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1. 发明申请

WO1996026690A1 CORNEAL IMPLANT FOR CHANGING REFRACTIVE PROPERTIES 审中-公开
标题翻译：用于改变折射性的角膜植入物
公开(公告)号：WO1996026690A1
公开(公告)日：1996-09-06
申请号：PCT/US1996003078
申请日：1996-03-04
申请人： KERAVISION, INC. , SILVESTRINI, Thomas, A. , MATHIS, Mark, L. , SCHOLL, John, A. , PROUDFOOT, Robert, A.
发明人： KERAVISION, INC.
IPC分类号： A61F02/14
CPC分类号： A61F2/147
摘要： A device (102, 102a, 102b, 102''') for refractive correction of the eye in order to improve the vision of the eye is disclosed. The device is an intrastromal corneal ring where the cone angle "N" ( theta ) is varied according to the desired change in corneal refractive properties. That is, the cone angle is selected to effect a desired change in refractive correction of the eye.
摘要翻译：公开了一种用于眼睛的屈光矫正以改善眼睛视力的装置（102,102,102b，102“'）。该装置是根据角膜折射特性的期望变化而改变锥角“N”（θ）的根际角膜环。也就是说，选择锥角来实现眼睛的屈光矫正的期望变化。

2. 发明申请

WO2011050250A1 VISUAL INDICATION OF RUPTURE OF DRUG RESERVOIR 审中-公开
标题翻译：药物残留破裂的可视化指标
公开(公告)号：WO2011050250A1
公开(公告)日：2011-04-28
申请号：PCT/US2010/053705
申请日：2010-10-22
申请人： ON DEMAND THERAPEUTICS, INC. , HORNE, Kenneth, N. , SPOONER, Gregory, J.R. , SCHOLL, John, A. , SANTINI, John, T. Jr.
发明人： HORNE, Kenneth, N. , SPOONER, Gregory, J.R. , SCHOLL, John, A. , SANTINI, John, T. Jr.
IPC分类号： A61F2/00
CPC分类号： A61F9/0017 , A61F2002/30714 , A61F2250/0068 , A61F2250/0089 , A61F2250/0097 , A61K9/0009 , A61K9/0051
摘要： The present disclosure relates to methods for visualizing the opening of a drug reservoir of an implantable medical device. The methods include implanting a drug delivery device within an anatomy of a subject. The drug device includes a plurality of reservoirs, each loaded with a therapeutic agent and a marker. Furthermore, the drug delivery device comprises a plurality of barrier layers for separating the contents of one of the plurality of reservoirs from the anatomy. The method further includes irradiating at least one of the plurality of barrier layers such that at least one of the plurality of reservoirs is breached, thereby triggering release of the therapeutic agent and the marker from the device. By visually detecting release of the marker into the anatomy, release of the therapeutic agent into the anatomy is verified.
摘要翻译：本公开涉及用于可视化可植入医疗装置的药物储存器的开口的方法。所述方法包括将药物递送装置植入受试者的解剖结构内。药物装置包括多个储存器，每个储存器装载有治疗剂和标记物。此外，药物递送装置包括用于将多个储存器中的一个的内容物与解剖结构分离的多个阻挡层。该方法还包括照射多个阻挡层中的至少一个，使得多个储存器中的至少一个被破坏，从而触发治疗剂和标记物从装置释放。通过目视检测将标记物释放到解剖结构中，验证了治疗剂释放到解剖结构中。

