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1. 发明申请

WO2008122434A8 BIS-MET HISTONES 审中-公开
公开(公告)号：WO2008122434A8
公开(公告)日：2010-10-21
申请号：PCT/EP2008002746
申请日：2008-04-07
申请人： SYMBIOTEC GMBH , GROSS PETER , JOERNVALL HANS , THIRY MICHEL , FORMICKA-ZEPPEZAUER GRAZYNA , ZEPPEZAUER MICHAEL
发明人： GROSS PETER , JOERNVALL HANS , THIRY MICHEL , FORMICKA-ZEPPEZAUER GRAZYNA , ZEPPEZAUER MICHAEL
IPC分类号： C07K14/47 , A61K38/00 , A61K38/17 , C12P21/02
CPC分类号： C07K14/47 , A61K38/00 , Y10T436/143333
摘要： The present invention provides a nucleic acid molecule which encodes a polypeptide consisting of two methionine residues as the first and second N-terminal amino acid residues linked via a peptide bond to a mature eukaryotic histone. The present invention furthermore relates to a vector containing said nucleic acid molecule, a host transformed with said vector, polypeptides encoded by the nucleic acid molecule and pharmaceutical and diagnostic compositions. The present invention also relates to the use of the nucleic acid molecule, vectors, hosts and the polypeptide of the invention for the preparation of a composition for the treatment of diseases. Furthermore, the present invention relates to a method of testing for the presence of the nucleic acid molecule or the polypeptide in a sample and to a kit.
摘要翻译：本发明提供了一种核酸分子，其编码由两个甲硫氨酸残基组成的多肽，作为通过肽键与成熟真核组蛋白连接的第一和第二N-末端氨基酸残基。本发明还涉及含有所述核酸分子的载体，用所述载体转化的宿主，由核酸分子编码的多肽和药物和诊断组合物。本发明还涉及本发明的核酸分子，载体，宿主和多肽在制备用于治疗疾病的组合物中的用途。此外，本发明涉及测试样品和试剂盒中核酸分子或多肽的存在的方法。

2. 发明申请

WO2007017212A2 USE OF AN ACTIVE BIOLOGICAL SUBSTANCE IN ABNORMAL CELLULAR AND VIRAL MEMBRANE PHYSIOLOGIES 审中-公开
标题翻译：生物活性物质的异常细胞和病毒膜生理机能使用
公开(公告)号：WO2007017212A2
公开(公告)日：2007-02-15
申请号：PCT/EP2006007764
申请日：2006-08-04
申请人： SYMBIOTEC GMBH , ZEPPEZAUER MICHAEL , GROSS PETER
发明人： ZEPPEZAUER MICHAEL , GROSS PETER
IPC分类号： A61K48/00 , A61P35/00
CPC分类号： A61K38/1709 , A61K49/0056 , G01N33/5091 , G01N2800/52
摘要： An active biological substance is disclosed for use in abnormal cellular and viral membrane physiologies in human and mammal organisms. The active substance has diagnostic and/or therapeutic properties and contains or consists of at least one component selected from the group of substances including: histones, covalently modified histones, histone-like polypeptides, biologically active histone sequences and histone-like polypeptides as agents for stopping the supply to solid tumours over their blood vessels, for killing cells infected by virus and for killing tumour cells with disturbed lipid asymmetry.
摘要翻译：本发明涉及在人类和哺乳动物生物体异常细胞和病毒膜生理机能，其中活性成分的诊断和/或治疗性质的生物活性剂和含有至少一种组分或由它，从以下组成的组的物质选自：组蛋白共价修饰的组蛋白组蛋白生物活性的多肽的组蛋白和组蛋白样多肽经由他们的血管停止实体瘤的供给的装置的序列 - 杀由病毒感染的细胞。杀死肿瘤细胞与不安脂质不对称。

3. 发明申请

WO0144302A3 NANOSCALED FUNCTIONAL LAYER 审中-公开
标题翻译：纳米级故事片
公开(公告)号：WO0144302A3
公开(公告)日：2002-06-06
申请号：PCT/EP0012605
申请日：2000-12-12
申请人： ZEPPEZAUER MICHAEL , KRUEGER JAN KRISTIAN , MUECKLICH FRANK , POSSART WULFF , GROSS PETER
发明人： ZEPPEZAUER MICHAEL , KRUEGER JAN KRISTIAN , MUECKLICH FRANK , POSSART WULFF , GROSS PETER
IPC分类号： C07K17/14 , C07K14/00 , C07K14/78 , G03F7/16
CPC分类号： B82Y30/00 , B82Y5/00 , B82Y15/00 , C07K17/14
摘要： The invention relates to a nano- to mesoscaled, two-dimensional anisotropic SAM layer (self assembling monolayer) consisting of identical molecular functional components which are provided with identical reproducible structural changes by virtue of specific outer influences and are adhesively bonded on surfaces of selected substrates.
摘要翻译：纳米到mesoskalierte，二维各向异性SAM层（自组装单层），由相同的分子功能块，每个具有通过特定的外部影响，并且在同一再现的结构的变化粘结到所选基底的表面上。

