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1. 发明申请

WO2011097634A1 LOW-PERMEABILITY, LASER-ACTIVATED DRUG DELIVERY DEVICE 审中-公开
标题翻译：低渗透性，激光激活药物递送装置
公开(公告)号：WO2011097634A1
公开(公告)日：2011-08-11
申请号：PCT/US2011/024074
申请日：2011-02-08
申请人： ON DEMAND THERAPEUTICS, INC. , MICROCHIPS, INC. , COPPETA, Jonathan, Robert , HORNE, Kenneth, N. , SANTINI, John, T. , SCHOLL, John, A. , SPOONER, Gregory, J.r. , STEVENSON, Cynthia, L. , SHAMS, Naveed , POUTIATINE, Andrew
发明人： COPPETA, Jonathan, Robert , HORNE, Kenneth, N. , SANTINI, John, T. , SCHOLL, John, A. , SPOONER, Gregory, J.r. , STEVENSON, Cynthia, L. , SHAMS, Naveed , POUTIATINE, Andrew
IPC分类号： A61F9/00 , A61K9/00
CPC分类号： A61F9/0017 , A61F9/008 , A61K9/0009 , A61K9/0051
摘要： An implantable drug delivery device that uses multiple reservoir elements to contain and release doses of active pharmaceutical ingredients. The device includes a first shell element, which has a first enclosed cavity volume and forms a low-permeability barrier. The first shell element is configured to absorb light irradiation from a laser source, the laser irradiation causing a breach in the first shell element. A first active pharmaceutical ingredient is contained in the first enclosed cavity volume and is released when the first shell element is breached. The device also includes a second shell element, which has a second enclosed cavity volume and also forms a low- permeability barrier. A second active pharmaceutical ingredient is contained in the second enclosed cavity volume. The device also includes an envelope element containing the first and second shell elements.
摘要翻译：一种可植入药物递送装置，其使用多个贮存器元件来容纳和释放剂量的活性药物成分。该装置包括第一壳单元，其具有第一封闭空腔体积并形成低渗透屏障。第一壳单元被配置为吸收来自激光源的光照射，激光照射引起第一壳单元中的破裂。第一活性药物成分包含在第一封闭空腔体积中，并且当第一壳元件被破坏时被释放。该装置还包括第二壳单元，其具有第二封闭空腔体积并且还形成低渗透屏障。第二活性药物成分包含在第二封闭空腔体积中。该装置还包括包含第一和第二壳单元的包络元件。

2. 发明申请

WO2013023115A1 LASER-ACTIVATED DRUG DELIVERY DEVICE 审中-公开
标题翻译：激光激活药物递送装置
公开(公告)号：WO2013023115A1
公开(公告)日：2013-02-14
申请号：PCT/US2012/050240
申请日：2012-08-10
申请人： ON DEMAND THERAPEUTICS, INC. , COPPETA, Jonathan, R. , DYER, Robert , TANEJA, Vipul , SANTINI, John, T.
发明人： COPPETA, Jonathan, R. , DYER, Robert , TANEJA, Vipul , SANTINI, John, T.
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61K9/0051 , A61L27/54 , A61L2430/16
摘要： Devices (100, 180, 200, 300, 400, 470) and. methods are provided for selectively- delivering a drug by laser activation. The device includes structural elements forming a hermetic, enclosed reservoir, and at least one drug (140, 240, 340, 440) unit contained in the enclosed reservoir. The at least one drag unit includes a drug. The device is able to absorb laser irradiation effective to open the enclosed reservoir to permit release of the drug. The method includes implanting a drug delivery device into a tissue site of a patient, and irradiating at least a portion of the drug delivery device to breach the enclosed reservoir to permit the drug to be released in tissues at the tissue site.
摘要翻译：设备（100,180,200,300,400,470）和。提供了通过激光激活选择性递送药物的方法。该装置包括形成密封的封闭储存器的结构元件和包含在封闭储存器中的至少一种药物（140,240,340,440）单元。所述至少一个牵引单元包括药物。该装置能够吸收有效打开封闭储存器的激光照射以允许释放药物。该方法包括将药物递送装置植入患者的组织部位，以及照射药物递送装置的至少一部分以破坏封闭的容器以允许药物在组织部位的组织中释放。

