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1. 发明申请

WO2018182852A1 ELECTROWETTING INTRAOCULAR LENS WITH ISOTONIC AQUEOUS PHASE 审中-公开
公开(公告)号：WO2018182852A1
公开(公告)日：2018-10-04
申请号：PCT/US2018/017097
申请日：2018-02-06
申请人： VERILY LIFE SCIENCES LLC
发明人： OTTS, Daniel
IPC分类号： G02C7/08 , A61F2/16
CPC分类号： A61F2/1635 , A61F2/1627 , A61F2/1637 , A61F2250/0002 , A61F2250/0003 , A61F2250/0053 , G02B1/043 , G02B1/14 , G02B3/14 , G02B26/004 , G02B26/005 , G02B2207/115 , G02C7/085 , C08L23/08 , C08L23/10
摘要： An eye-implantable device including an eiectrowetting lens is provided that can be operated to control an overall optical power of an eye in which the device is implanted, A lens chamber of the eiectrowetting lens contains first and second fluids that are immiscible with each other and that differ with respect to refractive index. By applying a voltage to electrodes of the lens, the optical power of the lens can be controlled by affecting the geometry of the interface between the fluids. One of the fluids is an aqueous fluid that is isotonic relative to the aqueous humor of the eye to prevent flux of water into or out of the lens chamber. Tims, the lens chamber may be composed of water-permeable materials. Such water-permeable materials may be flexible, to permit the lens to be folded into a smaller profile during implantation.

2. 发明申请

WO2018067359A1 OPEN, SEAL-LESS INTRAOCULAR LENS 审中-公开
标题翻译：开放，无密封的眼内镜片
公开(公告)号：WO2018067359A1
公开(公告)日：2018-04-12
申请号：PCT/US2017/053756
申请日：2017-09-27
申请人： VERILY LIFE SCIENCES LLC
发明人： OTTS, Daniel, B.
IPC分类号： A61F2/16 , G02B26/00 , G02C7/08
CPC分类号： A61F2/1635 , A61F2/1627 , A61F2/1648 , A61F2/1675 , A61F2002/16905 , A61F2210/0076 , A61F2250/0001 , A61F2250/0002 , A61F2250/0091 , A61F2250/0092 , A61F2250/0096 , G02B26/005 , G02C7/085
摘要： An open, seal-less intraocular lens is disclosed herein. An example intraocular lens may include an annular substrate (102) including an oil electrode (104) disposed in or on an inner sidewall of the annular substrate to electrostatically manipulate a volume of electrowetting oil, an optical window (106) coupled to the substrate, where a side of the optical window adjacent to the inner sidewall and the inner sidewall of the annular substrate define a region for constraining the volume of electrowetting oil, and a saline electrode (116) coupled to the annular substrate, the saline electrode positionable within an aqueous humor of an eye upon implantation.
摘要翻译：本文公开了一种开放的无密封眼内晶状体。一个示例的人工晶状体可以包括环形衬底（102），光学窗口（106）包括设置在环形衬底的内侧壁中或上的油电极（104）以静电操纵一定体积的电润湿油，光学窗口（106）其中光学窗口的与环形衬底的内侧壁和内侧壁相邻的一侧限定用于约束电润湿油的体积的区域，以及耦合到环形衬底的盐水电极（116），盐水电极可定位在植入后眼睛的房水。

