
公开(公告)日：1995-06-08
申请号：PCT/EP1994003969
申请日：1994-11-30
申请人： ZEPPEZAUER, Michael , ZALUD, Petra , WACHS, Wolfgang, Oliver , NYMAN, Per, Olaf
IPC分类号： C07H19/10
CPC分类号： C07H19/10
摘要： The invention pertains to an active agent that has essentially the same effect as dUTP in its interaction with the enzyme dUTPase.
摘要翻译：本发明涉及基本上在其与所述酶相互作用的dUTPase的效果相同的dUTP的活性物质。

10. 发明申请

WO2008122434A8 BIS-MET HISTONES 审中-公开
公开(公告)号：WO2008122434A8
公开(公告)日：2010-10-21
申请号：PCT/EP2008002746
申请日：2008-04-07
申请人： SYMBIOTEC GMBH , GROSS PETER , JOERNVALL HANS , THIRY MICHEL , FORMICKA-ZEPPEZAUER GRAZYNA , ZEPPEZAUER MICHAEL
发明人： GROSS PETER , JOERNVALL HANS , THIRY MICHEL , FORMICKA-ZEPPEZAUER GRAZYNA , ZEPPEZAUER MICHAEL
IPC分类号： C07K14/47 , A61K38/00 , A61K38/17 , C12P21/02
CPC分类号： C07K14/47 , A61K38/00 , Y10T436/143333
摘要： The present invention provides a nucleic acid molecule which encodes a polypeptide consisting of two methionine residues as the first and second N-terminal amino acid residues linked via a peptide bond to a mature eukaryotic histone. The present invention furthermore relates to a vector containing said nucleic acid molecule, a host transformed with said vector, polypeptides encoded by the nucleic acid molecule and pharmaceutical and diagnostic compositions. The present invention also relates to the use of the nucleic acid molecule, vectors, hosts and the polypeptide of the invention for the preparation of a composition for the treatment of diseases. Furthermore, the present invention relates to a method of testing for the presence of the nucleic acid molecule or the polypeptide in a sample and to a kit.
摘要翻译：本发明提供了一种核酸分子，其编码由两个甲硫氨酸残基组成的多肽，作为通过肽键与成熟真核组蛋白连接的第一和第二N-末端氨基酸残基。本发明还涉及含有所述核酸分子的载体，用所述载体转化的宿主，由核酸分子编码的多肽和药物和诊断组合物。本发明还涉及本发明的核酸分子，载体，宿主和多肽在制备用于治疗疾病的组合物中的用途。此外，本发明涉及测试样品和试剂盒中核酸分子或多肽的存在的方法。

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