3. 发明申请

WO2008008845A2 MULTI-RESERVOIR PUMP DEVICE FOR DIALYSIS, BIOSENSING, OR DELIVERY OF SUBSTANCES 审中-公开
标题翻译：用于透析，生物传感或物质输送的多储液泵装置
公开(公告)号：WO2008008845A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/073271
申请日：2007-07-11
申请人： MICROCHIPS, INC. , SANTINI, John, T. , CIMA, Michael, F. , COPPETA, Jonathan, R. , PRESCOTT, James, H. , SBIAA, Zouhair , STAPLES, Mark, A.
发明人： SANTINI, John, T. , CIMA, Michael, F. , COPPETA, Jonathan, R. , PRESCOTT, James, H. , SBIAA, Zouhair , STAPLES, Mark, A.
IPC分类号： A61M37/00 , A61M5/14
CPC分类号： A61M37/0015 , A61M5/1409 , A61M5/14248 , A61M5/1452 , A61M5/14526 , A61M2005/14204 , A61M2005/14268 , A61M2037/0023
摘要： A pump patch device is provided for drug delivery. The device may include a substrate having a plurality of discrete reservoirs, each reservoir having a reservoir opening; a drug disposed in the reservoirs; a pump for delivering a carrier fluid through or adjacent to the reservoir openings; a flow channel for receiving and combining the carrier fluid from the pump with the drug from the reservoirs to form a fluidized drug; and a needle for delivering the fluidized drug into the skin or another biological tissue of a patient. A device is provided for use in dialysis that includes a non-disposable module including a pump or pressure generator; and a disposable cassette operably connected to the pump or pressure generator and including a plurality of discrete reservoirs containing drug and sensors. A fluidics connection device is provided that includes a compression cold weld seal for a microfluidic via.
摘要翻译：提供用于药物输送的泵补片装置。该装置可以包括具有多个不连续的储存器的基底，每个储存器具有储存器开口; 放置在储存器中的药物; 用于通过或邻近贮存器开口输送载液的泵; 用于接收和组合来自泵的载体流体与来自储存器的药物以形成流化药物的流动通道; 以及用于将流化药物输送到患者的皮肤或另一生物组织中的针。提供用于透析的装置，其包括包括泵或压力发生器的非一次性模块; 以及可操作地连接到泵或压力发生器并包括多个含有药物和传感器的不连续储存器的一次性盒。提供流体连接装置，其包括用于微流体通孔的压缩冷焊接密封。

4. 发明申请

WO2008017042A1 CARDIAC BIOSENSOR DEVICES AND METHODS 审中-公开
标题翻译： CARDIAC生物传感器设备和方法
公开(公告)号：WO2008017042A1
公开(公告)日：2008-02-07
申请号：PCT/US2007/075099
申请日：2007-08-02
申请人： MICROCHIPS, INC.
发明人： SHEPPARD, Norman, F. , SANTINI, John, T.
IPC分类号： A61N1/05 , G01N33/50 , A61B5/00 , A61B5/0215 , A61B5/026
CPC分类号： A61N1/05 , A61B5/0002 , A61B5/0215 , A61B5/026 , A61B5/145 , A61B5/14532 , A61B5/14539 , A61N1/36557
摘要： Implantable medical devices for cardiac care are provided that include a housing having a power source and control electronics; at least one lead extending from the housing and having one or more discrete reservoirs therein, each reservoir having an opening to an outer surface of the lead; one or more sensors, which monitor or detects an analyte, biomarker, or physical parameter that is associated with cardiac health, located in the reservoirs and in operable communication with said control electronics; and at least one selectively dtsintegratable reservoir cap sealing each of the reservoir openings, wherein the reservoir cap is operably connected to the power source and control electronics to disintegrate the reservoir cap and expose the sensors in vivo. The sensor may detect an analyte or biomarker selected from potassium ion, sodium ion, lithium ion, magnesium ion, ammonium ion, ionized calcium, lactate, oxygen, carbon dioxide, and creatinine, urea, BUN, and bilirubin.
摘要翻译：提供了用于心脏护理的可植入医疗装置，其包括具有电源和控制电子器件的壳体; 至少一个引线，其从所述壳体延伸并且在其中具有一个或多个分立的储存器，每个储存器具有到所述引线的外表面的开口; 一个或多个传感器，其监测或检测与心脏健康相关联的分析物，生物标志物或物理参数，所述分析物，生物标志物或物理参数位于储存器中并且与所述控制电子器件可操作地通信; 以及密封每个储存器开口的至少一个选择性密封储存器盖，其中所述储存器盖可操作地连接到所述电源和控制电子装置以分解储存器盖并在体内暴露所述传感器。传感器可以检测选自钾离子，钠离子，锂离子，镁离子，铵离子，离子化钙，乳酸，氧，二氧化碳和肌酸酐，尿素，BUN和胆红素的分析物或生物标志物。

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