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1. 发明申请

WO2017212354A1 DUAL REGION ACCOMODATING INTRAOCULAR LENS DEVICES 审中-公开
标题翻译：双区域眼内人工晶状体装置
公开(公告)号：WO2017212354A1
公开(公告)日：2017-12-14
申请号：PCT/IB2017/052729
申请日：2017-05-10
申请人： NOVARTIS AG
发明人： CAMPIN, John Alfred , PETTIT, George , CURATU, Costin Eugene , ERDEN, Erdem
IPC分类号： A61F2/16 , G02C7/08
CPC分类号： A61F2/161 , A61F2/1624 , A61F2/1627 , A61F2/1659 , A61F2002/169 , A61F2002/1696 , A61F2002/16965 , A61F2250/0002 , G02C7/083
摘要： Disclosed herein is an implantable accommodative IOL device for insertion into an eye of a patient, comprising an active region and a passive region. The active region has a first thickness and first refractive index, and the active region comprises an electrically responsive optical lens having variable optical power. The passive region is disposed at a periphery of the active region, and the passive region has a second thickness and a second refractive index. The second refractive index is different than the first refractive index. Thus, the light beams passing through the active and passive regions have a phase difference, thereby providing an extended depth of field.
摘要翻译：本文公开了用于插入患者眼睛中的可植入调节性IOL装置，其包括有源区和无源区。有源区具有第一厚度和第一折射率，并且有源区包括具有可变光焦度的电响应光学透镜。无源区域设置在有源区域的外围，无源区域具有第二厚度和第二折射率。第二折射率不同于第一折射率。因此，通过有源和无源区域的光束具有相位差，从而提供了更大的景深。

2. 发明申请

WO2017103734A1 FLEXIBLE, HERMETIC ELECTRICAL INTERCONNECT FOR ELECTRONIC AND OPTOELECTRONIC DEVICES FOR IN VIVO USE 审中-公开
标题翻译：用于体内电子和光电子器件的柔性，密封电连接
公开(公告)号：WO2017103734A1
公开(公告)日：2017-06-22
申请号：PCT/IB2016/057383
申请日：2016-12-06
申请人： NOVARTIS AG
发明人： ZIELKE, Mark A. , MATTES, Michael F.
IPC分类号： A61F2/16 , B29D11/00 , G02C7/08 , A61N1/375 , A61N1/36
CPC分类号： A61F2/1624 , A61F2/16 , A61F2002/1681 , A61F2220/0025 , A61F2250/0069 , A61N1/36046 , A61N1/3754 , B29D11/00807 , B29D11/00817 , B29D11/00826 , B29D11/023 , G02C7/083 , H05K3/007 , H05K3/28 , H05K3/4038
摘要： An electronic device can comprise a first electronic module; a second electronic module; and a hermetic electric interconnect to hermetically couple them, The hermetic electric interconnect can comprise a bottom metal layer; a bottom insulating layer, deposited on the bottom metal layer to insulate the bottom metal layer; an interconnect metal layer, deposited on the bottom insulating layer, and deposited to form a bottom sealing ring; and patterned to form electrical connections between contact pads, and to form a middle sealing ring: a patterned top insulating layer, deposited on the interconnect metal layer to insulate the interconnect metal layer; and patterned to form feedthrough holes; and a top metal layer, deposited on the top insulating layer to start forming contacts by filling the feedthrough holes; and patterned to complete forming contacts through the feedthrough holes, to form a separate barrier layer, and to complete forming the top sealing ring.
摘要翻译：电子设备可以包括第一电子模块; 第二电子模块; 以及密封的电互连件以气密地耦合它们。密封电互连件可以包括底部金属层; 底部绝缘层，沉积在底部金属层上以绝缘底部金属层; 沉积在底部绝缘层上并沉积以形成底部密封环的互连金属层; 并且被图案化以形成接触垫之间的电连接，并且形成中间密封环：沉积在互连金属层上以使互连金属层绝缘的图案化顶部绝缘层; 并被图案化以形成馈通孔; 以及顶部金属层，沉积在顶部绝缘层上以通过填充馈通孔开始形成接触; 并构图以完成通过穿通孔形成触点，形成单独的阻挡层，并完成形成顶部密封环。