3. 发明申请

WO2017015328A1 INTRAOCULAR LENS SYSTEMS AND RELATED METHODS 审中-公开
标题翻译：内窥镜系统及相关方法
公开(公告)号：WO2017015328A1
公开(公告)日：2017-01-26
申请号：PCT/US2016/043068
申请日：2016-07-20
申请人： ELWHA LLC
发明人： CHEATHAM, Jesse R., III , HYDE, Roderick A. , MARSHALL, John , TEGREENE, Clarence T. , WOOD, Lowell L., Jr. , ZALDIVAR, Roberto , ZALDIVAR, Roger
IPC分类号： A61F2/16 , A61F2/48
CPC分类号： A61F2/1627 , A61B3/103 , A61F2/16 , A61F2/1648 , A61F2/1659 , A61F2250/0002
摘要： Embodiments disclosed herein are directed to intraocular lens systems includes at least one intraocular lens device and methods of using the same. The at least one intraocular lens device includes one or more photodetectors and an intraocular lens exhibiting a modifiable focal length. The one or more photodetectors are configured to detect light that is used to determine a presence of the object or the apparent object distance. The focal length of the intraocular lens can be modified depending on the determined presence of the object or the apparent object distance.
摘要翻译：本文公开的实施例涉及眼内透镜系统，其包括至少一个眼内透镜装置及其使用方法。所述至少一个眼内透镜装置包括一个或多个光电检测器和呈现可修改焦距的眼内透镜。一个或多个光电检测器被配置为检测用于确定物体的存在或表观物体距离的光。可以根据确定的物体的存在或表观物体距离来修改眼内透镜的焦距。

4. 发明申请

WO2017015325A1 INTRAOCULAR LENS SYSTEMS AND RELATED METHODS 审中-公开
标题翻译：内窥镜系统及相关方法
公开(公告)号：WO2017015325A1
公开(公告)日：2017-01-26
申请号：PCT/US2016/043062
申请日：2016-07-20
申请人： ELWHA LLC
发明人： HYDE, Roderick, A. , MARSHALL, John , TEGREENE, Clarence, T. , ZALDIVAR, Roberto , ZALDIVAR, Roger
IPC分类号： A61F2/16 , A61F2/48
CPC分类号： A61F2/1627 , A61B5/0031 , A61F2/1654 , A61F2250/0002
摘要： Embodiments disclosed herein are directed to intraocular lens systems having a plurality of materials therein, with at least some of the materials having a diffraction pattern therein and an electrically-modifiable index of refraction collectively configured to selectively alter the focal length of the intraocular lens system. Methods of modifying a focal length of an intraocular lens system are also disclosed.
摘要翻译：本文公开的实施例涉及其中具有多种材料的眼内透镜系统，其中至少一些材料在其中具有衍射图案，并且电可修改的折射率共同配置为选择性地改变眼内透镜系统的焦距。还公开了修改眼内透镜系统的焦距的方法。

5. 发明申请

WO2016183424A1 LIGHT ADJUSTABLE INTRAOCULAR LENSES USING UPCONVERTING NANOP ARTICLES AND NEAR INFRARED (NIR) LIGHT 审中-公开
标题翻译：使用近年来纳米材料和近红外（NIR）灯的光可调节内窥镜
公开(公告)号：WO2016183424A1
公开(公告)日：2016-11-17
申请号：PCT/US2016/032325
申请日：2016-05-13
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： GRUBBS, Robert H. , MANGOLD, Shane L.
IPC分类号： C08J3/28 , C08J5/00 , C08J3/24 , C08K3/08 , A61F2/16 , A61K9/00 , C08L71/02 , C08L5/08
CPC分类号： A61L27/50 , A61F2/1627 , A61F2/1635 , A61F2/1659 , A61F9/00 , A61L27/047 , A61L27/14 , A61L2400/06 , A61L2400/12 , A61L2430/16 , C08F2/48 , C08F222/385 , C08F220/20
摘要： This disclosure relates compositions comprising upconverting nanocrystals and photoactive compositions and methods using these compositions to modify treat myopia and other ocular conditions. In some cases, the methods use near infrared irradiation to adjust the refractive power of light adjustable ocular lenses. Other methods improve the mechanical strength of the sclera directly.
摘要翻译：本公开涉及包含上转换纳米晶体和光活性组合物的组合物以及使用这些组合物改进治疗近视和其它眼部病症的方法。在某些情况下，该方法使用近红外辐射来调整光调节眼镜的屈光度。其他方法直接改善巩膜的机械强度。