3. 发明申请

WO2009015240A3 LENS DELIVERY SYSTEM 审中-公开
标题翻译：镜头传送系统
公开(公告)号：WO2009015240A3
公开(公告)日：2009-06-25
申请号：PCT/US2008070938
申请日：2008-07-23
申请人： POWERVISION INC , SMILEY TERAH WHITING , SCHOLL JOHN A , SMITH DAVID JOHN , REDMOND RUSSELL J , MORAN DEREK L , CHESKIN BARRY , REGGIE JOHN , MATTHEWS GREGORY VINTON , ARGENTO CLAUDIO
发明人： SMILEY TERAH WHITING , SCHOLL JOHN A , SMITH DAVID JOHN , REDMOND RUSSELL J , MORAN DEREK L , CHESKIN BARRY , REGGIE JOHN , MATTHEWS GREGORY VINTON , ARGENTO CLAUDIO
IPC分类号： A61F2/16
CPC分类号： A61F2/1675 , A61F2/1678
摘要： A delivery device (2) for delivering an IOL (100) is described. IOL (100) comprises optic portion (102) and haptics (104) positioned within the delivery- device in an unstressed, or expanded, configuration. Delivery device (2) includes inserter body (4), pull block (6), and belts (8). The pull block is connected to the belts on the belt portions that are on the exterior surfaces and bottom surface of the inserter body, but is not connected to the belts on the inside of the inserter body. Movement of the pull block in either of the direction of arrows D and P moves the portion of the belts on the inside of the inserter body to move in the direction generally opposite the direction of movement of the pull block. For example, when pull block (6) is moved in the proximal, or P direction, the belt portions on the interior of the body move generally in the D direction. The belts act generally as conveyor belts to move the IOL the pull block is actuated.
摘要翻译：描述了用于递送IOL（100）的输送装置（2）。 IOL（100）包括位于递送装置内的光学部分（102）和触觉件（104），其处于无应力或膨胀的构型。输送装置（2）包括插入体（4），拉块（6）和带（8）。拉块连接到位于插入体的外表面和底表面上的带部分上的带，但不连接到插入体的内侧的带。拉动块在箭头D和P的任一方向上的移动使得插入器主体内侧的皮带的部分沿与拉块移动方向大致相反的方向移动。例如，当拉块（6）沿近端或P方向移动时，主体内部的带部分大致沿D方向移动。带通常作为输送带起作用以移动IOL，拉动块被致动。

4. 发明申请

WO2009015240A2 LENS DELIVERY SYSTEM 审中-公开
标题翻译：镜头传送系统
公开(公告)号：WO2009015240A2
公开(公告)日：2009-01-29
申请号：PCT/US2008/070938
申请日：2008-07-23
申请人： POWERVISION, INC. , SMILEY, Terah, Whiting , SCHOLL, John, A. , SMITH, David, John , REDMOND, Russell, J. , MORAN, Derek, L. , CHESKIN, Barry , REGGIE, John , MATTHEWS, Gregory, Vinton , ARGENTO, Claudio
发明人： SMILEY, Terah, Whiting , SCHOLL, John, A. , SMITH, David, John , REDMOND, Russell, J. , MORAN, Derek, L. , CHESKIN, Barry , REGGIE, John , MATTHEWS, Gregory, Vinton , ARGENTO, Claudio
IPC分类号： A61F2/16
CPC分类号： A61F2/1675 , A61F2/1678
摘要： Delivery devices for delivering an ophthalmic device into an eye. In some embodiments the delivery devices are adapted to deliver an intraocular lens into an eye.
摘要翻译：用于将眼科装置输送到眼睛中的输送装置。在一些实施例中，递送装置适于将眼内透镜输送到眼睛中。

5. 发明申请

WO2008082957A2 ACCOMMODATING INTRAOCULAR LENS SYSTEM HAVING SPHERICAL ABERRATION COMPENSATION AND METHOD 审中-公开
标题翻译：具有球形屈曲补偿和方法的住院镜片系统
公开(公告)号：WO2008082957A2
公开(公告)日：2008-07-10
申请号：PCT/US2007/087944
申请日：2007-12-18
申请人： POWERVISION, INC. , SMITH, David, John , SMILEY, Terah, Whiting , SCHOLL, John, A. , BURNS, Denise, Horrilleno , ESCH, Victor
发明人： SMITH, David, John , SMILEY, Terah, Whiting , SCHOLL, John, A. , BURNS, Denise, Horrilleno , ESCH, Victor
IPC分类号： A61F2/16
CPC分类号： A61F2/1637 , A61F2/1635 , A61F2002/1681
摘要： An accommodating intraocular lens includes an optic portion, a haptic portion. The optic portion of the lens includes an actuator that deflects a lens element to alter the optical power of the lens responsive to forces applied to the haptic portion of the lens by contraction of the ciliary muscles and a secondary deflection mechanism. Movement of the lens element by the actuator causes the lens element to deform and the secondary deflection mechanism causes the lens to further deform.
摘要翻译：容纳人造眼镜包括光学部分，触觉部分。透镜的光学部分包括使透镜元件偏转的致动器，其响应于通过睫状肌的收缩和次级偏转机构施加到镜片的触觉部分的力而改变透镜的光焦度。透镜元件由致动器的移动导致透镜元件变形，并且次级偏转机构导致透镜进一步变形。