3. 发明申请

WO2016178133A1 METHOD AND DEVICE FOR OPTIMIZING VISION VIA CUSTOMIZATION OF SPHERICAL ABERRATION OF EYE 审中-公开
标题翻译：通过眼睛眼球定型来优化视觉的方法和装置
公开(公告)号：WO2016178133A1
公开(公告)日：2016-11-10
申请号：PCT/IB2016/052487
申请日：2016-05-02
申请人： MEDICEM OPTHALMIC (CY) LIMITED
发明人： STOY, Vladimir
IPC分类号： A61F2/16
CPC分类号： A61F2/1616 , A61F2/1613 , A61F2/1624 , A61F2240/002
摘要： Artificial lenses and methods for optimizing vision in an eye of a patient comprising the steps of determining a target optical configuration including the optimum defocus and aberrations that the patients' eye should have in order to match or approximate the original optical configuration of the patient; determining the refractive change of the patient's eye required to achieve the optical configuration best corresponding to target optical configuration for the patient; and implementing the selected refractive change to achieve the target optical configuration.
摘要翻译：用于优化患者眼睛中的视力的人造镜片和方法，包括以下步骤：确定包括患者眼睛应具有的最佳散焦和像差的目标光学配置以匹配或近似患者的原始光学配置; 确定实现最佳对应于患者的目标光学配置的光学配置所需的患者眼睛的折射变化; 并实现所选择的折射变化以实现目标光学配置。

4. 发明申请

WO2015165584A1 MITTEL ZUR STEUERUNG DER AKKOMMODATIONSBEDARFSERFASSUNG IN EINEM KÜNSTLICHEN AKKOMMODATIONSSYSTEM 审中-公开
标题翻译：用于控制AKKOMMODATIONSBEDARFSERFASSUNG IN A人工的住宿
公开(公告)号：WO2015165584A1
公开(公告)日：2015-11-05
申请号：PCT/EP2015/000868
申请日：2015-04-28
申请人： KARLSRUHER INSTITUT FÜR TECHNOLOGIE (KIT)
发明人： GUTH, Helmut , GENGENBACH, Ulrich , BRETTHAUER, Georg , FLIEDNER, Jan , KOKER, Liane , NAGEL, Jörg , MARTIN, Thomas , BECK, Christoph
IPC分类号： A61B5/11 , A61B3/113 , G02C7/04 , G02C7/08
CPC分类号： A61B5/1123 , A61B3/1015 , A61B3/113 , A61B3/14 , A61B3/18 , A61B5/1101 , A61B5/1103 , A61B5/161 , A61B8/10 , A61F2/1624 , A61F2009/00846 , A61F2250/0002 , G02C7/04 , G02C7/083 , G06F3/013 , G06K9/0061
摘要： Mittel zur Steuerung der Akkommodationsbedarfserfassung in einem ophthalmischen technischen System (OTS) (6), umfassend mindestens einen Sensor (1) zur Erfassung, einer körpereigenen Signalfolge oder einer Umfeldsignalfolge und Wandlung dieser in Messsignale (3) sowie mindestens eine Erfassungseinheit (4) zur Wandlung der Messsignale (3) in ein Steuersignal (5), das die Akkommodationsbedarfserfassung beeinflusst. Die Aufgabe besteht darin, diese Mittel so zu gestalten, dass eine signifikante Energieeinsparung eines künstlichen Akkommodationssystems (oder OTS) ohne eine nennenswerte Einschränkung des Nutzers ermöglicht oder der Nutzerkomfort gesteigert wird. Die Aufgabe wird dadurch gelöst, dass die Erfassungseinheit (4) eine Signalerkennung aufweist, die die Messsignale (3) mit Referenzsignalbandbreite vergleicht und bei einer Überdeckung der Messsignale durch eine vorgegebene Referenzsignalbandbreite das Steuersignal (5) erzeugt.
摘要翻译：装置，用于控制在眼科技术系统的Akkommodationsbedarfserfassung（OTS）（6）包括至少一个传感器（1），用于转换检测人体自身信号序列，或环境信号序列和在测量信号变换此（3）和至少一个检测单元（4）测量信号（3）转换成控制信号（5），这影响Akkommodationsbedarfserfassung。目的是使这些试剂，使未经用户（或OTS）或用户的便利性的显着减少人工容纳可能的显著节能增加。该目的的实现在于所述检测单元（4）包括信号检测，其中所测量的信号（3）与参考信号的带宽和与预定的基准信号的带宽的测量信号的重叠进行比较，（5）产生的控制信号。

