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    • 3. 发明申请
    • TUNABLY CROSSLINKED HYALURONIC ACID COMPOSITIONS
    • TUNABLY交联的羟丙酸组合物
    • WO2009018076A1
    • 2009-02-05
    • PCT/US2008/070985
    • 2008-07-24
    • ALLERGAN, INC.STROUMPOULIS, DimitriosTEZEL, Ahmet
    • STROUMPOULIS, DimitriosTEZEL, Ahmet
    • C08B37/08A61L27/20
    • C08B37/0072A61L27/20A61L2430/34C08L5/08
    • The present invention relates to biocompatible crosslinked hyaluronic acid gel compositions, methods of their manufacture and use, and the crosslinkers used to make them. In one aspect of the invention, a polyethylene glycol crosslinking agent is described for crosslinking hyaluronic acid preferably a multifunctional one like 4-Arm Star PEG. In another aspect of the invention, crosslinking agents comprising more than two functional groups are described. These multifunctional crosslinking agents can be used on their own to crosslink hyaluronic acid, or they may be combined with bifunctional crosslinking agents in varying ratios to make hyaluronic acid of tunable mechanical strength and hardness. The present invention also discloses hyaluronic acid compositions that have been coated with polyethylene glycol and methods of their use.
    • 本发明涉及生物相容的交联透明质酸凝胶组合物,其制造和使用方法以及用于制备它们的交联剂。 在本发明的一个方面,描述了用于交联透明质酸的聚乙二醇交联剂,优选为诸如4-臂星形PEG的多官能团。 在本发明的另一方面,描述了包含多于两个官能团的交联剂。 这些多功能交联剂可以单独使用以交联透明质酸,或者它们可以以不同比例与双功能交联剂组合以制备具有可调节的机械强度和硬度的透明质酸。 本发明还公开了已经涂覆有聚乙二醇的透明质酸组合物及其使用方法。