4. 发明申请

WO2010139447A3 DATA TRANSMISSION DEVICE FOR REMOTE MONITORING AND REMOTE CONTROLLING A DISTRIBUTED PROCESS SYSTEM 审中-公开
标题翻译：数据传输设备，实现远程监控和控制分布式过程系统
公开(公告)号：WO2010139447A3
公开(公告)日：2011-02-10
申请号：PCT/EP2010003304
申请日：2010-06-01
申请人： ABB TECHNOLOGY AG , GROSS PETER
发明人： GROSS PETER
IPC分类号： H04L12/66 , H04L29/06
CPC分类号： H04L12/4625 , H04L12/66 , H04L69/08 , H04L2012/4026
摘要： The invention relates to a data transmission device for remotely monitoring and controlling a distributed process system, exchanging data with a superordinate communication unit via an interface and a communication connection in accordance with an IEC 61850 standard, and connected to a subordinate process via a further interface and a station bus. The following functional units (11, 12, 13, 14) implemented as interfaces are integrated in the data transmission device for connecting the process to at least one superordinate communication unit in accordance with the IEC 61850 standard: - at least one IEC 61850 server (11) for connecting to superordinate communication units, - at least one IEC 61850 client (14) for connecting a subordinate station level via a station bus, - at least one unit (12) for connecting the superordinate communication unit and/or for connecting intelligent electronic device, and - at least one further unit (13) for directly coupling the process for connecting control and monitoring signals to an IEC 61850 station bus.
摘要翻译：本发明涉及一种用于远程监视和分布式处理系统，该系统通过一个接口，并根据标准IEC与更高级别的通信单元的通信链路交换61850点的数据和通过另一接口连接的控制，以及与下属处理的站级总线的数据传输装置。在数据通信装置下面设计为接口功能单元（11，12，13，14）根据标准IEC为进程的连接的至少61850集成了一个较高级别的通信单元：-wenigstens用于连接到更高级别的通信单元的IEC61850服务器（11）-wenigstens 一个IEC61850客户机（14），用于经由站总线连接的下位站级，-wenigstens一个单元（12），用于连接较高级别的通信单元和/或用于智能电子设备的连接，和-wenigstens另一单元（13），用于直接工艺耦合命令和控制信号的一个IEC61850站级总线的连接。

5. 发明申请

WO2008073319A3 DC POWER SYSTEM 审中-公开
标题翻译：直流电源系统
公开(公告)号：WO2008073319A3
公开(公告)日：2008-08-07
申请号：PCT/US2007025119
申请日：2007-12-07
申请人： VALIDUS DC SYSTEMS LLC , KRAUS RUDY , GROSS PETER
发明人： KRAUS RUDY , GROSS PETER
IPC分类号： H02J9/00
CPC分类号： H02J1/10 , H02J9/061 , Y10T307/391
摘要： There is provided a system that includes a power feed that distributes a direct current (DC) voltage in a building. The DC voltage is in a range of about 300 - 600 volts DC. The system also includes a motor, and a motor drive. The motor drive receives the DC voltage via the power feed, and from the DC voltage, derives an output that drives the motor.
摘要翻译：提供了一种包括在建筑物中分配直流（DC）电压的馈电的系统。直流电压在约300-600伏直流电压的范围内。该系统还包括一个电机和一个电机驱动器。电机驱动器通过馈电接收直流电压，并从直流电压得到驱动电机的输出。

6. 发明申请

WO02069498A2 RAPID SINGLE FLUX QUANTUM PROGRAMMABLE GATE ARRAY 审中-公开
标题翻译：快速单通道量子可编程门阵列
公开(公告)号：WO02069498A2
公开(公告)日：2002-09-06
申请号：PCT/ZA0200023
申请日：2002-02-28
申请人： UNIV STELLENBOSH , GROSS PETER , PEROLD WILLEM JACOBUS
发明人： GROSS PETER , PEROLD WILLEM JACOBUS
IPC分类号： H03K19/177 , H03K19/195
CPC分类号： H03K19/1778 , H03K19/17728
摘要： A configurable logic block (10) comprising rapid single flux quantum (RSFQ) superconducting circuitry comprises first and second input arrangements (12,14) connected to an imput selector (16). The input selector is connected to an address decoder (18) for a look-up table (LUT) (20). An output of the LUT is connected via an output selector (22) to output arrangements (24,26). An interconnect resource enables uni-directional propagation of RSFQ pulses between adjacent blocks in an array of blocks.
摘要翻译：包括快速单通量量子（RSFQ）超导电路的可配置逻辑块（10）包括连接到输入选择器（16）的第一和第二输入装置（12,14）。输入选择器连接到用于查找表（LUT）（20）的地址解码器（18）。 LUT的输出经由输出选择器（22）连接到输出配置（24,26）。互连资源使得能够在块阵列中的相邻块之间的RSFQ脉冲的单向传播。

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