5. 发明申请

WO2013059663A3 PATIENT SCREENING FACTORS FOR ACCOMMODATIVE IMPLANTABLE OPHTHALMIC DEVICES 审中-公开
标题翻译：住院可植入手术器械的患者筛查因素
公开(公告)号：WO2013059663A3
公开(公告)日：2015-06-25
申请号：PCT/US2012061124
申请日：2012-10-19
申请人： ELENZA INC
发明人： MORRIS MICHAEL , SINNOTT LORAINE , FEHR JEAN-NOEL , MICHAELY ROLAND , MONTICONE PIER PAOLO , MUEHLEMANN THOMAS , GUPTA AMITAVA
IPC分类号： A61B3/10
CPC分类号： A61B3/09 , A61B3/16 , A61F2/1624 , A61F9/0017 , A61F9/00781
摘要： A patient screening apparatus identifies candidates suitable for receiving accommodative implantable ophthalmic devices, such as dynamic intraocular lenses, based on pupil measurements under different viewing conditions. A pupillometer measures pupil size (pupil diameter or pupil area) and changes in pupil size as a function of ambient light level and/or object distance. For instance, the pupillometer may determine how much the pupil's size changes when the subject transitions from sustained viewing of a distant target to sustained viewing of a near target. These measurements may be used to determine variations in pupil response, including the standard deviation and/or median absolute deviation in pupil size under a given viewing condition, and ratios of pupil sizes and variances in pupil size. The apparatus uses these metrics to estimate whether a patient is likely to benefit from an accommodative implantable ophthalmic device. It can also use them to tune an implantable ophthalmic device.
摘要翻译：患者筛选装置基于不同观察条件下的瞳孔测量来识别适合于接收适应性可植入眼科装置的候选者，例如动态眼内透镜。瞳孔尺度测量瞳孔大小（瞳孔直径或瞳孔面积）以及瞳孔大小随着环境光线水平和/或物体距离的变化而变化。例如，瞳孔尺度可以确定当对象从远距离目标的持续观看转移到近目标的持续观看时，瞳孔的大小变化多少。这些测量可用于确定瞳孔响应的变化，包括在给定观察条件下的瞳孔尺寸的标准偏差和/或中值绝对偏差，以及瞳孔大小和瞳孔大小方差的比率。该装置使用这些度量来估计患者是否可能受益于调节性可植入眼科装置。它还可以使用它们来调整可植入眼科装置。

6. 发明申请

WO2015084786A1 SOFT HYDROPHOBIC ACRYLIC MATERIALS 审中-公开
标题翻译：软质疏水性丙烯酸酯材料
公开(公告)号：WO2015084786A1
公开(公告)日：2015-06-11
申请号：PCT/US2014068052
申请日：2014-12-02
申请人： NOVARTIS AG , JIANG XUWEI , SCHLUETER DOUGLAS
发明人： JIANG XUWEI , SCHLUETER DOUGLAS
IPC分类号： C08F220/24
CPC分类号： A61L27/16 , A61F2/1624 , C08F220/18 , C08F220/24 , C08F222/10 , C08F222/1006 , G02B1/043 , C08L33/08 , C08L33/10 , C08F2220/1825 , C08F2220/1858 , C08F2222/1013
摘要： Soft hydrophobic acrylic materials with improved resistance to fluid diffusion and suitable mechanical properties that allow deformation upon application of force are disclosed. The acrylic materials are particularly suitable for use in fluid-based accommodating intraocular lenses and comprises combination of a perfluoro-substituted alkyl (meth)acrylate and an alkyl (meth)acrylate, and a cross-linking agent.
摘要翻译：公开了具有改善的对流体扩散的抵抗力的柔性疏水性丙烯酸材料以及允许在施加力时变形的合适的机械性能。丙烯酸类材料特别适用于基于流体的容纳人工晶状体，并且包括全氟取代的（甲基）丙烯酸烷基酯和（甲基）丙烯酸烷基酯和交联剂的组合。

7. 发明申请

WO2014063135A3 SYSTEMS AND METHODS FOR CUSTOMIZING ADJUSTABLE INTRAOCULAR LENSES 审中-公开
标题翻译：用于定制可调节的眼内透镜的系统和方法
公开(公告)号：WO2014063135A3
公开(公告)日：2014-08-14
申请号：PCT/US2013065858
申请日：2013-10-21
申请人： 1CO INC , DEBOER CHARLES , TAI YU-CHONG , HUMAYUN MARK S , CAFFEY SEAN
发明人： DEBOER CHARLES , TAI YU-CHONG , HUMAYUN MARK S , CAFFEY SEAN
IPC分类号： A61F2/16
CPC分类号： A61F2/1618 , A61B3/0025 , A61B3/09 , A61B3/10 , A61F2/1624 , A61F2240/002
摘要： The lens geometry and power of an intraocular lens is optimized to provide both distance and near vision correction for a patient. The optimization may be based on one or more measured accommodation-related parameters and one or more estimated accommodation-related parameters. An accommodative amplitude may be predicted based on the measured and estimated accommodation-related parameters, and the optimized the intraocular lens geometry and power established based thereon.
摘要翻译：优化人工晶状体的晶状体几何形状和功率，以为患者提供距离和近距离视力矫正。该优化可以基于一个或多个测得的适应相关参数和一个或多个估计的适应相关参数。可以基于测量和估计的适应相关参数来预测适应性幅度，并且基于此优化基于所建立的眼内晶状体几何形状和功率。