6. 发明申请

WO1995018569A1 SYSTEM FOR INSERTING MATERIAL INTO CORNEAL STROMA 审中-公开
标题翻译：将材料插入到角部的系统
公开(公告)号：WO1995018569A1
公开(公告)日：1995-07-13
申请号：PCT/US1995000063
申请日：1995-01-06
申请人： KERAVISION, INC. , MATHIS, Mark, L. , SCHOLL, John, A. , PROUDFOOT, Robert, A. , SILVESTRINI, Thomas, A.
发明人： KERAVISION, INC.
IPC分类号： A61B17/00
CPC分类号： A61F2/147 , A61B17/32053 , A61B2017/306 , A61B2017/320052 , A61F9/013
摘要： This invention is an improved method and kit for producing a desired channel or pathway in the interlamellar space in the corneal stroma for inserting a bio-compatible material. The bio-compatible polymer may be an intrastromal corneal ring (ICR) (100). The method involves the use of clockwise and counter-clockwise dissectors (80, 84), and optionally channel connectors and finish channel connectors (170, 171). The kit contains clockwise and counter-clockwise dissectors (80, 84) and optionally channel connectors (170, 171), finish channel connectors and probes.
摘要翻译：本发明是用于在角膜基质的层间空间中产生用于插入生物相容性材料的期望的通道或途径的改进方法和试剂盒。该生物相容性聚合物可以是一个根际角膜环（ICR）（100）。该方法包括使用顺时针和逆时针解剖器（80,84），以及可选的通道连接器和完成通道连接器（170,171）。套件包含顺时针和逆时针解剖器（80,84）和可选的通道连接器（170,171），完成通道连接器和探头。

7. 发明申请

WO2011097634A1 LOW-PERMEABILITY, LASER-ACTIVATED DRUG DELIVERY DEVICE 审中-公开
标题翻译：低渗透性，激光激活药物递送装置
公开(公告)号：WO2011097634A1
公开(公告)日：2011-08-11
申请号：PCT/US2011/024074
申请日：2011-02-08
申请人： ON DEMAND THERAPEUTICS, INC. , MICROCHIPS, INC. , COPPETA, Jonathan, Robert , HORNE, Kenneth, N. , SANTINI, John, T. , SCHOLL, John, A. , SPOONER, Gregory, J.r. , STEVENSON, Cynthia, L. , SHAMS, Naveed , POUTIATINE, Andrew
发明人： COPPETA, Jonathan, Robert , HORNE, Kenneth, N. , SANTINI, John, T. , SCHOLL, John, A. , SPOONER, Gregory, J.r. , STEVENSON, Cynthia, L. , SHAMS, Naveed , POUTIATINE, Andrew
IPC分类号： A61F9/00 , A61K9/00
CPC分类号： A61F9/0017 , A61F9/008 , A61K9/0009 , A61K9/0051
摘要： An implantable drug delivery device that uses multiple reservoir elements to contain and release doses of active pharmaceutical ingredients. The device includes a first shell element, which has a first enclosed cavity volume and forms a low-permeability barrier. The first shell element is configured to absorb light irradiation from a laser source, the laser irradiation causing a breach in the first shell element. A first active pharmaceutical ingredient is contained in the first enclosed cavity volume and is released when the first shell element is breached. The device also includes a second shell element, which has a second enclosed cavity volume and also forms a low- permeability barrier. A second active pharmaceutical ingredient is contained in the second enclosed cavity volume. The device also includes an envelope element containing the first and second shell elements.
摘要翻译：一种可植入药物递送装置，其使用多个贮存器元件来容纳和释放剂量的活性药物成分。该装置包括第一壳单元，其具有第一封闭空腔体积并形成低渗透屏障。第一壳单元被配置为吸收来自激光源的光照射，激光照射引起第一壳单元中的破裂。第一活性药物成分包含在第一封闭空腔体积中，并且当第一壳元件被破坏时被释放。该装置还包括第二壳单元，其具有第二封闭空腔体积并且还形成低渗透屏障。第二活性药物成分包含在第二封闭空腔体积中。该装置还包括包含第一和第二壳单元的包络元件。