6. 发明申请

WO2014140905A1 MODULATION OF REFRACTIVE INDEX FOR PRESBYNSERT AND ESTHETICAL INTACS 审中-公开
标题翻译： PRESBYNSERT和ESTHETICIC INTACS的折射指数调制
公开(公告)号：WO2014140905A1
公开(公告)日：2014-09-18
申请号：PCT/IB2014/001161
申请日：2014-03-13
申请人： TELANDRO, Alain
发明人： TELANDRO, Alain
IPC分类号： A61F2/14 , A61F2/16
CPC分类号： A61F2/145 , A61F2/1618 , A61F2/1627 , A61F9/00834 , A61F2009/00895 , A61F2250/0014 , A61F2250/0053
摘要： The present invention relates in one aspect to improving the performance of an ophthalmic lens for the eye by creating a progressive optical system wherein the lens is made of different materials having different optical refractive indeces (RI), in another aspect use of refractive indeces to form esthetical Intacs.
摘要翻译：本发明在一个方面涉及通过创建渐进式光学系统来改善眼睛的眼科镜片的性能，其中透镜由具有不同光学屈光度（RI）的不同材料制成，另一方面使用折射式凹痕形成美学Intacs。

7. 发明申请

WO2014077983A1 HYDROPHILICITY ALTERATION SYSTEM AND METHOD 审中-公开
标题翻译：水力变化系统与方法
公开(公告)号：WO2014077983A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/064098
申请日：2013-10-09
申请人： PERFECT IP, LLC
发明人： SAHLER, Ruth , ZHOU, Stephen, Q. , BILLE, Josef, F.
IPC分类号： B29D11/00
CPC分类号： A61F2/16 , A61F2/1613 , A61F2/1627 , A61F2/1648 , A61F9/008 , A61F9/00834 , B29C71/04 , B29C2035/0838 , B29C2791/009 , B29D11/00125 , B29K2995/0092
摘要： A system/method allowing hydrophilicity alteration of a polymeric material (PM) is disclosed. The PM hydrophilicity alteration changes the PM characteristics by decreasing the PM refractive index, increasing the PM electrical conductivity, and increasing the PM weight. The system/method incorporates a laser radiation source that generates tightly focused laser pulses within a three- dimensional portion of the PM to affect these changes in PM properties. The system/method may be applied to the formation of customized intraocular lenses comprising material (PLM) wherein the lens created using the system/method is surgically positioned within the eye of the patient. The implanted lens refractive index may then be optionally altered in situ with laser pulses to change the optical properties of the implanted lens and thus achieve optimal corrected patient vision. This system/method permits numerous in situ modifications of an implanted lens as the patient's vision changes with age.
摘要翻译：公开了一种允许聚合材料（PM）的亲水性改变的系统/方法。 PM亲水性改变通过降低PM折射率，提高PM电导率和增加PM重量来改变PM特性。该系统/方法包括激光辐射源，其在PM的三维部分内产生紧密聚焦的激光脉冲，以影响PM性质的这些变化。该系统/方法可以应用于包括材料（PLM）的定制眼内透镜的形成，其中使用系统/方法产生的透镜被手术地定位在患者的眼睛内。然后可以用激光脉冲任意地改变植入透镜折射率以改变植入透镜的光学性质，从而实现最佳校正的患者视力。当患者的视力随年龄变化时，该系统/方法允许植入式晶状体的许多原位修改。

8. 发明申请

WO2012143304A2 LIQUID FORMULATION FOR OPHTALMIC DEVICES 审中-公开
标题翻译：液态装置的液体配方
公开(公告)号：WO2012143304A2
公开(公告)日：2012-10-26
申请号：PCT/EP2012/056846
申请日：2012-04-13
申请人： PARROT SA , MAILLARD, Mathieu
发明人： MAILLARD, Mathieu
IPC分类号： G02B3/14 , G02B26/00 , A61F2/16 , G02C7/08
CPC分类号： A61F2/1627 , A61F2/1635 , A61F2250/0043 , B29D11/00009 , G02B3/14 , G02B26/005 , G02C7/085
摘要： According to a first aspect, the invention relates to an intraocular variable focus implant comprising a non-conducting liquid with a melting temperature above 0° C, a conducting liquid, a liquid interface formed by the non-conducting and conducting liquids, a first electrode in contact with the conducting liquid, a second electrode insulated from the conducting liquid, wherein the liquid interface is movable by electro wetting according to a change in a voltage applied between the first and second electrodes.
摘要翻译：根据第一方面，本发明涉及一种眼内可变焦点植入物，其包括熔点高于0℃的非导电液体，导电液体，由非导电和导电液体形成的液体界面，第一电极与所述导电液体接触的第二电极与所述导电液体绝缘，其中所述液体界面可根据施加在所述第一和第二电极之间的电压的变化通过电润湿而移动。