8. 发明申请

WO2014058735A1 REMOTE MULTIFOCAL TO MONOFOCAL OPTIC CONVERSION 审中-公开
标题翻译：远程多功能到单模光学转换
公开(公告)号：WO2014058735A1
公开(公告)日：2014-04-17
申请号：PCT/US2013/063469
申请日：2013-10-04
申请人： PORTNEY, Valdemar , PORTNEY, Nathaniel G.
发明人： PORTNEY, Valdemar , PORTNEY, Nathaniel G.
IPC分类号： G02C7/08 , A61F2/16
CPC分类号： A61F2/1618 , A61F2/1601 , A61F2/1624 , A61F2/1654 , A61F2002/1699
摘要： An ophthalmic multifocal switchable lens includes a deformable element manifesting elevated strain with a formable surface of a multifocal surface shape to provide far and near vision. A transparent chamber is filled with optical matching fluid adjacent to the side of the deformable element opposite to the formable surface. The optical matching fluid has a refractive index that matches a refractive index of the deformable element material. A holding chamber is also filled with the optical matching fluid and connected with the transparent chamber with a means for preventing the optical fluid from being transported from the holding chamber to the transparent chamber which would reduce a strain of the deformable element. A split of light between far and near vision of the multifocal switchable lens changes upon a removal of the means to allow a flow of the optical matching fluid into the transparent chamber.
摘要翻译：眼科多焦点可切换透镜包括可变形元件，其表现出具有多焦点表面形状的可形成表面的升高的应变以提供远近视觉。透明室中充满了与可形成表面相对的可变形元件侧面附近的光学匹配流体。光学匹配流体具有与可变形元件材料的折射率相匹配的折射率。保持室还填充有光学匹配流体并且与透明室连接，具有用于防止光学流体从保持室传输到透明室的装置，这将减少可变形元件的应变。多焦点可切换透镜的远视和近视之间的光分离在移除装置以允许光学匹配流体流入透明室时改变。

9. 发明申请

WO2013176979A1 ACCOMMODATING INTRAOCULAR COMPOSITE LENS AND RELATED METHODS 审中-公开
标题翻译：配合内镜复合镜片及相关方法
公开(公告)号：WO2013176979A1
公开(公告)日：2013-11-28
申请号：PCT/US2013/041545
申请日：2013-05-17
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , UNIVERSITY OF SOUTHERN CALIFORNIA , DEBOER, Charles , TAI, Yu-Chong , HUMAYUN, Mark
发明人： DEBOER, Charles , TAI, Yu-Chong , HUMAYUN, Mark
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2/1616 , A61F2/1624 , A61F2/1629 , A61F2/1635 , A61F2/1648 , A61F2002/1699
摘要： An implantable intraocular lens and methods of manufacturing them provide a target degree of optical accommodation. In various embodiments, the lens includes at least one internal optic, an outer shell for enclosing at least a portion of the internal optic, and a fluid at least partially filling the outer shell.
摘要翻译：可植入人工晶状体及其制造方法提供目标光学适应度。在各种实施例中，透镜包括至少一个内部光学元件，用于封闭内部光学元件的至少一部分的外壳以及至少部分地填充外壳的流体。

10. 发明申请

WO2013169652A2 ACCOMMODATIVE-DISACCOMMODATIVE INTRAOCULAR LENS 审中-公开
公开(公告)号：WO2013169652A2
公开(公告)日：2013-11-14
申请号：PCT/US2013039708
申请日：2013-05-06
申请人： LENS LLC Z
发明人： BEER PAUL MARIUS
IPC分类号： A61F2/16
CPC分类号： A61F2/1624 , A61F2/1629 , A61F2/1635 , A61F9/007 , A61F2002/1682 , A61F2002/1683 , A61F2002/1686 , A61F2002/16901 , A61F2210/0014 , A61F2220/0008 , A61F2310/00023
摘要： Embodiments of the invention relate to an intraocular lens system having a plurality of haptics for use with an optic. In general, the haptics are adapted to move independently in response to forces associated with a ciliary muscle and/or zonules of an eye when implanted. The optic may be releasably secured to the system using, for example, a plurality of optic securing arms. Alternatively, the optic may be fused to the haptics, which may project radially outward from the optic. A restraining arm may be included to limit movement of the haptics during accommodation and/or disaccommodation. Clamping members may be included for securing the system to a capsular bag of the eye. Methods of implanting the intraocular lens system into the eye are also described.
摘要翻译：本发明的实施例涉及具有用于光学元件的多个触觉件的人工晶状体系统。通常，触觉件适于在植入时响应于与睫状肌和/或眼睛的小环相关联的力而独立地移动。光学元件可以使用例如多个光学固定臂可释放地固定到系统。或者，光学元件可以融合到触觉件，触觉件可以从光学器件径向向外突出。可以包括限制臂以限制住宿和/或不适应期间襻的移动。可以包括夹紧构件以将系统固定到眼睛的囊袋上。还描述了将眼内透镜系统植入眼睛的方法。

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