8. 发明申请

WO2009015234A3 POST-IMPLANT LENS POWER MODIFICATION 审中-公开
标题翻译：后植入镜头电源修改
公开(公告)号：WO2009015234A3
公开(公告)日：2009-04-30
申请号：PCT/US2008070931
申请日：2008-07-23
申请人： POWERVISION INC , SMILEY TERAH WHITING , SHADDUCK JOHN H , ESCH VICTOR C , SCHOLL JOHN A , ARGENTO CLAUDIO , CHESKIN BARRY , SMITH DAVID JOHN , BURNS DENISE H
发明人： SMILEY TERAH WHITING , SHADDUCK JOHN H , ESCH VICTOR C , SCHOLL JOHN A , ARGENTO CLAUDIO , CHESKIN BARRY , SMITH DAVID JOHN , BURNS DENISE H
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2/1624 , A61F2/1627 , A61F2/1635 , A61F2/1648 , A61F2210/0047 , A61F2250/0003 , A61F2250/0004 , A61F2250/0053
摘要： An accommodating intraocular lens (50) adapted for a post-implant modification is described. The lens includes an optic portion (56, 58, 62), a non-optic portion (52, 54) disposed peripherally from the optic portion and adapted to engage a lens capsule, wherein the intraocular lens is adapted to change power in response to ciliary muscle movement. The lens also includes an actuatable element (60) adapted to be actuated by an external energy source to change an optical parameter of the intraocular lens.
摘要翻译：描述适于植入后修改的适应性眼内透镜（50）。透镜包括光学部分（56,58,62），从光学部分周向设置并适于接合透镜胶囊的非光学部分（52,54），其中眼内透镜适于响应于睫状肌运动。透镜还包括适于由外部能量源致动以改变眼内透镜的光学参数的致动元件（60）。

9. 发明申请

WO2009015226A3 ACCOMMODATING INTRAOCULAR LENSES AND METHODS OF USE 审中-公开
标题翻译：容纳内窥镜和使用方法
公开(公告)号：WO2009015226A3
公开(公告)日：2009-03-12
申请号：PCT/US2008070918
申请日：2008-07-23
申请人： POWERVISION INC , SMILEY TERAH WHITING , SMITH DAVID JOHN , CHOI STEVEN , SCHOLL JOHN A , WU HENRY , BURNS DENISE H
发明人： SMILEY TERAH WHITING , SMITH DAVID JOHN , CHOI STEVEN , SCHOLL JOHN A , WU HENRY , BURNS DENISE H
IPC分类号： A61F2/16
CPC分类号： A61F2/1648 , A61F2/1601 , A61F2/1635 , A61F2002/1682
摘要： An accommodating intraocular lens IOL (10) including a peripheral non-optic portion comprising haptics (12) and (14). The IOL also includes an optic portion including anterior lens element (16), intermediate layer (18) which comprises actuator (20), and substrate, or posterior element (22). ' Anterior element (16) is bonded to intermediate layer (18) at its periphery. The anterior element, may also be bonded to actuator (20). The intermediate layer is also bonded to posterior element (22). The inner surface of haptics (12) and (14) define interior volumes (24) which are in fluid communication with active channel (26) defind by posterior element (22) and intermediate layer (18). As shown, actuator (20) is integral with intermediate layer (18). Posterior element (22) is molded with buttresses (11) which include a buttress bore (13) therethrough. The haptics have a haptic attachment element (15) which is sized and shaped to fit within buttless bore (13).
摘要翻译：包括包括触觉件（12）和（14）的外围非光学部分的适应性眼内透镜IOL（10）。 IOL还包括光学部分，其包括前透镜元件（16），包括致动器（20）的中间层（18）和基底或后部元件（22）。 '前部元件（16）在其周边结合到中间层（18）。前部元件也可以结合到致动器（20）。中间层也结合到后部元件（22）。触觉件（12）和（14）的内表面限定内部容积（24），其与由后部元件（22）和中间层（18）确定的活动通道（26）流体连通。如图所示，致动器（20）与中间层（18）成一体。后部元件（22）由支撑件（11）模制，其中包括穿过其中的支撑孔（13）。触觉件具有触觉附接元件（15），其尺寸和形状适于安装在无孔孔（13）内。

10. 发明申请

WO2009015234A2 POST-IMPLANT LENS POWER MODIFICATION 审中-公开
标题翻译：后植入镜头电源修改
公开(公告)号：WO2009015234A2
公开(公告)日：2009-01-29
申请号：PCT/US2008/070931
申请日：2008-07-23
申请人： POWERVISION, INC. , SMILEY, Terah, Whiting , SHADDUCK, John, H. , ESCH, Victor, C. , SCHOLL, John, A. , ARGENTO, Claudio , CHESKIN, Barry , SMITH, David, John , BURNS, Denise, H.
发明人： SMILEY, Terah, Whiting , SHADDUCK, John, H. , ESCH, Victor, C. , SCHOLL, John, A. , ARGENTO, Claudio , CHESKIN, Barry , SMITH, David, John , BURNS, Denise, H.
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2/1624 , A61F2/1627 , A61F2/1635 , A61F2/1648 , A61F2210/0047 , A61F2250/0003 , A61F2250/0004 , A61F2250/0053
摘要： Post-implant modifications to an intraocular lens. In some embodiments the lens is an accommodating intraocular lens.
摘要翻译：植入后修改眼内透镜。在一些实施例中，透镜是容纳的眼内透镜。

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