9. 发明申请

WO2012044607A1 LIQUID MENISCUS LENS WITH NON-SPHERICAL MENISCUS WALL 审中-公开
标题翻译：液体MENISCUS镜头与非球形男式墙壁
公开(公告)号：WO2012044607A1
公开(公告)日：2012-04-05
申请号：PCT/US2011/053414
申请日：2011-09-27
申请人： JOHNSON & JOHNSON VISION CARE, INC. , PUGH, Randall, B. , OTTS, Daniel, B. , TONER, Adam , KERNICK, Edward, R. , RIALL, James, Daniel , SNOOK, Sharika
发明人： PUGH, Randall, B. , OTTS, Daniel, B. , TONER, Adam , KERNICK, Edward, R. , RIALL, James, Daniel , SNOOK, Sharika
IPC分类号： G02B3/14 , G02B26/02 , G02C7/04 , G02C7/08
CPC分类号： G02B3/14 , A61F2/1627 , A61F2/1635 , G02B1/041 , G02B1/043 , G02B3/12 , G02B26/004 , G02C7/085 , C08L27/18 , C08L25/02 , C08L101/12
摘要： The present invention relates generally to an arcuate liquid meniscus lens with a meniscus wall. Some specific embodiments include a liquid meniscus lens with a meniscus wall essentially in the shape of a conical frustum, a cross section of which is non-spherical. Embodiments may also include a lens of suitable size and shape for inclusion in a contact lens.
摘要翻译：本发明一般涉及具有弯液面壁的弓形液体弯月透镜。一些具体实施例包括具有弯月面壁的液体弯月形透镜，弯月面壁基本上呈锥形截头锥体的形状，其横截面为非球形。实施例还可以包括适合于包含在隐形眼镜中的尺寸和形状的镜片。

10. 发明申请

WO2012015719A1 LIQUID MENISCUS LENS WITH CONVEX TORUSSEGMENT MENISCUS WALL 审中-公开
标题翻译：液体男式镜片，带凹凸纹身男士胸衣
公开(公告)号：WO2012015719A1
公开(公告)日：2012-02-02
申请号：PCT/US2011/045149
申请日：2011-07-25
申请人： JOHNSON & JOHNSON VISION CARE, INC. , PUGH, Randall, B. , OTTS, Daniel, B. , TONER, Adam , KERNICK, Edward, R. , RIALL, James, Daniel , SNOOK, Sharika
发明人： PUGH, Randall, B. , OTTS, Daniel, B. , TONER, Adam , KERNICK, Edward, R. , RIALL, James, Daniel , SNOOK, Sharika
IPC分类号： G02B3/14 , A61F2/16 , G02B1/04 , G02C7/04 , G02C7/08
CPC分类号： G02B3/14 , A61F2/1627 , A61F2/1635 , G02C7/085
摘要： The present invention relates generally to a liquid meniscus lens with a meniscus wall. Some specific embodiments include a liquid meniscus lens with a meniscus wall essentially in the shape of a conical frustum with at least a portion of the conical frustum convex toward the optical axis. Embodiments may also include a lens of suitable size and shape for inclusion in a contact lens.
摘要翻译：本发明一般涉及具有弯液面壁的液体弯月透镜。一些具体实施例包括具有弯月面壁的液体弯月透镜，其基本上为锥形截头锥体的形状，其中锥形截头锥体的至少一部分朝向光轴凸出。实施例还可以包括适合于包含在隐形眼镜中的尺寸和形状的镜片。

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